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| 1 | ETME,a novel β-elemene derivative,synergizes with arsenic trioxide in inducing apoptosis and cell cycle arrest in hepatocarcinoma cells via a p53-dependent pathway显示文摘Arsenic trioxide(ATO)has been identified as an effective treatment for acute promyelocytic leukemia(APL)but is much less effective against solid tumors such as hepatocellular carcinoma(HCC).In the search for ways to enhance its therapeutic efficacy against solid tumors,we have examined its use in combination with a novel derivative ofβ-elemene,N-(β-elemene-13-yl)tryptophan methyl ester(ETME).Here we report the effects of the combination on cell viability,apoptosis,the cell cycle and mitochondria membrane potential(MMP)in HCC SMMC-7721 cells.We found that the two compounds acted synergistically to enhance antiproliferative activity and apoptosis.The combination also decreased the MMP,down-regulated Bcl-2 and pro-proteins of the caspase family,and up-regulated Bax and BID,all of which were reversed by the p53 inhibitor,pifithrin-α.In addition,the combination induced cell cycle arrest at the G2/M phase and reduced tumor volume and weight in an xenograft model of nude mice.Overall,the results suggest that ETME in combination with ATO may be useful in the treatment of HCC patients particularly those unresponsive to ATO alone. | Zhiying Yu Fangling Wu Liang Chen Qian Li Chaojie Wang Jinhua Dong Song-qiang Xie | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 7 |
| 2 | Economy Analysis of Flexible LCC-HVDC Systems with Controllable Capacitors显示文摘Commutation failure(CF)is a frequent dynamic event at inverter of LCC-HVDC systems caused by AC side faults which can lead to inverter blocking,interruption of active power transfer,and even system blackout.To eliminate CFs and improve system performance,new Flexible LCC-HVDC topologies have been proposed in previous research but with limited analysis on its economic performance.Therefore,to further validate the applicability of Flexible LCC-HVDC topologies,this paper utilizes Life-Cycle Cost Analysis model to analyze the life-cycle cost of inverter stations for conventional LCCHVDC,Capacitor Commutated Converter based HVDC(CCCHVDC)topology and Flexible LCC-HVDC topologies including Controllable Capacitor based Flexible LCC-HVDC,AC Filterless Controllable Capacitor based Flexible LCC-HVDC and improved Flexible LCC-HVDC.Through a case study based on a 500 kV,1000 MW LCC-HVDC scheme,comparison results show that the AC Filterless Controllable Capacitor based Flexible LCCHVDC topology and the improved Flexible LCC-HVDC topology have lower cost than the conventional LCC-HVDC and CCCHVDC topologies,which proves that the elimination of CFs can be achieved with reduced cost. | Nan Chen Kunpeng Zha Haitao Qu Fangling Li Ying Xue Xiao-Ping Zhang | 2022 | CSEE Journal of Power and Energy Systems2022，8，6： | 2 |
| 3 | Photocatalytic decarboxylative coupling between α-oxocarboxylicacids and alkenes显示文摘Photocatalytic decarboxylative cross-coupling which achieves the derivatization of widespread organic acids has become a hot topic in organic synthesis.As special acids,α-oxocarboxylicacids show the great potential in running decarboxylation to construct ketone derivatives.In this article,we have developed a photocatalytic decarboxylative cross-coupling ofα-oxocarboxylic acids and olefins to the synthesis of diverse aryl ketones.Various alkenes andα-oxocarboxylicacids were compatible,generating the desired products in up to 90%yield.Preliminary mechanism studies suggest that a free radical pathway is involved in this process. | Ziyue Chen Fangling Lu Feng Yuan Juanjuan Sun Linyu Du Zhen Li Meng Gao Renyi Shi Aiwen Lei | 2019 | Science China Chemistry2019，62，11： | 2 |
| 4 | Cosine-Modulated Transceivers for TV White Space Cognitive Access显示文摘 | ZHAO Nan PU Fangling XU Xin CHEN Nengcheng | 2012 | Chinese Journal of Electronics2012，21，2： | 2 |
