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| 1 | Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM显示文摘Trichosanthin(TCS),extracted from the Chinese medicinal herb Trichosanthes kirilowi,has shown promise for the inhibition of tumor growth.However,its immunomodulatory effect on tumor–host interaction remains unknown.In this study,we focused on the effect of TCS on murine anti-tumor immune response in the 3LL Lewis lung carcinoma tumor model and explored the possible molecular pathways involved.In addition to inhibiting cell proliferation and inducing apoptosis in the 3LL tumor,TCS retarded tumor growth and prolonged mouse survival more significantly in C57BL/6 immunocompetent mice than in nude mice.This reflected the fact that the host immune system was involved in tumor eradication.Using FACS analysis,we found that TCS increased the percentage of effector T cells,particularly Interferon-gamma(IFN-c)producing CD41 and CD81 T cells from tumor-bearing mice.TCS also promoted the vigorous proliferation of antigen-specific effector T cells,markedly increased Th1 cytokine secretion and elicited more memory T cells in tumor-bearing mice,consequently enhancing the anti-tumor response and inducing immune protection.Furthermore,we found that TCS upregulated the expression of tumor suppressor in lung cancer 1(TSLC1)in 3LL tumor cells and the expression of its ligand,class I-restricted T cell-associated molecule(CRTAM),in effector T cells.Blocking TSLC1 expression with small interfering RNA(siRNA)significantly eliminated the effects of TCS on the proliferation and cytokine secretion of effector T cells,suggesting that TCS enhances anti-tumor immune response at least partially by boosting the interaction between TSLC1 and CRTAM.Collectively,our data demonstrate that TCS not only affects tumor cells directly,but also enhances anti-tumor immunity via the interaction between TSLC1 and CRTAM.These findings may lead to the development of a novel approach for tumor regression. | Yuchan Cai Shudao Xiong Yijie Zheng Feifei Luo Pei Jiang Yiwei Chu | 2011 | Cellular & Molecular Immunology2011，8，4： | 12 |
| 2 | Joint statistical-dynamical approach to decadal prediction of East Asian surface air temperature显示文摘A joint statistical-dynamical method addressing both the internal decadal variability and effect of anthropogenic forcing was developed to predict the decadal components of East Asian surface air temperature(EATs)for three decades(2010–2040).As previous studies have revealed that the internal variability of EATs(EATs_int)is influenced mainly by the ocean,we first analyzed the lead-lag connections between EATs_int and three sea surface temperature(SST)multidecadal modes using instrumental records from 1901 to 1999.Based on the lead-lag connections,a multiple linear regression was constructed with the three SST modes as predictors.The hindcast for the years from 2000 to 2005 indicated the regression model had high skill in simulating the observational EATs_int.Therefore,the prediction for EATs_int(Re_EATs_int)was obtained by the regression model based on quasi-periods of the decadal oceanic modes.External forcing from greenhouse gases is likely associated with global warming.Using monthly global land surface air temperature from historical and projection simulations under the Representative Concentration Pathway(RCP)4.5 scenario of 19 Coupled General Circulation Models participating in the fifth phase of the Coupled Model Intercomparison Project(CMIP5),we predicted the curve of EATs(EATs_trend)relative to1970–1999 by a second-order fit.EATs_int and EATs_trend were combined to form the reconstructed EATs(Re_EATs).It was expected that a fluctuating evolution of Re_EATs would decrease slightly from 2015 to 2030 and increase gradually thereafter.Compared with the decadal prediction in CMIP5 models,Re_EATs was qualitatively in agreement with the predictions of most of the models and the multi-model ensemble mean,indicating that the joint statistical-dynamical approach for EAT is rational. | LUO FeiFei LI ShuangLin | 2014 | Science China Earth Sciences2014，57，12： | 5 |
