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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 3 | Research on diagenesis of the sandstone-type uranium deposits in Dongsheng area, Ordos Basin显示文摘Synthetic methods of thin section petrography, scanning electron microscope, electron microprobe, energy spectrum analysis, cathodoluminescence, isotopic analysis and temperature measuring for fluid inclusions were used in analyzing sandstone samples collected from the Zhiluo Formation in order to fully understand the diagenesis evolution and the mineralizing response as well as the genesis of the uranium-bearing sandstone in Dongsheng area. The result shows that (1) the sandstone include lithic silicarenite, feldspathic litharenite and litharenite; (2) the authigenic minerals include clay minerals, carbonate minerals, siliceous and ferric minerals; (3) the physical property of sandstone is obviously controlled by diagenesis; and (4) the sandstone with favorable physical property is propitious to migration and storage of ore-forming fluid, and finally, forming the ore deposit. The sandstone of the Zhiluo Formation had undergone the early diagenetic stage (periods A and B) and the epidiagenetic stage. The evolution of diagenetic environment is in the order of acidic oxidation, alkalescent deoxidization, acidity to transitional environment of oxidation-deoxidization and acidity-alkalescence. The uranium exists in forms of pre-enrichment uranyl ion, active uranyl ion, dispersive adsorptive uranium and uranium mineral, respectively. In addition, the authors also hold that the formation of the sandstone-type uranium is not only related to the oxidation-deoxidization environment, but also closely related to the acidic-alkaline transitional environment, which are propitious to uranium mineralization in sandstone. | FAN AiPing LIU YiQun YANG RenChao FENG Qiao ZHANG FuXin HAN ZuoZhen | 2007 | Science China Earth Sciences2007，50，z2： | 6 |
| 4 | The First Two Imported Cases of SARS-CoV-2 Omicron Variant—Tianjin Municipality,China,December 13,2021显示文摘On December 9,2021,2 international passengers arrived in Tianjin Binhai International Airport from Warsaw,Poland via airplane and tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),using nucleic acid tests.The first case(Patient A)was a flight crew member,a 35-year-old male,who had returned to Warsaw on the same flight on December 10,2021.The second case(Patient B)was a 17-year-old female student,who has been transferred to Haihe Hospital for isolation.Both cases are Polish nationality that had recently lived in Warsaw,Poland.According to the investigation,neither patient had disease symptoms nor medication history.Patient B received the Pfizer/BNT162b2 vaccine on September 27,2021.Patient A was vaccinated on May 25,2021,but no further vaccine information was collected as Patient A had left China.No other infections from this flight have been detected. | Zhaolin Tan Zhixiao Chen Aiping Yu Xiaoyan Li Yenan Feng Xiang Zhao Wenbo Xu Xu Su | 2022 | China CDC weekly2022，4，4： | 5 |
| 5 | Sedimentary Records of Mangrove Evolution During the Past one Hundred Years Based on Stable Carbon Isotope and Pollen Evidences in Maowei, SW China显示文摘Mangroves accumulate sedimentary sequences, where cores can provide historical records of mangrove evolution with past climate change and human activity. The study traced the history of mangrove evolution during the past one hundred years in a mangrove swamp of Maowei Sea, SW China. The sedimentation rates(0.38-0.95 cm yr^(-1)) were calculated on the basis of ln(^(210)Pb_(xs)/Al) and mass depth in the core sediments. Chemical tracers, such as δ^(13)C_(org) and C:N values, were utilized to trace the contribution of mangrove-derived organic matter using a ternary mixing model. Because of potential diagenetic alteration and / or overlap in the isotopic signatures of different components, simultaneous use of mangrove pollen diagrams can help to supplement some of these limitations. Combined with mangrove pollen, mangrove evolution was reconstructed and could be divided into three stages: flourishment(1886-1905 AD), slight degradation(1905-1949 AD) and rapid degradation period(1949-2007 AD), which was consistent with previous reports. The reclamation of mangrove swamps to shrimp ponds was the major reason for rapid degradation of mangrove ecosystems in recent years, rather than climate change in the region. | XIA Peng MENG Xianwei LI Zhen FENG Aiping | 2016 | Journal of Ocean University of China2016，15，3： | 3 |
