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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea 显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydr Poly2002，49，： | 1 |
| 3 | Efeito da pimenta rosa assoeiada a diversas dosagens de antibioticos em frangos de eorte显示文摘 | Gonealves F G Zanini S F Feitosa S F | 2012 | Cieneia Rural2012，，8： | 1 |
| 4 | FLT3 internal tandem duplication during myelodysplastic syndrome follow-up: a marker of transformation to acute myeloid leukemia显示文摘 | Ronald Feitosa Pinheiro Eloisa de Sá Moreira Maria Regina Régis Silva Fernando Lopes Alberto Maria de Lourdes L.F. Chauffaille | 2008 | Cancer Genetics and Cytogenetics2008，，2： | 1 |
| 5 | Effect of cleansing methods on saliva-contaminated zireonia-an evaluatinn of resin bond du- rability 显示文摘 | Feitosa S Patel D Borges A | 2015 | Oper Dent2015，40，2： | 1 |
| 6 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | MELO M R S FEITOSA J P A FREITAS A L P | 2002 | Carbohyd Polym2002，49，： | 1 |
| 7 | Isolation and characterization of soluble sulfated polysaccharide from the redseaweed Gracilada cornea显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydrate Polymers2002，49，4： | 1 |
| 8 | Interpretation of apparent resistivity data from Apodi Valley,Rio Grande de Norte,Brazil显示文摘 | Rijo L Pelton W Feitosa E Wars S | | 0，，： | 1 |
| 9 | Reconstruction of electrical impedance tomography images using genetic algorithms and non-blind search显示文摘 | RIBEIRO R R FEITOSA A R S SOUZA R E | 2014 | Biomedical Imaging(ISBI)2014，，5： | 1 |
| 10 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydrate Polymers2002，49，4： | 1 |
| 11 | Reconstruction of electrical impedance tomography images using particle swarm optimization,genetic algorithms and non-blind search显示文摘 | FEITOSA R S RIBEIRO R R BARBOSA V F | 2014 | Biosignals and Robotics for Better and Safer Living(BRC)2014，，5： | 1 |
| 12 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Graccilaria cornea显示文摘 | M R S Melo J P A Feitosa A L P Freitas | 2002 | Carbohydrate Polymers2002，，49： | 1 |
| 13 | Thyroid hormones may influence cortical bone healing around titanium implants:a histometric study in rats显示文摘 | Feitosa S Bezerra B Ambrosano GM | 2008 | Periodontol2008，79，5： | 1 |
| 14 | Stroke awareness in Brazil:alarming results in a community-based study显示文摘 | Pontes-Neto O M Silva G S Feitosa M R | | 0，，02： | 1 |
| 15 | Isolation and characterization of soluble sulfated polysaccharide from red seaweed Gracilaria cornea显示文摘 | Feitosa J P A Freitas A L P | 2002 | Carbohadrate Polymers2002，49，2： | 1 |
| 16 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | MELO M R S FEITOSA J P A FRE1TAS A L P | 2002 | Carbohydrate Polymers2002，49，4： | 1 |
| 17 | Thyroid hormones may influence cortical bone healing a- round titanium implants : a histometric study in rats 显示文摘 | Feitosa Dda S Bezerra Bde B Ambrosano GM | 2008 | J Periodontol2008，79，5： | 1 |
| 18 | Epistatic interactions of CDKN2B- TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyc- eride/high-density lipoprotein ratio longitudinal change:evidence from the Framingham Heart Study显示文摘 | An P Feitosa M Ketkar S | 2009 | BMC Proc2009，3，7： | 1 |
| 19 | Effects of reducing agents on birefringence dentin collagen after use of different endodontic auxiliary chemical substances显示文摘 | Moreira D M de Andrade Feitosa J P Line S R | 2011 | J Endod2011，37，10： | 1 |
| 20 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | MELO M R S FEITOSA J P A FREITAS A L P | 2002 | Carbohydrate Polymers2002，49，： | 1 |
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