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| 1 | Neuroprotection of aucubin in primary diabetic encephalopathy显示文摘Hippocampal neuronal apoptosis accompanied by impairment of cognitive function occurs in primary diabetic encephalopathy. In this study, we investigated the neuroprotective mechanism of the iridoid glycoside, aucubin, using rats (n=8). Diabetes mellitus was induced in the rats by intraperitoneal (i.p.) injection of streptozotocin (60 mg/kg body weight). After 65 d, half of the DM rats were administered aucubin (5 mg/kg; i.p.) for 15 d, yielding treatment DM+A. A third group of rats received no strepto- zotocin or aucibin, and served as controls (CON). Encephalopathy was assessed using Y-maze be- havioral testing. Rats were euthanized on Day 87, and hippocampi were excised for visual (light and transmission electron microscopic) and immunochemical (Western blot; immunohistochemical) as- sessments of the CA1 subfield for apoptosis and expression of regulatory proteins Bcl-2 and Bax. Treatment responses to all the parameters examined (body weight, plasma glucose, Y-maze error rates, pyramidal cell ultrastructure, proportions of apoptotic cells, levels of expression of Bcl-2 and Bax, and survivability of neuronal cells) were identical: there were highly significant differences between DM and CON groups (P<0.001), but the effects were significantly moderated (P<0.01) in DM+A compared with DM. These findings confirm the association of apoptosis with the encephalopathic effects of diabetes mellitus, and suggest a major role of the expression levels of Bcl-2 and Bax in the regulation of apop- totic cell death. All of the results suggest that aucubin could effectively inhibit apoptosis by modulating the expressions of Bcl-2 and Bax genes. | XUE HongYu1, JIN LiJi1,2, JIN Lei1, ZHANG Peng1, LI DanQing4, XIA YanQiu1, LU YaNan1 & XU YongPing1,3 1 Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China 2 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China 3 Dalian SEM Bioengineer and Biotech Ltd., Dalian 116024, China 4 The Second Affiliated Hospital, Dalian Medical University, Dalian 116024, China | 2008 | Science China(Life Sciences)2008，51，6： | 22 |
| 2 | Adaptive Backstepping Sliding Mode Trajectory Tracking Control for a Quad-rotor显示文摘A quad-rotor aircraft is an under-actuated,strongly coupled nonlinear system with parameter uncertainty and un-modeled disturbance.In order to make the aircraft track the desired trajectory,a nested double-loops control system is adopted in this paper.A position error proportional-derivative(PD) controller is designed as the outer-loop controller based on the coupling action between rotational and translational movement,and an adaptive backstepping sliding mode control algorithm is used to stabilize the attitude.Finally,both the numerical simulation and prototype experiment are utilized to demonstrate the effectiveness of the proposed control system. | Xun Gong 1 Zhi-Cheng Hou 1 Chang-Jun Zhao 2 Yue Bai 2 Yan-Tao Tian 1 1 School of Telecommunication Engineering,Jilin University,Changchun 130025,China 2 Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Changchun 130080,China | 2012 | International Journal of Automation and computing2012，9，5： | 5 |
| 3 | Microstructures and characteristics of deep trap levels in ZnO varistors doped with Y_2O_3显示文摘In this paper discussions on ZnO based varistor ceramics doped with different ratios of Y2O3 are presented.Analysis on the phase and microstructures of the samples indicates that an additional phase is detected in the samples doped with Y2O3,and the average grain size of the specimens decreases from about 9.2μm to 4.5μm,with an increase in the addition of Y2O3 from 0 mol%to 3 mol%.The corresponding varistor’s voltage gradient markedly increases from 462 V/mm to 2340 V/mm,while the nonlinear coefficient decreases from 22.3 to 11.5,respectively.Furthermore,the characteristics of deep trap levels in these ZnO samples are investigated by measuring their dielectric spectroscopies.The trap energy level and capture cross section evaluated by relaxation