|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification and Typing of Respiratory Adenoviruses in Guangzhou, Southern China Using a Rapid and Simple Method显示文摘Human adenoviruses (HAdVs), especially HAdV-B3, -E4 and -B7, are associated with Acute Respiratory Disease in Chinese children, and occasionally in adults. In order to establish and document the profiles of the respiratory adenovirus pathogen among children in Guangzhou, Southern China, a rapid, simple and practical method for identification and typing of respiratory adenoviruses was developed and evaluated. One pair of universal PCR primers was designed according to the conserved region of the hexon gene, which can detect not only HAdV-B3, -E4 and -B7, but also HAdV-B14, -F40 and -F41, with a specific 300bp PCR product. Three pairs of type-specific PCR primers were also designed according to the hypervariable regions of the hexon gene to type HAdV-B3, -E4 and -B7 by three independent PCR reactions, making it easy to optimize the PCR conditions. By using this method, one hundred throat swab specimens collected during Oct 2010 to Dec 2011 and suspected of being positive for adenoviral infection were identified and typed for adenoviruses. Of these samples, fifty-five were adenovirus-positive. The most common HAdV type was HAdV-B3, identified in 92.7% of samples, which is not only consistent with the data reported in 2004-2006, but also consistent with the recent report in Hangzhou, eastern China, indicating that HAdV-B3 has been circulating in Guangzhou, and maybe in eastern China, for many years. The method for the respiratory adenovirus identification and typing we developed is rapid, simple and practical, which has a potential in the real-time surveillance of circulating adenovirus strains and also to provide etiological evidence for the adenovirus-relative disease control and prevention in China. | Guiyuan Han Hongling Niu Suhui Zhao Bing Zhu Changbing Wang Yungang Liu Mingjie Zhang Shu Yang Feitong Liu Chengsong Wan Qiwei Zhang | 2013 | Virologica Sinica2013，28，2： | 10 |
| 2 | Pharmacokinetics of oxiracetam and its degraded substance (HOPAA) after oral and intravenous administration in rats显示文摘The pharmacokinetics of oxiracetam and its degraded substance(4-hydroxy-2-oxo-1-pyrrolidine acetic acid,HOPAA)after oral and intravenous administration in rats were studied using an established UPLC-MS/MS method.Three groups of rats after an overnight fasted received 10 g/kg(n=6)oxiracetam suspensions orally,and 2 g/kg(n=6)normal or degraded oxiracetam injections intravenously via a caudal tail vein,respectively.Before the pharmacokinetic experiment,a simple safety evaluation testwas conducted on the degraded oxiracetam injections containing 16.16% HOPAA in mice.There was no mortality by a single intravenous dose of 2 g/kg of degraded oxiracetam injections within twoweeks,demonstrating that HOPAA was non-toxic in mice.Following intravenous administration of the normal injections,the plasma concentration-time curves of oxiracetam and HOPAA both showed a rapid elimination phase.The values of t_(1/2)were 3.1±1.5 h for oxiracetamand 0.8±0.2 h for HOPAA,andthemean residencetimes(MRT)were 1.2±0.1h and 0.8±0.1h,respectively.Oxiracetam and HOPAA after intravenous administration of the degraded oxiracetam injections presented elimination patterns similar to those observed in the normal injections.Oral pharmacokinetic results showed that the Tmax was less than 1.5 h for the two analytes,and both had a longer t_(1/2) and MRT than those of intravenous administration.Contents of HOPAA in three groupswere calculated based on AUC_(0-t) values of the two analytes.The quantitative change of HOPAA in vivo was also evaluated by comparing the plasma concentrations of HOPAA and oxiracetamat the same time for every group.Additionally,the values of absolute bioavailability of oxiracetam were about 8.0%and 7.4%calculated by the normal or degraded oxiracetam injections,whichwere far less than the value of 75%reported in literature,indicating the necessity of further study. | Xinhuan Wan Xiaohong Liu Zheng Liu Panqin Ma Feitong Zhang Xiangrong Zhang Jin Sun | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 2 |
| 3 | Texture synthesis via the matching compatibility between patches显示文摘A new patch-based texture synthesis method is presented in this paper. By the method, a set of patches that can be matched with a sampled patch for growing textures effectively, called the matching compat- ibility between patches, is generated first for each patch, and the set is further optimized by culling the patches that may cause synthesis confficts. In this way, similarity measurement calculation for selecting suitable patches in texture synthesis can be greatly saved, and synthesis confficts between neighbouring patches are substantially reduced. Furthermore, retrace computation is integrated in the synthesis process to improve the texture quality. As a result, the new method can produce high quality textures as texture optimization, the best method to date for producing good textures, and run in a time complexity linear to the size of the output texture. Experimental results show that the new method can interactively generate a large texture in 1024 × 1024 pixels, which is very difficult to achieve by existing methods. | WANG WenCheng LIU FeiTong HUANG PeiJie WU EnHua | 2009 | Science in China(Series F)2009，52，3： | 2 |
