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| 1 | Transcriptome analysis reveals long noncoding RNAs involved in fiber development in cotton (Gossypium arboreum)显示文摘Long noncoding RNAs(lnc RNAs)play important roles in various biological regulatory processes in yeast,mammals,and plants.However,no systematic identification of lnc RNAs has been reported in Gossypium arboreum.In this study,the strand-specific RNA sequencing(ss RNA-seq)of samples from cotton fibers and leaves was performed,and lnc RNAs involved in fiber initiation and elongation processes were systematically identified and analyzed.We identified 5,996 lnc RNAs,of which 3,510 and 2,486 can be classified as long intergenic noncoding RNAs(linc RNAs)and natural antisense transcripts(lnc NAT),respectively.Linc RNAs and lnc NATs are similar in many aspects,but have some differences in exon number,exon length,and transcript length.Expression analysis revealed that 51.9%of linc RNAs and 54.5%of lnc NATs transcripts were preferentially expressed at one stage of fiber development,and were significantly highly expressed than protein-coding transcripts(21.7%).During the fiber and rapid elongation stages,rapid and dynamic changes in lnc RNAs may contribute to fiber development in cotton.This work describes a set of lnc RNAs that are involved in fiber development.The characterization and expression analysis of lnc RNAs will facilitate future studies on their roles in fiber development in cotton. | Changsong Zou Qiaolian Wang Cairui Lu Wencui Yang Youping Zhang Hailiang Cheng Xiaoxu Feng Mtawa Andrew Prosper Guoli Song | 2016 | Science China(Life Sciences)2016，59，2： | 9 |
| 2 | Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital显示文摘Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods: 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results: Among the 15 cases (10 males and 5 females), the age ranged from 22 to 74 years old (the mean age was 50.67-year old). The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions: Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients. | Hailiang Tang Huaping Sun Hong Chen Ye Gong Ying Mao Qing Xie Liqian Xie Mingzhe Zheng Daijun Wang Hongda Zhu Xiaoming Che Ping Zhong Kang Zheng Shiqi Li Weimin Bao Jianhong Zhu Xuanchun Wang Xiaoyuan Feng Xiancheng Chen Liangfu Zhou | 2013 | Chinese Journal of Cancer Research2013，25，1： | 6 |
| 3 | Diversity of microbial plankton across the Three Gorges Dam of the Yangtze River,China显示文摘长江的三个峡水坝(TGD ) ,中国,在世界上是最大的灌溉和水力发电的工程工程之一。效果巨大人造象动物志和 macrophyte 上的 TGD 一样的工程是明显的,主要通过水动力学和流动模式的变化;然而,微生物怎么对如此的变化作出回应,是不太清楚的。这研究被瞄准在不同季节和地点在微生物引起的差异检验差别(在前面并且在 TGD 后面) 。另外,依附粒子、免费生活的社区之间的差别也被检验。在水列在后面并且在 TGD 前面的全部、潜在地活跃的微生物的社区结构与基于 DNA 、基于 RNA 的 16S rRNA 基因被分析在三个不同季节的种系发生的途径。16S rRNA 基因的克隆图书馆从提取 DNA 在扩大以后被准备并且为一些样品,在从提取 rRNA 准备 cDNA 以后。差别在不同季节并且在免费生活、依附粒子的社区之间在地点之间被观察。细菌并且 archaeal 社区比在冬季在夏天是更多样的,由于在夏天的更高滋养的层次和更温暖的温度比在冬季。依附粒子的微生物比免费生活的社区更多样,可能因为在粒子的更高滋养的层次和异构的 geochemical 微型环境。在细菌的社区结构的空间变化被观察,即,在 TGD 后面的水水库(在上游) 比在水坝前面招待了更多样的细菌的人口(下游) ,因为沉积和水从的多样的来源对水库在上游。这些结果在水坝建设影响的河生态系统为我们对环境变化的微生物引起的社区的回答的理解有重要含意。 | Shang Wang Raymond M. Dong Christina Z. Dong Liuqin Huang Hongchen Jiang Yuli Wei Liang Feng Deng Liu Guifang Yang Chuanlun Zhang Hailiang Dong | 2012 | Geoscience Frontiers2012，3，3： | 4 |
| 4 | Intraoperative ultrasound assistance in resection of intracranial meningiomas显示文摘Objective: Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due to their complicated anatomy structures and adjacent vessels. It's essential to locate the tumor and its vessels precisely during operation to reduce the risk of neurological deficits. The purpose of this study was to evaluate intraoperative ultrasonography in displaying intracranial meningioma and its surrounding arteries, and evaluate its potential to improve surgical precision and minimize surgical trauma. Methods: Between December 2011 and January 2013, 20 patients with anterior and middle skull base meningioma underwent surgery with the assistance of intraoperative ultrasonography in the Neurosurgery Department of Shanghai Huashan Hospital. There were 7 male and 13 female patients, aged from 31 to 66 years old. Their sonographic features were analyzed and the advantages of intraoperative ultrasonography were discussed. Results: The border of the meningioma and its adjacent vessels could be exhibited on intraoperative ultrasonography. The sonographic