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| 1 | Characterization of a region involved in binding of measles virus H protein and its receptor SLAM (CD150)显示文摘 | Chunling Hu Peng Zhang Xin Liu Yipeng Qi Tingting Zou Qin Xu | 2004 | Biochemical and Biophysical Research Communications2004，，3： | 2 |
| 2 | Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice显示文摘Advanced maternal age is characterized by declines in the quantity and quality of oocytes in the ovaries,and the aging process is accompanied by changes in gut microbiota composition.However,little is known about the relationship between gut microbiota and ovarian aging.By using fecal microbiota transplantation(FMT)to transplant material from young(5-week-old)into aged(42-week-old)mice,we find that the composition of gut microbiota in FMT-treated mice presents a“younger-like phenotype”and an increase of commensal bacteria,such as Bifidobacterium and Ruminococcaceae.Moreover,the FMT-treated mice show increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN-γ.Fertility tests for assessing ovarian function reveal that the first litter size of female FMT-treated mice is significantly higher than that of the non-FMT group.Morphology analysis demonstrates a dramatic decrease in follicle atresia and apoptosis as well as an increase in cellular proliferation in the ovaries of the FMT-treated mice.Our results also show that FMT improves the immune microenvironment in aged ovaries,with decreased macrophages and macrophage-derived multinucleated giant cells(MNGCs).These results suggest that FMT from young donors could be a good choice for delaying ovarian aging. | Li Xu Qiankun Zhang Xiaowei Dou Yipeng Wang Jianwei Wang Yong Zhou Xingyin Liu Jing Li | 2022 | Journal of Genetics and Genomics2022，49，11： | 2 |
| 3 | Cesium lead halide perovskite nanocrystals for ultraviolet and blue light blocking显示文摘Using cesium lead halide perovskite nanocrystals, CsPb(Cl/Br)3, as a light absorber, we report a highly effective UV and blue light blocking film. The CsPb(Cl/Br)3 nanocrystals are well dispersed in the ethyl cellulose(EC) matrix to compose a UV and blue light shielding film, and the absorption edge of the film is tunable by adjusting Cl to Br ratio using anion exchange. The CsPbCl2 Br-EC film exhibits a transmittance of 5% at 459 nm, 90% at 478 nm and 95% in the range of 500–800 nm, which makes it excellent for UV and blue light shielding. In addition, the as-prepared EC-CsPb(Cl/Br)3 film shows excellent photostability under UV irradiation. Results demonstrate that this EC-CsPb(Cl/Br)3 based materials with sharp absorbance edges, tunable blocking wavelength, and high photostability can be useful for the applications in UV and blue light blocking and optical filters. | Guihua Huang Yipeng Huang Wei Xu Qiuhong Yao Xiaofang Liu Caifeng Ding Xi Chen | 2019 | Chinese Chemical Letters2019，30，5： | 2 |
| 4 | Roles of autophagy?related genes Beclin?1 and LC3 in the developmentand progression of prostate cancer and benign prostatic hyperplasia显示文摘 | Chengyi Liu Pengcheng Xu Degang Chen Xinhuan Fan Yipeng Xu Mengqiang Li Xu Yang Congfei Wang | 2013 | Biomedical Reports2013，，6： | 1 |
| 5 | Landform classification based on optimal texture feature extraction from DEM data in Shandong Hilly Area, China显示文摘Texture and its analysis methods are crucial for image feature extraction and classification. Digital elevation model (DEM) is the most important data source of digital terrain analysis and landform classification, and considerable research values are gained from texture feature extraction and analysis from DEM data. In this research, on the basis of optimal texture feature extraction, the hilly area in Shandong, China, was selected as the study area, and DEM data with a resolution of 500 m were used as the experimental data for landform classification. First, second-order texture measures and texture image were extracted from DEM data by using a gray level cooccurrence matrix (GLCM). Second, the variation characteristics of each texture measure were analyzed, and the optimal feature parameters, such as direction, gray level, and texture window, were determined. Meanwhile, the texture feature