|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | Deep Learning and Its Applications in Biomedicine显示文摘Advances in biological and medical technologies have been providing us explosive volumes of biological and physiological data,such as medical images,electroencephalography,genomic and protein sequences.Learning from these data facilitates the understanding of human health and disease.Developed from arti?cial neural networks,deep learning-based algorithms show great promise in extracting features and learning patterns from complex data.The aim of this paper is to provide an overview of deep learning techniques and some of the state-of-the-art applications in the biomedical?eld.We?rst introduce the development of arti?cial neural network and deep learning.We then describe two main components of deep learning,i.e.,deep learning architectures and model optimization.Subsequently,some examples are demonstrated for deep learningapplications,including medical image classi?cation,genomic sequence analysis,as well as protein structure classi?cation and prediction.Finally,we offer our perspectives for the future directions in the?eld of deep learning. | Chensi Cao Feng Liu Hai Tan Deshou Song Wenjie Shu Weizhong Li Yiming Zhou Xiaochen Bo Zhi Xie | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 22 |
| 3 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 4 | Arc corrosion behavior of Cu-Ti_3AlC_2 composites in air atmosphere显示文摘The arc corrosion evolution of Cu-20 vol.% Ti_3 AlC_2 cathodes is presented here. After eroded by 3, 4, 5, 6, 7, 8, 9, 10 kV DC voltage, respectively, the surface morphologies were characterized by field emission scanning electron microscope with craters and protrusions. Compared to small craters and dense protrusions of the morphology by high voltage, the eroded surface was covered with bigger craters and sparse protrusions at low voltage. No crack was discovered on the surface even at 10 kV. By means of energy dispersive spectroscopy and Raman spectroscopy, the decomposition of Cu-20 vol.% Ti_3 AlC_2 cathode to CuO,Al__2 O_3 and TiO_2 were proved. Meanwhile, W anode is oxidized to WO_2. The peak current increases with the increasing breakdown voltage, which is recorded by a digital memory oscilloscope. | HUANG XiaoChen FENG Yi QIAN Gang ZHAO Hao SONG ZhaoKun ZHANG JingCheng ZHANG XueBin | 2018 | Science China(Technological Sciences)2018，61，4： | 6 |
| 5 | Experimental investigations on cavity-actuated under-expanded supersonic oscillating jet显示文摘As one type of potential flow control actuators, cavity-actuated supersonic jet oscillators,which consist of a 2-D convergent nozzle and two face to face cavities, need to be investigated deeply to get the knowledge of their oscillating feature and underlying mechanism. Wind tunnel testing are conducted under different back pressures in a vacuum-type wind tunnel for two supersonic jet oscillators, to obtain their characteristics and the conditions for jet oscillating. The experimental results show that the continuous, nearly symmetric or asymmetric flipping between the two cavities appears over certain nozzle pressure ratio(NPR) range for both oscillators according to schlieren visualizations. Compared to the free jet, the oscillating jet with large exit achieves larger mixing; the oscillating jet with small exit has less mixing, based on the analysis of jet axial peak velocity and the entrainment. The cross-junction mode for estimating the resonance frequency in a pipe with two closed side branches is modified and obtained comparable estimations of the frequency of jet flipping with experimental data, but further investigations are needed to discover the underlying mechanism for the jet flipping. | Sun Bo Luo Xiaochen Feng Feng Wu Xiaosong | 2015 | Chinese Journal of Aeronautics2015，28，5： | 4 |