visualization allowed the neurosurgeon to choose an appropriate approach before the operation. In addition, intraoperative ultrasonography could inform neurosurgeons about the location of the tumor, its relation to the surrounding arteries during the operation, thus these essential arteries could be protected carefully. Conclusions: Intraoperative ultrasonography is a useful intraoperative technique. When appropriately applied to assist surgical procedures for intracranial meningioma, it could offer very important intraoperative information (such as the tumor supplying vessels) that helps to improve surgical resection and therefore might reduce the postoperative morbidity. | Hailiang Tang Huaping Sun Liqian Xie Qisheng Tang Ye Gong Ying Mao Qing Xie Mingzhe Zheng Daijun Wang Hongda Zhu Jianhong Zhu Xiaoyuan Feng Zhenwei Yao Xiancheng Chen Liangfu Zhou | 2013 | Chinese Journal of Cancer Research2013，25，3： | 3 |
| 5 | Uncertainty analysis of cross-calibration for HJ-1 CCD camera显示文摘Radiometric calibration of sensor is the basis of quantitative remote sensing,and uncertainty analysis is critical to ensure the accuracy of cross-calibration.Therefore,firstly,cross-calibration formulas were improved by redefining calibration coefficient and spectral band matching factor.In these formulas,cci was redefined as the calibration coefficient of normalized apparent reflectance,and spectral band matching factor as the ratio of normalized apparent reflectance.Secondly,based on the contrast of ideal and actual conditions in cross-calibration,8 sources of cross-calibration uncertainty were proposed:calibration uncertainty of standard sensor;pixel matching uncertainty;spectral band matching factor uncertainty caused by site altitude setting error,atmospheric parameters setting error,surface spectrum source,surface bidirectional reflectance characteristic,and error of atmospheric radiative transfer model;and uncertainty caused by other factors which were not considered.Finally,the contribution of each uncertainty was further analyzed and discussed for the HJ-1 CCD camera.The results provide many valuable references for evaluating the feasibility of alternative cross-calibration measurements. | WANG Zuo XIAO PengFeng GU XingFa FENG XueZhi LI XiaoYing GAO HaiLiang LI Hui LIN JinTang ZHANG XueLiang | 2013 | Chinese Science Bulletin2013，58，7： | 3 |
| 6 | Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence显示文摘 | Bo Zhang Jordan Price Guosong Hong Scott M. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng Paul J. Utz Hongjie Dai | 2013 | Nano Research2013，6，2： | 2 |
| 7 | Network Topology Inference Based on Traceroute and Tomography显示文摘 | Liao Hailiang Hu Guangmin Qian Feng | 2010 | Journal of Software2010，21，1： | 1 |
| 8 | Ear recognition based on uncorrelated local Fisher diserimi- nant analysis 显示文摘 | Hong Huang Jiamin Liu Hailiang Feng | 2011 | Neurocomputing2011，74，17： | 1 |
| 9 | VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type Ⅰ receptor degradation显示文摘The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue homeostasis.However,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well understood.Inhibitory(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of Smad7.Mis-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene expression.VprBP was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 poly-ubiquitination.In multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced responses.In the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish embryogenesis.Our findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction. | Yihao Li Chao Cui Feng Xie Szymon Kietbasa Hailiang Mei Maarten van Dinther Hans van Dam Andreas Bauer Long Zhang Peterten Dijke | 2020 | Journal of Molecular Cell Biology2020，12，2： | 1 |
| 10 | Complete local Fisher discriminant analysis with Laplacian score ranking for face recognition 显示文摘 | HUANG Hong FENG Hailiang PENG Chengyu | 2012 | Neurocomputing(S0925-2312)2012，89，： | 1 |
| 11 | Uncorrelated local Fisher discriminant analysis for face recognition 显示文摘 | HUANG Hong LIU Jiamin FENG Hailiang | 2011 | International Journal of Pattern Recognition and Artifieial Intelligence(S0218-0014)2011，25，06： | 1 |