value, combined with maximum information, was calculated, and the multiband texture image was obtained by resolving three optimal texture measure images. Finally, a support vector machine (SVM) method was adopted to classify landforms on the basis of the multiband texture image. Results indicated that the texture features of DEM data can be sufficiently represented and measured via the quantitative GLCM method. However, the feature parameters during the texture feature value calculation required further optimization. Based on the image texture from DEM data, efficient classification accuracy and ideal classification effect were achieved. | Hongchun ZHU Yuexue XU Yu CHENG Haiying LIU Yipeng ZHAO | 2019 | Frontiers of Earth Science2019，13，3： | 1 |
| 6 | Detrital Zircon U-Pb Geochronology of the Xilin Group: Constraints for the Early Paleozoic Tectonic Evolution of the Songliao Massif显示文摘The Xilin Group, composed of the Chenming, Laodaomiaogou, Qianshan and Wuxingzhen formations, is one of the Early Paleozoic terranes in the eastern Songliao Massif, mainly consisting of thick layers of fine clastic and carbonate rocks. This study presents LA-ICP-MS zircon U-Pb geochronological data for the Laodaomiaogou and Qianshan formations, further constraining their provenance and the Early Paleozoic tectonic evolution of the Songliao Massif on the eastern Central Asian Orogenic Belt. Most zircons from the Laodaomiaogou and Qianshan formations show magmatic oscillatory zoning and high Th/U ratios(0.26–2.41). Zircon U-Pb dating results indicate that the detrital zircons from the silty mudstone of the Laodaomiaogou Formation yield peak ages of 634 Ma, 775 Ma, 820 Ma, 880 Ma and 927 Ma, as well as multi-episodic Archean to Paleoproterozoic and Mesoproterozoic ages(1405–643 Ma), implying its deposition time is younger than ~634 Ma. Furthermore, the occurrence of Early Cambrian fossils indicates that the Laodaomiaogou Formation was deposited during the late stage of the Early Cambrian(~514 Ma). The zircons from the K-bentonite of the Qianshan Formation show four peak ages of 444 Ma, 471 Ma, 489 Ma and 518 Ma and the youngest age peak of 444 ± 4 Ma(n = 6) indicates that the Qianshan Formation was deposited during the Late Ordovician. In addition, the peak ages of the detrital zircons in the silty mudstone of the Qianshan Formation are 472 Ma and 498 Ma, as well as two other concordant points with;Pb/;Pb apparent ages of 1824 Ma and 1985 Ma. The dating results in this study, together with published data, indicate the absence of Pan-African magmatic events in the Songliao Massif prior to the initial deposition of the Xilin Group, in contrast to those distributed widely in the Jiamusi Massif. Taken together, we conclude that the depositional provenance of the Laodaomiaogou and Qianshan formations was derived from the Songliao Massif. Furthermore, the characteristics of the detrital zircon age composition and rock associations indicate that the Laodaomiaogou Formation formed in a passive continental margin environment, in contrast to the Qianshan Formation, which formed in an active continental margin environment. The above results also imply that the Songliao and Jiamusi massifs might not have collided before the Late Ordovician. | SANG Tianjiao PEI Fuping XU Wenliang WANG Zhiwei JIAO Ji WEI Jingyang WANG Yipeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 1 |
| 7 | Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis显示文摘As the major cell precursors in osteogenesis, mesenchymal stem cells(MSCs) are indispensable for bone homeostasis and development. However, the primary mechanisms regulating osteogenic differentiation are controversial. Composed of multiple constituent enhancers, super enhancers(SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. The present study demonstrated that SEs were indispensable for MSC osteogenesis and involved in osteoporosis development. Through integrated analysis, we identified the most common SE-targeted and osteoporosis-related osteogenic gene,ZBTB16. ZBTB16, positively regulated by SEs, promoted MSC osteogenesis but was expressed at lower levels in osteoporosis.Mechanistically, SEs recruited bromodomain