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| 1 | HBV cccDNA in patients' sera as an indicator for HBV reactivation and an early signal of liver damage显示文摘AIM: To evaluate the covalently closed circle DNA (cccDNA)level of hepatitis B virus (HBV) in patients' liver and sera. METHODS: HBV DNA was isolated from patients' liver biopsies and sera. A sensitive real-time PCR method, which is capable of differentiation of HBV viral genomic DNA and cccDNA, was used to quantify the total HBV cccDNA. The total HBV viral DNA was quantitated by real-time PCR using a HBV diagnostic kit (PG Biotech, LTD, Shenzhen, China)described previously. RESULTS: For the first time, we measured the level of HBV DNA and cccDNA isolated from ten HBV patients' liver biopsies and sera. In the liver biopsies, cccDNA was detected from all the biopsy samples. The copy number of cccDNA ranged from from 0.03 to 173.1 per ceil, the copy number of total HBV DNA ranged from 0.08 to 3 717 per cell. The ratio of total HBV DNA to cccDNA ranged from 1 to 3 406. In the sera,cccDNA was only detected from six samples whereas HBV viral DNA was detected from all ten samples. The ratio of cccDNA to total HBV DNA ranged from 0 to 1.77%. To further investigate the reason why cccDNA could only be detected in some patients' sera, we performed longitudinal studies. The cccDNA was detected from the patients' sera with HBV reactivation but not from the patients' sera without HBV reactivation. The level of cccDNA in the sera was correlated with ALT and viral load in the HBV reactivation patients. CONCLUSION: HBV cccDNA is actively transcribed and replicated in some patients' hepatocytes, which is reflected by a high ratio of HBV total DNA vs cccDNA. Detection of cccDNA in the liver biopsy will provide an end-point for the anti-HBV therapy. The occurrence of cccDNA in the sera is an early signal of liver damage, which may be another important clinical parameter. | Johnny Sze | 2004 | World Journal of Gastroenterology2004，10，1： | 107 |
| 2 | Influence of South China Sea SST and the ENSO on Winter Rainfall over South China显示文摘The present study investigates the influence of South China Sea (SCS) SST and ENSO on winter (January-February-March; JFM) rainfall over South China and its dynamic processes by using station observations for the period 1951-2003, Met Office Hadley Center SST data for the period 1900-2008, and ERA-40 reanalysis data for the period 1958-2002. It is found that JFM rainfall over South China has a sig- nificant correlation with Nio-3 and SCS SST. Analyses show that in El Nio or positive SCS SST anomaly years, southwesterly anomalies at 700 hPa dominate over the South China Sea, which in turn transports more moisture into South China and favors increased rainfall. A partial regression analysis indicates that the independent ENSO influence on winter rainfall occurs mainly over South China, whereas SCS SST has a larger independent influence on winter rainfall in northern part of South China. The temperature over South China shows an obvious decrease at 300 hPa and an increase near the surface, with the former induced by Nio-3 and the latter SCS SST anomalies. This enhances the convective instability and weakens the potential vorticity (PV), which explains the strengthening of ascending motion and the increase of JFM rainfall over South China. | 周连童 Chi-Yung TAM 周文 Johnny C. L. CHAN | 2010 | Advances in Atmospheric Sciences2010，27，4： | 34 |
| 3 | 在EBEX-2000实验资料中湍流谱和局地各向同性特征显示文摘采用 2 0 0 0年 8月在美国加州棉花地两个高度上应用超声三分量仪、快速响应温度和湿度仪进行的EBEX 2 0 0 0(InternationalEnergyBalanceExperiment,2 0 0 0 ,EBEX 2 0 0 0 )风速三分量、温度和湿度湍流实验观测数据 ,计算分析了湍流速度、温度和湿度谱在不同稳定度下的特征。对湍流的局地各向同性进行了讨论并与Kansas和长白山原始森林湍流实验得到的结果进行了比较 ,得到了一些湍流特征量在不同下垫面情况下的一些有意义的特征。 | 刘树华 李洁 刘和平 梁福明 王建华 Johnny C.L.CHAN Andrew Y.S.CHENG 胡非 刘辉志 | 2005 | 大气科学2005，29，2： | 24 |
