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| 1 | The complete mitochondrial genome of the Chinese oak silkmoth, Antheraea pernyi (Lepidoptera: Saturniidae)显示文摘我们从中国橡树丝绸蛾决定了 mitogenome 的完全的核苷酸顺序, Antheraea pernyi (鳞翅目:Saturniidae ) 。15,566 bp 通报染色体为鳞翅类的 mitogenomes 包含不正常的基因组织和顺序。mitogenome 在已知的鳞翅类的 mitogenome 序列之中包含最低 A+T 内容(80.16%) 。一个不平常的特征比作为是更多的 T 的出现,与一在偏斜度(−0.021 ) 稍微否定,在主要染色体海滨的作文。所有编码蛋白质的基因被 ATN 鳕鱼 ons 开始,除了细胞色素 oxidase 子单元我,它被在另外的 lepidopterans 观察了的 TTAG 顺序建议。所有转移 RNA (tRNAs ) 有 mitochondrial tRNA 的典型四叶苜蓿形的立体道路交叉点结构,除了 tRNA 重量的单位 (AGN), 哪个不能形成稳定的茎环结构的 DHU 手臂。二与一段超过 50 bp 排列了顺序块, 90% 顺序身份在 Saturniidae 和 Bombycoidae 种类的 A+T 富有的区域被识别。 | Yanqun Liu Yuping Li Minhui Pan Fangyin Dai Xuwei Zhu Cheng Lu Zhonghuai Xiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 21 |
| 2 | Development of 'Multi-Resistance Rice' by Pyramiding of Insect (Cry1C) and Blast Resistance (Pi1 and Pi2) Genes显示文摘[Objective] The paper was to improve the blast resistance of insect-resistant transgenic rice. [Method] The Japonica rice variety Jikang10, a new transgenic variety with exogenous insect-resistant gene Cry1C, was used as the receptor, and Kongyu 131, a traditional breeding variety with broad-spectrum high blast resistance genes Pi1 and Pi2, was used as the donor to breeding new rice varieties. The genes were polymerized by hybridization and multi-generation backcrossing, and the offspring of each generation was screened by molecular marker assisted selection, field identification of multi-resistance against insect pests and diseases and agronomic trait selection. [Result] Four lines SK01, SK02, SK03 and SK04 with better resistances to insect pests and blast and outstanding agronomic traits in field were selected. [Conclusion] The results will lay foundations for breeding new multi-resistance rice varieties in Huanghuai rice region. | Xu Liu Hua Zhang Pingbo Li Mengqi Zhang Fang Liu Fangyin Yao | 2021 | Plant Diseases and Pests2021，12，3： | 3 |
| 3 | Single‑Atom Cobalt‑Based Electrochemical Biomimetic Uric Acid Sensor with Wide Linear Range and Ultralow Detection Limit显示文摘Uric acid(UA)detection is essential in diagnosis of arthritis,preeclampsia,renal disorder,and cardiovascular diseases,but it is very challenging to realize the required wide detection range and low detection limit.We present here a single-atom catalyst consisting of Co(Ⅱ)atoms coordinated by an average of 3.4 N atoms on an N-doped graphene matrix(A-Co-NG)to build an electrochemical biomimetic sensor for UA detection.The A-Co-NG sensor achieves a wide detection range over 0.4-41,950μM and an extremely low detection limit of 33.3±0.024 nM,which are much better than previously reported sensors based on various nanostructured materials.Besides,the A-Co-NG sensor also demonstrates its accurate serum diagnosis for UA for its practical application.Combination of experimental and theoretical calculation discovers that the catalytic process of the A-Co-NG toward UA starts from the oxidation of Co species to form a Co^3+-OH-UA*,followed by the generation of Co^3+-OH+^*UA_H,eventually leading to N-H bond dissociation for the formation of oxidized UA molecule and reduction of oxidized Co^3+to Co^2+for the regenerated A-Co-NG.This work provides a promising material to realize UA detection with wide detection range and low detection limit to meet the practical diagnosis requirements,and the proposed sensing mechanism sheds light on fundamental insights for guiding exploration of other biosensing processes. | Fang Xin Hu Tao Hu Shihong Chen Dongping Wang Qianghai Rao Yuhang Liu Fangyin Dai Chunxian Guo Hong Bin Yang Chang Ming Li | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 4 | Strategic Significance of the 21^(st) Century Maritime Silk Road and Tactics in its Development显示文摘In a speech delivered at the Indonesian Parliament in October 2013,Chinese President Xi Jinping said:'we should further strengthen our maritime partnerships and jointly build the 21st century Maritime Silk Road',articulating China’s willingness to beef up maritime cooperation with ASEAN countries.The Decision of the Central Committee of the Communist Party of China | Zhou Fangyin Li Yuanxing | 2014 | International Understanding2014，，2： | 2 |
