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| 1 | Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature显示文摘BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are rare.The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect.Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care.However,under specific circumstances,a cytoreductive approach may represent a therapeutic option.We describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric mass.Abdominal computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the liver.The initial approach was transarterial embolization of the tumor,which elicited no appreciable response.Considering the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was indicated.Due to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be achieved.Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver.Considering the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSION E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection surgery.However,a cytoreductive surgery will be necessary when a complete resection is no possible. | Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 3 |
| 2 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 3 | Detection of contaminants in cell cultures, sera and trypsin显示文摘 | Tatiana Flávia Pinheiro de Oliveira Ant?nio Augusto Fonseca Marcelo Fernandes Camargos Anapolino Macedo de Oliveira Ana Cláudia Pinto Cottorello Antonizete dos Reis Souza Iassudara Garcia de Almeida Marcos Bryan Heinemann | 2013 | Biologicals2013，，6： | 2 |
| 4 | ADAMTS13 and Von Willebrand factor in patients undergoing hemodialysis显示文摘 | Danyelle Rios Maria Carvalho Roberta Figueiredo Cláudia Ferreira Valério Rodrigues Regina Souza Ana Silva Ana Fernandes Karina Gomes Luci Dusse | 2012 | Journal of Thrombosis and Thrombolysis2012，，1： | 1 |
| 5 | Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload显示文摘BACKGROUND Patients with hepatitis C virus(HCV) and hepatocellular carcinoma(HCC) may or not develop iron overload(IO),which is associated with worst prognosis,because can cause serious damage to organs.HFE gene controls the iron uptake from gut,particularly in patients with hereditary hemochromatosis(HH).AIM To identify associations between HFE coding region in patients exhibiting hereditary hemochromatosis and in diseases associated with acquired IO.METHODS We sequenced exons 2 to 5 and boundary introns of HFE gene,evaluating all polymorphic sites in patients presenting hereditary(hemochromatosis) or acquired iron overload HCV and HCC) and in healthy controls,using Sanger sequencing.We also determined the ensemble of extended haplotype in healthy control individuals,including several major histocompatibility complex loci,using sequence specific probes.Haplotype reconstruction was performed using the Arlequin and Phase softwares,and linkage disequilibrium(LD) between histocompatibility loci and HFE gene was performed using the Haploview software.RESULTS The HFE*003 allele was overrepresented(f = 71%) and HFE*001 allele was underrepresented(f = 14%) in HH patients compared to all groups.A strong linkage disequilibrium was observed among the H63 D-G,IVS2(+4)-C and C282 YG gene variants,particularly in HH;however,the mutation IVS2(+4)T>C was not directly associated with HH susceptibility.The HFE*001/HFE*002 genotype conferred susceptibility to HCC in HCV patients exhibiting IO(P = 0.02,OR =14.14).Although HFE is telomeric to other histocompatibility genes,the H63 DG/IVS2(+4)-C(P ≤ 0.00001/P ≤ 0.0057) combination was in LD with HLA-B*44 allele group in healthy controls.No LD was observed between HFE alleles and other major histocompatibility loci.CONCLUSION A differential HFE association was observed for HH and for diseases associated with acquired IO(HCV,HCC).Since HFE is very distant from other histocompatibility loci,only weak associations were observed with these alleles. | Wagner Narciso de Campos Juliana Doblas Massaro Eduardo Luiz Rachid Can?ado Cláudia Emília Vieira Wiezel Aguinaldo Luiz Sim?es Andreza Correa Teixeira Fernanda Fernandes de Souza Celso Teixeira Mendes-Junior Ana de Lourdes Candolo Martinelli Eduardo Ant?nio Donadi | 2019 | World Journal of Hepatology2019，11，2： | 1 |
| 6 | Cold-induced repression of the rice anther-specific cell wall invertase gene OSINV4 is correlated with sucrose accumulation and pollen sterility 显示文摘 | Oliver SN Dongen JT vanAIfred SC Mamun EA Zhao XC Saini HS Fernandes SF Blanchard CL Sutton BG Geigenberger P Dennis ES Dolferus R | 2005 | Plant Cell Environ2005，28，12： | 1 |
| 7 | Comparison of two- and three-dimensional ultrasonography in the evaluation of fetal heart: image quality and time spent in the exam显示文摘 | Hélio Antonio Guimar?es Filho Lavoisier Linhares Dias da Costa Edward Araujo Júnior Sebasti?o Marques Zanforlin Filho Cláudio Rodrigues Pires Luciano M. M. Nardozza Antonio Fernandes Moron Rosiane Mattar | 2007 | Archives of Gynecology and Obstetrics2007，，3： | 1 |