peak of the Cole-Cole plot vary slightly as the addition of Y2O3 increases.These traps may be ascribed to the intrinsic defects of ZnO lattice. | LIU Jun 1 ,HU Jun 1 ,HE JinLiang 1 ,LIN YuanHua 2 &LONG WangCheng 1 1State Key Laboratory of Power Systems,Department of Electrical Engineering,Tsinghua University,Beijing 100084,China 2State Key Laboratory of New Ceramics and Fine Processing,Department of Material Science and Engineering,Tsinghua University, Beijing 100084,China | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 4 | Laser altimeter of CE-1 payloads system显示文摘The design and operation of the Laser Altimeter of CE-1 Payloads System are presented in this paper.The paper includes the design of the system and spacecraft-level laser,the description of the emitting-system and receiving system,and the testing of the laser altimeter.The CE-1 laser altimeter is the first Chinese deep-space probe using a laser.It has one beam and operates at 1 Hz,with a nominal accuracy of 5 m.The laser altimeter has operated successfully in lunar orbit since November 28,2007.It has obtained 9120 thousand data values about the lunar altitude. | WANG JianYu1*,SHU Rong1,CHEN WeiBiao2,JIA JianJun1,WANG BingYong1,HUANG GengHua1,HU YiHua1 & HOU Xia2 1 Shanghai Institute of Technical Physics,Chinese Academy of Sciences,Shanghai 200083,China 2 Shanghai Institute of Fine Optical Mechanical,Chinese Academy of Sciences,Shanghai 201800,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 4 |
| 5 | Single crystal β-Ga_2O_3: Cr grown by floating zone technique and its optical properties显示文摘β-Ga2O3: Cr single crystals were grown by floating zone technique. Absorption spectra and fluorescence spectra were measured at room temperature. The values of field splitting parameter Dq and Racah parameter B were obtained by the peak values of absorption spectra. The value 10Dq/B=23.14 manifests that in β-Ga2O3 crystals Cr3+ ions are influenced by low energy crystal field. After high temperature annealing in air, the Cr3+ intrinsic emission was enhanced and the green lumines-cence disappeared. The strong and broad 691 nm emission was obtained at 420 nm excitation due to the electron transition occurred from 4T2 to 4A2. The studies manifest that the β-Ga2O3 crystals have the potential application for tunable laser. | ZHANG JunGang1, 2, LI Bin3, XIA ChangTai1, XU Jun1, DENG Qun4, XU XiaoDong1, WU Feng1, XU WuSheng4, SHI HongSheng4, PEI GuangQing1, 2 & WU YongQing1,2 1 Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China 2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3 Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China 4 GE (China) Research and Development Center Co. Ltd., Shanghai 201203, China | 2007 | Science China(Technological Sciences)2007，50，1： | 4 |
| 6 | A systematic investigation of high harmonic generation using mid-infrared driving laser pulses显示文摘We report on a systematic investigation of the influences of gas pressure,focal position and focusing geometry on high harmonic generation by use of mid-infrared femtosecond laser pulses. We also discuss the spatial characteristics of harmonics under different focusing conditions. By optimizing the parameters,we experimentally observed the generation of 1 kHz,low divergence coherent X-ray beams in the water-window region. | YAO JinPing 1,2 ,XIONG Hui 1 ,XU Han 1 ,FU YuXi 1,2 ,ZENG Bin 1,2 ,CHU Wei 1,2 ,CHENG Ya 1 ,XU ZhiZhan 1 ,LIU XiaoJun 3 & CHEN Jing 4,5 1 State Key Laboratory of High Field Laser Physics,Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences,Wuhan 430071,China 4 Institute of Applied Physics and Computational Mathematics,Beijing 100088,China 5 Center for Applied Physics and Technology,Peking University,Beijing 100084,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 3 |
