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| 1 | The material and biological characteristics of osteoinductive calcium phosphate ceramics显示文摘The discovery of osteoinductivity of calcium phosphate(Ca-P)ceramics has set an enduring paradigm of conferring biological regenerative activity to materials with carefully designed structural characteristics.The unique phase composition and porous structural features of osteoinductive Ca-P ceramics allow it to interact with signaling molecules and extracellular matrices in the host system,creating a local environment conducive to new bone formation.Mounting evidence now indicate that the osteoinductive activity of Ca-P ceramics is linked to their physicochemical and three-dimensional structural properties.Inspired by this conceptual breakthrough,many laboratories have shown that other materials can be also enticed to join the rank of tissue-inducing biomaterials,and besides the bones,other tissues such as cartilage,nerves and blood vessels were also regenerated with the assistance of biomaterials.Here,we give a brief historical recount about the discovery of the osteoinductivity of Ca-P ceramics,summarize the underlying material factors and biological characteristics,and discuss the mechanism of osteoinduction concerning protein adsorption,and the interaction with different types of cells,and the involvement of the vascular and immune systems. | Zhurong Tang Xiangfeng Li Yanfei Tan Hongsong Fan Xingdong Zhang | 2018 | Regenerative Biomaterials2018，5，1： | 20 |
| 2 | Wet-spinning fabrication of shear-patterned alginate hydrogel microfibers and the guidance of cell alignment显示文摘Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way,and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization.In this study,a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography.The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed.Afterwards,the effect of fiber topography on cellular longitudinal spread and elongation was investigated by culturing rat neuron-like PC12 cells and human osteosarcoma MG63 cells with the spun hydrogel microfibers,respectively.The results suggested that the stronger shear flow force would lead to more distinct aligned submicron topography on fiber surface,which could induce cell orientation along with fiber axis and therefore form the cell-matrix dual-alignment.Finally,a multi-hierarchical tissue-like structure constructed by dual-oriented cell-matrix assemblies was fabricated based on this wet-spinning method.This work is believed to be a potentially novel biofabrication scheme for bottom-up constructing of engineered linear tissue,such as nerve bundle,cortical bone,muscle and hepatic cord. | You Yang Jing Sun Xiaolu Liu Zhenzhen Guo Yunhu He Dan Wei Meiling Zhong Likun Guo Hongsong Fan Xingdong Zhang | 2017 | Regenerative Biomaterials2017，4，5： | 2 |
| 3 | The effect of collagen hydrogels on chondrocyte behaviors through restricting the contraction of cell/hydrogel constructs显示文摘Collagen is a promising material for tissue engineering,but the poor mechanical properties of collagen hydrogels,which tend to cause contraction under the action of cellular activity,make its application challengeable.In this study,the amino group of type I collagen(Col I)was modified with methacrylic anhydride(MA)and the photo-crosslinkable methacrylate anhydride modified type I collagen(CM)with three different degrees of substitution(DS)was prepared.The physical properties of CM and Col I hydrogels were tested,including micromorphology,mechanical properties and degradation properties.The results showed that the storage modulus and degradation rate of hydrogels could be adjusted by changing the DS of CM.In vitro,chondrocytes were seeded into these four groups of hydrogels and subjected to fluorescein diacetate/propidium iodide(FDA/PI)staining,cell counting kit-8(CCK-8)test,histological staining and cartilage-related gene expression analysis.In vivo,these hydrogels encapsulating chondrocytes were implanted subcutaneously into nude mice,then histological staining and sulfated glycosaminoglycan(sGAG)/DNA assays were performed.The results demonstrated that contraction of hydrogels affected behaviors of chondrocytes,and CM hydrogels with suitable DS could resist contraction of hydrogels and promote the secretion of cartilage-specific matrix in vitro and in vivo. | Longpeng Dong Qingli Liu Yongli Gao Hengxing Jia Wenling Dai Likun Guo Hongsong Fan Yujiang Fan Xingdong Zhang | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 4 | Directional terahertz holography with thermally active Janus metasurface显示文摘Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows. | Benwen Chen Shengxin Yang Jian Chen Jingbo Wu Ke Chen Weili Li Yihui Tan Zhaosong Wang Hongsong Qiu Kebin Fan Caihong Zhang Huabing Wang Yijun Feng Yunbin He Biaobing Jin Xinglong Wu Jian Chen Peiheng Wu | 2023 | Light(Science & Applications)2023，12，6： | 1 |
| 5 | Experimental study on seismic behavior of high strength concrete filled double-steel-plate composite walls 显示文摘 | Nie Jianguo Hu Hongsong Fan Jiansheng | 2013 | Journal of Constructional Steel Research2013，88，9： | 1 |
