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| 1 | Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility显示文摘Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability.However,the in vivo rapid degradation rate and the insufficient biocompatibility restrict its clinical applications.In this study,the magnesium alloy(AZ31B)was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid,followed by the immobilization of chitosan-functionalized graphene oxide(GOCS).Heparin(Hep)and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer(LBL)to construct the GOCS/Hep bioactive multilayer coating,and the corrosion resistance and biocompatibility were extensively explored.The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent in vitro corrosion resistance.The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation,resulting in an excellent blood compatibility.In addition,the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells,but also promote the vascular endothelial growth factor(VEGF)and nitric oxide(NO)expression of the attached endothelial cells on the surfaces.Therefore,the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys,which is expected to promote the application of magnesium alloys in biomaterials or medical devices,especially cardiovascular stent. | Fan Gao Youdong Hu Guicai Li Sen Liu Li Quan Zhongmei Yang Yanchun Wei Changjiang Pan | 2020 | Bioactive Materials2020，5，3： | 12 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Preparation of nano-sized cerium and titanium pyrophosphates via solid-state reaction at room temperature显示文摘Nano-sized cerium-titanium pyrophosphates Ce1-xTixP2O7 (with x = 0, 0.2, 0.5, 0.7, 0.9, and 1.0) were obtained by grinding a mixture of Ce(SO4)2·4H2O, Ti(SO4)2, and Na4P2O7·10H2O in the presence of surfactant PEG-400 at room temperature, washing the mixture with water to remove soluble inorganic salts, and drying at 100°C. The products and their calcined samples were characterized using ultraviolet-visible spectroscopy (UV-vis), thermogravimetry and differential thermal analyses (TG/DTA), X-ray powder diffraction (XRD), and transmission electron microscopy (TEM). The results show that nano-sized Ce1-xTixP2O7 behave as an excellent UV-shielding material. Thereinto, the CeP2O7 has the most excellent UV-shielding effect, and the amorphous state of Ce0.8Ti0.2P2O7 can keep at a higher temperature than CeP2O7. Therefore, the stabilization of the amorphous state of the cerium pyrophosphates was carried out by doping titanium. This stabilization is a significant improvement, which enables to apply these amorphous pyrophosphates not only to cosmetics and paints, but also plastics and films. | WU Wenwei FAN Yanjin WU Xuehang LIAO Sen HUANG Xiufu LI Xuanhai | 2009 | Rare Metals2009，28，1： | 6 |
| 4 | Prospective evaluation of heparin-induced thrombocytopenia expert probability and 4T scores in Chinese patients with suspected heparin-induced thrombocytopenia显示文摘Background: Diagnosis of heparin-induced thrombocytopenia (HIT) is challenging. This study aimed to compare the diagnostic performance of HIT expert probability (HEP) and 4T scores, and to evaluate the inter-observer reliability for the 4T score in a clinical setting. Methods: This prospective study included HIT-suspected patients between 2016 and 2018. Three hematologists assessed the HEP and 4T scores. Correlations between scores and anti-platelet factor 4 (anti-PF4)/heparin antibodies were evaluated. Receiver operating characteristic curves and area under the curve (AUC) were used to assess the predictive accuracy of these two scoring models. The intraclass correlation coefficient (ICC) was used to assess the inter-observer agreement of 4T scores between residents and hematologists. Results: Of the 89 subjects included, 22 (24.7%) were positive for anti-PF4/heparin antibody. The correlations between antibody titer and either HEP or 4T scores were similar (r = 0.392, P < 0.01 for the HEP score;r = 0.444, P < 0.01 for the 4T score). No significant difference in the diagnostic performance was displayed between these two scores (AUC for the HEP score: 0.778 vs. AUC for the 4T score: 0.741, P = 0.357). Only 72 4T scores were collected from the residents, with a surprisingly low percentage of observers (43.1%) presenting the four individual item scores which made up their 4T score. The AUC of 4T score assessed by residents and hematologists was 0.657 (95% confidence interval [CI]: 536–0.765) and 0.780 (95% CI: 0.667–0.869, P < 0.05), respectively. The ICC of 4T score between residents and hematologists was 0.49 (95% CI: 0.29–0.65, P < 0.01), demonstrating a fair inter-observer agreement. Conclusions: The HEP score does not display a better performance for predicting HIT than the 4T score. With the unsatisfactory completion rate, the inter-observer agreement of 4T score in a tertiary hospital is fair, underscoring the necessity for continuing education for physicians. | Sen Li Lian-Kai Fan Shu-Jie Wang Yong-Qiang Zhao | 2019 | Chinese Medical Journal2019，，12： | 5 |
