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| 1 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 3 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 4 | BCL-1, cyclinD1+CD5-mantle cell lymphoma显示文摘 | Zukerberg LR Ferry JA | 1998 | Mod Pathol1998，11，： | 1 |
| 5 | Non-lipid-related effects of statins显示文摘 | Bellosta S Ferri N Bernini F | 2000 | Ann Med2000，32，3： | 1 |
| 6 | Non lipid related effects of statins 显示文摘 | Bellosta S Ferri N Bermini F | 2002 | Ann Med2002，32，3： | 1 |
| 7 | Age-related changes of cortical excitability in subjects with sleep-enhanced centrotemporal spikes:a somatosensory evoked potential study显示文摘 | Ferri R Del Gracco S Elia M | 2000 | Clin Neurophysiol2000，111，4： | 1 |
| 8 | Clinical significance of mi- crometastases detection in lymph nodes from head and neck squamous ceil carcinoma 显示文摘 | Ferris R Xi L Raja S | 2008 | Otolaryngol Head Neck Surg2008，139，3： | 1 |
| 9 | L-selectin shedding in sepsis limits leukocyte mediated microvascular injury at remote sites 显示文摘 | Benay C Chia S Ferri LE | 2009 | Surgery2009，145，4： | 1 |
| 10 | Soil inhabiting nema- todes of the genera Trischistoma, Tripylina and Tripyla from Mexico and the USA with descriptions of new species 显示文摘 | Cid del Prado-Vera I Ferris H Nadler S A | 2010 | Journal of Nema- tode Morphology and Systematics2010，13，： | 1 |
| 11 | Engineering and economic applications of complementarity problems显示文摘 | Ferris M C Pang J S | 1997 | Siam Review1997，39，4： | 1 |
| 12 | Direct vascular effects of HMG-CoA reductase inhibitor显示文摘 | Bernini F Ferri N | 1998 | Atherosclerosis1998，137，： | 1 |
| 13 | EGFR,pMAPK,pAkt and PTEN status by immunohistochemistry:correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab显示文摘 | Gori S Sidoni A Colozza M Ferri I Mameli MG Fenocchio D | 2009 | Ann Oncol2009，20，4： | 1 |
| 14 | Studying the Role of Political Competition in the Evolution of Government Size Over Long Horizons 显示文摘 | Ferris J S Park S P Winer S L | 2008 | Public Choice2008，，： | 1 |
| 15 | Strain and loading of the second metatarsal during heel lift 显示文摘 | Sharkey N A Ferris L Smith T S | 1995 | J Bone Joint Surg Am1995，77，7： | 1 |
| 16 | Development of a rapid chromato graphic strip test for the pen-side detection of foot-and mouth disease virus antigen显示文摘 | Reid S M Ferris N P Bruning A | 1996 | J Virol Methods1996，2，： | 1 |
| 17 | Estimating the prevalence of low back pain in the general population显示文摘 | Papageorgiou A C Croft P R Ferry S | | 0，，17： | 1 |
| 18 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 19 | Oxygen free radicals in ischemic acute renal failure in the rat 显示文摘 | PALLER M S HOIDAL J R FERRIS T F | 1984 | Clin Invest1984，74，4： | 1 |
| 20 | Pen-side test for investigating FMD显示文摘 | Ferris N Reid S Hutching | 2001 | Vet Rec2001，148，26： | 1 |
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