| 6 | Synthesis of photo-reactive poly(vinyl alcohol)and construction of scaffold-free cartilage like pellets in vitro显示文摘Photo-reactive poly(vinyl alcohol)(PRPVA)was synthesized by introduction of phenyl azido groups into poly(vinyl alcohol)(PVA)and applied for surface modification.PRPVA was grafted onto cell culture plate surface homogeneously or in a micropattern.Human mesenchymal stem cells(hMSCs)cultured on cell culture plate surface and PVA-modified surface showed different behaviors.Cells adhered and spread well on cell culture plate surface,while they did not adhere on PVA-grafted surface at all.When hMSCs were cultured on PVA-micropatterned surface,they formed a cell micropattern.Cells formed pellets after cultured on PVA homogeneously modified surface in chondrogenic induction medium for 2 weeks.The pellets were positively stained by hematoxylin/eosin,safranin-O/fast green and toluidin blue,and they were also stained brown by Type II collagen and proteoglycan immunohistological staining.Real-time PCR analysis was conducted to investigate the expression of colI,colII,colX,aggrecan and sox9 mRNA.Results of gene expression were in agreement with those of histological and immunohistological observations.These results indicated that hMSCs cultured on PVA-modified surface performed chondrogenic differentiation,and it was possible to construct scaffold-free cartilage like pellets with PVA-modified surface in vitro. | Bao Li Yongli Gao Likun Guo Yujiang Fan Naoki Kawazoe Hongsong Fan Xingdong Zhang Guoping Chen | 2018 | Regenerative Biomaterials2018，5，3： | 1 |
| 7 | CdS magic-size clusters exhibiting one sharp ultraviolet absorption singlet peaking at 361 nm显示文摘We report,for the first time,the synthesis of CdS magic-size clusters (MSCs) which exhibit a single sharp absorption peaking at ~ 361 nm,along with sharp band edge photoemission at ~ 377 nm and broad trap emission peaking at ~ 490 nm.These MSCs are produced in a singleensemble form without the contamination of conventional quantum dots (QDs) and/or other-bandgap clusters.They are denoted as MSC-361.We present the details of several controlled syntheses done in oleylamine (OLA),using C,d(NO3)2 or C,d(OAc)2 as a C,d source and thioacetamide (TAA) or elementary sulfur (S) as a S source.A high synthetic reproducibility of the reaction of Cd(NO3)2 and TAA to single-ensemble MSC-361 is achieved,the product of which is not contaminated by other bandgap clusters and/or QDs.In some cases,the reaction product exhibits an additional absorption peak at ~ 322 nm.We demonstrate that the two peaks,at 361 and 322 nm,do not evolve synchronously.Therefore,the 322 nm peak is not a higher order electronic transition of MSC-361,but due to the presence of another ensemble,namely MSC-322.The present study suggests that there is an outstanding need for the development of a physical model to narrow the knowledge gap regarding the electronic structure in these colloidal semiconductor CdS MSCs. | Junbin Tang Juan Hui Meng Zhang Hongsong Fan Nelson Rowell Wen Huang Yingnan Jiang Xiaoqin Chen Kui Yu | 2019 | Nano Research2019，12，6： | 1 |
| 8 | Fabrication and characterization of porous hydroxyapatite/β-triealcium phosphate ceramics by microwave sintering显示文摘 | FAN Hongsong XIAO Yumei | 2006 | Mater Lett2006，60，： | 1 |
| 9 | Fabrication and characterization of porous hydroxyapatite/β-tricalcium phosphate ceramics by microwave sintering显示文摘 | Wang Xinlong Fan Hongsong Xiao Yumei | 2006 | Materials Letters2006，60，4： | 1 |
| 10 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 11 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 http://gffzzd3cc09b8251d45dfsf56bv906qn0q6fxk.ffgz.tsg.suse.edu.cn/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
| 12 | Facile synthesis of nano-sized CuFe2S3:morphology and diverse functional tuning and crystal growth mechanism exploring显示文摘Ternary chalcogenide compounds are such promising and have been used for much practical applications.As a sort of these compounds,cubanite(CuFe2S3)possess some unique properties which can be used in different fields.In our study,we developed a facile one pot synthesis of CuFe2S3 nanocrystals(NCs)at a low reaction temperature,and achieved a morphology and phase composition tuning of the NCs through changing a variety of precursors and surfactants,meanwhile improved their magnetism and optical properties.Eventually,well-ordered and‘nano-brick’like CuFe2S3 NCs were obtained and showed best magnetism and near-infrared fluorescence properties.Furthermore,the NCs were proved with good biocompatibility and possibility for cell labeling.This kind of materials with lower toxicity and potential of magnetic is bound to remedy the defects of photoluminescence quantum dots(QDs)and be with higher potential in the field of biological diagnosis and multi-functional system construction. | Xiao Zhang Huan Zhao Yuda Zhu You Yang Dongli Jiang Xiaoqin Chen Jing Sun Jiaoming Luo Bing Cai Hongsong Fan | 2017 | Regenerative Biomaterials2017，4，4： | 0 |
| 13 | Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications显示文摘Konjac glucomannan(KGM)is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry.In recent decades,the combination of collagen and KGM attracts more attentions for biomedical purpose,especially the hybrid films of collagen-KGM or collagen-KGM-polysaccharide.In this study,to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials,a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously.The chemical composition,microcosmic architectures,swelling behavior,biodegradation and dynamic mechanic properties of such resulted composite hydrogels were systematically investigated.Biologic experiments,including cell culture in vitro and hypodermic implantation in vivo,were also conducted on these collagen/KGM composite hydrogels to evaluate their biologic performances.The relevant results prove that,based on collagen self-assembly behavior,this synthesis strategy is efficient to construct a composite hydrogel of collagen/KGM with improved mechanical properties,biodegradability,excellent biocompatibility and bioactivity,which are promising for potential biomedical applications such as tissue engineering and regenerative medicine. | Jiayuan Tang Jinlin Chen Jing Guo Qingrong Wei Hongsong Fan | 2018 | Regenerative Biomaterials2018，5，4： | 0 |
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