| 5 | Research progress on construction and energy storage performance of MXene heterostructures显示文摘MXenes are a family of two-dimensional (2D) transition metal carbides, carbonitrides/nitrides with superior physical and chemical properties, which have attracted extensive attention since the discovery in 2011. The impressive electrochemical activity of MXene makes it one of the most potential electrode materials in rechargeable batteries and supercapacitors. However, single-component MXene electrodes are difficult to achieve high specific capacity, efficient ion/electron transport, and high stability compatibility in an electrochemical environment. Studies have shown that it is an effective method to introduce nanomaterials between MXene layers to construct heterostructures and to improve the electrochemical performance through the synergistic effect among the components in the heterostructures. The introduction of nanomaterials can effectively suppress the restacking of MXene nanosheets, shorten the diffusion path of ions and promote the electrolyte transport, which is beneficial to enhance the rate performance of MXene;moreover, the excellent mechanical flexibility of MXene can reduce the volume expansion of nanomaterials during charge/discharge, thereby effectively protecting the integrity of the electrode structure and improving the cycling stability. Therefore, in this review, combined with theoretical calculations, we summarize the recent advances of MXene heterostructures in terms of synthesis strategies and energy storage applications, including supercapacitors, metal-ions batteries (Li, Na, K, Mg, Zn, Al) and metal anode protection. Furthermore, potential challenges and application perspectives for MXene heterostructures are also outlined. | Fanfan Liu Sen jin Qixun Xia Aiguo Zhou Li-Zhen Fan | 2021 | Journal of Energy Chemistry2021，30，11： | 5 |
| 6 | A Novel Green Preparation ofα,α′-Bis(substituted benzylidene)-cycloalkanones Promoted by FeCl3·6H2O in Ionic Liquid显示文摘α, α'-Bis(substituted benzylidene)cycloalkanones were efficiently prepared fromcycloalkanones and benzaldehydes in [bmim][BF4] by using iron(Ⅲ) chloride hexahydrate as acatalyst. It is shown that [bmim][BF4] and iron(Ⅲ) chloride hexahydrate can be quantitativelyrecovered and be reused effectively for many times. Compared with the known methods, thisnovel process has the advantage of being an environmentally benign process together with goodyields and mild reaction conditions. | Xin Ying ZHANG, Xue Sen FAN, Hong Ying NIU, Jian Ji WANGSchool of Chemical and Environmental Sciences, Henan Normal University, Key Laboratory ofEnvironmental Science and Engineering of Henan Education Department,Xinxiang 453002 | 2003 | Chinese Chemical Letters2003，14，10： | 5 |
| 7 | Room-temperature production of silver-nanofiber film for large-area, transparent and flexible surface electromagnetic interference shielding显示文摘A kind of pollution known as electromagnetic interference(EMI),which results from ubiquitous usage of various electronic communication and military radar equipment,has been receiving increasing attention recently.However,large-area EMI shielding on transparent and/or curved surfaces,including building windows,curved glass wall,and special requirements spaces(SRSs),remains hard to achieve.In this paper,a silver nanofiber(AgNF)based flexible and transparent EMI shielding film was successfully assembled via a room-temperature roll-to-roll production method.For transparent application scenario,AgNF with 89%transmittance in visible range and 1μm thickness shows~20 dB shielding efficiency(EMI SE).On the other hand,total shielding(>50 dB)is obtained when the thickness of AgNF increases to 10μm,while its transmittance in visible range remains higher than 75%.Considering the facile and scale-free production technology,this material can be readily applied in large-scale,transparent,and/or SRSs EMI shielding. | Sen Lin Haiyang Wang Fan Wu Qingmin Wang Xiaopeng Bai Di Zu Jianan Song Dong Wang Zhenglian Liu Ziwei Li Nian Tao Kai Huang Ming Lei Bo Li Hui Wu | 2019 | npj Flexible Electronics2019，3，1： | 4 |
