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| 1 | Seismic damage of highway bridges during the 2008 Wenchuan earthquake显示文摘Many highway bridges were severely damaged or completely collapsed during the 2008 Wenchuan earthquake.A fi eld investigation was carried out in the strongly affected areas and over 320 bridges were examined.Damage to some representative highway bridges is briefly described and a preliminary analysis of the probable causes of the damage is presented in this paper.The most common damage included shear-flexural failure of the pier columns,expansion joint failure,shear key failure,and girder sliding in the transversal or longitudinal directions due to weak connections between girder and bearings.Lessons learned from this earthquake are described and recommendations related to the design of curved and skewed bridges,design of bearings and devices to prevent girder collapse,and ductility of bridge piers are presented.Suggestions for future seismic design and retrofi tting techniques for bridges in moderate to severe earthquake areas are also proposed. | Han Qiang Du Xiuli Liu Jingbo Li Zhongxian Li Liyun Zhao Jianfeng | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 60 |
| 2 | Potential and challenges of tannins as an alternative to in-feed antibiotics for farm animal production显示文摘Naturally occurring plant compounds including tannins, saponins and essential oils are extensively assessed as natural alternatives to in-feed antibiotics.Tannins are a group of polyphenolic compounds that are widely present in plant region and possess various biological activities including antimicrobial,anti-parasitic, anti-viral, antioxidant, anti-inflammatory, immunomodulation, etc.Therefore, tannins are the major research subject in developing natural alternative to in-feed antibiotics.Strong protein affinity is the well-recognized property of plant tannins, which has successfully been applied to ruminant nutrition to decrease protein degradation in the rumen, and thereby improve protein utilization and animal production efficiency.Incorporations of tannin-containing forage in ruminant diets to control animal pasture bloat, intestinal parasite and pathogenic bacteria load are another 3 important applications of tannins in ruminant animals.Tannins have traditionally been regarded as 'anti-nutritional factor' for monogastric animals and poultry, but recent researches have revealed some of them, when applied in appropriate manner, improved intestinal microbial ecosystem, enhanced gut health and hence increased productive performance.The applicability of plant tannins as an alternative to in-feed antibiotics depends on many factors that contribute to the great variability in their observed efficacies. | Qianqian Huang Xiuli Liu Guoqi Zhao Tianming Hu Yuxi Wang | 2018 | Animal Nutrition2018，，2： | 54 |
| 3 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 4 | Preparation of Zn-doped TiO_2 nanotubes electrode and its application in pentachlorophenol photoelectrocatalytic degradation显示文摘Zn-doped titanium oxide (TiO2) nanotubes electrode was prepared on a titanium plate by direct anodic oxidation and immersing method in sequence. Field emission scanning electron microscopy (FESEM) showed that the Zn-doped TiO2 nanotubes were well aligned and organized into high density uniform arrays with diameter ranging from 50 to 90 nm. The length and the thickness were about 200 and 15 nm respectively. TiO2 anatase phase was identified by X-ray diffraction (XRD). X-ray photoelectronspec-troscopy (XPS) indicated that Zn ions were mainly located on the surface of TiO2 nanotubes in form of ZnO clusters. Compared with TiO2 nanotubes electrode,about 20 nm red shift in the spectrum of UV-vis absorption was observed. The degradation of pentachlorophenol (PCP) in aqueous solution under the same condition (initial concentration of PCP: 20 mg/L; concentration of Na2SO4: 0.01 mol/L and pH: 7.03) was carried out using Zn-doped TiO2 nanotubes electrode and TiO2 nanotubes electrode. The degradation rates of PCP using Zn-doped TiO2 nanotubes electrode were found to be twice and 5.8 times as high as that using TiO2 nanotubes electrode by UV radiation (400 μw/cm2) and visible light radiation (4500 μw/cm2),respectively. 