| 4 | Interannual and Interdecadal Variability of Winter Precipitation over China in Relation to Global Sea Level Pressure Anomalies显示文摘Based on the method of rotated principal component (RPC) analysis and wavelet transforms, the win-ter precipitation from 36 stations over China for the period 1881-1993 is examined. The results show thatthe three leading space-time modes correspond, in sequence, to winter rainfall anomalies over the reaches ofthe Yangtze River, the bend of the Yellow River, and the northeastern region of China. The three modes ex-hibit interannual oscillations with quasi-biennial and 8-year periods as well as interdecadal oscillationswith 16- and 32-year periods. The interannual oscillation (< 10 years) occurs in phase over the differentareas, and its maximum amplitude migrates northward considerably with prominent interdecadal variations.However, the interdecadal oscillations (10-32 years) are out of phase over the different regions, and theamplitude variations have the characteristics of stationary waves.The rainfall anomalies appear to be closely re lated to the anti-phase changes of mean sea-level pres-sure (SLP) over the Asian mainland and the North Pacific. When the SLP rises over the North Pacific anddecreases over the Asian mainland, the precipitation over East China increases noticeably. The linkage be-tween the rainfall over China and the SLP anomalies apparently results from the strength of the East Asianwinter monsoon and its associated temperature and moisture advection. | Jianjun Xu Johnny C.L Chan | 2002 | Advances in Atmospheric Sciences2002，19，5： | 15 |
| 5 | Wafer-scale synthesis of monolayer WS2 for high-performance flexible photodetectors by enhanced chemical vapor deposition显示文摘 | Changyong Lan Ziyao Zhou Zhifei Zhou Chun Li Lei Shu Lifan Shen Dapan Li Ruoting Dong SenPo Yip Johnny C. Ho | 2018 | Nano Research2018，11，6： | 12 |
| 6 | 在EBEX-2000实验资料中的湍流宏观量特征显示文摘采用2000年8月在美国加州棉花地两个高度上应用超声三分量仪、快速响应温度和湿度仪进行的EBEX2000(InternationalEnergyBalanceExperiment,2000)风速三分量、温度和湿度湍流实验观测数据,计算分析了湍流宏观量(即u,T,σu/u,σv/u,σw/u和σT/T等),湍流动能和感热通量等的特征,并与其他湍流实验得到的结果进行了比较。 | 刘树华 李洁 刘和平 梁福明 王建华 Johnny C.L.CHAN Andrew Y.S.CHENG 胡非 刘辉志 | 2005 | 大气科学2005，29，4： | 11 |
| 7 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 8 | Van der Waals magnets: Wonder building blocks for two-dimensional spintronics?显示文摘The unprecedented realization of two-dimensional(2D)van der Waals magnets excitingly extends the synergy between spintronics and 2D materials,started with graphene over the last decade.This article reviews the recent milestones in the development of 2D magnets and its derived heterostructures.In particular,a number of critical challenges centered around the scalability,ambient stability and Curie temperature of these atomically thin magnets are discussed.This mini-review also provides an outlook on what the future might hold for this integrated field of 2D spintronics,and assesses its potential in postsilicon electronics. | Wen Zhang Ping Kwan Johnny Wong Rui Zhu Andrew T.S.Wee | 2019 | InfoMat2019，1，4： | 8 |
| 9 | Mesoscale Vortex Generation and Merging Process: A Case Study Associated with a Post-Landfall Tropical Depression显示文摘An observational analysis of satellite blackbody temperature (TBB) data and radar images suggests that the mesoscale vortex generation and merging process appeared to be essential for a tropical-depression-related heavy rain event in Shanghai, China. A numerical simulation reproduced the observed mesoscale vortex generation and merging process and the corresponding rain pattern, and then the model outputs were used to study the related dynamics through diagnosing the potential vorticity (PV) equation. The tropical depression (TD) was found to weaken first at lower levels and then at upper levels due to negative horizontal PV advection and diabatic heating effects. The meso-vortices developed gradually, also from the lower to the upper levels, as a result of positive horizontal PV advection and diabatic heating effects in the downshear left quadrant of the TD. One of these newly-generated vortices, V1, replaced the TD ultimately, while the other two, V2 and V3, merged due to the horizontal PV advection process. Together with the redevelopment of V1, the merging of V2 and V3 triggered the very heavy rain in Shanghai. | 喻自凤 梁旭东 余晖 Johnny C. L. CHAN | 2010 | Advances in Atmospheric Sciences2010，27，2： | 7 |
