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| 1 | Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma显示文摘The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma(HCC) after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1(HMGB1) expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence(85.5% vs. 62.4%, P<0.001). We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients(P<0.001). Notably, expression of HMGB1 was positively correlated with OV6 in density(R2=0.032, P<0.001) and reversely related to HCC outcomes. Abnormal expression of HMGB1 in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone(area under curve(AUC) survival=0.696). Therefore, HMGB1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC. | Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 2 | A Single-cell Transcriptome Atlas of Cashmere Goat Hair Follicle Morphogenesis显示文摘Cashmere,also known as soft gold,is produced from the secondary hair follicles(SHFs)of cashmere goats.The number of SHFs determines the yield and quality of cashmere;therefore,it is of interest to investigate the transcriptional profiles present during cashmere goat hair follicle development.However,mechanisms underlying this development process remain largely unexplored,and studies regarding hair follicle development mostly use a murine research model.In this study,to provide a comprehensive understanding of cellular heterogeneity and cell fate decisions,single-cell RNA sequencing was performed on 19,705 single cells of the dorsal skin from cashmere goat fetuses at induction(embryonic day 60;E60),organogenesis(E90),and cytodifferentiation(E120)stages.For the first time,unsupervised clustering analysis identified 16 cell clusters,and their corresponding cell types were also characterized.Based on lineage inference,a detailed molecular landscape was revealed along the dermal and epidermal cell lineage developmental pathways.Notably,our current data also confirmed the heterogeneity of dermal papillae from different hair follicle types,which was further validated by immunofluorescence analysis.The current study identifies different biomarkers during cashmere goat hair follicle development and has implications for cashmere goat breeding in the future. | Wei Ge Weidong Zhang Yuelang Zhang Yujie Zheng Fang Li Shanhe Wang Jinwang Liu Shaojing Tan Zihui Yan Lu Wang Wei Shen Lei Qu Xin Wang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 3 |
| 3 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 4 | Muscle architecture of the forelimb of the Golden Pheasant(Chrysolophus pictus)(Aves: Phasianidae)and its implications for functional capacity in flight显示文摘Background: Flight is the central avian adaptation in evolution. Wing muscles form an important anatomical basis for avian flight, affecting wing performance and determine modes of flight. However, the roles of distal muscles in adjusting the wing, as well as their functional specializations, remain largely unknown. The importance of muscle fiber architecture has long been recognized. In this study, we provide quantitative anatomical data on the muscle architecture of the forelimb of the Golden Pheasant(Chrysolophus pictus), with an emphasis on brachial,antebrachial and manual segments.Methods: The forelimbs of five Golden Pheasants were dissected and detailed measurements of all muscles were made, including muscle mass, muscle belly length, fascicle length. From these values, muscle volume, physiological cross-sectional area(PCSA) and maximum isometric force were derived.Results: General trends such as the distribution of muscle mass, fascicle length and the ratio of tendon length/belly length are revealed. Comparing PCSAs between antebrachial depressors and elevators and between intrinsics of the alular digit and major digit yielded significant differences(p < 0.05). Pronounced development of the antebrachial depressors suggests that ventral rotation of the distal half of the wing is a pivotal factor in shape change and orientation modulation. Large PCSAs in tandem with the force generation capability of the major digit intrinsics may help stabilize the digits while enhancing support of the primary feathers. The architectural properties of the alular digit confirm that alular adjustment is essential to rapid adduction and abduction.Conclusions: These observations illustrate the underlying structural basis for the functional capacities of the distal forelimb muscles and may provide additional information useful in further biomechanical and in vivo investigations. | Yan Yang Huan Wang Zihui Zhang | 2015 | Chinese Birds2015，，1： | 1 |
| 5 | A biomass based photonic crystal made of 'konjac tofu'显示文摘Konjac tofu is a traditional Chinese food whose main ingredient is the water-soluble polysaccharide from konjac tubers-konjac glucomannan(KGM).Herein we report an interpenetrating double network polymeric film by crosslinking KGM and polyvinyl alcohol(PVA) with glutaraldehyde under acidic conditions.PVA was introduced into the hydrogel system as a hard skeleton,which not only maintained the biocompatibility of KGM,but also gave the hydrogel superior mechanical properties and solvent resistance.Implanting a colloidal array inside the above film,we obtained a new type of biomass based photonic crystal that is sensitive to a variety of physical and chemical stimulus,especially for methanol.This photonic crystal responds to metha nol and methanol vapo r,and has the ability to detect methanol in gasoline,which has a good application prospect. | Wenxin Zhang Min Xue Kenneth J.Shea Lili Qiu Zhibin Xu Jing Fan Dan Yan Zihui Meng | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 6 | FTO stabilizes MIS12 and counteracts senescence显示文摘Dear Editor, N6-methyladenosine(m6A)is an abundant epitranscriptomic modification that regulates messenger RNA(mRNA)biology.The m6A modification regulates mRNA splicing,transport,stability,and translation through coordinated activities by methyltransferases(writers),binding proteins(readers),and demethylases(erasers)(Huang et al.,2020;Wu et al.,2020).Among m6A regulators,fat mass of obesity-associ-ated protein(FTO),is the first discovered eraser with RNA m6A demethylation activity(Jia et al.,2011).Since then,FTO has been reported to play m6A-dependent roles in a variety of physiological processes including adipogenesis,neuro-genesis and tumorigenesis(Fischer et al.,2009;Li et al.,2017;Huang et al.,2020).Consequently,FTO deficiency in mice leads to dramatic phenotypes,such as decreased fat mass and impaired brain development(Fischer et al.,2009;Li et al.,2017).Similarly,inhibition of FTO reduces tumori-genesis in multiple types of cancer models,while FTO is highly expressed in many cancers(Huang et al.,2020). | Sheng Zhang Zeming Wu Yue Shi Si Wang Jie Ren Zihui Yu Daoyuan Huang Kaowen Yan Yifang He Xiaoqian Liu Qianzhao Ji Beibei Liu Zunpeng Liu Jing Qu Guang-Hui Liu Weimin Ci Xiaoqun Wang Weiqi Zhang | 2022 | Protein & Cell2022，13，12： | 0 |