| 6 | Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease:a multi-center retrospective analysis of 4,334 patients显示文摘The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention(PCI) with stent remain unclear.The present study was aimed to compare clinical outcomes in such two populations.From May 1999 to December 2009,4,334 patients with acute myocardial infarction(MI),unstable angina,stable angina,or silent ischemia,who underwent PCI,were registered at our centers.Among these,3,089 were men and 1,245 were women.We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events(MACE) including cardiac death,MI,target lesion revascularization,target vessel revascularization(TVR),stent thrombosis(ST),definite ST and probable ST at one-year follow-up.Chinese male patients had a higher MACE rate(13%vs.10.7%,P =0.039),mainly led by TVR(9.09%vs.6.98%,P=0.024) at one year,which was significantly different than female patients.Chinese male and female patients showed a significant difference on MACEs.However,there was no significant difference with respect to MI between these groups. | Rajiv Shrestha Jing Xu Dujiang Xie Zhizhong Liu Tian Xu Fei Ye Shiqing Din Xuesong Qian Song Yang Yueqiang Liu Feng Li Aiping Zhang Shaoliang Chen | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 7 | Organic carbon isotope and pollen evidence for mangrove development and response to human activity in Guangxi(Southwest China) over the last 140 years显示文摘Mangrove degradation must reduce carbon sequestration in recent years, thereby aggravating global warming.Thus, short-term impacts of human activity on mangrove ecosystems are cause for concern from local governments and scientists. Mangroves sediments can provide detailed records of mangrove species variation in the last one hundred years, based on detailed 210 Pb data. The study traced the history of mangrove development and its response to environmental change over the last 140 years in two mangrove swamps of Guangxi, Southwest China. Average sedimentation rates were calculated to be 0.48 cm/a and 0.56 cm/a in the Yingluo Bay and the Maowei Sea, respectively. Chemical indicators(δ13Corg and C:N) were utilized to trace the contribution of mangrove-derived organic matter(MOM) using a ternary mixing model. Simultaneous use of mangrove pollen can help to supplement some of these limitations in diagenetic/overlap of isotopic signatures. We found that vertical distribution of MOM was consistent with mangrove pollen, which could provide similar information for tracing mangrove ecosystems. Therefore, mangrove development was reconstructed and divided into three stages: flourishing, degradation and re-flourishing/re-degradation period. The significant degradation, found in the period of 1968–1998 and 1907–2007 in the Yingluo Bay and the Maowei Sea, respectively, corresponding to a rapid increase of reclamation area and seawall length, rather than climate change as recorded in the region. | XIA Peng MENG Xianwei LI Zhen FENG Aiping | 2017 | Acta Oceanologica Sinica2017，36，2： | 3 |