| 8 | A novel synthesis of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction in ionic liquid显示文摘An efficient and novel procedure for the preparation of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][BF4] is described in this paper. Advantages of the method presented here include mild conditions, high yields together with a green nature and ease of recovery and reuse of the reaction medium. | Xin Ying Zhang Xiao Yan Li Xue Sen Fan Xia Wang Jian Ji Wang Gui Rong Qu | 2008 | Chinese Chemical Letters2008，19，2： | 3 |
| 9 | First genetic assessment of brackish water polychaete Tylorrhynchus heterochaetus: mitochondrial CO/sequences reveal strong genetic differentiation and population expansion in samples collected from southeast China and north Vietnam显示文摘Tylorrhynchus heterochaetus is a widespread benthic polychaete worm found in coastal brackish waters of the west Pacific.It has high ecological and economic value as a biomarker of water quality and as a high-quality feed in aquaculture and fisheries and is considered a delicacy in some areas of Asia.However,it has experienced a marked reduction in recent years due to overexploitation as well as changes in the environment and climate.Here,to comprehensively understand its genetic background and thus provide insights for better conservation and utilization of this species,we assessed the genetic variability and demographic history of T.heterochaetus individuals sampled from eight locations along the coasts of southeast China and north Vietnam based on mitochondrial cytochrome c oxidase I(COI)sequences.We observed high haplotype diversity(Hd),with an average of 0.926,but relatively low nucleotide diversity(π),with a mean of 0.032 across all samples.A total of 94 polymorphic sites and 85 haplotypes were identified among 320 individuals.The pairwise genetic distances among haplotypes ranged from 0.001 to 0.067,with the high intraspecific divergence possibly reflecting geographic isolation and gene pool fragmentation.Significant genetic structures were revealed among the studied locations;specifically,the eight locations could be treated as six genetically different populations based on pairwiseΦST results(0.026–0.951,P<0.01).A significant pattern of isolation-by-distance was detected between the genetic and geographic distances(r=0.873,P=0.001).Three geographic lineages were defined based on phylogenetic tree and network analyses of COI haplotypes.AMOVA results indicated that genetic variations mainly occurred among the three lineages(89.96%).Tests of neutrality and mismatch distribution suggested that T.heterochaetus underwent recent population expansion.These results provide the first report on the genetic status of T.heterochaetus and will be valuable for the management of genetic resources and better understanding of the ecology and evolution in this species. | Xing-Han Chen Sen Yang Wei Yang Yuan-Yuan Si Rui-Wen Xu Bin Fan Le Wang Zi-Ning Meng | 2020 | Zoological Research2020，41，1： | 3 |
| 10 | Rapid and Sparse Labeling of Neurons Based on the Mutant Virus-Like Particle of Semliki Forest Virus显示文摘Sparse labeling of neurons contributes to uncovering their morphology, and rapid expression of a fluorescent protein reduces the experiment range. To achieve the goal of rapid and sparse labeling of neurons in vivo, we established a rapid method for depicting the fine structure of neurons at 24 h post-infection based on a mutant viruslike particle of Semliki Forest virus. Approximately 0.014 fluorescent focus-forming units of the mutant virus-like particle transferred enhanced green fluorescent protein into neurons in vivo, and its affinity for neurons in vivo was stronger than for neurons in vitro and BHK21(baby hamster kidney) cells. Collectively, the mutant virus-likeparticle provides a robust and convenient way to reveal the fine structure of neurons and is expected to be a helper virus for combining with other tools to determine their connectivity. Our work adds a new tool to the approaches for rapid and sparse labeling of neurons in vivo. | Fan Jia Xutao Zhu Pei Lv Liang Hu Qing Liu Sen Jin Fuqiang Xu | 2019 | Neuroscience Bulletin2019，35，3： | 3 |
