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| 1 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 3 | CRISPR/Cas9: Development and Application in Rice Breeding显示文摘Rice(Oryza sativa L.)is an important staple food crop worldwide due to its adaptability to different environmental conditions.Because of its great economic and social importance,there is a constant requirement for new varieties with improved agronomic characteristics,such as tolerance to different biotic(such as bacterium,fungus,insect and virus)and abiotic stresses(such as salinity,drought and temperature),higher yield and better organoleptic and nutritional value.Among the new genome editing technologies,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)(CRISPR/Cas)system allows precise and specific edition in a targeted genome region.It is one of the most frequently used techniques for the study of the function of new genes and for the development of mutant lines with enhanced tolerance to biotic and abiotic stresses,herbicide resistance or improved yield.The wide varieties of applications for this technology include simple non-homologous end joining,homologous recombination,gene replacement,and base editing.In this review,we analyzed how some of these applications have been used in rice cultivars to obtain rice varieties better adapted to current environmental conditions and market requirements. | Fernando Matías ROMERO Andrés GATICA-ARIAS | 2019 | Rice science2019，26，5： | 6 |
| 4 | Ileocolic intussusception due to intestinal metastatic melanoma. Case report and review of the literature显示文摘 | Fernando A. Alvarez Matías Nicolás Jeremías Goransky Carlos A. Vaccaro Axel Beskow Demetrio Cavadas | 2011 | International Journal of Surgery Case Reports2011，，6： | 2 |
| 5 | Hyperhomocysteinemia in Liver Cirrhosis: Mechanisms and Role in Vascular and Hepatic Fibrosis显示文摘 | Elena Ruiz García-Tevijano Carmen Berasain José Antonio Rodríguez Fernando José Corrales Roberto Arias Antonio Martín-Duce Juan Caballería José María Mato Matías Antonio Avila | 2001 | Hypertension: Journal of the American Heart Association2001，，5： | 1 |
| 6 | Local cytokine profiles of patients with cervical intraepithelial and invasive neoplasia显示文摘 | Bethanea Crema Peghini Douglas Reis Abdalla Ana Cristina Macedo Barcelos Lívia das Gra?as Vieito Lombardi Teodoro Eddie Fernando Candido Murta Márcia Antoniazi Michelin | 2012 | Human Immunology2012，，9： | 1 |
| 7 | Phylogeography and population genetic structure of the Talas tuco-tuco (Ctenomys talarum): integrating demographic and habitat histories显示文摘 | Mora Mat?as S Cutrera Ana P Lessa Enrique P Vassallo Aldo I D’Anatro Alejandro Mapelli Fernando J | 2013 | Journal of Mammalogy2013，，2： | 1 |
| 8 | Population structure and landscape genetics in the endangered subterranean rodent Ctenomys porteousi显示文摘 | Fernando J. Mapelli Matías S. Mora Patricia M. Mirol Marcelo J. Kittlein | 2012 | Conservation Genetics2012，，1： | 1 |
| 9 | Nultile epitope interactions in the two-step sandwich immunoassay显示文摘 | Fernando AS Wilson GS | 1992 | Immunol Methods1992，151，： | 1 |
| 10 | Strategies for successful clinical management of schizophrenia with ziprasidone显示文摘 | Andrea Fagiolini Fernando Ca?as Bernd Gallhofer Ilkka Larmo Pedro Levy José Manuel Montes Georgios Papageorgiou Mathias Zink Alessandro Rossi | 2010 | Expert Opinion on Pharmacotherapy2010，，13： | 1 |
| 11 | Efficient anchorage of Pt clusters on N-doped carbon nanotubes and their catalytic activity显示文摘 | Xavier Lepró Eduardo Terrés Yadira Vega-Cantú Fernando J. Rodríguez-Macías Hiroyuki Muramatsu Yoon Ahm Kim Takuya Hayahsi Morinobu Endo Miguel Torres R. Mauricio Terrones | 2008 | Chemical Physics Letters2008，，： | 1 |
| 12 | Transcriptional regulation of tocopherol biosynthesis in tomato显示文摘 | Leandro Quadrana Juliana Almeida Santiago N. Otaiza Tomas Duffy Junia V. Corrêa da Silva Fabiana Godoy Ramon Asís Luisa Bermúdez Alisdair R. Fernie Fernando Carrari Magdalena Rossi | 2013 | Plant Molecular Biology2013，，3： | 1 |
| 13 | Lethal photosensitization and guided bone regeneration in treatment of peri - implantitis: an experimental study in dogs显示文摘 | Jamil AS Marilia CM Fernando SR | 2006 | Clin Oral lmpl Res2006，17，3： | 1 |
| 14 | Metabolic correction as a tool to improve diabetes type 2 management显示文摘 | Miranda-Massari JR Gonzalez MJ Fernando AS | 2015 | Bol Asoc Med PR2015，107，2： | 1 |
