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| 1 | c-Met targeted therapy of cholangiocarcinoma显示文摘Cholangiocarcinoma continues to be a challenging disease to treat. Systemic therapy is used in unresectable disease, disease progression after surgery, and in the palliative setting. Unfortunately, results of multiple phase Ⅱ trials have rarely yielded positive results. As data on the molecular carcinogenesis of cholangiocarcinoma is developing, we are more able to understand the disease process and can use this understanding to create unique targeted therapies. We reviewed the role of c-Met/ hepatocyte growth factor (HGF) in the development of cholangiocarcinoma. Furthermore, we explored the use of the c-Met guided cascade as a target to treat cholangiocarcinoma. We reviewed the current use and options for future development of c-Met agents to treat this disease. | Matei P Socoteanu Frank Mott Gianfranco Alpini Arthur E Frankel | 2008 | World Journal of Gastroenterology2008，14，19： | 16 |
| 2 | 基于综合计量技术的人民币汇率制度演化分析显示文摘为更好地理解人民币汇率制度实际改革进程,本文运用综合计量技术,分析了人民币汇率制度自2005年7月实施改革以来12年间的真实演变过程。我们发现,除了全球金融危机爆发的2008—2010年,人民币汇率的浮动性一直处于不断提高之中,而'一篮子'货币中赋予美元的权重从改革最初的高于0.9逐渐降低到近年来的0.45-0.50之间并趋于稳定。我们特别对'8·11汇改'后汇率制度的演化进行了更细致的分析。'8·11汇改'进一步提高了人民币的浮动性和市场化程度,之后一系列后续改革措施的出台,体现出'渐进性''稳健性'和'累加性'等诸多特点。本研究不仅分析总结了中国汇率制度改革的实际效果与经验,对其他国家的相关改革也具有很好的借鉴意义。 | Jeffrey Frankel 谢丹夏 | 2018 | 国际金融研究2018，0，2： | 12 |
| 3 | The discovery of magnetotactic/magnetosensitive bacteria显示文摘Magnetotactic bacteria orient and migrate along magnetic field lines in aquatic habitats. The | Richard B. FRANKEL | 2009 | Chinese Journal of Oceanology and Limnology2009，27，1： | 12 |
| 4 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 5 | Currency crashes in emerging markets: An empirical treatment显示文摘 | Jeffrey A. Frankel Andrew K. Rose | 1996 | Journal of International Economics1996，，3： | 3 |
| 6 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 7 | On the Yuan: The Choice between Adjustment under a Fixed Exchange Rate and Adjustment under a Flexible Rate显示文摘 | Jeffrey Frankel | 2006 | CESifo Economic Studies2006，，： | 2 |
| 8 | Minidose Bupivacaine–Fentanyl Spinal Anesthesia for Surgical Repair of Hip Fracture in the Aged显示文摘 | Bruce Ben-David Roman Frankel Tatianna Arzumonov Yuri Marchevsky Gershon Volpin | 2000 | Anesthesiology2000，，1： | 2 |
| 9 | Term-Dependent Confidence Normalisation for Out-of-Vocabulary Spoken Term Detection显示文摘An important component of a spoken term detection (STD) system involves estimating confidence measures of hypothesised detections.A potential problem of the widely used lattice-based confidence estimation,however,is that the confidence scores are treated uniformly for all search terms,regardless of how much they may differ in terms of phonetic or linguistic properties.This problem is particularly evident for out-of-vocabulary (OOV) terms which tend to exhibit high intra-term diversity.To address the impact of term diversity on confidence measures,we propose in this work a term-dependent normalisation technique which compensates for term diversity in confidence estimation.We first derive an evaluation-metric-oriented normalisation that optimises the evaluation metric by compensating for the diverse occurrence rates among terms,and then propose a linear bias compensation and a discriminative compensation to deal with the bias problem that is inherent in lattice-based confidence measurement and from which the Term Specific Threshold (TST) approach suffers.We tested the proposed technique on speech data from the multi-party meeting domain with two state-ofthe-art STD systems based on phonemes and words respectively.The experimental results demonstrate that the confidence normalisation approach leads to a significant performance improvement in STD,particularly for OOV terms with phonemebased systems. | Javier Tejedo Simon King Joe Frankel | 2012 | Journal of Computer Science & Technology2012，27，2： | 2 |
| 10 | Clinical Deterioration Following Improvement in the NINDS rt-PA Stroke Trial显示文摘 | James C. Grotta K.M.A. Welch Susan C. Fagan Mei Lu Michael R. Frankel Thomas Brott Steven R. Levine Patrick D. Lyden | 2001 | Stroke: Journal of the American Heart Association2001，，3： | 2 |
| 11 | Antioxidant Activity of Grape Extracts in a Lecithin Liposome System显示文摘 | Yi O S Meyer A S Frankel E N | 1997 | JAOCS1997，74，10： | 1 |
| 12 | Cardiac involvement in patients with sarcoidosis: diagnostic and prognostic value of outpatient testing显示文摘 | MEHTA D LUBITZ SA FRANKEL Z | 2008 | Chest2008，133，6： | 1 |
| 13 | Inhibition of human LDL oxidation by resveratml显示文摘 | FRANKEL E N WATERHOUSE A L KINSELLA J E | 1993 | Lancet1993，341，8852： | 1 |
| 14 | Infusion of β-FNA into the thalamus attenuates morphine-induced c-Fos induction in the rat caudate putamen 显示文摘 | Frankel PS Garcia MM Harlan RE | 1999 | Brain Res1999，838，12： | 1 |
| 15 | Fiber:effect on bacterial translocation and intestinal mucin content显示文摘 | Frankel W Zhang W Singh A | 1995 | World J Surg1995，19，1： | 1 |
| 16 | Phase Ⅰ trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia显示文摘 | Frankel AE Powell BL Hall PD | 2002 | Clin Cancer Res2002，8，5： | 1 |
| 17 | Phase Ⅰ trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia显示文摘 | Frankel AE Powell BL Hall PD | 2002 | Clin Cancer Res2002，8，5： | 1 |
| 18 | Big data: Distilling meaning from data 显示文摘 | Frankel F Reid R | 2008 | Nature2008，455，7209： | 1 |
| 19 | The forces and moments in the leg during level walking显示文摘 | FRANKEL B BRESLER J P | 1950 | J Appl Mech1950，72，： | 1 |
| 20 | Storage and release of soluble hexavalent chromium from chromate conversion coatings 显示文摘 | XIA L AKIYAM E FRANKEL G McCREERY R | 2000 | Journal of Electrochemical Society2000，147，7： | 1 |
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