| 10 | 在EBEX-2000实验资料中湍流耗散率、长度尺度和结构参数特征显示文摘采用2000年8月在美国加州棉花地两个高度上应用超声三分量仪、快速响应温度和湿度仪进行的EBEX2000(InternationalEnergyBalanceExperiment,2000,简称EBEX2000)风速三分量、温度和湿度湍流实验观测数据,计算分析了在不同稳定度下的湍流能量和热量耗散率和湍流结构参数特征。并与Kansas和长白山原始森林湍流实验得到的结果进行了比较,得到了一些湍流特征量在不同下垫面情况下的一些有意义的特征。 | 刘树华 刘和平 李洁 梁福明 王建华 Johnny C.L.CHAN AndrewY.S.CHENG 胡非 刘辉志 | 2005 | 大气科学2005，29，3： | 7 |
| 11 | Mapping sea surface velocities in the Changjiang coastal zone with advanced synthetic aperture radar显示文摘Range Doppler velocities derived from the Envisat advanced synthetic aperture radar(ASAR) wide swath images are analyzed and assessed against the numerically simulated surface current fields derived from the finite volume coastal ocean model(FVCOM) for the Changjiang Estuary. Comparisons with the FVCOM simulations show that the European Space Agency(ESA) Envisat ASAR based Doppler shift anomaly retrievals have the capability to capture quantitative information of the surface currents in the Changjiang Estuary. The uncertainty analysis of the ASAR range Doppler velocity estimates are discussed with regard to the azimuthal and range bias corrections, radar incidence angles, inaccuracy in the wind field corrections and the presence of rain cells.The corrected range Doppler velocities for the Changjiang Estuary area are highly valuable as they exhibit quantitative expressions related to the multiscale upper layer dynamics and surface current variability around the East China Sea, including the Changjiang Estuary. | WANG Lihua ZHOU Yunxuan GE Jianzhong JOHANNESSEN Johnny A. SHEN Fang | 2014 | Acta Oceanologica Sinica2014，33，11： | 5 |
| 12 | The Effect of Three-Dimensional Variational Data Assimilation of QuikSCAT Data on the Numerical Simulation of Typhoon Track and Intensity显示文摘In this paper, the three-dimensional variational data assimilation scheme (3DVAR) in the mesoscale model version 5 (MM5) of the US Pennsylvania State University/National Center for Atmospheric Research is used to study the effect of assimilating the sea-wind data from QuikSCAT on the prediction of typhoon track and intensity. The case of Typhoon Dujuan (2003) is first tested and the results show appreciable improvements. Twelve other cases in 2003 are then evaluated. The assimilation of the QuikSCAT data produces significant impacts on the structure of Dujuan in terms of the horizontal and vertical winds, sealevel pressure and temperature at the initial time. With the assimilation, the 24-h (48-h) track prediction of 11 (10) out of the 12 typhoons is improved. The 24-h (48-h) prediction of typhoon intensity is also improved in 10 (9) of the 12 cases. These experiments therefore demonstrate that assimilation of the QuikSCAT sea-wind data can increase the accuracy of typhoon track and intensity predictions through modification of the initial fields associated with the typhoon. | 曾智华 端义宏 梁旭东 马雷鸣 Johnny Chung-leung CHAN 陈仲良 | 2005 | Advances in Atmospheric Sciences2005，22，4： | 5 |
| 13 | 访美国导演克林特·伊斯特伍德显示文摘克林特·伊斯特伍德凭借《百万宝贝》一片夺得了金球奖最佳导演奖,随后又成为2005年的奥斯卡奖的最大赢家。他很激动,确实,对于一个一辈子驰骋于西部电影上的好汉来说,也许这个荣誉,已经宣告了他某个人生阶段的告别。伊斯特伍德说当他饰演《百万宝贝》中那个有双重角色的人物时,也成功完成了他演员和导演双重身份的分裂,接下来,他将慢慢退隐幕昏——'站在镜头后,我非常非常满意。'全能电影人:演、导、制片甚至配乐都插上—手伊斯特伍德是从意大利西部片中客串无名小卒起步的,1966年的《善、恶、丑》中他也只是小人物。现在伊斯特伍德回忆起来会笑着说:'都是些老式的西部片。' | Johnny | 2005 | 电影文学2005，，6： | 5 |
