|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of memantine in the treatment of psychiatric disorders other than the dementias:a review of current preclinical and clinical cvidencc 显示文摘 | Gabrielc Sani Giulia Serra Giorgio D Kotzalidis | 2012 | CNS Drags2012，26，8： | 1 |
| 2 | Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings显示文摘Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic effects.Central toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and adults.The present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and nicotine.Detailed elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes. | Marcello Serra Nicola Simola Alexia E.Pollack Giulia Costa | 2024 | Neural Regeneration Research2024，19，9： | 0 |
| 3 | Implantable(Bio)sensors as new tools for wireless monitoring of brain neurochemistry in real time显示文摘Implantable electrochemical microsensors are characterized by high sensitivity, while amperometric biosensors are very selective in virtue of the biological detecting element. Each sensor, specific for every neurochemical species, is a miniaturized hightechnology device resulting from the combination of several factors: electrode material, shielding polymers, applied electrochemical technique, and in the case of biosensors, biological sensing material, stabilizers, and entrapping chemical nets. In this paper, we summarizethe available technology for the in vivo electrochemical monitoring of neurotransmitters(dopamine, norepinephrine, serotonin, acetylcholine, and glutamate), bioenergetic substrates(glucose, lactate, and oxygen), neuromodulators(ascorbic acid and nitric oxide), and exogenous molecules such as ethanol. We also describe the most represented biotelemetric technologies in order to wirelessly transmit the signals of the abovelisted neurochemicals. Implantable(Bio)sensors, integrated into miniaturized telemetry systems, represent a new generation of analytical tools that could be used for studying the brain's physiology and pathophysiology and the effects of different drugs(or toxic chemicals such as ethanol) on neurochemical systems. | Donatella Farina Maria D Alvau Giulia Puggioni Giammario Calia Gianfranco Bazzu Rossana Migheli Ottavio Sechi Gaia Rocchitta Maria S Desole Pier Andrea Serra | 2014 | World Journal of Pharmacology2014，3，1： | 0 |
| 4 | Memantine: New prospective in bipolar disorder treatment显示文摘We review preclinical and clinical evidences strongly suggesting that memantine, an old drug currently approved for Alzheimer's dementia, is an effective treatment for acute mania and for the prevention of manic/hypomanic and depressive recurrences of manicdepressive illness. Lithium remains the first line for the treatment and prophylaxis of bipolar disorders, but currently available treatment alternatives for lithium resistant patients are of limited and/or questionable efficacy. Thus, research and development of more effective mood stabilizer drugs is a leading challenge for modern psychopharmacology. We have demonstrated that 21 d administration of imipramine causes a behavioural syndrome similar to a cycle of bipolar disorder, i.e., a mania followed by a depression, in rats. Indeed, such treatment causes a behavioural supersensitivity to dopamine D2 receptor agonists associated with an increase sexual activity and aggressivity(mania). The dopamine receptor sensitization is followed, after imipramine discontinuation, by an opposite phenomenon(dopamine receptor desensitization) and an increased immobility time(depression) in the forced swimming test of depression. Memantine blocks the development of the supersensitivity and the ensuing desensitization associated with the depressive like behavior. On the basis of these observations we have suggested the use of memantine in the treatment of mania and in the prophylaxis of bipolar disorders. To test this hypothesis we performed several naturalistic studies that showed an acute antimanic effect and a long-lasting and progressive mood-stabilizing action(at least 3 years), without clinically relevant side effects. To confirm the observations of our naturalistic trials we are now performing a randomized controlled clinical trial. Finally we described the studies reporting the efficacy of memantine in maniclike symptoms occurring in psychiatric disorders other than bipolar. Limitations: A randomized controlled clinical trial is needed to confirm our naturalistic observations.Conclusion: We believe that this review presents enough pharmacological and clinical information to consider the administration of memantine in the treatment of bipolar disorders that no respond to standard mood stabilizers. | Giulia Serra Francesca Demontis Francesca Serra Lavinia De Chiara Andrea Spoto Paolo Girardi Giulio Vidotto Gino Serra | 2014 | World Journal of Psychiatry2014，4，4： | 0 |
| 5 | The role of neuroinflammation in juvenile bipolar disorder显示文摘A pathophysiological relationship has been reported between inflammatory processes,decreased levels of neurotrophins,increased oxidative stress and psychiatric disorders in both juvenile and adult ages.Moreover,this relationship remains unclear in juvenile bipolar disorder(BD).We performed a systematic literature review of studies reporting measurements of inflammatory markers,oxidative stress markers or neurotrophins in juvenile and young adult subjects with BD.Concordant findings showed that inflammatory markers are increased since the earlier stages of BD.A positive correlation between decreased levels of a peripheral brain-derived neurotrophic factor and juvenile BD is controversial suggesting that those changes might occur only during the late stage of BD.No changes in central glutathione levels were reported in young adult age BD indicating that oxidative stress may be an outcome of long illness duration and repeated affective episodes.In conclusion,preliminary findings indicate that a certain relationship exists between inflammatory process and juvenile BD but evidence are insufficient to support a causal relationship.Adequately powered and prospective studies are warranted to clarify the role of inflammation,neurotrophins and oxidative stress in juvenile BD. | Giulia Serra Lavinia De Chiara Ciro Marangoni Gianni LFaedda | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员