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| 1 | A survey of social network and information dissemination analysis显示文摘In recent years,with the rapid growth of social network services(SNS),social networks pervade nearly every aspect of our daily lives.Social networks are influencing today’s societal and cultural issues,and changing the way of people seeing themselves.To fully understand the running mechanisms of social networks,in this paper,we aim at series of high knitted and important elements of online social networks.We mainly focus on 3 important but also open research problems,they are(1)structural properties and evolving laws,(2)social crowds and their interaction behaviors and(3)information and its diffusion.In this paper,we review the related work on the 3 problems.Then,we briefly introduce some interesting research directions and our progress on these research problems. | Binxing Fang Yan Jia Yi Han Shasha Li Bin Zhou | 2014 | Chinese Science Bulletin2014，59，32： | 7 |
| 2 | The rising star in photovoltaics-perovskite solar cells: The past, present and future显示文摘Perovskite solar cell(PVSC), after its invention since 2009, has attracted tremendous attention from both academia and industry, because of its low cost, ease of manufacturing features and the sky-rocketing efficiencies being achieved within such a short period of time. Currently, the new efficiency record has reached 21.0%, comparable to that of the commercialized PV technologies developed for decades, such as multi-crystalline Si, CIGS and Cd Te thin film solar cells. It is very possible that PVSCs would one day step over the threshold of marketization, share or even overturn the current PV market dominated by crystalline-Si solar cells. However, there are still several obstacles to be overcome on the road towards PVSC industrialization. This paper has reviewed the brief developing history and the current research status of PVSCs, and explained: Why PVSCs are so important in the next-generation solar cells, why organometal halide perovskites work so well as light absorbers, and what the inherent differences are among different cell configurations. The prospects on how to realize scale-up industrialization of PVSCs have also been given in the sequence of efficiency, stability, cost, toxicity, and short-term objectives. Resolutions to the remaining challenges according to their orders of technical difficulty and importance have also been discussed. | FANG Rui ZHANG WenJun ZHANG ShaSha CHEN Wei | 2016 | Science China(Technological Sciences)2016，59，7： | 6 |
| 3 | Phytosterol content and the campesterol:sitosterol ratio influence cotton fiber development: role of phytosterols in cell elongation显示文摘Phytosterols play an important role in plant growth and development,including cell division,cell elongation,embryogenesis,cellulose biosynthesis,and cell wall formation.Cotton fiber,which undergoes synchronous cell elongation and a large amount of cellulose synthesis,is an ideal model for the study of plant cell elongation and cell wall biogenesis.The role of phytosterols in fiber growth was investigated by treating the fibers with tridemorph,a sterol biosynthetic inhibitor.The inhibition of phytosterol biosynthesis resulted in an apparent suppression of fiber elongation in vitro or in planta.The determination of phytosterol quantity indicated that sitosterol and campesterol were the major phytosterols in cotton fibers;moreover,higher concentrations of these phytosterols were observed during the period of rapid elongation of fibers.Furthermore,the decrease and increase in campesterol:sitosterol ratio was associated with the increase and decease in speed of elongation,respectively,during the elongation stage.The increase in the ratio was associated with the transition from cell elongation to secondary cell wall synthesis.In addition,a number of phytosterol biosynthetic genes were down-regulated in the short fibers of ligon lintless-1mutant,compared to its near-isogenic wild-type TM-1.These results demonstrated that phytosterols play a crucial role in cotton fiber development,and particularly in fiber elongation. | Shasha Deng Ting Wei Kunling Tan Mingyu Hu Fang Li Yunlan Zhai Shue Ye Yuehua Xiao Lei Hou Yan Pei Ming Luo | 2016 | Science China(Life Sciences)2016，59，2： | 5 |