| 7 | Boosting Multi-modal Ocular Recognition via Spatial Feature Reconstruction and Unsupervised Image Quality Estimation显示文摘In the daily application of an iris-recognition-at-a-distance(IAAD)system,many ocular images of low quality are acquired.As the iris part of these images is often not qualified for the recognition requirements,the more accessible periocular regions are a good complement for recognition.To further boost the performance of IAAD systems,a novel end-to-end framework for multi-modal ocular recognition is proposed.The proposed framework mainly consists of iris/periocular feature extraction and matching,unsupervised iris quality assessment,and a score-level adaptive weighted fusion strategy.First,ocular feature reconstruction(OFR)is proposed to sparsely reconstruct each probe image by high-quality gallery images based on proper feature maps.Next,a brand new unsupervised iris quality assessment method based on random multiscale embedding robustness is proposed.Different from the existing iris quality assess-ment methods,the quality of an iris image is measured by its robustness in the embedding space.At last,the fusion strategy exploits the iris quality score as the fusion weight to coalesce the complementary information from the iris and periocular regions.Extensive experi-mental results on ocular datasets prove that the proposed method is obviously better than unimodal biometrics,and the fusion strategy can significantly improve therecognition performance. | Zihui Yan Yunlong Wang Kunbo Zhang Zhenan Sun Lingxiao He | 2024 | Machine Intelligence Research2024，21，1： | 0 |
| 8 | Types of the Cambrian platform margin mound-shoal complexes and their relationship with paleogeomorphology in Gucheng area,Tarim Basin,NW China显示文摘Based on the observation of outcrops and cores,thin section identification,restoration of paleogeomorphology by residual thickness method,fine description of seismic facies,etc.,the coupling relationships between the development patterns of various types of Cambrian platform margin mound-shoal complexes and paleogeomorphology in the Gucheng area of Tarim Basin have been examined.The Cambrian platform margin mound-shoal complex is divided into mound base,mound core,mound front,mound back and mound flat microfacies,which are composed of dolomites of seven textures with facies indication.The different paleogeomorphology before the deposition of mound-shoal complex in each period was reconstructed,and three types of mound-shoal complex sedimentary models corresponding to the paleogeomorphologies of four stages were established:namely,the first stage of gentle slope symmetric accretion type,the second stage of steep slope asymmetric accretion type and the third and fourth stages of steep slope asymmetric progradation type.Their microfacies are respectively characterized by-mound base-mound back+(small)mound core+mound front-mound flat'symmetric vertical accretion structure,'mound base-(large)mound core+mound front-mound flat'asymmetric vertical accretion structure,'mound base-(small)mound core+mound front-mound flat'asymmetric lateral progradation structure.With most developed favorable reservoir facies belt,the steep slope asymmetric accretion type mound-shoal complex with the characteristics of'large mound and large shoal'is the exploration target for oil and gas reservoir. | ZHANG Junlong HU Mingyi FENG Zihui LI Qiang HE Xiangxiang ZHANG Bin YAN Bo WEI Guoqi ZHU Guangyou ZHANG You | 2021 | Petroleum Exploration and Development2021，48，1： | 0 |
| 9 | Reduced graphene oxide/2D colloidal array composite membrane fabricated layer-by-layer显示文摘Photonic crystal(Ph C) presents unique optical properties and functionality, and are used widely as detectors, modulators, plasmonics and light generating devices. However, the low electrical conductivity and mechanical strength limit its applications. We introduced here a layer-by-layer composite membrane based on reduced graphene oxide(RGO) and two-dimensional(2 D) colloidal crystal array(CCA). The 2 D CCA was fabricated by an air/water interface deposition technique using polystyrene(PS)and polymethyl methacrylate(PMMA) colloidal particles. The composite membrane were characterized by SEM, Debye diffraction, reflectance spectra and electrical resistance measurement. The results indicated that layer-by-layer composite membrane have highly periodicity, and the monolayer of RGO and 2 D CCA combined tightly. The Debye diffraction rings of the layer-by-layer heterostructure composite are the superimposition of the individual monolayers of 2 D CCA. The reflection spectrum of the layer-by-layer heterostructure composite membrane showed that two peaks of reflection curve located in near ultraviolet region and visible region respectively, and the RGO sheet have no influence on the peak position and shape of reflection curve of the Ph C. The RGO improved the electrical conductivity of the layer-by-layer heterostructure composite. The layer-by-layer heterostructure composite showed promising potential for the applications as sensors and optoelectronic devices. | Dan Yan Lili Qiu Yanfeng Wang Zihui Meng Min Xue Fenglian Qi | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
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