| 14 | Role of microglial cells in photoreceptor degeneration显示文摘Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily cones.The mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of blindness.Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration process.Secondary cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a role.In this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor death.We also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial cells.The inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor degeneration.Furthermore,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations. | Johnny Di Pierdomenico Diego García-Ayuso Marta Agudo-Barriuso Manuel Vidal-Sanz María Paz Villegas-Pérez | 2019 | Neural Regeneration Research2019，14，7： | 4 |
| 15 | 多晶硅薄膜的表面处理工艺显示文摘采用NH3和N2O的等离子体分别对p-Si(多晶硅)薄膜表面进行了钝化处理,处理后的 p-Si TFT(薄膜晶体管)具有比未处理 TFT更优越的性能,通电试验与热应力试验后,处理后的器件呈现出更好的承受电负荷和热应力能力,钝化的微观机理是NH3和N2O等离子体中和了p-Si薄膜的悬挂键,形成牢固的Si-N键,减少了表面态密度. | 曾祥斌 Johnny K O Sin 徐重阳 饶瑞 | 2001 | 无机材料学报2001，16，4： | 4 |
| 16 | Sensitivity of the Simulation of Tropical Cyclone Size to Microphysics Schemes显示文摘The sensitivity of the simulation of tropical cyclone(TC) size to microphysics schemes is studied using the Advanced Hurricane Weather Research and Forecasting Model(WRF). Six TCs during the 2013 western North Pacific typhoon season and three mainstream microphysics schemes–Ferrier(FER), WRF Single-Moment 5-class(WSM5) and WRF Single-Moment6-class(WSM6)–are investigated. The results consistently show that the simulated TC track is not sensitive to the choice of microphysics scheme in the early simulation, especially in the open ocean. However, the sensitivity is much greater for TC intensity and inner-core size. The TC intensity and size simulated using the WSM5 and WSM6 schemes are respectively higher and larger than those using the FER scheme in general, which likely results from more diabatic heating being generated outside the eyewall in rainbands. More diabatic heating in rainbands gives higher inflow in the lower troposphere and higher outflow in the upper troposphere, with higher upward motion outside the eyewall. The lower-tropospheric inflow would transport absolute angular momentum inward to spin up tangential wind predominantly near the eyewall, leading to the increment in TC intensity and size(the inner-core size, especially). In addition, the inclusion of graupel microphysics processes(as in WSM6) may not have a significant impact on the simulation of TC track, intensity and size. | Kelvin T.F.CHAN Johnny C.L.CHAN | 2016 | Advances in Atmospheric Sciences2016，33，9： | 4 |
| 17 | Retinal remodeling following photoreceptor degeneration causes retinal ganglion cell death显示文摘The retina is the extension of the central nervous system that senses light.Cones and rods,situated in the outer retina,convert light into electrical signals that travel through intermediate neurons where these are further processed until they finally reach retinal ganglion cells(RGCs).The afferent neurons of the retina,the RGCs,send | Diego Garcia-Ayuso Johnny Di Pierdomenico Marta Agudo-Barriuso Manuel Vidal-Sanz Maria P. ViUegas-Perez | 2018 | Neural Regeneration Research2018，13，11： | 4 |
| 18 | Impacts of Urbanization on the Precipitation Characteristics in Guangdong Province, China显示文摘With the development of urbanization,whether precipitation characteristics in Guangdong Province,China,from 1981 to 2015 have changed are investigated using rain gauge data from 76 stations.These characteristics include annual precipitation,rainfall frequency,intense rainfall(defined as hourly precipitation≥20 mm),light precipitation(defined as hourly precipitation≤2.5 mm),and extreme rainfall(defined as hourly rainfall exceeding the 99.9 th percentile of the hourly rainfall distribution).During these 35 years,the annual precipitation shows an increasing trend in the urban areas.While rainfall frequency and light precipitation have a decreasing trend,intense rainfall frequency shows an increasing trend.The heavy and extreme rainfall frequency both exhibit