| 6 | Tree species classification using deep learning and RGB optical images obtained by an unmanned aerial vehicle显示文摘The diversity of tree species and the complexity of land use in cities create challenging issues for tree species classification.The combination of deep learning methods and RGB optical images obtained by unmanned aerial vehicles(UAVs) provides a new research direction for urban tree species classification.We proposed an RGB optical image dataset with 10 urban tree species,termed TCC10,which is a benchmark for tree canopy classification(TCC).TCC10 dataset contains two types of data:tree canopy images with simple backgrounds and those with complex backgrounds.The objective was to examine the possibility of using deep learning methods(AlexNet,VGG-16,and ResNet-50) for individual tree species classification.The results of convolutional neural networks(CNNs) were compared with those of K-nearest neighbor(KNN) and BP neural network.Our results demonstrated:(1) ResNet-50 achieved an overall accuracy(OA) of 92.6% and a kappa coefficient of 0.91 for tree species classification on TCC10 and outperformed AlexNet and VGG-16.(2) The classification accuracy of KNN and BP neural network was less than70%,while the accuracy of CNNs was relatively higher.(3)The classification accuracy of tree canopy images with complex backgrounds was lower than that for images with simple backgrounds.For the deciduous tree species in TCC10,the classification accuracy of ResNet-50 was higher in summer than that in autumn.Therefore,the deep learning is effective for urban tree species classification using RGB optical images. | Chen Zhang Kai Xia Hailin Feng Yinhui Yang Xiaochen Du | 2021 | Journal of Forestry Research2021，32，5： | 3 |
| 7 | Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein显示文摘 | Dongbo Sun Li Feng Hongyan Shi Jianfei Chen Xiaochen Cui Hongyan Chen Shengwang Liu Youen Tong Yunfeng Wang Guangzhi Tong | 2008 | Veterinary Microbiology2008，，1： | 2 |
| 8 | Effects of different atmospheres on the arc erosion behaviors of Ti_(3)SiC_(2)cathodes显示文摘The effects of ambient atmospheres on the arc erosion behaviors of Ti_(3)SiC_(2)cathodes were investigated at 5.5 kV in argon,nitrogen,air,and oxygen.The mass loss of the cathodes increased in the order of argon,nitrogen,air,and oxygen and the morphologies were measured by 3D laser scanning confocal microscope with a gradual blooming phenomenon.Raman spectroscopy,X-ray diffraction,and X-ray photoelectron spectroscopy were employed to detect the components of erosion regions.The erosion-chemical products mainly consisted of TiNx in nitrogen,TiN_(x),TiO_(2)and SiO_(2)in air,TiO_(2)and SiO_(2)in oxygen.The arc energy was responsible for the arc erosion characteristics in different atmospheres. | ZHOU ZiJue FENG Yi ZHAO Hao QIAN Gang ZHANG JingCheng ZHANG XueBin HUANG XiaoChen | 2021 | Science China(Technological Sciences)2021，64，3： | 2 |
| 9 | Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies显示文摘 | Feng Deng Wei Guo Xiaochen Liu Wu | 2012 | International Journal of Nanomedicine . 2012 (defa)2012，，： | 1 |
| 10 | Highly effective antifouling performance of N-vinyl-2-pyrrolidone modified polypropylene non-woven fabric membranes by ATRP method显示文摘 | Ranran Feng Chanchan Wang Xiaochen Xu | 2011 | Journal of Membrane Science2011，369，12： | 1 |
| 11 | Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein显示文摘 | Dongbo Sun Li Feng Hongyan Shi Jianfei Chen Xiaochen Cui Hongyan Chen Shengwang Liu Youen Tong Yunfeng Wang Guangzhi Tong | 2008 | Veterinary Microbiology2008，，1： | 1 |
| 12 | Discovery of Multiple Tectonic Reformations of the Eastern Yingen-Ejinaqi Basin:Evidence from Detrital Chronology显示文摘Objective The widely-distributed reformed basins in China are currently major areas for oil and gas exploration.Poststage tectonic movement of modified basins often plays an important role in controlling petroleum accumulation,migration and distribution(Liu and Yang,2000).The petroliferous Carboniferous-Permian Yingen-Ejinaqi Basin is located in the junction area between the North China Craton and the Central Asian Orogenic Belt(Fig.1 a). | PENG Heng LIU Chiyang WANG Jianqiang ZHANG Shaohua ZHAO Xiaochen MA Ming LI Keliang FENG Xiaolin GUAN Yuzhao | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 13 | Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula显示文摘 | Xiaochen Yin Jinghua Peng Liping Zhao Yunpeng Yu Xu Zhang Ping Liu Qin Feng Yiyang Hu Xiaoyan Pang | 2013 | Systematic and Applied Microbiology2013，，3： | 1 |
| 14 | Highly effective antifouling performance of N-vinyl-2-pyrrolidone modified polypropylene non-woven fabric membranes by AT- RPmethod 显示文摘 | FENG Ranran WANG Chanchan XU Xiaochen | 2011 | J MembrSci2011，369，12： | 1 |