containing 4(BRD4) at the site of ZBTB16, which then bound to RNA polymerase IIassociated protein 2(RPAP2) that transported RNA polymerase Ⅱ(POL Ⅱ) into the nucleus. The subsequent synergistic regulation of POL Ⅱ carboxyterminal domain(CTD) phosphorylation by BRD4 and RPAP2 initiated ZBTB16 transcriptional elongation, which facilitated MSC osteogenesis via the key osteogenic transcription factor SP7. Bone-targeting ZBTB16 overexpression had a therapeutic effect on the decreased bone density and remodeling capacity of Brd4^(fl/fl)Prx1-cre mice and osteoporosis(OP) models.Therefore, our study shows that SEs orchestrate the osteogenesis of MSCs by targeting ZBTB16 expression, which provides an attractive focus and therapeutic target for osteoporosis. | Wenhui Yu Zhongyu Xie Jinteng Li Jiajie Lin Zepeng Su Yunshu Che Feng Ye Zhaoqiang Zhang Peitao Xu Yipeng Zeng Xiaojun Xu Zhikun Li Pei Feng Rujia Mi Yanfeng Wu Huiyong Shen | 2023 | Bone Research2023，11，3： | 1 |
| 8 | Gut commensal bacteria in biological invasions显示文摘INTRODUCTION The interaction between the host and host-associated microbial communities has been an area of increasing interest during recent decades.In most animal species,microflora is known to inhabit the gut,surface or surroundings(Dillon&Dillon 2004;Engel&Moran 2013;Kovatcheva-Datchary et al.2013).The microflora encompasses a range of microbial relationships,including pathogenic,obligately mutualistic and commensal relationships.During the past few decades,beneficial microorganisms have received much attention due to a myriad of mutualistic effects(e.g.modifying a nutrient-poor diet,protecting the host from parasites or pathogens,affecting the mating and breeding of hosts,and producing insect pheromones).Such studies have aided our understanding of the diversification and evolutionary success of animals(Flórez et al.2015;Paniagua Voirol et al.2018).Furthermore,technological applications have been identified:for example,efficient microbial cellulases from termites are presently being used in industrial processes(Scharf&Tartar 2008). | Letian XU Yipeng LIU hijing XU Min LU | 2019 | Integrative Zoology2019，14，6： | 1 |
| 9 | Expression and significance of CHIP in canine mammary gland tumors显示文摘 | Huanan W Xu Y Yipeng J | 2015 | J Vet Med Sci2015，77，： | 1 |
| 10 | Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008显示文摘 | Yipeng Sun Juan Pu Zhanlei Jiang Tao Guan Yingju Xia Qi Xu Linqing Liu Bo Ma Fulin Tian E.G. Brown Jinhua Liu | 2010 | Veterinary Microbiology2010，，3： | 1 |
| 11 | The effect of Laves phase on heavy-ion radiation response of Nb-containing FeCrAl alloy for accident-tolerant fuel cladding显示文摘As a promising candidate material for the accident tolerant fuel cladding in light water reactors,the Nb-containing FeCrAl alloy has shown outstanding out-of-pile service performance due to the Laves phase precipitation.In this work,the radiation response in FeCrAl alloys with gradient Nb content under heavy ion radiation has been investigated.The focus is on the effect of the Laves phase on irradiation-induced defects and hardening.We found that the phase boundary between the matrix and Laves phase can play a critical role in capturing radiation defects,as verified by in-situ heavy-ion radiation experiments and molecular dynamic simulations.Additionally,the evolution of Laves phase under radiation is analyzed.Radiation-induced amorphization and segregations observed at high radiation doses will deepen the fundamental understanding of the stability of Laves phases in the radiation environment. | Hang Xu Shuyao Si Yipeng Li Xiangbing Liu Wenqing Li Changzhong Jiang Shijun Zhao Hui Wang Xiangheng Xiao | 2022 | Fundamental Research2022，2，3： | 1 |