| 5 | Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer显示文摘Propofol,a common intravenous anesthetic used in clinical,has been shown to regulate cells proliferation,inflammation,angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer.However,the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown.The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer(CRC).Scratches assay,Transwell assay were used to detect colon cells migration and invasion.Realtime Quantitative Polymerase Chain Reaction(RT-qPCR),Western blotting were utilized to detect the expression of related molecules.Dual-luciferase assay was performed to identify transcriptional activity of target genes,RNA pulldown assay was used to confirm the interactions of RNAs.Results indicated that propofol inhibited cell migration and invasion through suppressing lactic acid production in CRC.Moreover,propofol reduced lactic acid production by down-regulating the expression of hypoxia inducible factor-1α(HIF-1α)and monocarboxylate transporter 4(MCT4).In addition,propofol inhibited the expression of HIF-1αand cells migration/invasion via suppressing the interaction of HOX transcript antisense RNA(HOTAIR)with miR-93.The present study indicated that propofol inhibited colon cancer cell migration and invasion by reducing lactic acid production and the expression of HIF-1αand MCT4 via HOTAIR/miR-93 axis.These data may provide potential metabolic targets for CRC treatment. | RUONAN GU WENJING GUO WENYANG WANG GUIHUAN LI XIAOJU LAI ZHIBIN HUANG WANLU ZHAO ZHICONGWU HUA CHEN WENYANG LUO FANGYIN ZENG FAN DENG | 2021 | BIOCELL2021，45，6： | 0 |
| 6 | Application of AHP and DTOPSIS in Sugarcane Breeding显示文摘The weights of ten important traits of sugarcane,including the number of hair groups,plant height,defoliation capability,stalk diameter,ratooning property,stalk number of disease resistance,cane yield,sucrose content and sugar yield,were distributed with the Analytic Hierarchy Process( AHP) method. Ten Yuetang series of sugarcane lines were evaluated by Dynamic Technique for Order Preference by Similarity to Ideal Solution( DTOPSIS). AHP results indicated that the weights of ten traits were 0. 013 4,0. 022 7,0. 030 2,0. 040 8,0. 065 3,0. 088 1,0. 116 2,0. 160 6,0. 198 4 and 0. 264 5,respectively,with random consistency ratio C. R. = 0. 098 1 < 0. 1,suggesting that the distribution of the weights of evaluation indicators was reasonable. Comprehensive evaluation of 10 sugarcane lines by DTOPSIS method combining with the conclusion of AHP showed that the comprehensive performances of Yuetang 03-393 and Yuetang 03-373 were much better than other sugarcane lines,with relative approach degree C i ranking the first and second,respectively,which was basically consistent with the practical survey,suggesting that Yuetang 03-393 and Yuetang 03-373 were suitable for large-scale popularization. The above results confirmed the feasibility of applying AHP and DTOPSIS in comprehensive evaluation of new crop varieties and provided reference for the breeding of new sugarcane lines. | Jiantao WU Junxian YANG Fuye LIU Qiwei LI Wenlong WU Fangyin PAN Jing XIE Yuegui CHEN | 2013 | Agricultural Biotechnology2013，2，5： | 0 |
| 7 | Simulating androgen receptor selection in designer yeast显示文摘Androgen receptor(AR)mutation is closely associated with prostate cancer(PCa)and is one of the mechanisms of resistance to PCa therapies such as AR antagonists.Although sequencing technologies like next-generation sequencing(NGS)contributes to the high-throughput and precise detection of AR mutations carried by PCa patients,the lack of interpretations of these clinical genetic variants has still been a roadblock for PCa-targeted precision medicine.Here,we established a designer yeast reporter assay to simulate natural androgen receptor(AR)selection using AR antagonists.Yeast HIS3 gene transactivation was associated with the ligand-induced recruitment of steroid receptor coactivator-1(SRC-1)by AR mutants,where yeast growth in histidine-free medium was determined as the outcome.This assay is applicable to determine a wide range of clinical AR mutants including those with loss of function relating to androgen insensitivity syndrome(AIS),and those associated with PCa conferring resistance to AR antagonists such as enzalutamide(ENZ),bicalutamide(BIC),and cyproterone acetate(CPA).One clinical AR mutant previously reported to confer ENZ-resistance,F877L,was found to confer partial resistance to CPA as well using designer yeast.Our simple and efficient assay can enable precise one-pot screening of AR mutants,providing a reference for tailored medicine. | Haoran Zhang Lu Zhang Yipeng Xu Shaoyong Chen Zhenyi Ma Mingdong Yao Fangyin Li Bo Li Yingjin Yuan | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 0 |
| 8 | Bmelo12,an elongase of very long-chain fatty acids gene,regulates silk yield in Bombyx mori显示文摘In silkworm,cocoon shell weight(CSW),an index of silk yield,is a quantitative trait(Nagaraju and Goldsmith,2002),and multiple quantitative trait loci(QTLs)located on different chromosomes have been found(Zhan et al.,2009;Zhang et al.,2010;Li et al.,2015;Fang et al.,2020). | Weidong Zuo Chunlin Li Yanyu Liu Rui Gao Yue Luan Bili Zhang Hai Hu Minjin Han Xiaoling Tong Cheng Lu Fangyin Dai | 2022 | Journal of Genetics and Genomics2022，49，9： | 0 |
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