| 8 | Sediment transport in the Luanhe River delta:grain size trend analysis显示文摘Sediment grain size in the deltaic environment of the Luanhe River(LR),Liaoning,China,contains sediment transport pathway information useful in elucidating the shoreline change and fluvialmarine interaction.In this study,we utilized numerical partitioning of the sedimentary components and geostatistical grain size trend analysis(GSTA)to define the sediment transport pattern in the Luanhe River delta(LRD)and interpolated the sediment transport pattern using content changes of end numbers(EM).EM1(the mean grain size 7.12Ф,fine silt),EM2(2.37Ф,fine sand),and EM3(1.27Ф,medium sand)components were identified by the numerical partitioning by GSTA.Kriging interpolation method was used to interpolate the parameters of the grain size for the regular grid,and the interpolation radius was 0.015 decimal degree.We chose 0.09 decimal degree as the characteristic distance for GSTA in the semivariogram model using the geostatistical method.The FB(-)case(finer,better sorted and more negatively skewed)was adopted in GSTA for its satisfaction in the Global Moran’s I test.The result of the GSTA shows that the sediments in the south barriers(SBs)were transported to the southwest of the study area.The sediments in the north,in the SE direction of sediment transport trend from the river mouth,indicated that the sediments in the north of the study area were transported from the LR to the northern beaches,and to the south and east of the study area.The sediment transport trend that simplified by GSTA as the FB(-)case was approved by the content changes of sedimentary components(i.e.EM1,EM2,and EM3).In addition,the turbulent jet diffusion pattern indicated that the coarse sediments(EM3)were delivered by LR during the flood season,and the EM2 and EM1 were from wave and tide,respectively. | YU Xiaoxiao LI Tiegang GU Dongqi FENG Aiping LIU Shihao LI Ping XU Guoqiang YAN Wenwen ZHANG Zhiwei ZHU Zhengtao | 2019 | Journal of Oceanology and Limnology2019，37，3： | 3 |
| 9 | Dual-wavelength single-longitudinal-mode fiber laser with switchable wavelength spacing based on a graphene saturable absorber显示文摘We propose and demonstrate a dual-wavelength single-longitudinal-mode(SLM) fiber laser with switchable wavelength spacing based on a graphene saturable absorber(GSA) and a Wave Shaper. By virtue of the excellent saturable absorption ability of graphene, the linewidths of the lasing wavelengths can be effectively reduced and eventually SLM operation can be obtained. The linewidths of both wavelengths are measured to be narrower than 7.3 kHz. The obtained results suggest that the graphene would be a good candidate nonlinear optical material for applications in related photonic fields, such as SLM oscillation generation for microwave generation and optical sensing. | Jingjuan Zhou Aiping Luo Zhichao Luo Xudong Wang Xinhuan Feng Bai-ou Guan | 2015 | Photonics Research2015，3，2： | 2 |
| 10 | ^(210)Pb Chronology and Trace Metal Geochemistry in the Intertidal Sediment of Qinjiang River Estuary, China显示文摘Historical records of metal inputs were studied by using a sediment core collected from a sand-rich mudflat in the Qinjiang River estuary, China. 210Pb chronology was used to reconstruct the fluxes of Hg, Cu, Pb, Zn, Cd, Cr and As to the core site during the last 86 years. Based on the constant initial concentration model, the sedimentation rates are 1.18 cm year-1 in the top 30 cm sandy layer and 0.92 cm year-1 in the muddy bottom layer. To compensate for grain-size and mineralogy effects on metal concentra-tions, aluminum was used as the normalizing element. The enrichment factors (EF) indicate that the natural inputs had prevailed up to the early 1980s. After this period, the intensity of human activities has resulted in continual increasing trend of metals towards the surface. Recent sediment samples from the Qinjiang River estuary are found moderately enriched by Cd (EF>1.5) and slightly enriched by other metals (EF<1.5). Considering that the drainage area of the Qinjiang River is mostly agricultural land, the increased Cd may be due to the usage of fertilizers and pesticides in agricultural activities and the combustion of fossil fuels. | XIA Peng MENG Xianwei FENG Aiping YIN Ping WANG Xiangqin ZHANG Jun | 2012 | Journal of Ocean University of China2012，11，2： | 2 |
| 11 | Photo-initiated grafting of gelatin/N-maleic acyl-chitosan to enhance endothelial cell adhesion, proliferation and function on PLA surface显示文摘 | Zhu Aiping Zhao Feng Ma Teng | 2009 | Acta Biomaterialia2009，5，6： | 1 |