| 7 | Syntheses of 10-Hydroxy-5,10-dihydrophenophosphazine 10-Oxide and Its Methyl Derivatives显示文摘Ph 2NH and PCl 3 interacted at a molar ratio of 1∶1 05 and slow elevated temperature and then at 210-220 ℃ for 6 h. The brown solution obtained was treated with H 2O to produce a very hard brown solid believed to be a mixture of 5,10 dihydrophenophosphazine 10 oxide(1a) and 10,10(5H,5H) spirobipenophosphazinium chloride(1b). This brown solid was directly oxidized with peracetic acid in HOAc prior to the separation of them to give compound 10 hydroxy 5,10 dihydropheno phosphazine 10 oxide(2) with a higher yield(45%) than that of the literature(27%). When treated with excess SOCl 2, compound 2 could quantitatively be converted to the corresponding phosphinyl chloride and the latter could further be transformed into 10 methoxy 5,10 dihydrophenophosphazine 10 oxide in 70% as treated with NaOMe in methanol. Compound 2 could also be converted to a bisanion when treated with NaH in DMF. The resulted bisanion reacted with MeI to give 5 methyl 10 hydroxy 5,10 dihydrophenophosphazine 10 oxide in a 73% yield which would be converted to 5 methyl 10 methoxy 5,10 dihydrophenophosphazine 10 oxide in a 56% yield by the same way of synthesizing 10 methoxy 5,10 dihydrophenophosphazine 10 oxide. All these compounds obtained were identified by surveying their melting points, and spectra and elemental analysis. | YIN Zhi gang 1,2 and ZHAO De feng 1,** 1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, P. R. China 2. Chemical Engineering Department, Zhengzhou Institute of Light Industry, Zhengzhou 450002, P. R. China | 2003 | Chemical Research in Chinese Universities2003，19，1： | 2 |
| 8 | A theoretical analysis of optical-to-THz conversion efficiency via optical rectification显示文摘A theoretical analysis of an ultra-short pulse converted to Terahertz radiation via optical rectification in nonlinear optical crystal is presented here;several factors that affect optical-to-THz conversion efficiencies are discussed;pulse durations affect the conversion efficiency effectively:when crystal length is equal to the optimal crystal length lc,optical-to-THz conversion efficiency is the highest,but for the periodically-inverted electro-optic crystals,conversion efficiency is almost proportional to the crystal length when absorption can be neglected.Taking account of the absorption of crystals,effective length of crystal is Leff=0.63/α,there is no apparent increase of conversion efficiency and the conversion efficiency approaches to a constant eventually when the crystal length is increased. | LI DeHua1,QI XiaoDong2 & LIU ShengGang3 1 Terahertz Institute of Shandong University of Science & Technology,Qingdao 266510,China 2 Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Changchun 130033,China 3 Terahertz research center,Physical Electronics College,University of Electronics Science,Chengdu 610054,China | 2008 | Science China(Technological Sciences)2008，51，12： | 1 |
| 9 | 20-year outcomes following conservative management of clinically localized prostate cancer显示文摘 | Albertsen PC Hanley JA Fine 1 | 2005 | JAJMU\2005，293，17： | 1 |
| 10 | Regional accelerated phe- nomenon in the mandible following mucoperiosteal flap sur- gery显示文摘 | Yaffe A Fine N Binderman 1 | 1994 | J Periodontol1994，65，1： | 1 |
| 11 | Simplified circuit model of disk-shaped traveling wave ultrasonic motor显示文摘This paper presents a method of establishing simplified equivalent circuit model of traveling wave ultrasonic motor by using 1/2 wavelength stator with the similar vibration characteristics. Combined with the vibration mode characteristics of the composite stator, the method utilizes Hamilton principle to obtain precise solution of the simplified equivalent circuit. The model shows the mechanism of ultrasonic motor, considering the influence of non-axisymmetric vibration mode, tooth outline, anisotropy of PZT (Piezoelectric ceramic), etc. With this method, various electric parameters corresponding to different vibration modes, such as static capacitance, dynamic capacitance, dynamic inductance, dynamic resistance, equivalent input impedance, etc., can be solved. Experiments show good agreement with theoretical results. | CHU Xiangcheng LI Longtu(The State Key Laboratory of New Ceramics and Fine Processing, Dept. of Materials Science and Engineering, Tsinghua University Beijing 100084)CHEN Zaili(Faculty of Electromachine Engineering, Harbin Institute of Technology Harbin 1 | 2002 | Chinese Journal of Acoustics2002，21，3： | 1 |