73.5% of PCP was removed using Zn-doped TiO2 nanotubes electrode against 48.5% removed using TiO2 nanotubes electrode in 120 min under UV radiation. While under visible light radiation,the degradation efficiency of PCP was 18.4% using Zn-doped TiO2 nano-tubes electrode against 3.2% using TiO2 nanotubes electrode in 120 min. The optimum concentration of Zn doping was found to be 0.909%. The PCP degradation efficiencies of the 10 repeated experiments by Zn-doped TiO2 nanotubes electrode were rather stable with the deviation within 3.0%. | ZHAO HuiMin CHEN Yue QUAN Xie RUAN XiuLi | 2007 | Chinese Science Bulletin2007，52，11： | 14 |
| 5 | Poly(lactic-co-glycolic acid)-based composite bone-substitute materials显示文摘Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics.Recently,poly(lactic-co-glycolic acid)(PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility,degradability,mechanical properties,and capabilities to promote bone regeneration.In this article,we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances,elaborate on their applications for bone regeneration with or without bioactive factors,and prospect the challenges and opportunities in clinical bone regeneration. | Duoyi Zhao Tongtong Zhu Jie Li Liguo Cui Zhiyu Zhang Xiuli Zhuang Jianxun Ding | 2021 | Bioactive Materials2021，6，2： | 14 |
| 6 | Influence of Long-Term Fertilization on Selenium Accumulation in Soil and Uptake by Crops显示文摘Continuous applications of organic and inorganic fertilizers can affect soil and food quality with respect to selenium(Se) concentrations.A long-term(over 20 years) experimental field study,started in 1989,was conducted to investigate the changes in soil Se fractions and its uptake by crops,as affected by different fertilizer practices,in the North China Plain with an annual crop rotation of winter wheat and summer maize.The long-term experiment was arranged in a complete randomized block design consisting of 4replications with 7 fertilizer treatments:1) organic compost(OC),2) half organic compost plus half N-P-K chemical fertilizers(OC+ NPK),3) N-P-K fertilizers(NPK),4) N-P fertilizers(NP),5) P-K fertilizers(PK),6) N-K fertilizers(NK),and 7) an un-amended control.Soil samples from the surface(20 cm) were collected in 1989,1994,1999,2004 and 2009 to characterize Se and other soil properties.In 2009,the average soil Se concentrations in the treatments(149 ± 8 μg kg^(-1)) were higher than those in the soil samples collected in 1989 at the beginning of the experiment(112 ± 4 μg kg^(-1)),and decreased in the order of OC > OC + NPK > NPK≈NP > PK ≈NK > control.Sequential extraction showed the oxidizable fraction(50.06%± 3.94%) was the dominant form of Se in the soil,followed by the residual fraction(24.12%± 2.89%),exchangeable fraction(15.09%± 4.34%) and Fe-Mn oxides fraction(10.73%± 4.04%).With an increase of soil K,the exchangeable Se concentrations in the soil increased.The Se concentrations in the soil tillage layer(0-20 cm) were mainly related to soil organic carbon(SOC),although different contributions came from atmospheric deposition,irrigation and fertilizers.With the accumulation of SOC,the uptakes of soil Se by two crops were inhibited.For the OC and OC + NPK treatments,Se concentrations in wheat grains were lower than the critical standard of Se in stable food(100 μg kg^(-1)).Additionally,Se concentrations in grains were also decreased by the deficiencies of major soil nutrients,especially P. | WANG Qingyun ZHANG Jiabao ZHAO Bingzi XIN Xiuli DENG Xihai Hailin ZHANG | 2016 | Pedosphere2016，26，1： | 12 |
| 7 | Properties of TiAICrN coatings prepared by vacuum cathodic arc ion plating显示文摘TiAlCrN 涂层在 TC11 (Ti-6.5Al-3.5Mo-1.5Zr-0.3Si ) 钛合金底层上借助于真空 cathodic 弧离子 plating 技术被扔。氮化物涂层的作文,阶段结构,机械表演,和氧化抵抗被扫描电子调查显微镜学(SEM ) ,原子力量显微镜(AFM ) , X 光检查衍射(XRD ) ,钻电子光谱学(AES ) ,和 X 光检查光电子显微镜学(XPS ) 。为准备钛合金的保护的涂层的一个新过程成功地被获得。试验性的结果显示在 TiAlN 涂层的增加的元素铬做贡献形成(220 ) 比较喜欢方向。涂层的阶段由组成(Ti,艾尔) N 并且(Ti, Cr ) N。在 700 琠敨 ? 佩 ? 敷敲眠汥? 牣獹慴汬穩摥椠 ? 桴 ? 整牴条湯污猠牴 ' | RU Qiang HU Shejun HUANG Nacan ZHAO Lingzhi QIU Xiuli HU Xianqi | 2008 | Rare Metals2008，27，3： | 9 |