| 3 | In-situ Chemical Age of the Sandstone-hosted Uranium Deposit in Ningdong Area on the Western Margin of the Ordos Basin, North China显示文摘Objective The Ordos Basin located in the western part of the North China Craton bears various energy resources such as oil,gas,coal and uranium.It is one of the richest uranium-bearing basins in China.Since the discovery of the large-scale Dongsheng,Hangjinqi and Daying uranium deposits in the north of the Ordos Basin,a | WANG Feifei LIU Chiyang NIU Haiqing ZHOU Ningchao LI Xiuhua LUO Wei ZHANG Dongdong ZHAO Yan | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 4 | Role of TRIM33 in Wnt signaling during mesendoderm differentiation显示文摘Tripartite motif 33(TRIM33), a member of the transcription intermediate factor 1(TIF1) family of transcription cofactors,mediates transforming growth factor-beta(TGF-β) signaling through its PHD-Bromo cassette in mesendoderm differentiation during early mouse embryonic development. However, the role of the TRIM33 RING domain in embryonic differentiation is less clear. Here, we report that TRIM33 mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes, and this action is independent of its RING domain. We show that TRIM33 interacts with β-catenin, a central player in Wnt signaling in mouse embryonic stem cells(mESCs). In contrast to previous reports in cancer cell lines, the RING domain does not appear to function as the E3 ligase for β-catenin, since neither knockout nor overexpression of TRIM33 had an effect on β-catenin protein levels in mESCs. Furthermore, we show that although TRIM33 seems to be dispensable for Wnt signaling through a reporter assay, loss of TRIM33 significantly impairs the expression of a subset of Wnt target genes, including Mixl1,in a Wnt signaling-dependent manner. Together, our results indicate that TRIM33 regulates Wnt signaling independent of the E3 ligase activity of its RING domain for β-catenin in mESCs. | Xiaojie Xia Feifei Zuo Maoguo Luo Ye Sun Jianbo Bai Qiaoran Xi | 2017 | Science China(Life Sciences)2017，60，10： | 4 |
| 5 | Air–Sea Coupling Enhances the East Asian Winter Climate Response to the Atlantic Multidecadal Oscillation显示文摘A simple air–sea coupled model,the atmospheric general circulation model(AGCM) of the National Centers for Environmental Prediction coupled to a mixed-layer slab ocean model,is employed to investigate the impact of air–sea coupling on the signals of the Atlantic Multidecadal Oscillation(AMO). A regional coupling strategy is applied,in which coupling is switched off in the extratropical North Atlantic Ocean but switched on in the open oceans elsewhere. The coupled model is forced with warm-phase AMO SST anomalies,and the modeled responses are compared with those from parallel uncoupled AGCM experiments with the same SST forcing. The results suggest that the regionally coupled responses not only resemble the AGCM simulation,but also have a stronger intensity. In comparison,the coupled responses bear greater similarity to the observational composite anomaly. Thus,air–sea coupling enhances the responses of the East Asian winter climate to the AMO. To determine the mechanism responsible for the coupling amplification,an additional set of AGCM experiments,forced with the AMO-induced tropical SST anomalies,is conducted. The SST anomalies are extracted from the simulated AMO-induced SST response in the regionally coupled model. The results suggest that the SST anomalies contribute to the coupling amplification. Thus,tropical air–sea coupling feedback tends to enhance the responses of the East Asian winter climate to the AMO. | ZHOU Xiaomin LI Shuanglin LUO Feifei GAO Yongqi Tore FUREVIK | 2015 | Advances in Atmospheric Sciences2015，32，12： | 3 |
| 6 | Simulation by CMIP5 Models of the Atlantic Multidecadal Oscillation and Its Climate Impacts显示文摘This study focuses on the climatic impacts of the Atlantic Multidecadal Oscillation(AMO) as a mode of internal variability. Given the difficulties involved in excluding the effects of external forcing from internal variation, i.e., owing to the short record length of instrumental observations and historical simulations, we assess and compare the AMO and its related climatic impacts both in observations and in the 'Pre-industrial' experiments of models participating in CMIP5. First, we evaluate the skill of the 25 CMIP5 models' 'Historical' simulations in simulating the observational AMO, and find there is generally a considerable range of skill among them in this regard. Six of the