| 15 | Experimental Study on the Hydrodynamic Performance of a Heaving Buoy Assembled on a Net Cage Platform显示文摘To take advantage of the abundance of both fishery and wave energy resources in offshore sea areas,a novel floating platform with a heaving buoy-based wave energy converter(WEC)assembled with a set of net cages is presented in this work.The floating WEC system provides a power supply,while the net cages are used for aquaculture.It is designed to have an independent and self-operation breeding function.An experimental study is carried out to investigate the hydrodynamic performance of the device in a wave tank considering the factors of net cages,draft depth,and power take-off,and results show that these variables have significant effects on wave energy capture.Incident waves with short periods cause intense interactions that allow the device to undergo large relative motion.The draft depth could be determined according to wave period rather than wave height.This study also explores the response amplitude operator of the device and determines its resonance scope.The experimental results could provide reliable information for future studies on phase differences and the design of two-body WECs. | SHI Hongda DONG Xiaochen FENG Liang HAN Zhi | 2019 | Journal of Ocean University of China2019，18，5： | 1 |
| 16 | Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer显示文摘Objective:The choice of chemotherapeutic regimen for triple-negative breast cancer(TNBC)remains controversial.Homologous recombination deficiency(HRD)has attracted increasing attention in informing chemotherapy treatment.This study was aimed at investigating the feasibility of HRD as a clinically actionable biomarker for platinum-containing and platinum-free therapy.Methods:Chinese patients with TNBC who received chemotherapy between May 1,2008 and March 31,2020 were retrospectively analyzed with a customized 3D-HRD panel.HRD positivity was defined by an HRD score≥30 or deleterious BRCA1/2 mutation.A total of 386 chemotherapy-treated patients with TNBC were screened from a surgical cohort(NCT01150513)and a metastatic cohort,and 189 patients with available clinical and tumor sequencing data were included.Results:In the entire cohort,49.2%(93/189)of patients were identified as HRD positive(40 with deleterious BRCA1/2 mutations and 53 with BRCA1/2 intact with an HRD score of≥30).In the first-line metastatic setting,platinum therapy was associated with longer median progression-free survival(mPFS)than platinum-free therapy[9.1 vs.3.0 months;hazard ratio(HR),0.43;95%confidence interval 0.22–0.84;P=0.01].Among HRD-positive patients,the mPFS was significantly longer in those treated with platinum rather than platinum-free therapy(13.6 vs.2.0 months;HR,0.11;P=0.001).Among patients administered a platinum-free regimen,HRD-negative patients showed a PFS significantly superior to that of HRD-positive patients(P=0.02;treatment-biomarker P-interaction=0.001).Similar results were observed in the BRCA1/2-intact subset.In the adjuvant setting,HRD-positive patients tended to benefit more from platinum chemotherapy than from platinum-free chemotherapy(P=0.05,P-interaction=0.02).Conclusions:HRD characterization may guide decision-making regarding the use of platinum treatment in patients with TNBC in both adjuvant and metastatic settings. | Yimeng Chen Xue Wang Feng Du Jian Yue Yiran Si Xiaochen Zhao Lina Cui Bei Zhang Ting Bei Binghe Xu Peng Yuan | 2023 | Cancer Biology & Medicine2023，20，2： | 1 |
| 17 | Manganese-Based Lithium-Ion Battery: Mn_(3)O_(4) Anode Versus LiNi_(0.5)Mn_(1.5)O_(4) Cathode显示文摘Lithium-ion batteries(LIBs)are widely used in portable consumer electronics,clean energy storage,and electric vehicle applications.However,challenges exist for LIBs,including high costs,safety issues,limited Li resources,and manufacturingrelated pollution.In this paper,a novel manganese-based lithium-ion battery with a LiNi_(0.5)Mn_(1.5)O_(4) ‖ Mn_(3)O_(4) structure is reported that is mainly composed of environmental friendly manganese compounds,where Mn_(3)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) (LNMO)are adopted as the anode and cathode materials,respectively.The proposed structure improves battery safety and reduce costs compared with current battery technology,provides comparable energy density with that of traditional graphite-based batteries.First,the characteristics and the electrochemical performances of the Mn_(3)O_(4) anode and the LNMO cathode are investigated separately against Li metal in half cell configurations,with promising performances being demonstrated by both electrodes.Then,a full cell structure with Mn_(3)O_(4) against LNMO is constructed that provides an average discharge voltage of 3.5 V and an initial specific capacity of 86.2 mA;h;g−1.More importantly,the electrochemical performance of the LNMO‖ Mn_(3)O_(4) full cell and its possible decay mechanisms are discussed systemically;and efficient strategies are proposed to further improve both the electrochemical performance of Mn_(3)O_(4) and the stability of LNMO. | Wenfeng Mao Wei Yue Feng Pei Xiaochen Zhao Xiangdong Huang Guo Ai | 2020 | Automotive Innovation2020，3，2： | 1 |