| 12 | Highly dispersed NiMo@rGO nanocomposite catalysts fabricated by a two-step hydrothermal method for hydrogen evolution显示文摘Exploring and designing a high-performance non-noble metal catalyst for hydrogen evolution reaction(HER)are crucial for the large-scale application of H2 by water electrolysis.Here,novel catalysts with NiMo nanoparticles decorated on reduced graphene oxide(NiMo@r GO)synthesized by a two-step hydrothermal method were reported.Physical characterization results showed that the prepared NiMo@r GO-1 had an irregular lamellar structure,and the NiMo nanoparticles were uniformly dispersed on the rGO.NiMo@rGO-1 exhibited outstanding HER performance in an alkaline environment and required only 93 and 180 mV overpotential for HER in 1.0 M KOH solution to obtain current densities of-10 and-50 mA·cm^(-2),respectively.Stability tests showed that NiMo@rGO-1 had a certain operating stability for32 h.Under the same condition,the performance of NiMo@rGO-1 can be comparable with that of commercial Pt/C catalysts at high current density.The synergistic effect between NiMo particles and lamellate graphene can remarkably promote charge transfer in electrocatalytic reactions.As a result,NiMo@rGO-1 presented the advantages of high intrinsic activity,large specific surface area,and small electrical impedance.The lamellar graphene played a role in dispersion to prevent the aggregation of nanoparticles.The prepared NiMo@rGO-1 can be used in anion exchange membrane water electrolysis to produce hydrogen.This study provides a simple preparation method for efficient and low-cost water electrolysis to produce hydrogen in the future. | Duanhao Cao Xiaofeng Ma Yipeng Zhang La Ta Yakun Yang Chao Xu Feng Ye Jianguo Liu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，12： | 0 |
| 13 | Saddlepoint Approximation Method in Reliability Analysis:A Review显示文摘The escalating need for reliability analysis(RA)and reliability-based design optimization(RBDO)within engineering challenges has prompted the advancement of saddlepoint approximationmethods(SAM)tailored for such problems.This article offers a detailed overview of the general SAM and summarizes the method characteristics first.Subsequently,recent enhancements in the SAM theoretical framework are assessed.Notably,the mean value first-order saddlepoint approximation(MVFOSA)bears resemblance to the conceptual framework of the mean value second-order saddlepoint approximation(MVSOSA);the latter serves as an auxiliary approach to the former.Their distinction is rooted in the varying expansion orders of the performance function as implemented through the Taylor method.Both the saddlepoint approximation and third-moment(SATM)and saddlepoint approximation and fourth-moment(SAFM)strategies model the cumulant generating function(CGF)by leveraging the initial random moments of the function.Although their optimal application domains diverge,each method consistently ensures superior relative precision,enhanced efficiency,and sustained stability.Every method elucidated is exemplified through pertinent RA or RBDO scenarios.By juxtaposing them against alternative strategies,the efficacy of these methods becomes evident.The outcomes proffered are subsequently employed as a foundation for contemplating prospective theoretical and practical research endeavors concerning SAMs.The main purpose and value of this article is to review the SAM and reliability-related issues,which can provide some reference and inspiration for future research scholars in this field. | Debiao Meng Yipeng Guo Yihe Xu Shiyuan Yang Yongqiang Guo Lidong Pan Xinkai Guo | 2024 | Computer Modeling in Engineering & Sciences2024，139，6： | 0 |
| 14 | Fucoidan sulfate from Sargassum fusiforme regulates the SARS-CoV-2 receptor AXL expression in human embryonic lung diploid fibroblast cells显示文摘Coronavirus disease 2019(COVID-19)is a global infectious disease that seriously endangers human life and health and affects normal social activities.Since the pandemic outbreak from December 2019 to February 2023,the total number of confirmed cases has exceeded 753 million,and the deaths caused by COVID-19 have reached 6.6 million(http://gffzze7c39cdc9e894ca6s50wkbqk5uo696k9x.ffgz.tsg.suse.edu.cn;accessed on Feb.16,2023). | Xuqiang ZHOU Weihua JIN Di JIANG Yipeng XU Sanying WANG Xinna WU Yunchuang CHANG Huili SU Tianjun ZHU Xiaogang XU Genxiang MAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，11： | 0 |
