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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | A 50% reduction in the Psoriasis Area and Severity Index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis显示文摘 | Carlin C S Feldman S R Krueger J G | 2004 | J Am Acad Dermatol2004，50，6： | 1 |
| 3 | Hepatitis C in patients with porphyria cutanea tarda显示文摘 | Koester G Feldman J Bigler C | 1996 | JAm Acad Dermatol1996，34，2： | 1 |
| 4 | Investigation of the rapid chloride permeability test显示文摘 | FELDMAN R F CHAN G W BROUSSEAU R J | 1994 | ACI Materials Journal1994，91，3： | 1 |
| 5 | Retinoic acid signaling restricts the cardiac progenitor pool 显示文摘 | KEEGAN B R FELDMAN J L BEGEMANN G | 2005 | Science2005，307，5707： | 1 |
| 6 | Effect of fluticasone ropionate/salmeterol (250/50) on COPD exacerbations and impact on patient outcomes 显示文摘 | Anzueto A Ferguson GT Feldman G | 2009 | COPD2009，6，5： | 1 |
| 7 | The genetics of fibrodysplasia ossificans progressiva 显示文摘 | Shore E Feldman G Xu M | 2005 | Clin Rev Bone Miner Metab2005，3，： | 1 |
| 8 | Functional tuning of the nervous system with control of movement or maintenance of a steady posture : Controllable parameters of the muscles 显示文摘 | Feldman A G | 1966 | Biophysics1966，，11： | 1 |
| 9 | Impotencean dits medical and psychosocial correlates:results of the massachusetts male aging study显示文摘 | Feldman H A Goldstein I Hatzichristou D G | 1994 | J Urol1994，151，1： | 1 |
| 10 | Self-generated Validity and Other Effects of Measurement on Belief, Attitude, Intention and Behavior 显示文摘 | Feldman Jack M Lynch John G | 1988 | Journal of Applied Psychology1988，73，8： | 1 |
| 11 | The Otto Aufranc Award : i- dentification of a 4 Mb legion on chromosome 17q21 linked to devel- opmental dysplasia of the hip in one 18 - member, multigeneration family显示文摘 | Feldman G Dalsey C Fertala K | 2010 | Clin Orthop2010，468，： | 1 |
| 12 | A specific genomic location within the icm/dot pathogenesis region of different Legionella species enr codes fnnctionally similar but nonhomologous virulence proteins 显示文摘 | Feldman M Sengal G | 2004 | Infect Immun2004，72，： | 1 |
| 13 | Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage Ⅳ clear cell renal cancer显示文摘 | FELDMAN A L TAMARKIN L PACIOTH G F | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 14 | Ca2+-induced Ca2+ release through localized Ca2+ uncaging in smooth muscle 显示文摘 | Ji G Feldman M Doran R | 2006 | J Gen Physiol2006，127，： | 1 |
| 15 | Perpectives of arterial gene therapy for the pre vention of restenosis显示文摘 | Tahil O'Steg G | 1996 | Circ Res1996，32，： | 1 |
| 16 | Investigation of the Rapid chloride Permcbility Test显示文摘 | Feldman R H Chan G W Brousseau R J | 1994 | ACI Materials Journal1994，，6： | 1 |
| 17 | Self- generated Validity and Other Effects of Measurement on Belief, Attitude, Intention, and Behav- ior 显示文摘 | Feldman J M Lynch J G | 1988 | Journal of Applied Psychology1988，73，3： | 1 |
| 18 | The coronary atherosclerosis of the diabetic显示文摘 | Steg P G Karila-Cohen D Feldman L J | 2000 | Arch Mal Coeur Vaiss2000，93，： | 1 |
| 19 | Variability of the productive habitat in the Eastern Equatorial Pacific 显示文摘 | Feldman G C | 1986 | EOS Transactions1986，67，9： | 1 |
| 20 | Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine,bupivacaine and lidocaine in the consious dog显示文摘 | FELDMAN H S ARTHUR G R COVINO B G | 1989 | Anesth Analg1989，69，： | 1 |
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