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| 1 | Watch and wait approach in rectal cancer:Current controversies and future directions显示文摘According to the main international clinical guidelines,the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery.However,doubts have been raised about the appropriate definition of clinical complete response(cCR)after neoadjuvant therapy and the role of surgery in patients who achieve a cCR.Surgical resection is associated with significant morbidity and decreased quality of life(QoL),which is especially relevant given the favourable prognosis in this patient subset. Accordingly, therehas been a growing interest in alternative approaches with less morbidity,including the organ-preserving watch and wait strategy, in which surgery isomitted in patients who have achieved a cCR. These patients are managed with aspecific follow-up protocol to ensure adequate cancer control, including the earlyidentification of recurrent disease. However, there are several open questionsabout this strategy, including patient selection, the clinical and radiologicalcriteria to accurately determine cCR, the duration of neoadjuvant treatment, therole of dose intensification (chemotherapy and/or radiotherapy), optimal followupprotocols, and the future perspectives of this approach. In the present review,we summarize the available evidence on the watch and wait strategy in thisclinical scenario, including ongoing clinical trials, QoL in these patients, and thecontroversies surrounding this treatment approach. | Fernando López-Campos Margarita Martín-Martín Roberto Fornell-Pérez Juan Carlos García-Pérez Javier Die-Trill Raquel Fuentes-Mateos Sergio López-Durán JoséDomínguez-Rullán Reyes Ferreiro AlejandroRiquelme-Oliveira Asunción Hervás-Morón Felipe Couñago | 2020 | World Journal of Gastroenterology2020，26，29： | 10 |
| 2 | Anaerobic hydrolysis of primary sludge: influence of sludge concentration and temperature显示文摘 | Ferreiro N Soto M | 2003 | Water Science and Technology2003，47，： | 1 |
| 3 | Ultrasonographic measure- ment of fetal nasal bone in a low-risk population at 19-22 gesta- tional weeks 显示文摘 | Ga' mez F Ferreiro P Salmea' n J M | 2004 | Ultrasound Obstet Gynecol2004，23，： | 1 |
| 4 | Detection and identification of 700 drugs by multi- target screening with a 3200 Q TRAP LC-MSMS system and library searching 显示文摘 | DRESEN S FERREIROS N GNANN H | 2010 | Anal Bioanal Chem2010，396，： | 1 |
| 5 | A recessive form of central core disease, transiently presenting as multi-minicore disease, is associated with a homozygous mutation in the ryanodine receptor type 1 gene显示文摘 | Ferreiro A Monnier N Romero NB | 2002 | Ann Neurol2002，51，： | 1 |
| 6 | Thermodynamic analysis of a Brayton cycle and Rankine cycle arranged in series exploiting the cold exergy of LNG显示文摘 | Manuel Romero Gómez Ramón Ferreiro Garcia Javier Romero Gómez José Carbia Carril | 2013 | Energy2013，，： | 1 |
| 7 | Esophageal Carcinoma and Transthoracic Echocardiography显示文摘 | Tomás F. Cianciulli María C. Saccheri Jorge A. Lax Ricardo A. Bianchi Martín A. Beck Daniel E. Ferreiro | 2013 | Echocardiography2013，，9： | 1 |
| 8 | Optimización de la función intestinal en pacientes con fibrosis quística mediante la administración de probióticos显示文摘 | D. Infante Pina S. Redecillas Ferreiro A. Torrent Vernetta O. Segarra Cantón M. Maldonado Smith L. Gartner Tizziano E. Hidalgo Albert | 2008 | Anales de Pediatria2008，，6： | 1 |
| 9 | Development of a solid phase extraction procedure for HPLC-DAD determination of several angiotensin Ⅱ receptor antagonists in human urine using mixture design显示文摘 | Ferreiros N Iriarte G Alonso RM | 2007 | Talanta2007，73，5： | 1 |
| 10 | Everolimus-Based Immunosuppression in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Liver Transplantation: A Case Series显示文摘 | A.O. Ferreiro M.A. Vazquez-Millán F.S. López M.G. Gutiérrez S.P. Diaz M.J.L. Pati?o | 2014 | Transplantation Proceedings2014，，10： | 1 |
| 11 | Synthetic resorbable scaffolds for the treatment of isolated patellofemoral cartilage defects in young patients:magnetic resonance imaging and clinical evaluation显示文摘 | Joshi N Reverte-Vinaixa M Díaz Ferreiro EW | 2012 | Am J Sports Med2012，40，6： | 1 |
| 12 | Validated quantitation of angiotensin Ⅱ receptor antagonists ( ARA-Ⅱ) in human plasma by liquid- chromatography-tandem mass spectrometry using minimum sample clean- up and investigation of ion suppression显示文摘 | Ferreiros N Dresen S Alonso RM | 2007 | Ther Drag Monit2007，29，6： | 1 |
| 13 | A homozygous splicing rnuta tion causing a depletion of skeletal muscle RYR1 is associated with rnulti-rninicore disease congential myopathy with ophthalrnoplegia 显示文摘 | Monnier N Ferreiro A Marry I | 2003 | Hum Mol Genet2003，12，11： | 1 |
| 14 | Anaerobic hydrolysis of primary sludge: influence of sludge concentration and temperature显示文摘 | Ferreiro N Soto M | 2003 | War Sci Tech2003，47，12： | 1 |
| 15 | Anaerobic hydrolysis of primary sludge:Influence of sludge concentration and temperature显示文摘 | Ferreiro N Soto M | 2003 | Water Sci Technol2003，47，12： | 1 |
| 16 | Anaerobic hydrolysis of primary sludge: influence of sludge concentration and temperature 显示文摘 | Ferreiro N Soto M | 2003 | Water Science and Technology2003，47，12： | 1 |
| 17 | Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A (4) 显示文摘 | Hanson J Ferreiros N Pirotte B | 2013 | Biochem Pharmacol2013，85，12： | 1 |
| 18 | A recessive form of central core disease, transiently presenting as multi-minicore disease, is associated with a homozygous mutation in the ryanodine receptor type 1 gene显示文摘 | Ferreiro A Monnier N Romero NB | 2002 | Ann Neurol2002，51，6： | 1 |
| 19 | Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages显示文摘 | Claus Dieter Schuh Sandra Pierre Andreas Weigert Benjamin Weichand Kai Altenrath Yannick Schreiber Nerea Ferreiros Dong Dong Zhang Jing Suo Elsa-Marie Treutlein Marina Henke Hana Kunkel Manuel Grez Rolf Nüsing Bernhard Brüne Gerd Geisslinger Klaus Scholic | 2013 | Pain2013，，： | 1 |
| 20 | Anaerobic hydrolysis of primary sludge:influenceof sludge concentration and temperature显示文摘 | FERREIRO N SOTO M | 2003 | Water Science & Technology AJournal of the International Association on Water Pollution Research2003，47，12： | 1 |
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