| 12 | 显示文摘 | LIU Jun 1 HU Jun 1 HE JinLiang 1 LIN YuanHua 2 &LONG WangCheng 1 1State Key Laboratory of Power Systems Department of Electrical Engineering Tsinghua University Beijing 100084 China 2State Key Laboratory of New Ceramics and Fine Processing Department | 2009 | Science in China(Series E:Technological Sciences)2009，，12： | 1 |
| 13 | VEGF, flt-1 and KDR/flk-1 as prognostic indicators in endometrial carcinoma显示文摘 | Fine B A Valente P T Feinstein G 1 | 2000 | Gynecol Oncol2000，76，1： | 1 |
| 14 | A novel small molecule inhibitor targeted at Bcl-2显示文摘Recently, the heterocyclic compound 8-oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carboni-trile (S1) was synthesized and shown to induce apoptosis in both (H22) hematoma and (MCF-7) ade-nocarcinoma cells. The IC50 values of S1 against the two cell lines were 0.17 and 0.09 μmol/L, respec-tively. Furthermore, the apoptosis-inducing activity of this compound was highlighted both in vivo and in vitro. Subsequent experiments identified Bcl-2 as the primary target of S1, as a significant reduc-tion in Bcl-2 protein levels was observed in H22 cells following a two-hour treatment with 10 μmol/L S1. While rapid depolarization of mitochondrial membranes led immediately to caspase 9 activation, no changes were identified in either caspase 8 levels or levels in Bcl-2 mRNA. These data were consistent with the results of circular dichroism (CD) spectra analysis, revealing that S1 inactivated the Bcl-2 protein by destroying its critical alpha helices. Taken together, these results suggest the potential of S1 in the development of new therapeutic agents. | JIN LiJi1, ZHANG ZhiChao2,3, WANG YuanYuan2, WEI MeiJiao1 & XU Qin2 1 School of Environmental & Biological Science & Technology, Dalian University of Technology, Dalian 116024, China 2 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China 3 State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjing, China | 2007 | Science China(Life Sciences)2007，50，5： | 1 |
| 15 | Computational analysis of vibration modes of disk-shaped piezoelectric traveling wave motors显示文摘According to Kirchhoff-Love’s assumptions, this paper establishes linear system of equations for solving eigen frequency constant and corresponding mode shape. Using engineer-ing and numerical analysis software Matlab5.2 and method of coefficient determinant searching arithmetic, eigen frequency constant and mode shape of the stator with i.d./ o.d. ratio of 0.1, 0.3, 0.35, 0.6 and different vibration modes are accurately solved and analyzed. By means of Newton interpolation method, contributions of transverse deflection amplitude and vibration energy corresponding to various modes are determined. This paper offers a valid theoretical foundation for the optimum design of the stator of disk-shaped ultrasonic motors. Furthermore, according to results of numerical analysis, several choosing principles of vibration modes are summarized. | CHU Xiangcheng LI Longtu(The State Key Laboratory of New Ceramics and Fine Processing, Dept. of Materials Science and Engineering, Tsinghua University Beijing 100084)CHEN Zaili(Faculty of Electromachine Engineering, Harbin Institute of Technology Harbin 1 | 2002 | Chinese Journal of Acoustics2002，21，3： | 0 |
| 16 | 长波长垂直腔面发射激光器(英文)显示文摘给出了长波长垂直腔面发射激光器的器件结构的发展现状,同时对GaInNAs/GaAs垂直腔面发射激光器进行了详细的介绍。最后,给出了所设计的新型1.3μmGaInNAs/GaAs长波长垂直外腔面发射半导体激光器的结构设计,有源区量子阱由980nm半导体激光二极管进行泵浦。这种器件设计实现了激光二极管泵浦与长波长垂直腔面发射激光器的有机结合,同时具有两者的优点。此外,本文还对器件的阈值特性和光输出功率进行了理论计算。 | Yan Chang-ling*1,2, Ning Yong-qiang1, Qin Li1,Liu Yun1,Wang Qing1,Zhao Lu-min1,Sun Yan-fang1, Jin Zhen-hua1, Tao Ge-tao1, Wang Chao1, Liu Jun1, Wang Lijun1,Zhong Jingchang1.Laboratory of Excited State Processes, Chinese Academy of Sciences, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China 2.Changchun University of Science and Technology, State Key Lab of High Power Semiconductor Laser, Changchun 130022, China | 2004 | 光机电信息2004，，4： | 0 |