| 18 | Free-standing SnNb_(2)O_(6)@CSN film as flexible anode for high performance sodium-ion batteries显示文摘Free-standing electrodes are promising candidates for flexible rechargeable batteries, toward the application of flexible energy storage devices, due to their merits of additive-free, lightweight, and high energy density. Herein, we report a free-standing SnNb_(2)O_(6)@CSN flexible film with SnNb_(2)O_(6) encapsulated in 3D carbon skeleton nanofibers by electrospinning and carbonization processes as flexible anode for sodium-ion batteries(SIBs). The 3D carbon skeleton nanofibers serve as ion/electron transport pathway to improve the electrochemical reaction kinetics and meanwhile alleviate the volume changes of SnNb_(2)O_(6) during charge-discharge processes. The as-constructed half-cell(SnNb_(2)O_(6)@CSN‖Na) exhibits excellent cycling stability of 99.2 m Ah/g at 0.5 A/g after 950 cycles(coulombic efficiency of ~100%) and a high rate performance of 108.6 mAh/g at 10 A/g. In addition, the pouch cell can light up the LEDs at different bending angles(0°, 90°, 180°). This research shows a promising anode material for flexible energy storage electronics. | Xuemin Yin Tao Liu Xiuping Yin Xiaochen Feng Yiming Liu Qinhao Shi Xingli Zou Yufeng Zhao | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 19 | In-situ Synthesis of Cr_(3)C_(2) Nanosheets by Carbon Reduction Route from Cr_(2)AlC显示文摘Carbon black and Cr_(2)AlC were used as raw materials to obtain a large number of Cr_(3)C_(2)nanosheets by means of the molten salt heat treatment at 1100℃for 1.5 hours.Results showed that carbon black can promote the decomposition of a large number of Cr_(2)AlC to form Cr_(3)C_(2)and Cr_(7)C_(3)nanoparticles at 1100℃in the absence of molten salt.Under a molten salt environment,carbon black can promote the complete decomposition of Cr_(2)AlC to form Cr_(3)C_(2)and Cr_(7)C_(3)nanosheets.The thickness of chromium carbide nanosheets is approximately 10-20 nm,and the length is approximately 100-200 nm.The addition of excess carbon black can promote the complete decomposition of Cr_(2)AlC into a material with Cr_(3)C_(2)as the main phase. | 梁宝岩 DAI Zhen 张旺玺 JIAO Mingli FENG Xiaochen ZHANG Yanli LIU Ying ZHANG Ruijie YANG Li | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，3： | 0 |
| 20 | c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and in vivo显示文摘c-Met is a hepatocyte growth factor receptor overexpressed in many tumors such as hepatocellular carcinoma(HCC).Therefore,c-Met may serve as a promising target for HCC immunotherapy.Modifying T cells to express c-Met-specific chimeric antigen receptor(CAR)is an attractive strategy in treating c-Met-positive HCC.This study aimed to systematically evaluate the inhibitory effects of 2^(nd)-and 3^(rd)-generation c-Met CAR-T cells on hepatocellular carcinoma(HCC)cells.Here,2^(nd)-and 3^(rd)-generation c-Met CARs containing an anti-c-Met singlechain variable fragment(scFv)as well as the CD28 signaling domain and CD3ζ(c-Met-28-3ζ),the CD137 signaling domain and CD3ζ(c-Met-137-3ζ),or the CD28 and CD137 signaling domains and CD3ζ(c-Met-28-137-3ζ)were constructed,and their abilities to target c-Met-positive HCC cells were evaluated in vitro and in vivo.All c-Met CARs were stably expressed on T cell membrane,and c-Met CAR-T cells aggregated around c-Met-positive HCC cells and specifically killed them in vitro.c-Met-28-137-3ζCAR-T cells secreted more interferon-gamma(IFN-γ)and interleukin 2(IL-2)than c-Met-28-3ζCAR-T cells and c-Met-137-3ζCAR-T cells.Compared with c-Met low-expressed cells,c-Met CAR-T cells secreted more cytokines when co-cultured with c-Met high-expressed cells.Moreover,c-Met-28-137-3ζCAR-T cells eradicated HCC more effectively in xenograft tumor models compared with the control groups.This study suggests that 3^(rd)-generation c-Met CAR-T cells are more effective in inhibiting c-Met-positive HCC cells than 2^(nd)-generation c-Met CAR-T cells,thereby providing a promising therapeutic intervention for c-Met-positive HCC. | Xiaochen Huang Jiaojiao Guo Tao Li Lizhou Jia Xiaojun Tang Jin Zhu Qi Tang Zhenqing Feng | 2022 | The Journal of Biomedical Research2022，36，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员