| 4 | Clinical laboratory features of Meigs’syndrome:a retrospective study from 2009 to 2018显示文摘Meigs’syndrome(MS),a rare complication of benign ovarian tumors,is easily misdiagnosed as ovarian cancer(OC).We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018.Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma(OTF)and healthy control groups(all P<0.05).However,the serum HE4 levels were lower in the MS group than in the OC group(P<0.001).A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups(all P<0.05).However,these variables were higher in the MS group than in the OC group(both P<0.05).The neutrophil-to-lymphocyte ratio(NLR)was also significantly lower,whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group(both P<0.05).The NLR,platelet-to-lymphocyte ratio,and systemic immune index were significantly higher in the MS group than in the OTF and control groups(all P<0.05).The hypoxia-inducible factor-1 mRNA levels were also significantly higher,whereas the glucose transporter 1,lactate dehydrogenase,and enolase 1 mRNA levels were lower in peripheral CD4+T cells obtained preoperatively in a patient with MS than those in patients with OTF,patients with OC,and controls(all P<0.05).The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS(P<0.001).These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS. | Wenwen Shang Lei Wu Rui Xu Xian Chen Shasha Yao Peijun Huang Fang Wang | 2021 | Frontiers of Medicine2021，15，1： | 4 |
| 5 | Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia-reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination显示文摘Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention(PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in AMI patients. We revealed the effects of HSP47 on myocardial ischemia-reperfusion injury(IRI) and shed light on the underlying molecular mechanism.We generated adult mice with lentivirus-mediated or miRNA(mi1/133TS)-aided cardiac fibroblastselective HSP47 overexpression. Myocardial IRI was induced by 45-min occlusion of the left anterior descending(LAD) artery followed by 24 h reperfusion in mice, while ischemia-mediated cardiac remodeling was induced by four weeks of reperfusion. Also, the role of HSP47 in fibrogenesis was evaluated in cardiac fibroblasts following hypoxia-reoxygenation(HR). Extensive HSP47 was observed in murine infarcted hearts, human ischemic hearts, and cardiac fibroblasts and accelerated oxidative stress and apoptosis after myocardial IRI. Cardiac fibroblast-selective HSP47 overexpression exacerbated cardiac dysfunction caused by chronic myocardial IRI and presented deteriorative fibrosis and cell proliferation.HSP47 upregulation in cardiac fibroblasts promoted TGFβ1-Smad4 pathway activation and Smad4 deubiquitination by recruiting ubiquitin-specific peptidase 10(USP10) in fibroblasts. However, cardiac fibroblast specific USP10 deficiency abolished HSP47-mediated fibrogenesis in hearts. Moreover, blockage of HSP47 with Col003 disturbed fibrogenesis in fibroblasts following HR. Altogether, cardiac fibroblast HSP47 aggravates fibrosis post-myocardial IRI by enhancing USP10-dependent Smad4 deubiquitination,which provided a potential strategy for myocardial IRI and cardiac remodeling. | Saiyang Xie Yun Xing Wenke Shi Min Zhang Mengya Chen Wenxi Fang Shiqiang Liu Tong Zhang Xiaofeng Zeng Si Chen Shasha Wang Wei Deng Qizhu Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 6 | Heavy metals in coastal wetland sediments of the Pearl River Estuary, China显示文摘 | QuSheng Li ZhiFeng Wu Bei Chu Na Zhang ShaSha Cai JianHong Fang | 2007 | Environmental Pollution2007，，2： | 1 |
| 7 | Reduced salinity interacts with ultraviolet radiation to alter photosystem Ⅱ function in diatom Skeletonema costatum显示文摘To investigate the effect of reduced salinity on diatoms’ capacity to cope with changing ultraviolet radiation(U VR) and photosynthetically active radiation(PAR),Skeletonema costatum was grown in a range of salinity(15,25,and 35).The photo system Ⅱ(PSⅡ) function was analyzed by increasing PAR and UVR to mimic a mixing event in turbulent waters.The re sults show that high UVR exposure significantly reduced PSII activity,especially in cells grown at low salinity.UVR,but not salinity,stimulated the ’removal’ rate of PSII protein PsbA.Salinity alone,in the range of 15 to 35,did not regulate PSⅡ acceptor region;however,the low salinity+UVR treatment decreased the energy flux for electron transport per PSⅡ reaction center in S.costatum.It showed that low salinity exacerbated the damaging effect of UVR on PSⅡ function in S.costatum by suppressing Psb A protein synthe sis and modifying the photochemistry of PSⅡ.Although higher catalase(CAT) activity and NPQs were induced,they were unable to prevent the combined damage effect of low salinity+UVR.Our findings indicate that reduced salinity and increased UVR potentially affect the abundance and distribution of S.costatum with the escalation of climate disturbances. | Shasha ZANG Fang YAN Daode YU Jingjing SONG Lei WANG Zhiguang XU Hongyan WU | 2022 | Journal of Oceanology and Limnology2022，40，4： | 1 |
