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| 1 | Sirtuins and nonalcoholic fatty liver disease显示文摘Mammalian sirtuins are seven members belonging to the silent information regulator 2 family, a group of Class Ⅲ histone/protein deacetylases. Sirtuins(SIRT 1-7) have different subcellular localization and function and they regulate cellular protein function through various posttranslational modifications. SIRT1 and 3, the most studied sirtuins, use the product of cellular metabolism nicotinamide adenine dinucleotide as a cofactor to post-translationally deacetylate cellular proteins and consequently link the metabolic status of the cell to protein function. Sirtuins have been shown to play a key role in the development and rescue of various metabolic diseases including non-alcoholic fatty liver disease(NAFLD). NAFLD is currently the most chronic liver disease due mainly to high-calorie consumption and lower physical activity. No pharmacological approach is available to treat NAFLD, the current recommended treatment are lifestyle modification such as weight loss through calorie restriction and exercise. Recent studies have shown downregulation of sirtuins in human as well as animal models of NAFLD indicating an important role of sirtuins in the dynamic pathophysiology of NAFLD. In this review, we highlight the recent knowledge on sirtuins, their role in NAFLD and their unique potential role as novel therapeutic target for NAFLD treatment. | Fatiha Nassir Jamal A Ibdah | 2016 | World Journal of Gastroenterology2016，22，46： | 19 |
| 2 | Role of mitochondria in alcoholic liver disease显示文摘Alcohol abuse is the leading cause of liver related morbidity and mortality.Chronic or binge alcohol drinking causes hepatic steatosis which can develop to steatohepatitis,cirrhosis and ultimately hepatocellular carcinoma.The pathogenesis of alcoholic liver disease(ALD)is poorly characterized,however several recent studies point to a major role of mitochondria in this process.Mitochondria play a crucial role in cellular energy metabolism and in reactive species formation.Alcohol treatment causes mitochondrial DNA damage,lipid accumulation and oxidative stress.Studies in both animal models and in humans showed that alcohol administration causes changes in the mitochondrial morphology and function suggesting a role of these changes in the pathogenesis of ALD.We review recent findings on mechanisms by which alcohol negatively impacts mitochondrial biogenesis and function and we will discuss the specific intracellular pathways affected by alcohol consumption.Interestingly,recent findings indicate that a large number of mitochondrial proteins are acetylated and that mitochondrial proteins acetylation and sirtuins are modulated by alcohol.Un-derstanding the mechanisms behind alcohol mediated impaired mitochondrial biogenesis and function may help identify potential therapeutic targets for treating ALD in humans. | Fatiha Nassir Jamal A Ibdah | 2014 | World Journal of Gastroenterology2014，20，9： | 18 |
| 3 | A review of human carcinogens—Part B: biological agents显示文摘 | Véronique Bouvard Robert Baan Kurt Straif Yann Grosse Béatrice Secretan Fatiha El Ghissassi Lamia Benbrahim-Tallaa Neela Guha Crystal Freeman Laurent Galichet Vincent Cogliano | 2009 | Lancet Oncology2009，，4： | 4 |
| 4 | Easy removing of phenol from wastewater using vegetable oil-based organic solvent in emulsion liquid membrane process显示文摘Phenol is considered as pollutant due to its toxicity and carcinogenic effect.Thus,variety of innovative methods for separation and recovery of phenolic compounds is developed in order to remove the unwanted phenol from wastewater and obtain valuable phenolic compound.One of potential method is extraction using green based liquid organic solvent.Therefore,the feasibility of using palm oil was investigated.In this research,palm oil based organic phase was used as diluents to treat a simulated wastewater containing 300×10^(-6) of phenol solution using emulsion liquid membrane process(ELM).The stability of water-in-oil(W/O) emulsion on diluent composition and the parameters affecting the phenol removal efficiency and stability of the emulsion;such as emulsification speed,emulsification time,agitation speed,surfactant concentration,pH of external phase,contact time,stripping agent concentration and treat ratio were carried out.The results of ELM study showed that at ratio7 to 3 of palm oil to kerosene,5 min and 1300 r·min^(-1) of emulsification process the stabile primary emulsion were formed.Also,no carrier is needed to facilitate the phenol extraction.In experimental conditions of500 r·min^(-1) of agitation speed,3%Span 80,pH 8 of external phase,5 min of contact time,0.1 mol·L^(-1) NaOH as stripping agent and 1:10 of treat ratio,the ELM process was very promising for removing the phenol from the wastewater.The extraction performance at about 83%of phenol was removed for simulated wastewater and an enrichment of phenol in recovery phase as phenolate compound was around 11 times. | Norasikin Othman Norul Fatiha Mohamed Noah Lim Yin Shu Zing-Yi Ooi Norela Jusoh Mariani Idroas Masahiro Goto | 2017 | Chinese Journal of Chemical Engineering2017，25，1： | 4 |