| 17 | Experiment of X-ray Generations Using Laser-Compton Scattering at LINAC of SINAP显示文摘Laser Compton scattering(LCS) can generate X-rays or γ-rays with high brightness and easy controlled polarization by applying high-peak-power laser pulses to relativistic electron bunches. One of the most promising approaches to short pulsed X-ray sources is the laser synchrotron source. It is based on LCS between picoseconds relativistic electron bunches and picoseconds laser pulses. A project of Shanghai laser electron gamma source with LCS method has been proposed on Shanghai synchrotron radiation facility. Before that,a prototype has been developed in the beamline of the linear accelerator at the Shanghai Institute of Applied Physics,Chinese Academy of Sciences. The LCS experiment was carried out by using the 107 MeV,5 Hz,1 ns,0.1 nC electron bunches from the linear accelerator and the 18 ns,10 MW peak power,Nd∶YAG laser pulses. In this communication,we describe the details and report the first results of this experiment. | PAN Qiang-yan1,XU Wang1,LUO Wen1,3,FAN Gong-tao1,3,Yang Li-feng1,3,Fan Guang-wei1,3,LI Yong-jiang1,3,XU Ben-ji1,SHI Xiang-chun2,LIN Guo-qiang1, YAN Zhe1,XU Yi1,3,CHEN Jing-gen1,GUO Wei1,WANG Hong-wei1,WANG Cheng-bin1, XU Jia-qiang1,Ma Yu-gang1,CAI Xiang-zhou1, ZHAO Ming-hua1,SHEN Wen-qing1(1 Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China 2 Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China 3 Graduate School of Chinese Academy of Sciences,Beijing 100049,China) | 2009 | 原子核物理评论2009，26，S1： | 0 |
| 18 | Comparison of energy structure and spectral properties of Ce:LaAlO_3 and Ce:Lu_2(SiO_4)O显示文摘Undoped LaAlO3 and 1 at.%Ce:LaAlO3 single crystals were grown by the Czochralski process.Absorption and fluorescence spectra were measured at room temperature.Detailed energy levels structure of Ce:LaAlO3 was determined.In this paper,two viewpoints were provided.The first one is:the energy levels structure of Ce:LaAlO3 is very similar to that of Ce:Lu2(SiO4)O which is a well-known scintillator.In the energy levels structure of Ce:LaAlO3 and Ce:Lu2(SiO4)O,the lowest 5d energy level of Ce 3+ is located below the bottom of the conduction band of host crystal and the other higher 5d energy levels of Ce 3+ are located above the bottom of the conduction band of host crystal.The second one is:Ce:LaAlO3 single crystal may not be suitable for scintillation application;by comparing the energy levels structures of Ce:LaAlO3 and Ce:Lu2(SiO4)O,the large energy difference(1.13 eV)between the two lowest 5d energy levels of Ce 3+ in LaAlO3 is a crucial factor that causes the luminescence quenching. | WANG XiaoDan 1 ,PAN Tao 1 ,ZANG TaoCheng 1 ,LI JianKang 1 ,ZHAO ZhiWei 2 ,ZHANG LianHan 2 &XU Jun3 1Department of Applied Physics,University of Science and Technology of Suzhou,Suzhou 215009,China 2Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China 3Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 201800,China | 2009 | Science China(Technological Sciences)2009，52，12： | 0 |
| 19 | Formation Mechanism and Emission Spectrum of AlO Radicals in Reaction of Laser-ablated Al Atom and Oxygen显示文摘The emission spectrum of AlO radicals was analyzed in 440-540 nm in the reaction of laser ablated Al beam and O 2. The carrier of spectrum was assigned to Δ ν =0, ±1, ±2 vibrational sequences of B 2Σ +-X 2Σ + transition of AlO radicals, the observed maximum vibrational quantum number was ν ′=6. The rotational and vibrational temperatures of B state were estimated at 3000 and 7500 K by spectrally simulating the rovibronic population distribution. There is a strong evidence that the production of excited Al( 2 S ) atoms is essential to the formation of excited AlO radicals. | ZHANG Shu-dong 1,2,3 and LI Hai-Yang 1,2** 1. Laboratory of Environmental Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, P. R. China 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China 3. Physics and Electronic Engineering College, Northwest Normal University, Lanzhou 730070, P. R. China | 2003 | Chemical Research in Chinese Universities2003，19，3： | 0 |
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