| 11 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 12 | Synthesis of fused pyran and arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methane in ionic liquid显示文摘由离子的液体支持了并且调停 --[bmim ][BF 4], 熔化了 pyrans 或芳基二度(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl ) 甲烷高效地并且有选择地从醛和 4-hydroxy-6-methyl-2-oxo-pyran 的反应被准备与或没有醋性的酐。由使用这些新奇过程,嘧啶有潜在的生物活动的熔化 nucleoside 的 pyran 和芳基二度(pyranon-3-yl ) 甲烷混血儿被构造。 | Xue Sen Fan Ying Ying Qu Xin Ying Zhang Xia Wang Jian Ji Wang | 2009 | Chinese Chemical Letters2009，20，4： | 2 |
| 13 | Biomechanical behavior of brain injury caused by sticks using finite element model and Hybrid-III testing显示文摘 | Kui Li Jiawen wang Shengxiong Liu Sen Su Chenjian Feng Xiaoxiang Fan Zhiyong Yin | 2015 | Chinese Journal of Traumatology2015，18，2： | 2 |
| 14 | Reduced graphene oxide supported Pd-Cu-Co trimetallic catalyst:synthesis,characterization and methanol electrooxidation properties显示文摘Trimetallic palladium-copper-cobalt nanoparticles supported on reduced graphene oxide(PdCuCo/RGO)with different molar ratios of Pd,Cu and Co can be synthesized by facile chemical reduction with NaBH_4 as reductant and cetrimonium bromide as stabilizer.The morphology,structure and composition of the as-synthesized catalysts are characterized by transmission electron microscopy,X-ray diffraction and Xray photoelectron spectroscopy.The cyclic voltammetry and chronoamperometry are utilized to investigate the electrochemical activities and stabilities of the as-obtained catalysts.The results demonstrate that the PdCuCo/RGO catalyst shows superior catalytic activity and stability for methanol electrooxidation in alkaline media compared with PdCu/RGO,PdCo/RGO,and Pd/RGO catalysts.These findings suggest that the PdCuCo/RGO catalyst possesses a great potential as a promising anode catalyst for direct methanol fuel cells. | Fan Yang Bing Zhang Sen Dong Chunxia Wang Andong Feng Xiaoxu Fan Yongfeng Li | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
| 15 | Tribological behavior of hot-pressed boron carbide with oxidation显示文摘The oxidation behavior at 973 1 273 K and the effect of oxidation on the room temperature tribological properties of hot pressed boron carbide ceramic were investigated. Oxidized samples were studied by X ray diffractometer and scanning electron microscopy. It is demonstrated that the oxidation results in the formation of a thin transparent B 2O 3 film, and the oxide film is severely cracked during cooling due to the thermal expansion mismatch between the oxide film and B 4C substrate. B 2O 3 reacts with moisture in air to form boric acid, which is a kind of solid lubricant. The sliding friction factors of oxidized B 4C pair are about 0.05 0.08, compared to 0.25 0.35 of the as received B 4C pair. When the oxidation temperature is up to 1 273 K, severe unstability and increase of friction factor are observed. Visual inspection of the wear track reveals that the lubricant film is broken and some debris particles occur on and around the rubbing surfaces, because the friction interface is rough by the severe etching of grain boundaries. | WANG Ling sen,WU Fang,ZHANG Jin sheng,FAN Yi,LIU Bo wei,GAO You (State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，2： | 1 |
| 16 | SINGLE IMAGING MODALITY EVALUATION OF LIVING DONORS IN LIVER TRANSPLANTATION: MAGNETIC RESONANCE IMAGING1显示文摘 | Yu Fan Cheng Chao Long Chen Tung Liang Huang Tai Yi Chen Tze Yu Lee Yaw Sen Chen Chih Chi Wang Vanessa de Villa Shigeru Goto Yuan Cheng Chiang Hock Liew Eng Bruno Jawan Hak Kim Cheung | 2001 | Transplantation2001，，9： | 1 |
| 17 | Research on the Antitumor Effect of Plumbagin by Inhibiting IL-6/STAT3 Pathway in Large Cell Lung Cancer显示文摘Background and Objective Lung cancer, which has become the leading cause of tumor mortality in many countries, appears to be one of the most dangerous malignant tumors that | Tao YU Yu FAN Li MA Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 1 |
| 18 | Epidemiology of falls and os- teoporotic fractures: a systematic review 显示文摘 | Morrison A Fan T Sen SS | 2013 | Clinicoecon Out- comes Res2013，5，： | 1 |
| 19 | Epidemiology of falls and osteoporotic fractures: a systematic review 显示文摘 | Morrison A Fan T Sen SS | 2013 | Clinicoecon Outcomes Res2013，5，： | 1 |
| 20 | An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions显示文摘在没有溶剂的条件下面的 -aminophosphonates 的环境地良性、高度有效的一个壶准备被开发。由采用这个方法, 5-aminophosphonate 代替了嘧啶 nucleosides 被综合在对从 5-formyl-2-deoxyuridine,苯胺和 dimethylphosphite 开始的优秀收益好。 | Xin Ying Zhang Ying Ying Qu Xue Sen Fan | 2010 | Chinese Chemical Letters2010，21，10： | 1 |
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