| 8 | Stem cell cultivation in bioreactors显示文摘 | Carlos A.V. Rodrigues Tiago G. Fernandes Maria Margarida Diogo Cláudia Lobato da Silva Joaquim M.S. Cabral | 2011 | Biotechnology Advances2011，，6： | 1 |
| 9 | Elevations of hepatic quinone reductase,glutathione and alpha- and mu-class glutathione S-transferase isoforms in mice with chronic hepatitis: a compensatory response to injury 显示文摘 | Fernandes CL Dong JH Roebuck BD | 1996 | Arch Biochem Biophys1996，331，： | 1 |
| 10 | Variants of Human Papillomavirus Types 53, 58 and 66 Identified in Central Brazil显示文摘 | Daniela Marreco Cerqueira Geni Noceti de Lima Camara Márcio Rojas da Cruz Evandro Oliveira Silva Marcelo de Macedo Brígido Luciano Gon?alves de Souza Carvalho Cláudia Renata Fernandes Martins | 2003 | Virus Genes2003，，1： | 1 |
| 11 | Macrophage control of Brucella abortus : influence of cytokines and iron显示文摘 | Baldwin CL Jiang X Fernandes DM | 1993 | Trends Mi- erobiol1993，1，3： | 1 |
| 12 | In situ apoptosis of adaptive immune cells and the cellular escape of rabies in CNS from patients with human rabies transmitted by Desmodus rotundus显示文摘 | Fernandes ER de Andrade HF Jr Laneellotti CL | 2011 | Virus Res2011，156，12： | 1 |
| 13 | Violence, Condom Breakage, and HIV Infection Among Female Sex Workers in Benin, West Africa显示文摘 | Fatoumata K. Tounkara Souleymane Diabaté Fernand A. Guédou Clément Ahoussinou Frédéric Kintin Djimon M. Zannou Adolphe Kpatchavi Emmanuelle Bédard Rapha?l Bietra Michel Alary | 2014 | Sexually Transmitted Diseases2014，，5： | 1 |
| 14 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin显示文摘 | Eneiva Carla Carvalho Celeghini Rubens Paes de Arruda André Furugen Cesar de Andrade Juliana Nascimento Cláudia Fernandes Raphael Paulo Henrique Mazza Rodrigues | 2007 | Animal Reproduction Science2007，，2： | 1 |
| 15 | Forensic ethnic identification of crania: the role of the maxillary sinus - a new approach 显示文摘 | Fernandes CL | 2004 | Am J Forensic Med Pathol2004，25，4： | 1 |
| 16 | The 'in vitro' antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans显示文摘 | Fernandes FF Dias ALT Ramos CL | 2007 | Revista do Instituto de Medicina Tropical de Sao Paulo2007，49，2： | 1 |
| 17 | Interleukin-10 downregulatesprotective immunity to Brucella abortus 显示文摘 | Fernandes DM Baldwin CL | 1995 | Infect Immun1995，63，3： | 1 |
| 18 | Lack of a role for natural killer cells in early control ofBrucella abortus 2308 infections in mice显示文摘 | Fernandes DM Benson R Baldwin CL | 1995 | Infect Immun1995，63，10： | 1 |
| 19 | Drying of exotic tropical fruits: a comprehensive review显示文摘 | Fernandes FAN Rodrigues S Law CL | 2011 | Food and Bioprocess Technology2011，4，2： | 1 |
| 20 | Prevalence and factors associated with non-adherence to therapy among partners of pregnant women with syphilis in a city of northeastern Brazil显示文摘BACKGROUND One of the main difficulties faced in the prevention of the vertical transmission of syphilis is the inadequate treatment of pregnant women and their partners.The disease causes serious repercussions in infected newborns.AIM To evaluate the prevalence and factors associated with the therapeutic adhesion among partners of pregnant women with syphilis in a county in Northeastern Brazil.METHODS This is a descriptive,analytic,quantitative,cross-sectional study that was carried out through interviews with 46 pregnant women diagnosed with syphilis between 2017 and 2018 as well as with their partners.The interviews aimed at collecting data regarding sociodemographic characteristics,obstetric variables and information about syphilis,and partners’related variables.RESULTS Our results showed that 73.91%of the partners did not undergo appropriate treatments,and obtaining negative results in syphilis tests was the main reason for the absence of therapies.The following factors were significantly associated with the lack of treatment among partners:Being a partner that is not the current mate of the pregnant woman,having a level of schooling inferior to 8 years[oddsratio(OR)=10.28],and the pregnant woman undergoing up to two syphilis tests during the prenatal care(OR=8.6).The study found a higher odds of absent treatment among partners if the pregnant woman is not white(OR=13.88)or if the partner has less than 8 years of schooling(OR=21.00)or has a monthly income of less than half the minimum wage(OR=13.93).CONCLUSION The findings of this study show a high prevalence of partners that are not adequately treated for syphilis,a phenomenon that is strongly associated with socioeconomic factors. | Lilian Pinto Mota Rodrigues Fernandes Caline Novais Teixeira Oliveira Breno Bittencourt de Brito FabrícioFreire de Melo Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2022 | World Journal of Obstetrics and Gynecology2022，11，3： | 0 |
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