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| 1 | Predictive biomarkers in precision medicine and drug development against lung cancer显示文摘The molecular characterization of various cancers has shown that cancers with the same origins,histopathologic diagnoses,and clinical stages can be highly heterogeneous in their genetic and epigenetic alterations that cause tumorigenesis.A number of cancer driver genes with functional abnormalities that trigger malignant transformation and that are required for the survival of cancer cells have been identified.Therapeutic agents targeting some of these cancer drivers have been successfully developed,resulting in substantial improvements in clinical symptom amelioration and outcomes in a subset of cancer patients.However,because such therapeutic drugs often benefit only a limited number of patients,the successes of clinical development and applications rely on the ability to identify those patients who are sensitive to the targeted therapies.Thus,biomarkers that can predict treatment responses are critical for the success of precision therapy for cancer patients and of anticancer drug development.This review discusses the molecular heterogeneity of lung cancer pathogenesis;predictive biomarkers for precision medicine in lung cancer therapy with drugs targeting epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK),c-ros oncogene 1 receptor tyrosine kinase[ROSl),and immune checkpoints;biomarkers associated with resistance to these therapeutics;and approaches to identify predictive biomarkers in anticancer drug development.The identification of predictive biomarkers during anticancer drug development is expected to greatly facilitate such development because it will increase the chance of success or reduce the attrition rate.Additionally,such identification will accelerate the drug approval process by providing effective patient stratification strategies in clinical trials to reduce the sample size required to demonstrate clinical benefits. | Bingliang Fang Reza J Mehran John V Heymach Stephen G Swisher | 2015 | Chinese Journal of Cancer2015，34，7： | 5 |
| 2 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 3 | 显示文摘 | Fang J Raymond L V | 1978 | J Colloid Interface Sei1978，116，： | 1 |
| 4 | Stable carbon isotope biogeochemistu of a shallow sand aquifer contam- inated with fuel hydrocarbons显示文摘 | Fang J S Barcelona M J Krishnamurthy R V | 2000 | Applied Geochemistry2000，15，2： | 1 |
| 5 | Conductivity study of the microemuIsion system sodium dodecyl sulfate - hexylamine - heptane - water 显示文摘 | FANG J RAYMONDL V | 1978 | Colloid Inter Sci1978，116，： | 1 |
| 6 | Network embeddedness and technology transfer performance in R&D consortia in Taiwan 显示文摘 | Lin J L Fang S-C Fang S-R V | 2009 | Technovation2009，29，11： | 1 |
| 7 | Quantum-behaved particle swarm optimization with Gaussian distributed local attractor point显示文摘 | Sun J Fang W Palade V | | 0，，07： | 1 |
| 8 | A hierarchical neural network approach to the development of a library of neural models for microwave design显示文摘 | Wang Fang Devabhaktuni V K Zhang Q J | 1998 | IEEE Trans MTT1998，46，12： | 1 |
| 9 | Facemasks and Hand Hygiene to Prevent Influenza Transmission in Households: A Cluster Randomized trial显示文摘 | Cowling B J Chan K H Fang V J | 2009 | Ann Intern Med2009，151，7： | 1 |
| 10 | Conductivity study of the microemuslsion system sodium dodecyl sulfate-hexylamine-heptane-water 显示文摘 | Fang J Raymond L V | 1978 | J Colloid Interface Sci1978，116，2： | 1 |
| 11 | Quantum-behavedparticle swarm optimization with Ganssian distributed local attractor point 显示文摘 | SUN J FANG W PALADE V WU X J XU W B | 2011 | Applied Mathematics and Computation2011，21，87： | 1 |
| 12 | Comprehensive gene expression analysis by transcript profiling显示文摘 | Donson J Fang Y Espiritu-Santo G Xing W Salazar A Miyamoto S Armendarez V Volkmuth W | 2002 | Plant Mol Biol2002，48，： | 1 |
| 13 | Exploiting the versatile assembly of arylpyridine fluorophores for wavelength tun- ing and SAR 显示文摘 | Fang A G Mello J V Finney N S | 2003 | Org Lett2003，5，7： | 1 |
| 14 | Late Cenozoic magnetostraigraphy (0-11Ma) of the Dongshanding and Wangjiashan sections in the Longzhong Basin, western China显示文摘 | Li J J Fang X M Rob V D V | 1997 | Geolgie en Mijnbouw1997，76，： | 1 |
| 15 | Quantum-behaved particle swarm optimization with Gaussian distributed local attractor paint 显示文摘 | Sun J Fang W Palade V | 2011 | Applied Mathematics and Computation2011，218，7： | 1 |
| 16 | Resorcinol-formaldehyde aero- gels for CMOS-MEMS capacitive humidity sensor 显示文摘 | CHUNG V P J YIP M C FANG W | 2015 | SENSORS AND ACTUATORS B-CHEMICAL2015，214，： | 1 |
| 17 | Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent,hydroxylation-regulated association with p300/CBP显示文摘 | Fang J Srinivas V | 2002 | Mol Cell Biol2002，22，： | 1 |
| 18 | Targeted disruption of the melanoeortin 4- receptor results in obesity in mice显示文摘 | Huszar D Lynch C A Fairchild-Huntress V Dun- more J H Fang Q Berkemeier L R Gu W Kester- son R A Boston B A Cone R D Smith F J Campfield L A Burn P Lee F | 1997 | Cell1997，88，： | 1 |
| 19 | Targeted disruption of the melanocortin-4 receptor results in obesity in mice显示文摘 | Lynch C A Fairchild-Huntress V Dunmore J H Fang Q Berkemeier L R Gu W Kesterson R A Boston B A Cone R D Smith F J Campfield L A Burn P Lee F | 1997 | Cell1997，88，1： | 1 |
| 20 | Conductivity study of the microemulsion system sodium dodecylsulfate hexylamine heptane water显示文摘 | Fang J Raymond L V | 1978 | J Colloid Interface Science1978，116，2： | 1 |
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