models with higher skill relative to the other models are selected to investigate the AMO-related climate impacts, and it is found that their 'Pre-industrial' simulations capture the essential features of the AMO. A positive AMO favors warmer surface temperature around the North Atlantic,and the Atlantic ITCZ shifts northward leading to more rainfall in the Sahel and less rainfall in Brazil. Furthermore, the results confirm the existence of a teleconnection between the AMO and East Asian surface temperature, as well as the late withdrawal of the Indian summer monsoon, during positive AMO phases. These connections could be mainly caused by internal climate variability. Opposite patterns are true for the negative phase of the AMO. | Zhe HAN Feifei LUO Shuanglin LI Yongqi GAO Tore FUREVIK Lea SVENDSEN | 2016 | Advances in Atmospheric Sciences2016，33，12： | 2 |
| 7 | The potential connection between China surface air temperature and the Atlantic Multidecadal Oscillation(AMO) in the Pre-industrial Period显示文摘One recent study by using instrumental records suggested the correlation between East Asian surface air temperatures(EATs)and the Atlantic Multidecadal Oscillation(AMO)reaches the maximum when the former leads the latter by 5–7 years.This seems to disagree with a previous well-realized point that the AMO modulates the decadal variation of EATs,since the atmosphere responds swiftly to sea surface temperature anomalies(SSTA)if therein.It implies that the AMO-EATs correlation should reach the maximum when they are simultaneous or the AMO leads EATs slightly,rather than that the EATs lead the AMO.Thus,this poses an issue about the reality of the newly found lead-lag correlation.Because the instrumental record in the natural climate system may be contaminated by human activities,the EATs-AMO lead-lag correlation derived from the instrumental records may not be a realistic connection of the natural climate system.Thus,whether the connection also exists in the proxies prior to the industrial is essential to answer the issue.In this study the EATs-AMO lead-lag connection is analyzed by using the reconstructed data in the last 500 years,together with the control experimental data with the prescribed pre-industrial forcing in a multiple of coupled climate system models,which attend the international CMIP5 program.The results suggest that the connection,the EATs lead the AMO,also exists in the period from the Little Ice Age(LIA)to the industrial,1500–1860AD.Therefore,the connection may be realistic in the natural climate system.The mechanisms for the connection are then discussed briefly.The results from this paper provide some insights into the connection of the AMO with East Asian climate. | LI ShuangLin JING YuanYuan LUO FeiFei | 2015 | Science China Earth Sciences2015，58，10： | 2 |
| 8 | Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine显示文摘Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical trials.However,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully explored.Here,we demonstrate that oxidized mitochondrial DNA(mtDNA)and stimulator of interferon genes(STING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell vaccine.Elevations in ROS and oxidized mtDNA 8-OHG content could be induced in irradiated tumor cells.Oxidized mtDNA derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDNA,as a DAMP or adjuvant,activated the STING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor immunity.The results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines. | Chunju Fang Fei Mo Li Liu Jing Du Min Luo Ke Men Feifei Na Wei Wang Hanshuo Yang Xiawei Wei | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 9 | Ni3S2 nanorods growing directly on Ni foam for all-solid-state asymmetric supercapacitor and efficient overall water splitting显示文摘Transition metal compounds are attractive for their significant applications in supercapacitors and as non-noble metal catalysts for electrochemical water splitting.Herein,we develop Ni3 S2 nanorods growing directly on Ni foam,which act as multifunctional additive-free Ni3 S2@Ni electrode for supercapacitor and overall water splitting.Based on PVA-KOH gel electrolyte,the assembled all-solid-state Ni3 S2@Ni//AC asymmetric supercapacitor delivers a high areal energy density of 0.52 mWh cm^-2 at an areal power