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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 4 | An emotion-centered model of voluntary work behavior显示文摘 | Paul E Spector Suzy Fox | 2002 | Human Resource Management Review2002，，2： | 2 |
| 5 | Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stettroyl-CoA desaturase, and are cmmerved in alkane hydroxylase and xylene monooxygenase显示文摘 | Shankin J Whittle E Fox B G | 1994 | Bichemistry1994，33，12： | 1 |
| 6 | Tracer diffusion has exaggerated CNS maps of direct preganglionic innervation of pancreas显示文摘 | Fox E A Powley T L | 1986 | J Auton Nerv Syst1986，15，： | 1 |
| 7 | Prediction of ruminal volatile fatty acids and pH within the net carbohydrate and protein system显示文摘 | Pitt R E Van KesselJ S Fox D G | 1996 | J Anita Sci1996，74，： | 1 |
| 8 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 9 | An emotion-centered model of voluntary work behavior:Some parallels between counterproductive behavior and organizational citizenship behavior显示文摘 | Spector P E Fox S | | 0，，02： | 1 |
| 10 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 11 | Nuclear locali- zation of Myomesin-l: Possible functions显示文摘 | Reddy K B Fox J E Priee M G | 2008 | Muscle Res Cell Motil2008，29，1： | 1 |
| 12 | Social Media Use by Government:from the Routine to the Critical 显示文摘 | Kavanaugh A L Fox E A Sheetz S D | 2012 | Government Information Quarterly2012，29，： | 1 |
| 13 | Loss of neuro- trophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation 显示文摘 | Fox E A Biddinger J E Baquet Z C | 2013 | Am J Physiol Regul In- tegr Comp Physiol2013，305，11： | 1 |
| 14 | Methanogens: reevaluation of a unique biological group显示文摘 | BALCH W E FOX G E MAGRUM L J | 1979 | Microbiological Reviews1979，43，2： | 1 |
| 15 | Photoactivation of metal oxide surfaces:photocatalyzed oxidation of alcohols by heteropolytungstates显示文摘 | Fox M A Cardona R Gaillard E | 1987 | J Am Chem Soc1987，109，21： | 1 |
| 16 | Significance and applications of phenolic compounds in the production and quality of milk and dairy products:a review显示文摘 | O' Connell J E Fox P F | 2001 | Int Dairy J2001，，11： | 1 |
| 17 | Biomass and nutrient accumulation in montane evergreen broad-leaved forest (Lithocarpus xylocarpus type) in Ailao Mountains,SW China显示文摘 | Liu Wenyao Fox John E D Xu Zaifu | 2002 | Forest Ecology and Management2002，158，1： | 1 |
| 18 | Competitive formation of polymer cyclodextrin inclusion compounds显示文摘 | Cristian C Rusa Justin Fox Alan E Tonelli | 2003 | Macromolecules2003，36，： | 1 |
| 19 | Whouses nutritional labeling,and what effects does label usehave on diet quality显示文摘 | GUTHRIE J F FOX J J CLEVELAND L E | 1995 | J N Edu1995，27，4： | 1 |
| 20 | Desmoid tumours and current status of management显示文摘 | Hosalkar HS Fox E J Delaney T | 2006 | Orthop Clin North Am2006，37，： | 1 |
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