| 5 | Junceellin and praelolide,two briaranes from the gorgonian corals Junceella fragilis and Junceella juncea(Ellisellidae)显示文摘 | SUNG P FAN T CHEN M FANGL LIN M CHANG P | 2004 | Biochem Syst Ecol2004，32，1： | 1 |
| 6 | Potential use of peanut by -products in food processing:a review 显示文摘 | Xiaoyan Zhao Jun Chen Fangling Du | 2012 | Journal of Food Science and Technology2012，49，5： | 1 |
| 7 | Cyber-physical Geographical Information Service-Enabled Control of Diverse In-situ Sensors显示文摘 | Chen Nengcheng Xiao Changjiang Pu Fangling | 2015 | Sensors2015，15，2： | 1 |
| 8 | Adsorption and desorption of Cd in reclaimed soil under the influence of humic acid:characteristics and mechanisms显示文摘Exogenous humus can change the content and migration activity of cadmium(Cd)in soil.Humic acid(HA)is an important soluble humus component in soil.In order to explore the relationship between cadmium pollution mechanism and ecological environment of humic acid in reclaimed soil,the characteristics of humic acid adsorbing cadmium in alkaline conditions were studied.This study employed reclaimed soil from the Huainan mining area,China.The adsorption and desorption characteristics as well as influence mechanisms on the heavy metal cadmium(Cd)were explored under the influence of HA.The results show that:(1)When Cd concentration was low(0.2–10 mg/L),HA had little effect on Cd adsorption and desorption in reclaimed soil.When the Cd concentration was high(15–80 mg/L),HA had a great influence on the adsorption and desorption of Cd in reclaimed soil.The addition of HA can inhibit the adsorption of Cd by reclaimed soil and effectively improve the desorption capacity of Cd by reclaimed soil.(2)The kinetic curves of Cd adsorption and desorption of reclaimed soil with added HA show that both processes(adsorption and desorption)include two stages:rapid reaction and slow reaction.The adsorption of Cd by reclaimed soil under the influence of HA was 18.18%lower than that of normal reclaimed soil,and the increase of Cd desorption was 50.29%.(3)The factors affecting the adsorption and desorption of Cd in the soil were analyzed with gray theory,and their importance can be ordered as follows:Cd concentration>HA concentration>pH>temperature.Considering the influence of HA,a multi-factor coupling function model of adsorption and desorption of Cd in soil is established.This model provides theoretical guidance for the scientific prediction and evaluation of Cd environmental pollution risks in soil and will be useful for developing a new solution for engineering remediation of high concentration Cd contaminated soil. | Yonghong Zheng Zhiguo Zhang Yongchun Chen Shikai An Lei Zhang Fangling Chen Chengnan Ma Weiqing CAi | 2022 | International Journal of Coal Science & Technology2022，9，1： | 1 |
| 9 | Surgical instruments hyalinization:Occlusion removal in minimally invasive endoscopic surgery显示文摘Minimal invasion is an important trend in surgery.However,the endoscope,as one of the key devices for monitoring the process of minimally invasive surgery,is limited by its size and working space it operates in,which result in a considerably narrow field of view.In particular,when a surgical instrument enters through the tool channel,the instrument occupies most of the area in an endoscopic image.This hampers the surgeon’s field of view and has a negative impact on the surgery.This study proposes a novel method for removing the occlusion caused by surgical instruments in endoscopic images by making foreground occlusions on endoscopic images transparent using image restoration and interframe information filling.Compared with unprocessed images,this method can provide a clearer field of view that is necessary for minimally invasive endoscopic surgeries and improve the quality of surgeries.Clinical endoscopic images are used to verify the feasibility of the proposed method,and the results show that the proposed method improves the visual effect of endoscopic images by removing surgical-instrument occlusions.This demonstrates the considerable potential of the proposed method for use in clinical applications. | Dongsheng Xie Wenxin Chen Jin Zhao Xinya Song Kaifeng Wang Weiwei Xia Haiying Liu Fangle Chang Changsheng Li Xingguang Duan | 2023 | Biomimetic Intelligence & Robotics2023，3，3： | 1 |