| 15 | Effects of time-delayed vibration absorber on bandwidth of beam for low broadband vibration suppression显示文摘The effects of time-delayed vibration absorber(TDVA) on the dynamic characteristics of a flexible beam are investigated. First, the vibration suppression effect of a single TDVA on a continuous beam is studied. The first optimization criterion is given,and the results show that the introduction of time-delayed feedback control(TDFC) is beneficial to improving the vibration suppression at the anti-resonance band. When a single TDVA is used, the anti-resonance is located at a specific frequency by the optimum design of TDFC parameters. Then, in order to obtain low-frequency and broad bands for vibration suppression, multiple TDVAs are uniformly distributed on a continuous beam,and the relationship between the dynamic responses and the TDFC parameters is investigated. The obtained relationship shows that the TDVA has a significant regulatory effect on the vibration behavior of the continuous beam. The effects of the number of TDVAs and the nonlinearity on the bandgap variation are discussed. As the multiple TDVAs are applied, according to the different requirements on the location and bandwidth of the effective vibration suppression band, the optimization criteria for the TDFC parameters are given, which provides guidance for the applications of TDVAs in practical projects such as bridge and aerospace. | Xiuting SUN Yipeng QU Feng WANG Jian XU | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，10： | 0 |
| 16 | Simulating androgen receptor selection in designer yeast显示文摘Androgen receptor(AR)mutation is closely associated with prostate cancer(PCa)and is one of the mechanisms of resistance to PCa therapies such as AR antagonists.Although sequencing technologies like next-generation sequencing(NGS)contributes to the high-throughput and precise detection of AR mutations carried by PCa patients,the lack of interpretations of these clinical genetic variants has still been a roadblock for PCa-targeted precision medicine.Here,we established a designer yeast reporter assay to simulate natural androgen receptor(AR)selection using AR antagonists.Yeast HIS3 gene transactivation was associated with the ligand-induced recruitment of steroid receptor coactivator-1(SRC-1)by AR mutants,where yeast growth in histidine-free medium was determined as the outcome.This assay is applicable to determine a wide range of clinical AR mutants including those with loss of function relating to androgen insensitivity syndrome(AIS),and those associated with PCa conferring resistance to AR antagonists such as enzalutamide(ENZ),bicalutamide(BIC),and cyproterone acetate(CPA).One clinical AR mutant previously reported to confer ENZ-resistance,F877L,was found to confer partial resistance to CPA as well using designer yeast.Our simple and efficient assay can enable precise one-pot screening of AR mutants,providing a reference for tailored medicine. | Haoran Zhang Lu Zhang Yipeng Xu Shaoyong Chen Zhenyi Ma Mingdong Yao Fangyin Li Bo Li Yingjin Yuan | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 0 |
| 17 | An extended analysis of cardiovascular benefits of indoor air filtration intervention among elderly:a randomized crossover trial(Beijing indoor air purifier study,BIAPSY)显示文摘Objective Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter(PM)remains limited.We aimed to assess improvements in surrogate markers of cardiovascular injury in vulnerable populations at risks by using indoor air filtration units.Methods We conducted a randomized crossover trial for 2 separate 2-week air filtration interventions in 20 households of patients with stable chronic obstructive pulmonary disease and their partners in the winter of 2013,with concurrent measurements of indoor PM.The changes in biomarkers indicative of cardiac injury,atherosclerosis progression and systemic inflammation following intervention were evaluated using linear mixed-effect models.Results In the analysis,average levels of indoor PM with aerodynamic diameters<2.5µm(PM2.5)decreased significantly by 59.2%(from 59.6 to 24.3µg/m3,P<0.001)during the active air filtration.The reduction was accompanied by improvements in levels of high-sensitivity cardiac troponin I by−84.6%(95%confidence interval[CI]:−90.7 to−78.6),growth differentiation factor-15 by−48.1%(95%CI:−31.2 to−25.6),osteoprotegerin by−65.4%(95%CI:−56.5 to−18.7),interleukin-4 by−46.6%(95%CI:−62.3 to−31.0)and myeloperoxidase by−60.3%(95%CI:−83.7 to−3.0),respectively.Conclusion Indoor air filtration intervention may provide potential cardiovascular benefits in vulnerable populations at risks. | Jie Chen Tong Wang Hongbing Xu Yutong Zhu Yipeng Du Beibei Liu Qian Zhao Yi Zhang Lingyan Liu Ningman Yuan Jiakun Fang Yunfei Xie Shuo Liu Rongshan Wu Danqing Shao Xiaoming Song Bei He Bert Brunekreef Wei Huang | 2022 | Global Health Journal2022，6，1： | 0 |