| 12 | Diversity of the T4-like Myoviruses Community in Response to Salinity in Saline Lakes of the Qinghai-Tibetan Plateau显示文摘1 Introduction Viruses are the most abundant biological entities on Earth.They can influence the succession of individual microbial populations,biogeochemical cycles of C/N and,ultimately,microbial community structure through | WU Geng GUO Qinggong JIANG Hongchen YANG Jian GUO Feng LIU Wen ZHANG Guojing DONG Hailiang | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
| 13 | Analy- sis of Mine Ventilation Net work Using Genetic Algo- rithm 显示文摘 | XIE Manping FENG Changgen WANG Hailiang | 1999 | Journal of Beijng Institute of Technology1999，8，2： | 1 |
| 14 | Dynamic response of pulsed laser-irradiated space debris显示文摘High-velocity small-sized space debris with a diameter of 1—10 cm can cause huge damage to orbiting satellites and spacecraft.In recent years,the technology of actively removing small-sized space debris by high-energy pulsed laser irradiation has attracted widespread attention from scholars around the world,who strive for giving the maximum protection to the safety of the low-earth orbit environment.This paper focuses on exploring the dynamic behavior of centimeter-sized space debris under space-based pulsed laser irradiation.For this purpose,a fluid-structure-thermal-plasma multiphysics coupling model is built for space debris,and the effect law of plasma plumes produced by space debris after laser irradiation at different time is drawn.The simulation and measurement results are compared for analysis,verifying the validity and reliability of the proposed method and the built simulation model.The findings of this study are expected to provide an important theoretical reference and guidance for the research on the application of pulsed lasers to the active removal of centimeter-sized space debris. | LIANG Xiaobo FENG Tao QU Junli SHI Mingdong TANG Hailiang ZHU Chunyan | 2023 | Optoelectronics Letters2023，19，5： | 0 |
| 15 | Defective TiO_(2)hollow nanospheres as photo-electrocatalysts for photo-assisted Li-O_(2)batteries显示文摘The large overpotential for conventional Li-O_(2) batteries is an enormous challenge,which impedes their practical application.Here,we prepare a defective TiO_(2)(Ov-TiO_(2)) hollow nanosphere as photoelectrocatalyst for photo-assisted Li-O_(2) batteries to reduce the overpotential.Under illumination,the oxygen vacancies as a charge separation center contribute to the separation of electrons and holes.The generated electrons could promote reducing O_(2) to Li_(2)O_(2) during oxygen reduction reaction(ORR)process,while the generated holes are beneficial to Li_(2)O_(2) decomposition during oxygen evolution reaction(OER)process.Additionally,the proper concentration of oxygen vacancies will decrease the recombination rate between electrons and holes.The photo-assisted Li-O_(2) batteries with Ov-TiO_(2)-650 exhibit advanced performances,such as the low overpotential(0.70 V),the fine rate capability,and the considerable reversibility accompanied with the formation/decomposition of Li_(2)O_(2).We expect that these results could open a new mind to design of highly efficient photo-electrocatalysts for photo-assisted Li-O_(2) battery. | Hailiang Jiao Guiru Sun Yan Wang Zexu Zhang Zhao Wang Hairui Wang Haibo Li Ming Feng | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 16 | Improved Gossypium raimondii genome using a Hi-C-based proximity-guided assembly显示文摘Introduction:Genome sequence plays an important role in both basic and applied studies.Gossypium raimondii,the putative contributor of the D subgenome of upland cotton(G.hirsutum,highlights the need to improve the genome quality rapidly and efficiently.Methods:We performed Hi-C sequencing of G.raimondii and reassembled its genome based on a set of new Hi-C data and previously published scaffolds.We also compared the reassembled genome sequenee with the previously published G raimondii genomes for gene and genome sequence collinearity.Result:A total of 9842%of scaffold sequences were clustered successfully,among which 99.72%of the clustered sequences were ordered and 99.92%of the ordered sequences were oriented with high-quality.Further evaluation of results by heat-map and collinearity analysis revealed that the current reassembled genome is significantly improved than the previous one(Nat Genet 44:98-1103,2012).Conclusion:This improvement in G raimondii genome not only provides a better reference to increase study efficiency but also offers a new way to assemble cotton genomes.Furthermore,Hi-C data of G.raimondii may be used for 3D structure research or regulating analysis. | YANG Qiuhong ZUO Dongyun CHENG Hailiang ZHANG Youping WANG Qiaolian JAVARIA Ashraf FENG Xiaoxu LI Simin CHEN Xiaoqin LIU Shang SONG Guoli | 2021 | Journal of Cotton Research2021，4，3： | 0 |