| 10 | Room temperature in-situ preparation of hydrazine-linked covalent organic frameworks coated capillaries for separation and determination of polycyclic aromatic hydrocarbons显示文摘Covalent organic frameworks(COFs)have been increasingly used in capillary electrochromatography due to their excellent characteristics.In this work,hydrazine-linked TFPB-DHzDS(TFPB:1,3,5-tris(4-formylphenyl)benzene;DHzDS:2,5-bis(3-(ethylthio)propoxy)terephthalohydrazide)was first synthesized by a simpler and easier method at room temperature and introduced into capillary electrochromatography as coating material.The TFPB-DHzDS coated capillaries were prepared by an in-situ growth process at room temperature.After optimizing the coating concentration and experimental conditions of capillary electrochromatography,baseline separation of two groups of polycyclic aromatic hydrocarbons was achieved based on the TFPB-DHzDS coated capillary.And the established method was used successfully to determine PAHs in natural water and soil samples.The spiked recoveries of polycyclic aromatic hydrocarbons in these samples ranged from 90.01%to 111.0%,indicating that the method is reliable and could detect polycyclic aromatic hydrocarbons in natural samples.Finally,molecular simulation was applied to study and visualize the interaction between the analytes and coating COF materials to investigate the molecular level separation mechanism further. | Yanli Zhang Wenjuan Lv Fangling Wang Xiao Niu Guoxiu Wang Xuequan Wu Xiaoyun Zhang Xingguo Chen | 2023 | Frontiers of Chemical Science and Engineering2023，17，5： | 0 |
| 11 | External-Oxidant-Free Electrochemical Oxidative Trifluoromethylation of Arenes Using CF3SO2Na as the CF3 Source显示文摘Summary of main observation and conclusion An efficient and environmentally benign electrochemical oxidative radical C-H trifluoromethylation of arenes by employing Langlois reagent as the CF3 source was developed in this work.Neither transition metal catalysts nor external chemical oxidants were required in this trifluoromethylation process.The reaction could be conducted in gram scale with high reaction efficiency. | Yong Deng Fangling Lu Siqi You Tianrui Xia Yifan Zheng Cuifen Lu Guichun Yang Zuxing Chen Meng Gao Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，8： | 0 |
| 12 | Heat preservation,antifouling,hemostatic and antibacterial aerogel wound dressings for emergency treatment显示文摘Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents.In particular,the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage.In this study,gelatin(GN)and oxidized pectin(OP)were used for Schiff base cross-linking,and then polyvinyl alcohol(PVA)solution mixed with hemostatic caffeic acid(CA)was introduced to obtain aerogel substrate material(CB)after lyophilization.Polydimethylsiloxane(PDMS)and silver nanowires(Ag NWs)were used to construct a hydrophobic layer,an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation,antifouling,hemostasis and antibacterial properties(PDMS-Ag NW-CB).The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0,so that thermal energy loss from the body is minimized.The contact angles with water and blood are 129°and 120°,respectively,which have the effect of antifouling.This dressing can absorb blood quickly within 10 min,adhere to and gather platelets,and achieve hemostasis.It has good antibacterial and biocompatibility.Therefore,PDMS-Ag NW-CB has great potential in application to emergency treatment. | Fangling Li Xiaoman Han Dongdong Cao Junxia Yin Li Chen Dongmei Li Lin Cui Zhiyong Liu Xuhong Guo | 2023 | Frontiers of Materials Science2023，17，2： | 0 |
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