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| 1 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 2 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 3 | Radiation effects on poly (lactide-co-glycolide) ( PLGA ) and poly ( L-lactide ) (PLLA) 显示文摘 | Joachim L S C Ooi C P Freddy B Y C | 2004 | Polym Degrad Stab2004，83，2： | 1 |
| 4 | Global cancerstatistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | Ca Cancer J Clin2011，61，2： | 1 |
| 5 | Global cancer statistics 显示文摘 | Ahmedin J Freddie B Melissa MC | 2011 | CA Cancer J Clin2011，61，： | 1 |
| 6 | Estimates of worldwide burden of cancer in 2008 :GLOBOCAN 2008显示文摘 | Jacques F Hai-Rim S Freddie B | 2010 | Int J Cancer2010，127，12： | 1 |
| 7 | Global cancer statistics 显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 8 | One-step quantitative cortisol dipstick with proportional reading 显示文摘 | Wingman L Puiyee C Freddy B | 2003 | J Immunol Methods2003，281，： | 1 |
| 9 | Global Cancer- Statistics, 2002 显示文摘 | B Max Parkin Freddie Bray J Ferlay | 2005 | CA Cancer J Clin2005，55，： | 1 |
| 10 | Sex ratios, spawning seasonal- ity, sexual maturity, and fecundity of white marlin (Tetrapturus albidus) from the western central Atlantic 显示文摘 | Freddy A Alexander B | 2009 | Fisheries Research2009，95，： | 1 |
| 11 | Defect detection in unpolished Si wafers by shearography显示文摘 | Udupa G Ngoi B Freddy H | 2004 | Meas Sci Technol2004，15，： | 1 |
| 12 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，： | 1 |
| 13 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 14 | Global cancer statistics 显示文摘 | Ahmedin J Freddie B | 2011 | CA Cancer Jclin2011，6，1： | 1 |
| 15 | Global cancer statistics 显示文摘 | AHMEDIN J FREDDIE B MELISSA M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 16 | Global cancer statistics,2012 显示文摘 | Lindsey A Torte Freddie B | 2015 | CA Cancer J Clin2015，65，2： | 1 |
| 17 | Global cancer statistics 显示文摘 | AHMEDIN J FREDDIE B MELISSA M | 2011 | Ca Cancer J Clin2011，61，2： | 1 |
| 18 | Global Cancer Statistics 显示文摘 | Lindsey A T Freddie B Rebecca L | 2015 | CA Cancer J Clin2015，65，2： | 1 |
| 19 | Gancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | | 0，，： | 1 |
| 20 | Global cancer stastistics,2008显示文摘 | Ahmedin T Dvm Freddie B | 2011 | CA Cancer J Clin2011，61，2： | 1 |
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