| 18 | Aerodynamic characteristics of store during lateral jet assisted separation from cavity using free drop technique显示文摘Aimed at the problem of store separation from internal cavity,this paper innovatively puts forward a separation scheme of using lateral jet to assist store safe separation.The jet ensures that the store is continuously subjected to down head moment during separation,so as to ensure safe separation.The wind tunnel free drop test technique with lateral jet is established,which can ensure that there is no support interference in the motion process of the store and more truly simulate the motion of the store.The feasibility of the new separation scheme is proved by wind tunnel test.The test shows that the new scheme can also change the more dangerous state into a safe state.Through the analysis of the test data,the pitching moment coefficients of the store under different pressures in the high-pressure cylinder are obtained,and the effects of aircraft and cavity on the pitching moment of the store are obtained.The 3 stages of store passing through cavity shock wave are found.The results show that the lateral jet provides the store with continuous head down moment,and makes the store overcome the head up moment caused by the shock wave in front of the cavity,so as to ensure the safety of separation. | Fei XUE Yipeng REN Zheng LI Cong XU Dechen WEI Xiaolu MAO Zenghui JIANG | 2023 | Chinese Journal of Aeronautics2023，36，1： | 0 |
| 19 | Recent advances of bioresponsive polymeric nanomedicine for cancer therapy显示文摘A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined space.These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues.Moreover,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.In this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized.We mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric nanosystems.The important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented. | Tu Hong Xinyuan Shen Madiha Zahra Syeda Yang Zhang Haonan Sheng Yipeng Zhou JinMing Xu Chaojie Zhu Hongjun Li Zhen Gu Longguang Tang | 2023 | Nano Research2023，16，2： | 0 |
| 20 | A giant central red disk galaxy at redshift z=0.76:Challenge to theories of galaxy formation显示文摘We report a giant red central disk galaxy in the XMM-LSS north region. The region is covered with a rich variety of multi-band photometric and spectroscopic observations. Using the photometric data of the Canada-France-Hawaii Telescope Legacy Survey(CFHTLS) and spectroscopic observation of the baryon oscillation spectroscopic survey(BOSS), we find that the galaxy has a stellar mass of ~1011.6 M⊙. The galaxy has a red color and has an old stellar population, and thus its star formation has stopped.With the photometric image data of the Hyper Suprime-Cam(HSC) Subaru Strategic Program, we demonstrate that its luminosity profile is perfectly described by a Sérsic form with n=1.22 consistent with that of a disk. We also analyze its environment based on the VIMOS Public Extragalactic Redshift Survey(VIPERS) photometric catalog, and find that its close neighbors are all less massive, indicating that our observed galaxy is sitting at the center of its dark matter host halo. Existence of such a giant red central disk galaxy seriously challenges the current standard paradigm of galaxy formation, as there is no known physical mechanism to explain the quenching of its star formation. This conclusion is supported by state-of-the-art hydrodynamical simulations of galaxy formation. | Kun Xu ChengZe Liu YiPeng Jing Marcin Sawicki Stephen Gwyn | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，7： | 0 |
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