| 4 | Epithelial mesenchymal transition correlates with CD24+CD44+ and CD133+cells in pancreatic cancer显示文摘 | Ye Zhang Jishu Wei Hui Wang Xiaofeng Xue Yong An Dong Tang Zhongxu Yuan Feitong Wang Junli Wu Jingjing Zhang Yi Miao | 2012 | Oncology Reports2012，，5： | 1 |
| 5 | Shipborne oceanic high-spectral-resolution lidar for accurate estimation of seawater depth-resolved optical properties显示文摘Lidar techniques present a distinctive ability to resolve vertical structure of optical properties within the upper water column at both day-and night-time.However,accuracy challenges remain for existing lidar instruments due to the ill-posed nature of elastic backscatter lidar retrievals and multiple scattering.Here we demonstrate the high performance of,to the best of our knowledge,the first shipborne oceanic high-spectral-resolution lidar(HSRL)and illustrate a multiple scattering correction algorithm to rigorously address the above challenges in estimating the depth-resolved diffuse attenuation coefficient Kd and the particulate backscattering coefficient bbp at 532 nm.HSRL data were collected during day-and night-time within the coastal areas of East China Sea and South China Sea,which are connected by the Taiwan Strait.Results include vertical profiles from open ocean waters to moderate turbid waters and first lidar continuous observation of diel vertical distribution of thin layers at a fixed station.The root-mean-square relative differences between the HSRL and coincident in situ measurements are 5.6%and 9.1%for Kd and bbp,respectively,corresponding to an improvement of 2.7-13.5 and 4.9-44.1 times,respectively,with respect to elastic backscatter lidar methods.Shipborne oceanic HSRLs with high performance are expected to be of paramount importance for the construction of 3D map of ocean ecosystem. | Yudi Zhou Yang Chen Hongkai Zhao Cedric Jamet Davide Dionisi Malik Chami Paolo Di Grolamo James H.Churnside Aleksey Malinka Huade Zhao Dajun Qiu Tingwei Cui Qun Liu Yatong Chen Sornsiri Phongphattarawat Nanchao Wang Sijie Chen Peng Chen Ziwei Yao Chengfeng Le Yuting Tao Peituo Xu Xiaobin Wang Binyu Wang Feitong Chen Chuang Ye Kai Zhang Chong Liu Dong Liu | 2022 | Light(Science & Applications)2022，11，10： | 0 |
| 6 | Digital Simulation of Projective Non-Abelian Anyons with 68 Superconducting Qubits显示文摘Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary operations,rather than merely a phase factor,in a space spanned by topologically degenerate wavefunctions.They are the building blocks of topological quantum computing.However,experimental observation of non-Abelian anyons and their characterizing braiding statistics is notoriously challenging and has remained elusive hitherto,in spite of various theoretical proposals.Here,we report an experimental quantum digital simulation of projective non-Abelian anyons and their braiding statistics with up to 68 programmable superconducting qubits arranged on a two-dimensional lattice.By implementing the ground states of the toric-code model with twists through quantum circuits,we demonstrate that twists exchange electric and magnetic charges and behave as a particular type of non-Abelian anyons,i.e.,the Ising anyons.In particular,we show experimentally that these twists follow the fusion rules and non-Abelian braiding statistics of the Ising type,and can be explored to encode topological logical qubits.Furthermore,we demonstrate how to implement both single-and two-qubit logic gates through applying a sequence of elementary Pauli gates on the underlying physical qubits.Our results demonstrate a versatile quantum digital approach for simulating non-Abelian anyons,offering a new lens into the study of such peculiar quasiparticles. | Shibo Xu Zheng-Zhi Sun Ke Wang Liang Xiang Zehang Bao Zitian Zhu Fanhao Shen Zixuan Song Pengfei Zhang Wenhui Ren Xu Zhang Hang Dong Jinfeng Deng Jiachen Chen Yaozu Wu Ziqi Tan Yu Gao Feitong Jin Xuhao Zhu Chuanyu Zhang Ning Wang Yiren Zou Jiarun Zhong Aosai Zhang Weikang Li Wenjie Jiang Li-Wei Yu Yunyan Yao Zhen Wang Hekang Li Qiujiang Guo Chao Song H.Wang Dong-Ling Deng | 2023 | Chinese Physics Letters2023，40，6： | 0 |