| 17 | Map-based cloning of a recessive gene v_1 for virescent leaf expression in cotton(Gossypium spp.)显示文摘Background: Virescence, as a recognizable phenotype in the early development stage of cotton, is not only available for research on chloroplast development and photosynthesis but also for heterosis exploitation in cotton.Methods: In current study, for fine mapping of virescent-1(V_1) in cotton, three populations with a total of 5 678 individuals were constructed using T582 which has the virescent trait. Tobacco rattle virus, TRV1 and TRV2(pYL156),were used as vectors for the virus-induced gene silencing(VIGS) assay.Results: The v_1 gene was fine-mapped to a 20 kb interval on chromosome 20 of tetraploid cotton. We identified only one candidate gene with four single nucleotide polymorphisms between parents, among which the single nucleotide polymorphism at the position of 1 082 base pair caused the change of amino acid residue from Arg(3-79) to Lys(T582). The relative expression of the candidate gene in virescent plants was extensively lower than that in normal plants. Nullification of the gene by VIGS significantly turned the green leaf of normal cotton plants into yellow. We named this candidate gene as GhRVL.Conclusions: This study will facilitate the further research on virescent formation, and will be useful for breeding of hybrid cottons. | ZHANG Youping WANG Qiaolian ZUO Dongyun CHENG Hailiang LIU Ke ASHRAF Javaria LI Simin FENG Xiaoxu YU John Z. SONG Guoli | 2018 | Journal of Cotton Research2018，1，2： | 0 |
| 18 | The SMAD2/miR-4256/HDAC5/p16^(INK4a) signaling axis contributes to gastric cancer progression显示文摘The dysregulation of exosomal microRNAs(miRNAs)plays a crucial role in the development and progression of cancer.This study investigated the role of a newly identified serum exosomal miRNA miR-4256 in gastric cancer(GC)and the underlying mechanisms.The differentially expressed miRNAs were firstly identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics.Next,the expression of serum exosomal miR-4256 was analyzed in GC cells and GC tissues,and the role of miR-4256 in GC was investigated by in vitro and in vivo experiments.Then,the effect of miR-4256 on its downstream target genes HDAC5/p16^(INK4a) was studied in GC cells,and the underlying mechanisms were evaluated using dual luciferase reporter assay and Chromatin Immunoprecipitation(ChIP).Additionally,the role of the miR-4256/HDAC5/p16^(INK4a) axis in GC was studied using in vitro and in vivo experiments.Finally,the upstream regulators SMAD2/p300 that regulate miR-4256 expression and their role in GC were explored using in vitro experiments.miR-4256 was the most significantly upregulated miRNA and was overexpressed in GC cell lines and GC tissues;in vitro and in vivo results showed that miR-4256 promoted GC growth and progression.Mechanistically,miR-4256 enhanced HDAC5 expression by targeting the promoter of the HDAC5 gene in GC cells,and then restrained the expression of p16^(INK4a) through the epigenetic modulation of HDAC5 at the p16INK4a promoter.Furthermore,miR-4256 overexpression was positively regulated by the SMAD2/p300 complex in GC cells.Our data indicate that miR-4256 functions as an oncogene in GC via the SMAD2/miR-4256/HDAC5/p16^(INK4a) axis,which participates in GC progression and provides novel therapeutic and prognostic biomarkers for GC. | MIN WANG HAILIANG ZHAO WEIWEI CHEN CAIQUN BIE JINYING YANG WENRUI CAI CHUTIAN WU YANFANG CHEN SHUFEN FENG YING SHI YUTING LI HUIJUN TANG LIXIAN ZHONG LILIANGZI GUO SISI CHEN LINJING LONG SHAOHUI TANG | 2023 | Oncology Research2023，31，4： | 0 |
| 19 | 对250位成年双胞胎的宏基因组鸟枪法测序发现影响肠道菌群的遗传与环境因素显示文摘肠道菌群通常被看作是影响人体健康的环境因素。双胞胎这一群体是系统地解析塑造肠道菌群的遗传与环境因素的绝佳对象。 | Hailiang Xie Ruijin Guo Huanzi Zhong Qiang Feng Zhou Lan Bingcai Qin Kirsten J.Ward Matthew A.Jackson Yan Xia Xu Chen Bing Chen Huihua Xia Changlu Xu Fei Li Xun Xu Jumana Yousuf Al-Aama Huanming Yang Jian Wang Karsten Kristiansen Jun Wang Claire J.Steves Jordana T.Bell 李俊桦 Timothy D.Spector 贾慧珏 | 2017 | 科学新闻2017，19，4： | 0 |
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