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| 1 | Association of chronic hepatitis C with recurrent brief depression显示文摘 | Mauro G. Carta Jules Angst Maria Francesca Moro Gioia Mura Maria Carolina Hardoy Cinzia Balestrieri Luchino Chessa Giancarlo Serra Maria Eliana Lai Patrizia Farci | 2012 | Journal of Affective Disorders2012，，2： | 2 |
| 2 | Terentjev effects of solvent viscosity and polarity on the lsomerization of azobenzene 显示文摘 | Francesca Serra Eugene M | 2008 | Macromolecules2008，41，3： | 1 |
| 3 | Association of chronic hepatitis C with recurrent brief depression显示文摘 | Mauro G. Carta Jules Angst Maria Francesca Moro Gioia Mura Maria Carolina Hardoy Cinzia Balestrieri Luchino Chessa Giancarlo Serra Maria Eliana Lai Patrizia Farci | 2012 | Journal of Affective Disorders (-)2012，，2： | 1 |
| 4 | What good is the reserve? A translational perspective for the managing of cognitive decline显示文摘The concept of reserve appears in the neurological literature in the 1940s arising from the observation that there is no linear relationship between neurological damage and severity of the clinical symptoms.Basically,this concept sustains that the experiences pursued during life-span enrich the brain by making it more resilient to neuronal damage.However,in the last three decades the reserve concept has become very popular in the scientific field,mainly associated with the pathophysiological mechanisms underlying the Alzheimer’s Disease(AD)(Serra et al.,2018;Stern et al.,2018). | Laura Serra Francesca Gelfo | 2019 | Neural Regeneration Research2019，14，7： | 1 |
| 5 | Nontoxigenic Vibrio parahaemolyticus strains causing acute gastroenteritis显示文摘 | Donatella Ottaviania Francesca Leonia Roberto Serra | 2012 | Journal of Clinical Microbiology2012，50，12： | 1 |
| 6 | Non- toxigenic Vibrio parahaemolyticus Strains Causing Acute Gastroentcrtis显示文摘 | Ottaviani Donatella Leoni Francesca Serra Roberto | 2012 | Journal of Clinical2012，50，12： | 1 |
| 7 | Prevalence of functional gastrointestinal disorders in children with celiac disease on different types of gluten-free diets显示文摘BACKGROUND Functional gastrointestinal disorders(FGIDs)are common during the pediatric age.FGIDs are not related to biochemical or structural abnormalities.However,since they have a high prevalence,several studies have evaluated an overlap between FGIDs and organic diseases.Individuals with celiac disease(CD)have been shown to be at an increased risk for functional abdominal pain,even if they adhere well to a gluten-free diet(GFD).Little information is available for the pediatric age group.The aims of our study were to evaluate the prevalence of FGIDS in CD children 1 year after diagnosis and to compare the prevalence of FGIDs in CD children on a GFD with processed foods compared with those on a GFD with natural products.AIM To assess the prevalence of FGIDs in children with CD after 1 year of follow-up and to compare the prevalence of FGIDs in children with CD on a GFD with processed foods and in children on a GFD with natural products.METHODS We recruited pediatric patients aged 1-18 years with a new CD diagnosis.Participants were randomized to two groups:Group A on a GFD with processed foods(diet 1);and group B on a GFD with natural products(diet 2).Clinical monitoring,diet assessment and the questionnaire on pediatric gastrointestinal symptoms-Rome IV version were performed at diagnosis(T0)and after 12 mo of follow-up(T1).Dietary intake was assessed using a 3-d food diary record.Data from the diaries were evaluated using WinFood nutrient analysis software.We assessed the prevalence of FGIDs at T1 and the correlation with the type of GFD.RESULTS We registered 104 CD children,with 55 patients in group A(53.0%)and 49 patients in group B(47.0%).Initially,30 of the 55(54.5%)CD children were symptomatic in group A,while 25 of 49(51.0%)were symptomatic in group B.At T1,in spite of a low or negative serology for CD,FGIDs prevalence was 10/55(18.0%)in group A and 8/49(16.3%)in group B,with no statistically significant difference between the two groups(P=0.780).At T1 the macro-and micronutrient intake was similar across the two groups with no significant differences in nutrient analysis.However,in both groups at T1 we found that a lower prevalence of FGIDs(P=0.055)was associated with an inferior caloric(odds ratio=0.99,95%confidence interval:0.99-1.00)and fat(odds ratio=0.33,95%confidence interval:0.65-0.95)intake.CONCLUSION Our results showed that CD children on a GFD have gastrointestinal symptoms with an elevated prevalence of FGIDs.Our study suggests that developing FGIDs may be linked to caloric intake and percentage of food fat,but it does not change between a GFD with processed foods or a GFD with natural products.However,long-term monitoring is required to evaluate a correlation between FGIDs and various types of GFDs. | Francesca Fiori Nastro Maria Rosaria Serra Sabrina Cenni Daniela Pacella Massimo Martinelli Erasmo Miele Annamaria Staiano Carlo Tolone Renata Auricchio Caterina Strisciuglio | 2022 | World Journal of Gastroenterology2022，28，46： | 0 |