| 8 | Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese显示文摘动脉粥样硬化是 atherothrombotic 击(ATS ) 的一个重要 pathophysiological 基础,并且发炎在动脉粥样硬化形成起一个重要作用。在这研究,在三关键发炎相关的基因的单个核苷酸的多型性(SNP ) , 5-lipoxygenase 激活蛋白质(ALOX5AP ) , phosphodiesterase 4D (PDE4D ) ,和 interleukin-1 (IL-1 ) ,被调查用北汉汉语与 ATS 一起决定他们的协会。六 -- 182 个 ATS 病人和 598 无关的控制被招募。Genotyping 被聚合酶链反应限制碎片长度多型性和帮助矩阵的激光解吸附作用电离 time-of-flight 质量执行 spectrometry 教材扩展。每 SNP 的遗传型和等位基因频率统计上被分析。 ATS 的风险被作出对有利的裁决 ALOX5AP SG13S114A/T AA 遗传型( P = 0.040 )并且等位基因( P = 0.033 ), PDE4D SNP83C/T TT 遗传型( P = 0.010 )并且 T 等位基因( P = 0.008 )并且 SNP219A/G GG 遗传型( P = 0.025 )并且 G 等位基因( P = 0.022 ),并且 IL-1-889C/T T 等位基因( P = 0.035 )。差别在调整以后仍然保持重要。ALOX5AP HapA haplotype 没与 ATS 一起被相关(P = 0.834 ) ,但是 GCGA 代表了在风险 haplotype (P = 0.008 ) 。而且,在 SNP219-220 的 PDE4D AA haplotype 可能是在风险 haplotype (P = 0.013 ) ,当 GA 可能是保护的 haplotype 时(P = 0.005 ) 。ALOX5AP (SG13S114A/T ) , PDE4D (SNP83C/T, 219A/G ) ,并且 IL-1 (-889C/T) SNP 用北汉汉语与 ATS 的增加的风险被联系。 | Jiuhan Zhao Xiaohong Wang Jialiang Xu Nan Li Xiuli Shang Zhiyi He Jun Yang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 8 |
| 9 | Spatial and vertical variations of perfluoroalkyl substances in sediments of the Haihe River,China显示文摘The levels of six perfluoroalkyl substances(PFASs) in surface sediment and their vertical variations in dated sediment cores from the Haihe River were investigated; studied substances included perfluorooctanoic acid(PFOA),perfluorononanoic acid(PFNA),perfluorooctane sulfonate(PFOS),perfluorodecanoic acid(PFDA),perfluoroundecanoic acid(PFUnA),and perfluorododecanoic acid(PFDoA). Results showed that the total PFAS concentration in surface sediment ranged between 0.52 and 16.33 ng/g dry weight(dw) with an average of3.47 ng/g dw,with PFOS and PFOA as the dominant PFASs. In general,the PFAS concentrations in the mainstream increased from the upper to the lower reaches,except that a drop occurred downstream of the Erdao dam. Although the PFASs in the sediment cores did not show a clear decreasing or increasing trend with depth,the three cores had a similar vertical variation.The PFAS levels were relatively low in the surface sediment,and reached the first high point at8–20 cm as a result of the wide use of PFASs from 1990 to 2000. After that the PFAS levels decreased,and then increased to a second high point at about 40–48 cm,which might be caused by the leaching of PFASs in sediment. Because PFASs have hydrophilic groups and relatively high solubility,the PFASs will transfer from the upper to lower layers of sediment when water infiltration occurs,leading to the fluctuation of PFAS levels in sediment cores. This study suggests that both the temporal variation of sources and transfer processes of PFASs in sediments are important factors influencing the vertical variation of PFASs in sediment cores. | Xiuli Zhao Xinghui Xia Shangwei Zhang Qiong Wu Xuejun Wang | 2014 | Journal of Environmental Sciences2014，26，8： | 8 |
| 10 | Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides显示文摘Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage. | Feng Zhao Sujuan Wang Sheng Lin Chenggen Zhu Zhenggang Yue Yang Yu Bo Liu Xiuli Wu Yongchun Yang Yan Li Jiangong Shi | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 7 |
| 11 | The calcium-dependent protein kinase ZmCDPK7 functions in heat-stress tolerance in maize显示文摘Global warming poses a serious threat to crops.Calcium-dependent protein kinases(CDPKs)/CPKs play vital roles in plant stress responses,but their exact roles in plant thermotolerance remains elusive.Here,we explored the roles of heat-induced ZmCDPK7 in thermotolerance in maize.ZmCDPK7-overexpressing maize plants displayed higher thermotolerance,photosynthetic rates,and antioxidant enzyme activity but lower H2 O2 and malondialdehyde(MDA)contents than wild-type plants under heat stress.ZmCDPK7-knockdown plants displayed the opposite patterns.ZmCDPK7 is attached to the plasma membrane but can translocate to the cytosol under heat stress.ZmCDPK7 interacts with the small heat shock protein sHSP17.4,phosphorylates sHSP17.4 at Ser-44 and the respiratory burst oxidase homolog RBOHB at Ser-99,and up regulates their expression.Site-directed mutagenesis of sHSP17.4 to generate a Ser-44-Ala substitution reduced ZmCDPK7’s enhancement of catalase