| 7 | Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1显示文摘Introduction:Siva-1,as a pro-apoptotic protein,has been shown to induce extensive apoptosis in a number of different cell lines.In our previous study,we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer cells.So,we believe that it can also work as an anti-apoptotic protein.The present study aimed to determine the specific role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the mechanism.Materials and Methods:A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1 was established.The effect of Siva-1 downregulation on chemotherapeutic drug resistance was assessed by measuring the IC50 and pump rate of doxorubicin.Proliferation,apoptosis of cells,and cell cycle were detected via colony formation assay andflow cytometry,respectively.Additionally,migration and invasion of cells was detected via wound healing and transwell assays.Moreover,we determined in vivo effects of LV-Siva-1-RNAi on tumor size,and apoptotic cells in tumor tissues were detected using TUNEL and hematoxylin and eosin staining.Results:Siva-1 downregulation reduced the pump rate of doxorubicin and enhanced the response to drug treatment.Siva-1 negatively regulated proliferation and promoted apoptosis of cells by potentiality G2-M phase arresting.Inhibition of Siva-1 expression in MKN-28/VCR cells significantly weakened wound healing ability and decreased invasion ability.Poly(C)-binding protein 1(PCBP1)was identified as a Siva-1-interacting protein in yeast two-hybrid screening.Semiquantitative RT-PCR and western blotting revealed that Siva-1 downregulation could inhibit expression of PCBP1,Akt,and NF-κB and eventually decrease the expression of MDR1 and MRP1.Conclusion:The current study demonstrated that the downregulation of Siva-1,which functions as a regulator of MDR1 and MRP1 gene expression in gastric cancer cells by inhibiting PCBP1/Akt/NF-κB signaling pathway expression,enhanced the sensitivity of gastric cancer cells to certain chemotherapies. | FANBIAO KONG KUN WU LIMING PANG YULIANG HUANG LEI LI JING XU FEITONG LI YAN QING ZHONGYU WANG XIURONG HUANG SHENG XU XIAOGANG ZHONG ZHOU ZHU XIAOTONG WANG JIANRONG YANG | 2022 | Oncology Research2022，30，6： | 0 |
| 8 | Study on Changes of Nitrite Content in Two Kinds of Foods under Different Storage Conditions显示文摘[Objectives]This study was conducted to store and consume overnight vegetables more safely and reasonably.[Methods]Fried cabbage and barbecue was selected as raw materials,which were determine by Griess reagent colorimetry for the effects of storage time,storage temperature and storage method on the changes in nitrite content in the two foods.[Results]The nitrite content in fried cabbage and barbecue increased with the prolongation of storage time.Both types of food,whether stored in a sealed or open manner,had a nitrite content that increased with the storage temperature.When barbecue was stored in an open manner,its nitrite content was greater than that in sealed storage.The condition of stir-fried cabbage was the same as barbecue when stored at 10℃,but the situation was opposite when stored at 20 and 30℃.In this study,except for the slightly excessive nitrite content in stir-fried cabbage stored at 30℃in open and sealed conditions for 72 h,the nitrite contents in both foods under other storage conditions all met the national standard limit.[Conclusions]This study provides a theoretical basis for the safe and reasonable storage and use of leftovers. | Xiulan WU Feitong ZHUO | 2023 | Agricultural Biotechnology2023，12，4： | 0 |
| 9 | Contributions of Cs and Rb on Inhibiting Photo-induced Phase Segregation and En-hancement Optoelectronic Performances of MA_(1-y)XyPbI_(1.8)Br_(1.2)(X=Cs,Rb)Single Crystals显示文摘Introducing inorganic cation into hybrid organic-inorganic perovskites(HOIPs)has attracted great attention because of the enhancement stabilities without sacrificing their excellent optoelectronic properties.Here,we introduce Cs and Rb into MAPbI_(1.8)Br_(1.2)single crystals(SCs)to dig out the mixed cation effect on optoelectronic performances and phase stabilities.Both Rb and Cs can increase the lattice capacity,which is sufficient to relieve the lattice stress caused by photon energy,thus achieving the purpose of stabilizing the lattice structure and inhibiting migration of halide ions,compared with MAPbI_(1.8)Br_(1.2)SC.On the other hand,the smaller polarity of Rb and Cs reduces the electron-phonon coupling,thus significantly inhibiting the migration of halide ions.Meanwhile,through planar photo-detectors,MA_(0.9)Cs_(0.1)PbI_(1.8)Br_(1.2)-based device behaves much excellent optoelectronic performance(R=0.170 A/W,EQE=51.39%,D^(*)=4.42×10^(12)Jones,on/off ratio:~522). | Qing Yao Kaiyu Wang Jie Zhang Changqian Li Chenyu Shang Feitong Chen Qi Huang Qiqi Zhao Weiwei Zhang Xiaoyuan Zhan Jianxu Ding | 2022 | Chinese Journal of Structural Chemistry2022，41，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员