| 8 | TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ显示文摘 | Youzhi Zhang Xiaoyan Yang Fang Bian Pinhui Wu Shasha Xing Gao Xu Wenjing Li Jiangyang Chi Changhan Ouyang Tao Zheng Dan Wu Yonghui Zhang Yongsheng Li Si Jin | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 9 | Surface modification of Ti-45Al-8.5 Nb alloys by microarc oxidation to improve high-temperature oxidation resistance显示文摘Microarc oxidation(MAO)electrolysis plasma deposition was used to prepare Al_2O_3coatings on Ti-45Al-8.5 Nb alloys to improve high temperature oxidation resistance.The surface and cross-section morphologies before and after high-temperature oxidation,the chemical composition,and the phase identification of the coatings were investigated by scanning electron microscopy(SEM),electron probe microanalyses(EPMA),and X-ray diffraction(XRD).The results show that Al_2O_3coatings with a thickness of approximately 8μm can be obtained on the Ti-45Al-8.5 Nb alloys by MAO for 600 s.The samples with the Al_2O_3coatings exhibited better high-temperature oxidation resistance.A minimal weight gain of only 0.396 g/m^2after 100 h oxidation at 900°C was observed for the coatings formed with a deposition voltage of 400 V and using a duty cycle of 3%.The deposition mechanism of the Al_2O_3coatings and the effect of the MAO parameters are also described. | Fang Cheng Shasha Li Wanyuan Gui Junpin Lin | 2018 | Progress in Natural Science:Materials International2018，28，3： | 1 |
| 10 | Characterization of polypropylene–polyethylene blends made of waste materials with compatibilizer and nano-filler显示文摘 | Changing Fang Long Nie Shaolong Liu Ruien Yu Ningli An Shasha Li | 2013 | Composites Part B2013，，： | 1 |
| 11 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 12 | Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2显示文摘Protein kinase CK2 consists of two catalytic subunits (CK2α) and two regulatory subunits (CK2β). Here, we report the crystal structures of rat CK2α mutant (rCK2α-△C, 1—335) and CK2β (rCK2β). The overall topology of rCK2α-△C and rCK2β are very similar to the human enzyme, although large structural differences could be observed in the N-terminal domain of rCK2α-△C. Our reported structure of rCK2α-△C is in the close conformation state while the counterpart hCK2α is in the open conformation state, indi- cating the conformation of CK2α molecule has high plasticity. The structure of rCK2β represents the conformation of free CK2β. Upon CK2α binding, the C-terminal region undergoes a drastic conformational change. The major region of interaction within the interface of CK2α/CK2β may serve as a bridge to transmit the conformational change and thus regulate the activity of CK2α. | ZHOU WeiHong QIN XiaoHong YAN XiaoJie XIE XingQiao LI Liang FANG ShaSha LONG JiaFu ADELMAN John TANG Wei-Jen SHEN YueQuan | 2009 | Chinese Science Bulletin2009，54，2： | 0 |
| 13 | Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA显示文摘Integrase plays a critical role in the recombination of viral DNA into the host genome.Therefore,over the past decade,it has been a hot target of drug design in the fight against type 1 human immunodeficiency virus(HIV-1).Bovine immunodeficiency virus(BIV)integrase has the same function as HIV-1 integrase.We have determined crystal structures of the BIV integrase catalytic core domain(CCD)in two different crystal forms at a resolution of 2.45Åand 2.2Å,respectively.In crystal form I,BIV integrase CCD forms a back-to-back dimer,in which the two active sites are on opposite sides.This has also been seen in many of the CCD structures of HIV-1 integrase that were determined previously.However,in crystal form II,BIV integrase CCD forms a novel face-toface dimer in which the two active sites are close to each other.Strikingly,the distance separating the two active sites is approximately 20Å,a distance that perfectly matches a 5-base pair interval.Based on these data,we propose a model for the interaction of integrase with its target DNA,which is also supported by many published biochemical data.Our results provide important clues for designing new inhibitors against HIV-1. | Xue Yao Shasha Fang Wentao Qiao Yunqi Geng Yuequan Shen | 2010 | Protein & Cell2010，1，4： | 0 |
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