| 5 | Small scale biodiesel synthesis from waste frying oil and crude methanol in Morocco显示文摘Biodiesel was produced at small scale by transesterification of used frying oil(UFO) recovered from Moroccan pastry shops and fish frying restaurants. Biodiesel was first synthesised at laboratory scale in order to optimize the transesterification parameters. The cost of the final product was also optimized using low-cost raw materials.The UFO and the produced biodiesel were characterized with several techniques including gas chromatography,1H NMR,13 C NMR, FTIR, and TGA–TDA techniques.1H NMR gas chromatographic analyses of the final product confirmed that the transesterification in the chosen experimental conditions was completed. These results were confirmed by TGA–TDA analysis used as new techniques to monitoring triglyceride conversion. The biodiesel did not contain any trace of glycerol, and it did meet the international standards. The transesterification at low cost in small scale conditions was performed at 60 °C using 1.2% of KOH and a methanol/oil molar ratio of 6:1. A yield of 80.8% was achieved. The properties of the produced biodiesel were found to be as good as those of biodiesels obeying to European standards. The biodiesel production was also performed at small-scale for individual utilisation. Thus, the product was tested in a kerosene stove for heating and non-modified commercial diesel engine producing electricity. | Fatiha Ouanji Marouane Nachid Mohamed Kacimi Leonarda F.Liotta Fabtizio Puleo Mahfoud Ziyad | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 3 |
| 6 | Effect of Verticillium lecanfi on biological characteristics and life table of Serangium japonicum (Coleoptera: Coccinellidae), a predator of whiteflies under laboratory conditions显示文摘 | Lazreg Fatiha Zhen Huang Shun-Xiang Ren Shaukat Ali | 2008 | Insect Science2008，15，4： | 3 |
| 7 | Surfactant remediation of diesel fuel polluted soil显示文摘 | Razika Khalladi Ouassila Benhabiles Fatiha Bentahar Naji Moulai-Mostefa | 2008 | Journal of Hazardous Materials2008，，2： | 2 |
| 8 | Carcinogenicity of alcoholic beverages显示文摘 | Robert Baan Kurt Straif Yann Grosse Béatrice Secretan Fatiha El Ghissassi Véronique Bouvard Andrea Altieri Vincent Cogliano | 2007 | Lancet Oncology2007，，4： | 2 |
| 9 | Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation显示文摘 | Antoine Hannoun Ghina Ghaziri Antoine Abu Musa Tony G. Zreik Fatiha Hajameh Johnny Awwad | 2009 | Reproductive BioMedicine Online2009，，： | 2 |
| 10 | Quantum Secret Sharing with Error Correction显示文摘We investigate in this work a quantum error correction on a five-qubits graph state used for secret sharing through five noisy channels. We describe the procedure for the five, seven and nine qubits codes. It is known that the three codes always allow error recovery if only one among the sent qubits is disturbed in the transmitting channel. However, if two qubits and more are disturbed, then the correction will depend on the used code. We compare in this paper the three codes by computing the average fidelity between the sent secret and that measured by the receivers. We will treat the case where, at most, two qubits are affected in each one of five depolarizing channels. | Aziz Mouzali Fatiha Merazka Damian Markham | 2012 | Communications in Theoretical Physics2012，58，11： | 2 |
| 11 | Carcinogenicity of nitrate, nitrite, and cyanobacterial peptide toxins显示文摘 | Yann Grosse Robert Baan Kurt Straif Béatrice Secretan Fatiha El Ghissassi Vincent Cogliano | 2006 | Lancet Oncology2006，，8： | 1 |
| 12 | Nickel iron layered double hydroxide (LDH)~ Textural properties upon hydrothermal treatments and application on dye sorption显示文摘 | Saiah Fatiha Boukraa Djellal Su Bao-Lian Bettahar Nourredine | 2009 | Hazardous Materials2009，165，： | 1 |
| 13 | Generalized discriminant analysis using a kernel approach 显示文摘 | G Baudat Fatiha Anouar | 2000 | Neural Computationn2000，，12： | 1 |
| 14 | Generalized discriminant analysis using a kernel approach显示文摘 | Fatiha Anouar | 2000 | Neural Computation2000，1，12： | 1 |
| 15 | A rigid imageregistration based on the nonsubsampled Contourlet transformand genetic algorithms 显示文摘 | Fatiha M Miloud C E M Nasreddine T | 2010 | Sensors2010，10，9： | 1 |
| 16 | Nickel-iron layered double hydroxide (LDH): Textural properties upon hydrothermal treatments and application on dye sorption 显示文摘 | Fatiha Boukraa Djellal Saiah Bao-Lian Su Nourredine Bettahar | 2009 | Journal of Hazardous Materials2009，165，： | 1 |
| 17 | Changes in polyamines synthesisduring anther development and pollen germination in tobacco (Nicotiana tabacum ) 显示文摘 | Fatiha C Angel J M Trimindad A | 1994 | Physiol Plant1994，92，： | 1 |
| 18 | A review of human carcinogens—Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish显示文摘 | Béatrice Secretan Kurt Straif Robert Baan Yann Grosse Fatiha El Ghissassi Véronique Bouvard Lamia Benbrahim-Tallaa Neela Guha Crystal Freeman Laurent Galichet Vincent Cogliano | 2009 | Lancet Oncology2009，，11： | 1 |
| 19 | Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts显示文摘 | Yann Grosse Robert Baan Béatrice Secretan-Lauby Fatiha El Ghissassi Véronique Bouvard Lamia Benbrahim-Tallaa Neela Guha Farhad Islami Laurent Galichet Kurt Straif | 2011 | Lancet Oncology2011，，4： | 1 |
| 20 | Analysis of dystrophin gene deletions by multiplex PCR in Moroccan patients 显示文摘 | Aziza S Fatiha EK Abdelaziz S | 2002 | J Biomed Biotechnol2002，2，3： | 1 |
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