density of 9.02 MW cm^-2,and exhibits an excellent cycling stability with a capacitance retention ratio of 89%after 10000 GCD cycles at a current density of 30 mA cm^-2.For hydrogen evolution reaction and oxygen evolution reaction in 1 M KOH,Ni3 S2@Ni electrode achieves a benchmark of 10 mA cm^-2at overpotentials of 82 mV and 310 mV,respectively.Furthermore,the assembled Ni3 S2@Ni‖Ni3 S2@Ni electrolyzer for overall water splitting attains a current density of 10 mA cm^-2 at 1.61 V.The in-situ synthesis of Ni3 S2@Ni electrode enriches the applications of additive-free transition metal compounds in high-performance energy storage devices and efficient electrocatalysis. | Baoxin Wu Hao Qian Zhongwu Nie Zhongping Luo Zixu Wu Peng Liu Hao He Jianghong Wu Shuguang Chen Feifei Zhang | 2020 | Journal of Energy Chemistry2020，29，7： | 2 |
| 10 | Enhanced treatment for cerebral ischemia-reperfusion injury of puerarin loading liposomes through neutrophils-mediated targeted delivery显示文摘The recovery of blood circulation following cerebral infarction-associated thrombolysis brings new damage to the brain,which is cerebral ischemia-reperfusion injury(CIRI).Inflammation is the main pathological mechanism of CIRI.The inflammatory response triggered by cerebral ischemia-reperfusion provides neutrophils with a special opportunity to facilitate drug delivery to the site of ischemic penumbra through the chemotaxis of inflammatory factors by neutrophils.Puerarin is an isoflavone derivative with a significant neuroprotective effect in vitro.But the blood-brain barrier(BBB)impedes its therapeutic efficacy on CIRI within the brain.Inspired by the pathological process,we have used neutrophils as carriers to enhance the BBB penetration of liposomes loaded with puerarin and improve the concentration of puerarin in the brain parenchyma in this study.These results showed that puerarin-containing liposomes were released in response to inflammatory conditions associated with brain injury to enhance the neuroprotection effect at the ischemic penumbra. | Wei Liu Haowei Lu Xiaoyong Rao Xiang Li Hongdan Lu Feifei Li Yan He Riyue Yu Rongsheng Zhong Yao Zhang Xiaojian Luo Hongliang Xin | 2021 | Nano Research2021，14，12： | 2 |
| 11 | Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women显示文摘 | Rong Yang Xiaojing Ma Xiaoping Pan Feifei Wang Yuqi Luo Chengchen Gu Yuqian Bao Weiping Jia | 2013 | Menopause: The Journal of The North American Menopause Society2013，，5： | 1 |
| 12 | Displacement amplification and electric characteristics of modified rectangular cymbal transducers using electroactive materials显示文摘 | Luo Laihui Tang Yanxue Wang Feifei | 2007 | Solid State Communications2007，143，： | 1 |
| 13 | Giant sharp converse magnetoelectric effect from the combination of a piezoelectric transformer with a piezoelectric/magnetostrictive laminated composite显示文摘 | WANG Yaojin WANG Feifei LUO Haosu | 2008 | Appl Pbys Lett2008，93，11： | 1 |
| 14 | 虫草素及其保护分子喷司他丁在真菌中的伴随生物合成显示文摘文章简介虫草素(cordycepin,即为3'-脱氧腺苷)最初从蛹虫草(Cordyceps militaris)中被鉴定,具有抗癌等活性;喷司他丁(pentostatin)最早于链霉菌(Streptomyces antiboticus)中被鉴定,能够抑制腺苷脱氨酶(adenosine deaminase,ADA)活性,是抗毛细胞白血病的商业药物。 | Yongliang Xia Feifei Luo Yanfang Shang Peilin Chen Yuzhen Lu 王成树 | 2018 | 科学新闻2018，0，4： | 1 |
| 15 | Resistive switching and artificial synaptic performances of memristor based on low-dimensional bismuth halide perovskites显示文摘Zero-dimensional(0D)-Cs_(3)Bi_(2)I_(9),two-dimensional(2D)-Cs_(3)Bi_(2)Br_(9),and one-dimensional(1D)-Cs3Bi2Cl9 perovskite films have been successfully grown on indium tin oxide(ITO)glass substrates,which were used to fabricate memristors with the structure of Al/Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)/ITO glass.The current three types of memristors exhibited bipolar resistive switching behaviors.Both the endurance and retention time tests clearly demonstrated the excellent stability of present devices.Especially,the ON/OFF ratio of the 0D-Cs_(3)Bi_(2)I_(9)device is close to 104 at the reading voltage of 0.1 V,which is nearly 100 and 1000 times larger than those of the 1D-Cs3Bi2Cl9 device and the 2D-Cs_(3)Bi_(2)Br_(9)device,respectively.The activation energy of halide vacancies in the Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)films was calculated using the density functional theory by considering a minimum