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| 1 | Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets显示文摘Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the metabolic syndrome. NAFLD is classified as nonalcoholic fatty liver(NAFL) or simple steatosis,and non-alcoholic steatohepatitis(NASH). NASH is characterized by the presence of steatosis and inflammation with or without fibrosis. The physiopathology of NAFL and NASH and their progression to cirrhosis involve several parallel and interrelated mechanisms,such as,insulin resistance(IR),lipotoxicity,inflammation,oxidative stress,and recently the gut-liver axis interaction has been described. Incretin-based therapies could play a role in the treatment of NAFLD. Glucagon-like peptide-1(GLP-1) is an intestinal mucosa-derived hormone which is secreted into the bloodstream in response to nutrient ingestion; it favors glucose-stimulated insulin secretion,inhibition of postprandial glucagon secretion and delayed gastric emptying. It also promotes weight loss and is involved in lipid metabolism. Once secreted,GLP-1 is quickly degraded by dipeptidyl peptidase-4(DPP-4). Therefore,DPP-4 inhibitors are able to extend the activity of GLP-1. Currently,GLP-1 agonists and DPP-4 inhibitors represent attractive options for the treatment of NAFLD and NASH. The modulation of lipid and glucose metabolism through nuclear receptors,such as the farsenoid X receptor,also constitutes an attractive therapeutic target. Obeticholic acid is a potent activator of the farnesoid X nuclear receptor and reduces liver fat content and fibrosis in animal models. Ursodeoxycholic acid(UDCA) is a hydrophilic bile acid with immunomodulatory,antiinflammatory,antiapoptotic,antioxidant and antifibrotic properties. UDCA can improve IR and modulate lipid metabolism through its interaction with nuclear receptors such as,TGR5,farnesoid X receptor-a,or the small heterodimeric partner. Finally,pharmacologic modulation of the gut microbiota could have a role in the therapy of NAFLD and NASH. Probiotics prevent bacterial translocation and epithelial invasion,inhibit mucosal adherence by bacteria,and stimulate host immunity. In animal models,probiotics prevent obesity,decrease transaminase levels,and improve IR and liver histology in NASH. | Fatima Higuera-de la Tijera Alfredo I Servin-Caamano | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 2 | Mean platelet volume as a novel predictor of systematic inflammatory response in cirrhotic patients with culturenegative neutrocytic ascites显示文摘AIM: To identify a mean platelet volume(MPV) cutoff value which should be able to predict the presence of bacterial infection.METHODS: An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology Department of 'Hospital General de México Dr. Eduardo Liceaga', we included 51 cirrhotic patients with ascites fluid infection(AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid infection.RESULTS: Of the 51 cases with AFI, 48 patients(94.1%) had culture-negative neutrocytic ascites(CNNA), 2(3.9%) had bacterial ascites, and one(2%)had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency(P < 0.0001), and lower mean arterial pressure compared with non-infected patients(P = 0.009). Leucocytes, polymorphonuclear count, MPV and cardiac frequency resulted to be good or very good predictive variables of presence of AFI in cirrhotic patients(area under the receiving operating characteristic > 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection. CONCLUSION: Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA. | Marisol Galvez-Martinez Alfredo I Servin-Caamano Eduardo Perez-Torres Francisco Salas-Gordillo Xaira Rivera-Gutierrez Fatima Higuera-de la Tijera | 2015 | World Journal of Hepatology2015，7，7： | 2 |
| 3 | Belief in a just world and subjective well-being:Mothers of normal and Down syndrome children显示文摘 | Fatima I Suhail K | | 0，，06： | 1 |
| 4 | The main benefits associated with health and safety management systems certification in Portuguese small and medium enterprises post quality management system certification 显示文摘 | Gilberto Santos S i ria Barros Fatima Mendes Nuno Lopes | 2013 | Safety Science2013，，51： | 1 |
| 5 | A Spirostanol glyco-sides from Cestrum nocturnum显示文摘 | Ahmad V U Baqai F T Fatima I | 1991 | Phytochemistry1991，30，9： | 1 |
| 6 | Recent developments and future prospects of SPECT myocardial perfusion imaging显示文摘 | Zaman MU Hashmi I Fatima N | 2010 | Ann Nucl Med2010，24，8： | 1 |
| 7 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 8 | Control of the chemical structure of perhydrous coals: FTIR and Py-GC/MS investigation显示文摘 | Maria J I Jose C R Fatima L D | 2002 | Journal of Analytical and Applied Pyrolysis2002，62，1： | 1 |
| 9 | Pollutant-induced over-activation of phagocytes is concomitantly associated with peroxidative damage in fish tissues显示文摘 | FATIMA M AHMAD I SAYEED I | 2000 | Aquatic Toxicology2000，49，4： | 1 |
| 10 | Trace element concentration in egg-yolk and egg-white of farm and domestic eggs显示文摘 | Waheed S Fatima I Mannan A | | 0，，： | 1 |
| 11 | The adenosine triphosphate test is a rapid and reliable audit tool to assess manual cleaning adequacy of flexible endoscope channels 显示文摘 | Alfa M J Fatima I Olson N | 2013 | Am J Infect Control2013，41，3： | 1 |
| 12 | Salvicins A and B, new lignans from Salvia santolinifolia 显示文摘 | Mehmood S Fatima I Malik A | 2011 | J Asian Nat Prod Res2011，13，17： | 1 |
| 13 | Antioxidant,anti- glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis显示文摘 | Al-Musayeib N Perveen S Fatima I | 2011 | Molecules2011，16，10： | 1 |
| 14 | Dimorphamides A-C,new polyphenolic amides from Atriplex dimorphostagia显示文摘 | Karim A Fatima I Hussain S | 2011 | HelvChim Acta2011，94，3： | 1 |
| 15 | Anthocyain pig- ments in strawberry 显示文摘 | Fatima L Maria T ose I et a | 2007 | LWT-Food Sci Technol2007，40，2： | 1 |
| 16 | The adenosine triphosphate test is a rapid and reliable audit tool to assess manual cleaning adequacy of flexible endoscope channels显示文摘 | Alfa MJ Fatima I Olson N | 2013 | Am J Infect Control2013，41，3： | 1 |
| 17 | Anti oxidative effect of black tea theaflavin on erythrocytes subjected to oxidative stress显示文摘 | FATIMA M RIZVI S I | 2015 | Na- tional Academy Science Letters2015，38，1： | 1 |
| 18 | 2,3-Diaryl-2H-1-benzopyran derivatives interfere with classical and non-classical estrogen recep- tor signaling pathways,inhibit Akt activation and induce apoptosis in human endometrial cancer cells 显示文摘 | Fatima I Chandra V Saxena R | 2012 | Mol Cell Endocrinol2012，348，1： | 1 |
| 19 | Path lanning of mobile robot based on modification of vector field histogram using neuro-fuzzy algorithm 显示文摘 | ALI H H FATIMA B I | 2010 | International Journal of Advancements in Computing Technology2010，2，3： | 1 |
| 20 | Measurement of natural radioactivity in bottled drinking water in Pakistan and consequent doseestimates显示文摘 | Fatima I Zaidi JH Arif M | 2007 | Radiation Protection Dosimetry2007，123，2： | 1 |
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