an increasing trend in the Pearl River Delta region,where urbanization is the most significant.These trends in both the warm seasons(May-October)and during the pre-flood season(April-June)appear to be more significant.On the contrary,the annual precipitation amount in rural areas has a decreasing trend.Although the heavy and extreme precipitation also show an increasing trend,it is not as strong and significant as that in the urban areas.During periods in which a tropical cyclone makes landfall along the South China Coast,the rainfall in urban areas has been consistently more than that in surrounding areas.The precipitation in the urban areas and to their west is higher after 1995,when the urbanization accelerated.These results suggest that urbanization has a significant impact on the precipitation characteristics of Guangdong Province. | Meng YAN Johnny C.LCHAN Kun ZHAO | 2020 | Advances in Atmospheric Sciences2020，37，7： | 4 |
| 19 | Synthesis,Contact Printing,and Device Characterization of Ni-Catalyzed,Crystalline InAs Nanowires显示文摘InAs nanowires have been actively explored as the channel material for high performance transistors owing to their high electron mobility and ease of ohmic metal contact formation.The catalytic growth of nonepitaxial InAs nanowires,however,has often relied on the use of Au colloids which is non-CMOS compatible.Here,we demonstrate the successful synthesis of crystalline InAs nanowires with high yield and tunable diameters by using Ni nanoparticles as the catalyst material on amorphous SiO_(2) substrates.The nanowires show superb electrical properties with field-effect electron mobility~2700 cm^(2)/Vs and ION/IOFF>10^(3).The uniformity and purity of the grown InAs nanowires are further demonstrated by large-scale assembly of parallel arrays of nanowires on substrates via the contact printing process that enables high performance,“printable”transistors,capable of delivering 510 mA ON currents(~400 nanowires). | Alexandra C.Ford Johnny C.Ho Zhiyong Fan Onur Ergen Virginia Altoe Shaul Aloni Haleh Razavi Ali Javey | 2008 | Nano Research2008，1，1： | 3 |
| 20 | Health Emergency and Disaster Risk Management (Health-EDRM):Developing the Research Field within the Sendai Framework Paradigm显示文摘The intersection of health and disaster risk reduction(DRR) has emerged in recent years as a field of critical inquiry.Health is recognized as an outcome and a goal of DRR,and the integration of both fields is essential to ensure the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.Health Emergency and Disaster Risk Management(Health-EDRM) has emerged as an umbrella field that encompasses emergency and disaster medicine,DRR,humanitarian response,community health resilience,and health systems resilience.In September 2016,an international group of experts met in Hong Kong to assess the current status and potential of the Health-EDRM research field,a research area that these scholars characterized as underdeveloped and fragmented.Key challenges identified include research overlap,lack ofstrategic research agenda,absence of consensus regarding terminology,and limited coordination between stakeholders.The Sendai Framework provides a useful paradigm within which to shape the research field's strategic development.The WHO Thematic Platform for Health-EDRM Research Group was established to coordinate activities,promote information-sharing,develop partnerships,and provide technical advice to strengthen the Health-EDRM research field.This group will promote the generation of robust and scientific health research to support the meaningful implementation of the Sendai Framework. | Sharon Tsoon Ting Lo Emily Ying Yang Chan Gloria Kwong Wai Chan Virginia Murray Jonathan Abrahams Ali Ardalan Ryoma Kayano Johnny Chung Wai Yau | 2017 | International Journal of Disaster Risk Science2017，8，2： | 3 |
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