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| 1 | Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients显示文摘Hepatocellular carcinoma(HCC) is one of the most frequent neoplasms worldwide and in most cases it is associated with liver cirrhosis.Liver resection is considered the most potentially curative therapy for HCC patients when liver transplantation is not an option or is not immediately accessible.This review is aimed at investigating the current concepts that drive the surgical choice in the treatment of HCC in cirrhotic patients;Eastern and Western perspectives are highlighted.An extensive literature review of the last two decades was performed,on topics covering various aspects of hepatic resection.Early post-operative and long-term outcome measures adopted were firstly analyzed in an attempt to define an optimal standardization useful for research comparison.The need to avoid the development of post-hepatectomy liver failure represents the 'conditio sine qua non' of surgical choice and the role of the current tools available for the assessment of liver function reserve were investigated.Results of hepatic resection in relationship with tumor burden were compared with those of available competing strategies,namely,radiofrequency ablation for early stages,and trans-arterial chemoembolization for intermediate and advanced stages.Finally,the choice for anatomical versus non-anatomical,as well as the role of laparoscopic approach,was overviewed.The literature review suggests that partial hepatectomy for HCC should be considered in the context of multi-disciplinary evaluation of cirrhotic patients.Scientific research on HCC has moved,in recent years,from surgical therapy toward non-surgical approaches and most of the literature regarding topics debated in the present review is represented by observational studies,whereas very few well-designed randomized controlled trials are currently available;thus,no robust recommendations can be derived. | Alessandro Cucchetti Matteo Cescon Franco Trevisani Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，44： | 22 |
| 2 | Surveillance for early diagnosis of hepatocellular carcinoma: How best to do it?显示文摘Surveillance for hepatocellular carcinoma(HCC)is considered a standard of care for patients with chronic liver disease who are at risk of developing this malignancy.Several studies have shown that surveillance can improve the prognosis of patients diagnosed with HCC through an increased likelihood of application of curative or effective treatments.Repetition of liver ultrasonography(US)every 6 mo is the recommended surveillance program to detect early HCCs,and a positive US has to entrain a well-defined recall policy based on contrast-enhanced,dynamic radiological imaging or biopsy for the diagnosis of HCC.Although HCC fulfills the accepted criteria regarding cost-effective cancer screening and surveillance,the implementation of surveillance in clinical practice is defective and this has a negative impact on the cost-effectiveness of the procedure.Education of both physicians and patients is of paramount importance in order to improve the surveillance application and its benefits in patients at risk of HCC.The promotion of specific educational programs for practitioners,clinicians and patients is instrumental in order to expand the correct use of surveillance in clinical practice and eventually improve HCC prognosis. | Edoardo G Giannini Alessandro Cucchetti Virginia Erroi Francesca Garuti Federica Odaldi Franco Trevisani | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 3 | Serum α-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status显示文摘 | Franco Trevisani Paola Emanuela D’Intino Antonio Maria Morselli-Labate Giuseppe Mazzella Esterita Accogli Paolo Caraceni Marco Domenicali Stefania De Notariis Enrico Roda Mauro Bernardi | 2001 | Journal of Hepatology2001，，4： | 3 |
| 4 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Cost-effectiveness of semi-annual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population显示文摘 | Alessandro Cucchetti Franco Trevisani Matteo Cescon Giorgio Ercolani Fabio Farinati Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Caturelli Maria Chiaramonte Antonio D | 2012 | Journal of Hepatology2012，，5： | 1 |
| 6 | Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival显示文摘 | Valentina Santi Franco Trevisani Annagiulia Gramenzi Alice Grignaschi Federica Mirici-Cappa Paolo Del Poggio Maria Anna Di Nolfo Luisa Benvegnù Fabio Farinati Marco Zoli Edoardo Giovanni Giannini Franco Borzio Eugenio Caturelli Maria Chiaramonte Mauro Ber | 2010 | Journal of Hepatology2010，，2： | 1 |
| 7 | Hepatocellular carcinoma in non-cirrhotic liver: A reappraisal显示文摘 | Franco Trevisani Marta Frigerio Valentina Santi Alice Grignaschi Mauro Bernardi | 2009 | Digestive and Liver Disease2009，，5： | 1 |
| 8 | Serum α-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status显示文摘 | Franco Trevisani Paola Emanuela D’Intino Antonio Maria Morselli-Labate Giuseppe Mazzella Esterita Accogli Paolo Caraceni Marco Domenicali Stefania De Notariis Enrico Roda Mauro Bernardi | 2001 | Journal of Hepatology2001，，4： | 1 |
| 9 | Partial Necrosis on Hepatocellular Carcinoma Nodules Facilitates Tumor Recurrence after Liver Transplantation显示文摘 | Matteo Ravaioli Gian Luca Grazi Giorgio Ercolani Michelangelo Fiorentino Matteo Cescon Rita Golfieri Franco Trevisani Walter Franco Grigioni Luigi Bolondi Antonio Daniele Pinna | 2004 | Transplantation2004，，12： | 1 |