migration path,demonstrating the dimensionality of the Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)film affected the formation and rupture of conductive filaments.Moreover,the short-term plasticity and long-term plasticity of biological synapse were simulated by evaluating the conductance responses of Al/Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)/ITO devices under various voltage pulses in detail.The duration time of long-term plasticity in all the present devices can last for up to 250 s.The 0D-Cs_(3)Bi_(2)I_(9)device showed both the highest spikeduration-dependent plasticity and paired-pulse facilitation indexes compared to the other two devices.Additionally,the 0DCs_(3)Bi_(2)I_(9)device successfully established the associative learning behavior by simulating the Pavlov’s dog experiment. | Feifei Luo Yanzhao Wu Junwei Tong Fubo Tian Xianmin Zhang | 2023 | Nano Research2023，16，7： | 1 |
| 16 | Displacement Amplification and Electric Characteristics of Modified Rectangular Cymbal Transducers Using Electroactive Materials 显示文摘 | Luo Laihui Tang Yanxue Wang Feifei | 2007 | Solid State Communications2007，143，： | 1 |
| 17 | UBA domain protein SUF1 interacts with NatA-complex subunit NAA15 to regulate thermotolerance in Arabidopsis显示文摘During recovery from heat stress,plants clear away the heat-stress-induced misfolded proteins through the ubiquitin-proteasome system(UPS).In the UPS,the recognition of substrate proteins by E3 ligase can be regulated by the N-terminal acetyltransferase A(NatA)complex.Here,we determined that Arabidopsis STRESS-RELATED UBIQUITIN-ASSOCIATED-DOMAIN PROTEIN FACTOR 1(SUF1)interacts with the NatA complex core subunit NAA15 and positively regulates NAA15.The suf1 and naa15 mutants are sensitive to heat stress;the NatA substrate NSNC1 is stabilized in suf1 mutant plants during heat stress recovery.Therefore,SUF1 and its interactor NAA15 play important roles in basal thermotolerance in Arabidopsis. | Ze-Ting Song Xiao-Jie Chen Ling Luo Feifei Yu Jian-Xiang Liu Jia-Jia Han | 2022 | Journal of Integrative Plant Biology2022，64，7： | 1 |
| 18 | The stimulating effect of ghrelin on gastric motility and firing activity of gastric‐distension‐sensitive hippocampal neurons and its underlying regulation by the hypothalamus显示文摘 | Luo Xu Yanling Gong Hongbo Wang Xiangrong Sun Feifei Guo Shengli Gao Fang Gu | 2014 | Experimental Physiology2014，，1： | 1 |
| 19 | A Novel Disease-Modifying Antirheumatic Drug, Iguratimod, Ameliorates Murine Arthritis by Blocking IL-17 Signaling, Distinct from Methotrexate and Leflunomide显示文摘 | Qiong Luo Yang Sun Wen Liu Cheng Qian Biao Jin Feifei Tao Yanhong Gu Xingxin Wu Yan Shen Qiang Xu | 2013 | The Journal of Immunology2013，，10： | 1 |
| 20 | Optimal biaxial prestretch ratios of soft dielectric elastomer actuators for maximal voltage-induced displacement显示文摘Prestretch plays an indispensable role in programming the voltage-induced deformation of dielectric elastomer actuators(DEAs).However,lacking rational design methods,the level of prestretch is usually determined through time-consuming experiments and trial-and-error tests.In this paper,we aim to quantitatively determine the optimal biaxial prestretch ratios for maximizing the voltage-induced displacement of interest.Based on the Lagrange method and adjoint sensitivity analysis,we obtain the derivative of the displacement field with respect to the principal prestretch ratios,in which the nonlinearities and complex electromechanical coupling of DEAs are rigorously taken into consideration.The derivative information allows for performing gradient-based optimization at a high convergence rate.We propose a comprehensive optimization framework connecting the nonlinear finite element analysis and sensitivity analysis to iteratively identify the optimal prestretch ratios.We validate our method on two classical types of DEAs,i.e.,planar DEAs with fixed boundaries and free-standing three-dimensional dielectric elastomer minimum energy structures(DEMES).The simulation and experiment results both show that remarkable improvements in concerned displacements are obtained compared with the non-optimized designs. | LUO Kai WU JiaNing CHEN FeiFei | 2023 | Science China(Technological Sciences)2023，66，10： | 1 |
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