| 8 | Orthotopic induction of CH157MN convexity and skull base meningiomas into nude mice using stereotactic surgery and MRI characterization显示文摘Meningioma in vivo research is hampered by the difficulty of establishing an easy and reproducible orthotopic model able to mimic the characteristics of a human meningioma. Moreover, leptomeningeal dissemination and high mortality are often associated with such orthotopical models, making them useless for clinical translation studies. An optimized method for inducing meningiomas in nude mice at two different sites is described in this paper and the high reproducibility and low mortality of the models are demonstrated. Skull base meningiomas were induced in the auditory meatus and convexity meningiomas were induced on the brain surface of 23 and 24 nude mice, respectively. Both models led to the development of a mass easily observable by imaging methods. Dynamic contrast enhanced MRI was used as a tool to monitor and characterize the pathology onset and progression. At the end of the study, histology was performed to confirm the neoplastic origin of the diseased mass. | Francesca La Cava Alberto Fringuello Mingo Pietro Irrera Aldo Di Vito Alessia Cordaro Chiara Brioschi Sonia Colombo Serra Claudia Cabella Enzo Terreno Luigi Miragoli | 2019 | Animal Models and Experimental Medicine2019，2，1： | 0 |
| 9 | Memantine: New prospective in bipolar disorder treatment显示文摘We review preclinical and clinical evidences strongly suggesting that memantine, an old drug currently approved for Alzheimer's dementia, is an effective treatment for acute mania and for the prevention of manic/hypomanic and depressive recurrences of manicdepressive illness. Lithium remains the first line for the treatment and prophylaxis of bipolar disorders, but currently available treatment alternatives for lithium resistant patients are of limited and/or questionable efficacy. Thus, research and development of more effective mood stabilizer drugs is a leading challenge for modern psychopharmacology. We have demonstrated that 21 d administration of imipramine causes a behavioural syndrome similar to a cycle of bipolar disorder, i.e., a mania followed by a depression, in rats. Indeed, such treatment causes a behavioural supersensitivity to dopamine D2 receptor agonists associated with an increase sexual activity and aggressivity(mania). The dopamine receptor sensitization is followed, after imipramine discontinuation, by an opposite phenomenon(dopamine receptor desensitization) and an increased immobility time(depression) in the forced swimming test of depression. Memantine blocks the development of the supersensitivity and the ensuing desensitization associated with the depressive like behavior. On the basis of these observations we have suggested the use of memantine in the treatment of mania and in the prophylaxis of bipolar disorders. To test this hypothesis we performed several naturalistic studies that showed an acute antimanic effect and a long-lasting and progressive mood-stabilizing action(at least 3 years), without clinically relevant side effects. To confirm the observations of our naturalistic trials we are now performing a randomized controlled clinical trial. Finally we described the studies reporting the efficacy of memantine in maniclike symptoms occurring in psychiatric disorders other than bipolar. Limitations: A randomized controlled clinical trial is needed to confirm our naturalistic observations.Conclusion: We believe that this review presents enough pharmacological and clinical information to consider the administration of memantine in the treatment of bipolar disorders that no respond to standard mood stabilizers. | Giulia Serra Francesca Demontis Francesca Serra Lavinia De Chiara Andrea Spoto Paolo Girardi Giulio Vidotto Gino Serra | 2014 | World Journal of Psychiatry2014，4，4： | 0 |
| 10 | Failure of memantine to “reverse” quinpirole-induced hypomotility显示文摘AIM: To evaluate antidepressant-like effect of memantine in a rat model.METHODS: Male Wistar rats were treated intraperitoneally with either vehicle, memantine(10 mg/kg) or imipramine(20 mg/kg), for 3 wk. Twenty-four hour after the last treatment animals were challenged with quinpirole(0.3 mg/kg s.c.) and tested for motor activity. After 1 h habituation to the motility cages, the motor response was recorded for the following 45-min and the data were collected in 5-min time bins. RESULTS: As expected, chronic treatment with imipramine potentiated the locomotor stimulant effect of quinpirole. On the contrary, chronic memantine administration failed to induce the behavioral supersensitivity to the dopamine agonist. CONCLUSION: The results show that memantine, at variance with antidepressant treatments, fails to induce dopaminergic behavioral supersensitivity. This observation is consistent with the results of preclinical and clinical studies suggesting that memantine does not have an acute antidepressant action but does have an antimanic and mood-stabilizing effect. | Francesca Demontis Gino Serra | 2016 | World Journal of Psychiatry2016，6，2： | 0 |
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