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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Solid phase microextraction(SPME)combined with gas-chromatography and olfactometry-massspectrometry for characterization ofcheesearoma compounds显示文摘 | FRANK D C OWEN C M PATTERSON J | 2004 | Lebensm-Wiss Technol2004，37，： | 1 |
| 4 | New constraints on the sources and behavior of neodymium and hafnium in seawater from Pacific Ocean ferromanganese crusts显示文摘 | VAN DE FLIERDT T FRANK M LEE D C | 2004 | Geochim et Cosmochim Acta2004，68，19： | 1 |
| 5 | Podophyllotoxin 显示文摘 | Canel C Moraes R M Frank E D | 2000 | Phytochem2000，54，2： | 1 |
| 6 | Copper isotope ratios in magmatic and hydrothermal ore-forming environments显示文摘 | Peter B Larson Kierran Maher Frank C Ramos Zhaoshan Chang Miguel Gaspar Lawrence D Meinert | 2003 | Chemical Geology2003，，3： | 1 |
| 7 | Quantifying the bullwhip effect in a simple supply chain:The impact of forecasting ,lead times,and information显示文摘 | FRANK C ZVI D JENNIFER R K el al | 2000 | Management Science2000，46，3： | 1 |
| 8 | Epidemic profile of Shiga-toxin-producing Escherichia coli O101:H4 outbreak in Germany 显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，： | 1 |
| 9 | The magnitude of Late Paleozoic glacioeustatic fluctuations: A synthesis显示文摘 | Rygel M C Fielding C R Frank T D | 2008 | Journal of Sedimentary Research2008，78，8： | 1 |
| 10 | A CFAR adaptive matched filter detector显示文摘 | Frank C Robey D R F | 1992 | IEEE Transactions on Aerospace and Electronic Systems1992，28，1： | 1 |
| 11 | A phase Ⅰ/Ⅱ study of subconjunctival carboplastin for intraocular retinoblastoma显示文摘 | ABRAMSON D H FRANK C M DUNKEL I J | 1999 | Ophthalmology1999，106，10： | 1 |
| 12 | Sommargren laser doppler velocimeter for velocity and length measurements of moving surfaces 显示文摘 | BRUCE E T FRANK C D GARY E | 1984 | Applied Optics January1984，23，1： | 1 |
| 13 | Highly efficient algorithm for percolative transport studies in two dimensions显示文摘 | FRANK D J LOBB C J | 1988 | Phys Rev B1988，37，： | 1 |
| 14 | Collagen fibril diameters in the rabbitmedial collateral ligament scar:A longer term assessment显示文摘 | Frank C McDonald D Shrive N | 1997 | ConnectTissue Res1997，，36： | 1 |
| 15 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 16 | Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany 显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，19： | 1 |
| 17 | Dominant T cells in idiopathic nephrotic syndrome of childhood显示文摘 | Frank C Herrmann M Fernandez S Dimecker D Boswald M Kolowos W ct al | 2000 | Kidney Int2000，57，2： | 1 |
| 18 | Circumpolar trends of PCBs and organochlorine pesticides in the Arctic marine environment inferred from levels in ringed seals显示文摘 | MUIR D FRANK R MARIANNE C | 2000 | Environmental Science and Technology2000，34，12： | 1 |
| 19 | Geological evolution of the West Luzon Basin (South China Sea, Philippines) 显示文摘 | Arfai J Franke D Gaedicke C | 2011 | Marince Geophysic Research2011，32，： | 1 |
| 20 | Post - ERCP pancreatitis and its pre- vention显示文摘 | FRANK C D ADLER D G | 2006 | Nat Clin Pract Gastroenterol Hepatol2006，3，12： | 1 |
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