| 10 | Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury显示文摘 | Paolo Caraceni Cristina Bianchi Marco Domenicali Anna Maria Pertosa Elisabetta Maiolini Giovanna Parenti Castelli Bruno Nardo Franco Trevisani Giorgio Lenaz Mauro Bernardi | 2004 | Journal of Hepatology2004，，1： | 1 |
| 11 | The reduced tolerance of rat fatty liver to ischemia reperfusion is associated with mitochondrial oxidative injury 1显示文摘 | Paolo Caraceni Marco Domenicali Gianluigi Vendemiale Ignazio Grattagliano Annamaria Pertosa Bruno Nardo Antonio Maria Morselli-Labate Franco Trevisani Giuseppe Palasciano Emanuele Altomare Mauro Bernardi | 2005 | Journal of Surgical Research2005，，2： | 1 |
| 12 | Hepatocellular Carcinoma in Patients With Cryptogenic Cirrhosis显示文摘 | Edoardo Giovanni Giannini Elisa Marabotto Vincenzo Savarino Franco Trevisani Maria Anna di Nolfo Paolo Del Poggio Luisa Benvegnù Fabio Farinati Marco Zoli Franco Borzio Eugenio Caturelli Maria Chiaramonte | 2009 | Clinical Gastroenterology and Hepatology2009，，5： | 1 |
| 13 | INCREASED GENERATION OF REACTIVE OXYGEN SPECIES IN ISOLATED RAT FATTY LIVER DURING POSTISCHEMIC REOXYGENATION1显示文摘 | Bruno Nardo Paolo Caraceni Patrizia Pasini Marco Domenicali Fausto Catena Giuseppe Cavallari Bruno Santoni Elisabetta Maiolini Ignazio Grattagliano Gianluigi Vendemiale Franco Trevisani Aldo Roda Mauro Bernardi Antonino Cavallari | 2001 | Transplantation2001，，12： | 1 |
| 14 | Rise and fall of HCV ‐related hepatocellular carcinoma in Italy: a long‐term survey from the ITA . LI . CA centres显示文摘 | Nora Cazzagon Franco Trevisani Gemma Maddalo Anna Giacomin Veronica Vanin Caterina Pozzan Paolo Del Poggio Gianludovico Rapaccini Anna M. Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo G. Giannini Eugenio Caturelli Maria Chiaramonte Francesco G. | 2013 | Liver Int2013，，9： | 1 |
| 15 | Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance显示文摘 | Tommaso Stroffolini Franco Trevisani Giovanbattista Pinzello Franco Brunello Maurizio A. Tommasini Massimo Iavarone Vito Di Marco Fabio Farinati Paolo Del Poggio Franco Borzio Mauro Borzio Eugenio Caturelli Maria Anna Di Nolfo Marta Frigerio Giuseppina Br | 2011 | Digestive and Liver Disease2011，，11： | 1 |
| 16 | Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience)显示文摘 | Franco Trevisani Stefania De Notariis Gianludovico Rapaccini Fabio Farinati Luisa Benvegnù Marco Zoli Gian Luca Grazi Paolo Del Poggio Maria Anna Di Nolfo Mauro Bernardi | 2002 | The American Journal of Gastroenterology2002，，3： | 1 |
| 17 | Refining sorafenib therapy: lessons from clinical practice显示文摘 | Luigi Bolondi Antonio Craxi Franco Trevisani Bruno Daniele Giovan Giuseppe Di Costanzo Stefano Fagiuoli Calogero Cammà Paolo Bruzzi Romano Danesi Federico Spandonaro Corrado Boni Armando Santoro Massimo Colombo | 2015 | Future Oncol2015，，3： | 1 |
| 18 | Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience)显示文摘 | Franco Trevisani Stefania De Notariis Gianludovico Rapaccini Fabio Farinati Luisa Benvegnù Marco Zoli Gian Luca Grazi Paolo Del Poggio Maria Anna Di Nolfo Mauro Bernardi | 2002 | The American Journal of Gastroenterology2002，，3： | 1 |
| 19 | Randomized Control Trials on Chemoembolization for Hepatocellular Carcinoma: Is There Room for New Studies?显示文摘 | Franco Trevisani Stefania De Notariis Cristina Rossi Mauro Bernardi | 2001 | Journal of Clinical Gastroenterology2001，，5： | 1 |
| 20 | How albumin administration for cirrhosis impacts on hospital albumin consumption and expenditure显示文摘AIM:To assess the impact of guidelines for albumin prescription in an academic hospital,which is a referral center for liver diseases.METHODS:Although randomized trials and guidelines support albumin administration for some complications of cirrhosis,the high cost of albumin greatly limits its use in clinical practice.In 2003,a multidisciplinary panel at Sant'Orsola-Malpighi University Hospital(Bologna,Italy)used a literature-based consensus method to list all the acute and chronic conditions for which albumin is indicated as first-or second-line treatment.Indications in hepatology included prevention of post-paracentesis circulatory dysfunction and renal failure induced by spontaneous bacterial peritonitis,and treatment of hepatorenal syndrome and refractory ascites.Although still debated,albumin administration in refractory ascites is accepted by the Italian health care system.We analyzedalbumin prescription and related costs before and after implementation of the new guidelines.RESULTS:While albumin consumption and costs doubled from 1998 to 2002,they dropped 20%after 2003,and remained stable for the following 6 years.Complications of cirrhosis,namely refractory ascites and paracentesis,represented the predominant indications,followed by major surgery,shock,enteric diseases,and plasmapheresis.Albumin consumption increased significantly after guideline implementation in the liver units,whereas it declined elsewhere in the hospital.Lastly,extra-protocol albumin prescription was estimated as<10%.CONCLUSION:Albumin administration in cirrhosis according to international guidelines does not increase total hospital albumin consumption if its use in settings without evidence of efficacy is avoided. | Federica Mirici-Cappa Paolo Caraceni Marco Domenicali Ernesto Gelonesi Barbara Benazzi Giacomo Zaccherini Franco Trevisani Cristina Puggioli Mauro Bernardi | 2011 | World Journal of Gastroenterology2011，17，30： | 1 |
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