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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States.The majority of patients are candidates only for palliative chemotherapy,which has proven largely ineffective in halting tumor progression.One proposed mechanism of chemoresistance involves signaling via the mesenchymalepithelial transition factor protein(MET),a previously established pathway critical to cell proliferation and migration.Here,we review the literature to characterize the role of MET in the development of tumorigenesis,metastasis and chemoresistance,highlighting the potential of MET as a therapeutic target in pancreatic cancer.In this review,we characterize the role of c-Met in the development of tumorigenesis,metastasis and chemoresistance,highlighting the potential of c-Met as a therapeutic target in pancreatic cancer. | Daniel Delitto Eva Vertes-George Steven J Hughes Kevin E Behrns Jose G Trevino | 2014 | World Journal of Gastroenterology2014，20，26： | 6 |
| 3 | 调节IL-1受体转位至焦点附着斑的观察显示文摘目的 探讨影响Ⅰ型IL 1受体 (IL 1RⅠ )转位至焦点附着斑的相关因素。方法 将含有绿色荧光蛋白 (GFP)基因的重组型和突变型 (C末端突变 )IL 1RⅠ质粒转染进入成纤维细胞 ,细胞生长于有或无纤维粘连蛋白的培养皿上 ,用激光共聚焦显微镜直接观察所表达的融合蛋白在细胞内的定位 ,IL 1β刺激后发生转位 ,并观察经免疫细胞化学染色后 ,细胞骨架蛋白Vinculin的位置。结果 转染了重组型IL 1R1质粒的细胞生长在纤维粘连蛋白上 ,表达的受体融合蛋白与Vinculin位于细胞膜的焦点附着斑 ,用IL 1β刺激可致受体转位至细胞内。转染突变型质粒的细胞 ,表达的融合蛋白位于胞质的核周区域 ,IL 1β刺激后不产生转位。 结论 Ⅰ型IL 1受体转位至焦点附着斑需要Vinculin等细胞外基质的参与并与受体C | 黄文燕 朱文渊 罗秀梅 许孟杰 Eva E QWARNSTROM | 2004 | 免疫学杂志2004，20，1： | 3 |
| 4 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 5 | Novel animal models of affective disorders显示文摘 | Eva E Redei Nasim Ahmadiyeh Amber E Baum | 2001 | Semin Clin Neuropsychiatry2001，6，1： | 1 |
| 6 | 显示文摘 | Blagodatskikh I V Vasil'eva O V Ivanova E M | 2004 | Polymer2004，45，： | 1 |
| 7 | Antifriction coatings of Pb-Sn-Cu alloy electro-deposited from methanesulphonate bath 显示文摘 | DANILOV F I PROTSENKO V S VASIL'EVA E A | 2011 | Transactions of the Institute of Metal Finishing2011，89，3： | 1 |
| 8 | Synthesis and immunomodulating activity of new amino acid derivatives of glycyrrhizic acid and its methyl ester显示文摘 | Baltina L A Vasil' eva E V | 2004 | Bioorg Khim2004，30，2： | 1 |
| 9 | Altered c-Jun expression: An early eve nt in human lung carcinogenesis显示文摘 | Maura E | 1996 | Caner Res1996，56，： | 1 |
| 10 | Long-term variability and methods of forecasting dates of ice break-up in the mouth area of the Ob and Yenisei rivers显示文摘 | Shevnina E V Solov' eva Z S | 2008 | Russian Meteorology and Hydrology2008，33，7： | 1 |
| 11 | Stress in Broiler Chickens Due to Acute Noise Exposure显示文摘 | Chloupek P Chloupek P Eva Vaskiova E | 2009 | Act V B2009，78，： | 1 |
| 12 | Transgenic mouse model for estrogen-regulated lipoprotein metabolism:studies on apoVLDL-Ⅱ expression in transgenic mice显示文摘 | EVA Z MELINDA K N FRANCA E | 1995 | J Lipid Res1995，36，7： | 1 |
| 13 | Developmental specifici- ty of auxin response by pairs of ARF and Aux/IAA tran- scriptional regulators显示文摘 | DOLF W EVA B KATJA E J | 2005 | The EMBO Journal2005，24，10： | 1 |
| 14 | Nonlinear absorption phenomena in optical materials for the UV-spectral range显示文摘 | Eva E Mann K | 1997 | Applied Surface Science1997，，： | 1 |
| 15 | Combined determination of spontaneous and antigen-induced production of cytokines for differential diagnostics of active tuberculosis of lungs and latent tuberculosis infection显示文摘 | Vasil'eva E V Verbov V N Ivanovskii V B | 2013 | J Mikrobiol Epide- miol Immunobiol2013，，4： | 1 |
| 16 | Rediscovering PDE3 inhibitors-new opportunities for a long neglected target 显示文摘 | Thompson Philip E Manganiello Vincent Degerman Eva | 2007 | Current Topics in Medicinal Chemistry (Sharjah United Arab Emirates)2007，7，4： | 1 |
| 17 | Repetitive element sequence based polymerase chain reaction for typing of Brucella strains显示文摘 | Tchern eva E Rijpens N Naydensky C | 1996 | Vet Microbiol1996，51，： | 1 |
| 18 | Plasma needle treatment of substrates with respect to wettability and growth of escherichia coli and streptococcus mutans显示文摘 | Raymond E J Sladek Tom A Baede Eva Stoffels | 2006 | IEEE Trans on Plasma Sci2006，34，4： | 1 |
| 19 | Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver显示文摘 | van de Steeg Evita Stránecky Viktor Hartmannová Hana Nosková Lenka Hrebícek Martin Wagenaar Els van Esch Anita de Waart Dirk R Elferink Ronald P J Oude Kenworthy Kathryn E Sticová Eva al-Edreesi Mohammad Knisely A S Kmoch Stanislav Jirsa Mi | 2012 | EN2012，，2： | 1 |
| 20 | The EMT signaling pathways in endometrial carcinoma显示文摘 | Eva Colas Nuria Pedrola Laura Devis Tug?e Ertekin Irene Campoy Elena Martínez Marta Llauradó Marina Rigau Mireia Olivan Marta Garcia Silvia Cabrera Antonio Gil-Moreno Jordi Xercavins Josep Castellvi Angel Garcia Santiago Ramon y Cajal Gema Moreno-Bueno Xa | 2012 | Clinical and Translational Oncology2012，，： | 1 |
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