| 12 | Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX-4 signaling pathway显示文摘Parkinson’s disease(PD)is a common neurodegenerative disorder with no cure.Astragalus membranaceus is used in Chinese culture as a food supplement to boost immunity.The present study aimed to explore the neuroprotective effects of total flavonoids extracted from A.membranaceus(TFA)and their protective mechanisms.TFA offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)in the mouse model of Parkinsonism,by improving behavior performance in the gait analysis and pole test,and inhibiting the decline of tyrosine hydroxylase(TH)positive neurons and TH protein expression in substantia nigra of mice.TFA also prevented 1-methyl-4-phenylpyridinium(MPP+)induced neurotoxicity in SHSY5Y cells,by increasing GSH and GSH/GSSG ratio,and reducing reactive oxygen species.In addition,the neuroprotective effects of TFA were associated with its ability to restore MPTP/MPP+induced downregulation of SLC7A11 and glutathione peroxidase 4(GPX-4).In conclusion,we demonstrated that TFA exerted significant neuroprotection against MPTP/MPP+induced neurodegeneration by inhibiting ferroptosis through the regulation of SLC7A11/GPX-4 axis,suggesting the use of TFA as a possible food supplement in the prevention of PD. | Zitian Gao Gaorui Wang Yujie Chen Wuke Yuan Jun Cai Aiping Feng Jie Fang Qi Xu Xiaojun Wu | 2024 | Food Science and Human Wellness2024，13，1： | 1 |
| 13 | Differences in CYP3A4 ? 1G genotype distribution and haplotypes of CYP3A4 , CYP3A5 and CYP3A7 in 3 Chinese populations显示文摘 | Jing Du Lan Yu Lei Wang Aiping Zhang Anli Shu Lingyun Xu Mingsheng Xu Yongyong Shi Xingwang Li Guoyin Feng Qinghe Xing Lin He | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 14 | 2012, Geochemical characteristics of heavy metals in coastal sediments from the northern Beibu Gulf (SW China): the background levels and recent contamination显示文摘 | XIA PENG MENG XIANWEI FENG AIPING | 2012 | Environ- mental Earth Science2012，66，5： | 1 |
| 15 | Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population显示文摘 | Jing Du Qinghe Xing Lingyun Xu Mingsheng Xu Anli Shu Yongyong Shi Lan Yu Aiping Zhang Lei Wang Hongsheng Wang Xingwang Li Guoyin Feng Lin He | 2006 | Pharmacogenomics2006，，6： | 1 |
| 16 | Cloning of le-pyrG, an Orotidine-5'-monophosphate Decarboxylase Encoding Gene from Lentinula edodes显示文摘 | BAO Dapeng FENG Aiping ZHANG Meiyan TAN Qi CHEN Mingjie NIU Liying PAN Yingjie | 2009 | 食用菌学报2009，16，2： | 1 |
| 17 | Spatial variability of the nutrient balance and related NPSP risk analysis for agro-ecosystems in China in 2010显示文摘 | Wang Xuelei Feng Aiping Wang Qiao | 2014 | Agriculture Ecosystems & Environment2014，193，： | 1 |
| 18 | Effects of SnO2 addition on the magnetic properties of manganese zinc ferrites显示文摘 | Huang Aiping He H H Feng Zekun | 2006 | Journal of Magnetism and Magnetic Materials2006，301，11： | 1 |
| 19 | Spatial variability of the nutrient balance and related NPSP risk analysis for agro- ecosystems in China in 2010 显示文摘 | WANG Xuelei FENG Aiping WANG Qiao | 2014 | Agriculture Ecosystems & Environment2014，193，： | 1 |
| 20 | Monte Carlo Likelihood Estimation of Mixed-Effects State Space Models with Application to HIV Dynamics显示文摘The statistical inference for generalized mixed-effects state space models(MESSM) are investigated when the random effects are unknown. Two filtering algorithms are designed both of which are based on mixture Kalman filter. These algorithms are particularly useful when the longitudinal measurements are sparse. The authors also propose a globally convergent algorithm for parameter estimation of MESSM which can be used to locate the initial value of parameters for local while more efficient algorithms. Simulation examples are carried out which validate the efficacy of the proposed approaches. A data set from the clinical trial is investigated and a smaller mean square error is achieved compared to the existing results in literatures. | ZHOU Jie TANG Aiping FENG Hailin | 2016 | Journal of Systems Science & Complexity2016，29，4： | 0 |
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