| 15 | Lactic acid bacteria isolated from young calves – Characterization and potential as probiotics显示文摘 | Natalia C. Maldonado Clara Silva de Ruiz María Claudia Otero Fernando Sesma María Elena Nader-Macías | 2011 | Research in Veterinary Science2011，，2： | 1 |
| 16 | Psychiatry-life events and social support in late life depression显示文摘 | Clovis AS Ferraz AT Fernando TL | 2011 | Clinics2011，66，2： | 1 |
| 17 | Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma显示文摘 | Matías A Avila Carmen Berasain Luis Torres Antonio Martín-Duce Fernando J Corrales Heping Yang Jesús Prieto Shelly C Lu Juan Caballería Juan Rodés José M Mato | 2000 | Journal of Hepatology2000，，6： | 1 |
| 18 | Muhiresidue analysis of pesticides in peanuts using modified QuEChERS sample preparation and liquid chromatography -mass spectrometry detection显示文摘 | Renata Pereira Lopes Fabiano AS Oliveira Fernando D Madureira | 2015 | Analytical Methods2015，7，11： | 1 |
| 19 | Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina显示文摘Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology practice.The Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a'hub and spoke'design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical cases.The Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal tumors.In our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each meeting.From our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical discussions.Additionally,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided. | Federico Esteso Natalia Soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón | 2022 | World Journal of Clinical Oncology2022，13，6： | 0 |
| 20 | Development of a warning score for early detection of colorectal anastomotic leakage:Hype or hope?显示文摘BACKGROUND Colorectal anastomotic leakage(CAL),a severe postoperative complication,is associated with high morbidity,hospital readmission,and overall healthcare costs.Early detection of CAL remains a challenge in clinical practice.However,some decision models have been developed to increase the diagnostic accuracy of this event.AIM To develop a score based on easily accessible variables to detect CAL early.METHODS Based on the least absolute shrinkage and selection operator method,a predictive classification system was developed[Early ColoRectAL Leakage(E-CRALL)score]from a prospective observational,single center cohort,carried out in a colorectal division from a non-academic hospital.The score performance and CAL threshold from postoperative day(POD)3 to POD5 were estimated.Based on a precise analytical decision model,the standard clinical practice was compared with the E-CRALL adoption on POD3,POD4,or POD5.A cost-minimization analysis was conducted,on the assumption that all alternatives delivered similar health-related effects.RESULTS In this study,396 patients who underwent colorectal resection surgery with anastomosis,and 6.3%(n=25)developed CAL.Most of the patients who developed CAL(n=23;92%)were diagnosed during the first hospital admission,with a median time of diagnosis of 9.0±6.8 d.From POD3 to POD5,the area under the receiver operating characteristic curve of the E-CRALL score was 0.82,0.84,and 0.95,respectively.On POD5,if a threshold of 8.29 was chosen,87.4%of anastomotic failures were identified with E-CRALL adoption.Additionally,score usage could anticipate CAL diagnosis in an average of 5.2 d and 4.1 d,if used on POD3 and POD5,respectively.Regardless of score adoption,episode comprehensive costs were markedly greater(up to four times)in patients who developed CAL in comparison with patients who did not develop CAL.Nonetheless,the use of the E-CRALL warning score was associated with cost savings of€421442.20,with most(92.9%)of the savings from patients who did not develop CAL.CONCLUSION The E-CRALL score is an accessible tool to predict CAL at an early timepoint.Additionally,ECRALL can reduce overall healthcare costs,mainly in the reduction of hospital costs,independent of whether a patient developed CAL. | Nuno J G Rama Óscar Lourenço Patrícia C Motta Lima Maria Pedro S Guarino Diana Parente Ricardo Castro Ana Bento Anabela Rocha Fernando Castro-Poças João Pimentel | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 0 |
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