activity but enhanced ZmCDPK7’s suppression of MDA accumulation in heat-stressed maize protoplasts.sHSP17.4,ZmCDPK7,and RBOHB were less strongly upregulated in response to heat stress in the abscisic acid-deficient mutant vp5 versus the wild type.Pretreatment with an RBOH inhibitor suppressed sHSP17.4 and ZmCDPK7 expression.Therefore,abscisic acid-induced ZmCDPK7 functions both upstream and downstream of RBOH and participates in thermotolerance in maize by mediating the phosphorylation of sHSP17.4,which might be essential for its chaperone function. | Yulong Zhao Hanwei Du Yankai Wang Huali Wang Shaoyu Yang Chaohai Li Ning Chen Hao Yang Yihao Zhang Yulin Zhu Luyao Yang Xiuli Hu | 2021 | Journal of Integrative Plant Biology2021，63，3： | 6 |
| 12 | Preparation and evaluation of poly(L-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells显示文摘In this study, a p H-sensitive micelle self-assembled from poly(L-histidine) based triblock copolymers of poly(ethylene glycol)–poly(D,L-lactide)–poly(L-histidine)(mPEG-PLA-PHis) was prepared and used as the intracellular doxorubicin(Dox) delivery for cancer chemotherapy. Dox was loaded into the micelles by thin-film hydration method and a Box–Behnken design for three factors at three levels was used to optimize the preparations. The optimized mPEG-PLA-Phis/Dox micelles exhibited good encapsulation efficiency of 91.12%,a mean diameter of 45 nm and narrow size distribution with polydispersity index of 0.256.In vitro drug release studies demonstrated that Dox was released from the micelles in a p Hdependent manner. Furthermore, the cellular evaluation of Dox loaded micelles displayed that the micelles possessed high antitumor activity in vitro with an IC50 of 35.30 μg/ml against MCF-7/ADR cells. The confocal microscopy and flow cytometry experiments indicated that m PEG-PLA-Phis micelles mediated efficient cytoplasmic delivery of Dox with the aid of poly(Lhistidine) mediated endosomal escape. In addition, blank m PEG-PLA-Phis micelles were shown to be nontoxic to MCF-7/ADR cells even at a high concentration of 200 μg/ml. The pHsensitive mPEG-PLA-PHis micelles have been demonstrated to be a promising nanosystem for the intracellular delivery of Dox for MDR reversal. | Nan Jia Yuqing Ye Qi Wang Xiuli Zhao Haiyang Hu Dawei Chen Mingxi Qiao | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 6 |
| 13 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 14 | A novel approach for assessing the susceptibility of Escherichia coli to antibiotics显示文摘The dynamic growth process of Escherichia coli CVCC249 under different concentrations of antibiotics was analyzed. The results suggested that the main reason that definitive results cannot be obtained by antibiotic susceptibility testing (AST) is that the ratio of drug concentration to the population of bacteria and the combined effect of drug concentration and action time cannot be completely determined with the methods used. Based on the analysis of the growth process with a series of concentrations of gentamicin acting for a certain time, and according to the forward difference method, a novel method for AST was proposed. The net increase in turbidity of the bacterial population was used to eliminate the existing effects of resting cells, and then the recurrent coefficient for a growing sequence was used to characterize the effect of antibiotics on bacterial division, and the contour plot was used to display and analyze the combined effect of drug concentration and action time. The inhibition rate of the antibiotics can be characterized as the dynamic change in the composite function of the antibiotic concentration and action time, which indicated that the inhibition rate was dependent on the combined effect of time and concentration of antibiotics. The effectiveness of this new method has been verified with different kinds of antibiotics, such as enrofloxacin, levofloxacin, and ceftriaxone, having different antibacterial mechanisms. | ZHANG HuaiQiang, ZHAO Yue, HE XiuLi & GAO PeiJi State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China | 2010 | Science China(Life Sciences)2010，53，11： | 5 |
| 15 | Promoting proliferation and differentiation of BMSCs by green tea polyphenols functionalized porous calcium phosphate显示文摘In this article,we proposed a facile protocol to functionalize porous calcium phosphate ceramics(PCPC)using dietary tea polyphenols(TP).TP molecules was attracted and anchored by Ca2t ions from the surface of CPC.These TP molecules modulated the nucleation and crystallization of calcium phosphate nanorods assemblies on the surface of PCPC.Our results prove that these calcium phosphate nanorods assemblies accompanies functional groups of TP make PCPC/TP effectively promote proliferation and differentiation of bone mesenchymal stem cells(BMSCs).We inferred that these calcium phosphate nanorods assemblies might change the surface microenvironment of PCPC,which is critical to promote the proliferation and differentiation of BMSCs.Compared with naked PCPC,PCPC/TP obviously increased BMP2,ErK/MAPK and JNK/MAPK level and mineralization capacity of cells(ALP level). | Kang Zhou Xiuli Ren Mengen Zhao Xifan Mei Peng Zhang Zhenhua Chen Xiangdong Zhu | 2018 | Regenerative Biomaterials2018，5，1： | 5 |
| 16 | Recent advances in nanomaterials for sonodynamic therapy显示文摘Sonodynamic therapy(SDT),as a novel non-invasive strategy for eliminating tumor,has the advantages of deeper tissue penetration,fewer side effects,and better patient compliance,compared with photodynamic therapy(PDT).In SDT,ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species(ROS),induce the collapse of vacuoles in solution,and bring about irreversible damage to cancer cells.In recent years,much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS.However,the traditional organic sonosensitizers,such as porphyrins,hypericin,and curcumins,suffer from complex synthesis,poor water solubility,and low tumor targeting efficacy which limit the benefits of SDT.In contrast,inorganic sonosensitizers show good in vivo stability,controllable physicochemical properties,ease of achieving multifunctionality,and high tumor targeting,which greatly expanded their application in SDT.In this review,we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers,and directly produce ROS under ultrasound.Moreover,the prospects of inorganic nanomaterials for SDT application are also discussed. | Ting Xu Shaojing Zhao Changwei Lin Xiuli Zheng Minhuan Lan | 2020 | Nano Research2020，13，11： | 5 |
| 17 | Seismic stability of jointed rock slopes under obliquely incident earthquake waves显示文摘Seismic stability of slopes has been traditionally analyzed with vertically propagated earthquake waves.However,for rock slopes,the earthquake waves might approach the outcrop still with a evidently oblique direction.To investigate the impact of obliquely incident earthquake excitations,the input method for SV and P waves with arbitrary incident angles is conducted,respectively,by adopting the equivalent nodal force method together with a viscous-spring boundary.Then,the input method is introduced within the framework of ABAQUS software and verified by a numerical example.Both SV and P waves input are considered herein for a 2 D jointed rock slope.For the jointed rock mass,the jointed material model in ABAQUS software is employed to simulate its behavior as a continuum.Results of the study show that the earthquake incident angles have significance on the seismic stability of jointed rock slopes.The larger the incident angle,the greater the risk of slope instability.Furthermore,the stability of the jointed rock slopes also is affected by wave types of earthquakes heavily.P waves induce weaker responses and SV waves are shown to be more critical. | Huang Jingqi Zhao Mi Xu Chengshun Du Xiuli Jin Liu Zhao Xu | 2018 | Earthquake Engineering and Engineering Vibration2018，17，3： | 4 |
| 18 | Detection of TNT by a molecularly imprinted polymer film-based surface plasmon resonance sensor显示文摘A surface plasmon resonance(SPR) sensor using a molecularly imprinted polymer(MIP) film as a recognition element for detection of 2,4,6-trinitrotoluene(TNT) was developed.The TNT-imprinted polymer film was prepared by thermo initiated polymerization on the bare Au surface of an SPR sensor chip.Template TNT molecules were quickly removed with an organic solution of acetonitrile/acetic acid(9:1,v/v),causing a shift of 0.7° in SPR angle.The limit of detection for TNT was demonstrated to be as low as 1×10-8 mol/L.In the concentration range of 1×10-8-1×10-5 mol/L,the change of SPR angle was linear with the negative logarithm of TNT concentration,Selectivity studies showed that the SPR sensor had no response to TNT analogues 2,4,5-trinitrotoluene and 1,3,5-trinitrohexahydro-1,3,5-triazine at a concentration of 1×10-4 mol/L.The results suggest that the SPR sensor combined with a MIP film has the advantages of high sensitivity and selectivity,and long-term stability toward the analyte TNT. | BAO Han WEI TianXin LI XiuLi ZHAO Zhe CUI He ZHANG Peng | 2012 | Chinese Science Bulletin2012，57，17： | 4 |
| 19 | Nested multiplex PCR——A feasible technique to study partial community of arbuscular mycorrhizal fungi in field-growing plant root显示文摘Plant can be infected by different arbuscular mycorrhizal fungi, but little is known about the interaction between them within root tissues mainly because different species cannot be distin-guished on the basis of fungal structure. Accurate species identification of Arbuscular mycorrhizal fungi (AMF) colonized in plant roots is the cornerstone of mycorrhizal study, yet this fundamental step is impossible through its morphological character alone. For accurate, rapid and inexpensive detec-tion of partial mycorrhizal fungal community in plant roots, a nested multiplex polymerase chain reac-tion (PCR) was developed in this study. Five discriminating primers designed based on the variable region of the 5′ end of the large ribosomal subunit were used in the experiment for testing their speci-ficity and the sensitivity in nested PCR by using spores from Glomus mosseae (BEG12), Glomus intraradices (BEG141), Scutellospora castaneae (BEG1) and two unidentified Glomus sp. HAUO3 and HAUO4. The feasibility assay of nested multiplex PCR was conducted by use of spore mixture, Astragalus sinicum roots co-inoculated with 4 species of arbuscular mycorrhizal fungi from pot cul-tures and 15 different field-growing plant roots respectively after analyses of the compatibility of primers. The result indicated that the sensitivity was in the same range as that of the corresponding single PCR reaction. Overall accuracy was 95%. The efficiency and sensitivity of this multiplex PCR procedure provided a rapid and easy way to simultaneously detect several of arbuscular mycorrhizal fungal species in a same plant root system. | DONG Xiuli ZHAO Bin | 2006 | Science China(Life Sciences)2006，49，4： | 3 |
| 20 | Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect显示文摘In osteoporosis scenario, tissue response to implants is greatly impaired by the deteriorated boneregeneration microenvironment. In the present study, a Mg-containing akermanite (Ak) ceramic wasemployed for the treatment of osteoporotic bone defect, based on the hypothesis that both beneficialions (e.g. Mg^2+ ect.) released by the implants and the weak alkaline microenvironment pH (μe-pH) itcreated may play distinct roles in recovering the abnormal bone regeneration by stimulating osteoblasticanabolic effects. The performance of Ak, b-tricalcium phosphate (β-TCP) and Hardystone (Har) in healinga 3 mm bone defect on the ovariectomized (OVX) osteoporotic rat model was evaluated. Our resultsindicated that, there's more new bone formed in Ak group than in β-TCP or Har group at week 9. Theinitial me-pHs of Ak were significantly higher than that of the β-TCP and Blank group, and this weakalkaline condition was maintained till at least 9 weeks post-surgery. Increased osteoblastic activity whichwas indicated by higher osteoid secretion was observed in Ak group at week 4 to week 9. An intermediatelayer which was rich in phosphorus minerals and bound directly to the new forming bone wasdeveloped on the surface of Ak. In a summary, our study demonstrates that Ak exhibits a superior boneregenerative performance under osteoporosis condition, and might be a promising candidate for thetreatment of osteoporotic bone defect and fracture. | Wenlong Liu Ting Wang Xiaoli Zhao Xiuli Dan William W.Lu Haobo Pan | 2016 | Bioactive Materials2016，1，2： | 3 |
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