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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | 成人缺血性卒中早期处理指南显示文摘本指南旨在对成年急性缺血性卒中患者评价和治疗各要素的现有证据做一回顾。目标读者是那些为发病后48h内的卒中患者提供治疗的内科医生和其他急诊医疗保健人员。另外,也包括向医疗保健政策制定者提供的信息。方法:专家小组成员由美国心脏协会(AHA)卒中委员会科学声明监督委员会任命,他们代表了来自不同领域的专家。专家小组以2003年后发表的报道为重点,对相关文献进行回顾,采用AHA卒中委员会的证据水平分级标准对证据进行分级并做出推荐。本声明经专家小组认可后,再由AHA科学顾问和协调委员会进行同行评议和正式批准。本指南打算在3年内做全面更新。结果:对急性缺血性卒中患者的处理仍然是多方面的,包括尚未在临床试验中进行过验证的一些医疗诊治方面。本声明包括从急诊医疗服务人员开始接触患者到入院初期处理的推荐意见。静脉重组组织型纤溶酶原激活剂仍然是已得到证实的最有效的卒中急诊治疗干预方法。包括动脉应用溶栓药和机械介入在内的一些方法显示出希望。因为许多推荐是在有限的证据基础上做出的,因此需要对急性缺血性卒中的治疗进行更多的研究。 | Harold P. Adams Gregory del Zoppo Mark J. Alberts Deepak L. Bhatt Lawrence Brass Anthony Furlan Robert L. Grubb Randall T. Higashida Edward C. Jauch Chelsea Kidwell Patrick D. Lyden Lewis B. Morgenstern Adnan I. Qureshi Robert H. Rosenwasser Phillip A. Scott Eelco F.M. Wijdicks 李焰生(译) 熊昕丽(译) 林岩(译) 沈沸(译) 俞羚(译) 邹静(译) 张静芳(译) 孙亚蒙(译) 周洁茹(译) 蒋仙国(译) 陈莺(译) | 2007 | 国际脑血管病杂志2007，15，6： | 18 |
| 3 | 大面积脑卒中患者中美国国立卫生研究院卒中量表因素的分析 | Lyden P. Claesson L. Havstad S. 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，3： | 4 |
| 4 | An exosome pathway without an ESCRT显示文摘Exosome biogenesis occurs via multiple mechanisms,but how these pathways are controlled remains poorly understood.In a recent study published in Cell Research,Wei et al.identify Rab31 GTPase as a regulator of lipid-mediated exosome biogenesis independent of other commonly-recognized ESCRT and tetraspanin pathways.Exosomes are 30-150 nm vesicles that mediate intercellular crosstalk by transferring bioactive cargos in normal physiology and disease.Exosomes originate in the multivesicular body(MVB)of endosomes;inward membrane budding produces intraluminal vesicles(ILVs)contained within MVBs that carry membrane cargos and molecules from the surrounding cytoplasm.MVBs fuse with the plasma membrane,secreting ILVs as exosomes(Fig.1). | Candia M.Kenific Haiying Zhang David Lyden | 2021 | Cell Research2021，31，2： | 3 |
| 5 | Intensity-Modulated Radiotherapy of Head and Neck Cancer Aiming to Reduce Dysphagia: Early Dose–Effect Relationships for the Swallowing Structures显示文摘 | Felix Y. Feng Hyungjin M. Kim Teresa H. Lyden Marc J. Haxer Mary Feng Frank P. Worden Douglas B. Chepeha Avraham Eisbruch | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，5： | 2 |
| 6 | Clinical Deterioration Following Improvement in the NINDS rt-PA Stroke Trial显示文摘 | James C. Grotta K.M.A. Welch Susan C. Fagan Mei Lu Michael R. Frankel Thomas Brott Steven R. Levine Patrick D. Lyden | 2001 | Stroke: Journal of the American Heart Association2001，，3： | 2 |
| 7 | Defining hematoma expansion in intracerebral hemorrhage: Relationship with patient outcomes显示文摘 | D. Dowlatshahi A.M. Demchuk M.L. Flaherty M. Ali P.L. Lyden E.E. Smith | 2011 | Neurology2011，，14： | 2 |
| 8 | Hemorrhagic transformation after cerebiral ischemia:mechanisms and incidence显示文摘 | Lyden PD Zivin JA | 1993 | Cerebrovasc Brain Metiu Rev1993，5，1： | 1 |
| 9 | Lack of significant correlation between rhinosinusiris symptoms and specific regions of sinus computer tomography scans显示文摘 | HOLBROOK E H BROWN C L LYDEN E R | 2005 | Am J Rhinol2005，19，： | 1 |
| 10 | Intravenous thrombolysis for acute stroke 显示文摘 | Lyden PD Grotta JC Levine SR | 1997 | Neurology1997，49，： | 1 |
| 11 | The secreted factors responsi-ble for pre-metastatic niche formation:old sayings and newthoughts显示文摘 | Peinado H Lavotshkin S Lyden D | 2011 | Semin Cancer Biol2011，21，2： | 1 |
| 12 | Hemorrhagic transformation after cerebralischemic:mechanisms and incidence显示文摘 | Lyden PD | 1993 | Cerebrovasc Brain Metab Rev1993，5，1： | 1 |
| 13 | Voice and swallowing outcomes of an organ-preservation trial for advanced la- ryngeal caneer显示文摘 | Fung K Lyden TH Lee J | 2005 | Intern J Radiat Oncol Biol Phys2005，63，5： | 1 |
| 14 | Induced hypothermia for acute stroke 显示文摘 | Hemmen TM Lyden PD | 2007 | Stroke2007，38，2： | 1 |
| 15 | Preparing the 'soil':the premetastatic niche显示文摘 | Kaplan PN Rafii S Lyden D | 2006 | Cancer Res2006，66，11： | 1 |
| 16 | NINDS TPA Stroke Study Group:improved reliability of the NIH stroke scale using video training显示文摘 | Brott T Tilley B | 1994 | Stroke1994，25，： | 1 |
| 17 | Endovascular management of juxtarenal aneurysms with fenestrated endovascular grafting显示文摘 | Greenberg RK Haulon S Lyden SP | 2004 | J Vasc Surg2004，39，2： | 1 |
| 18 | Impaired recruitment of bone marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth 显示文摘 | Lyden D Hattori K Dias S | 2001 | Nat Med2001，7，11： | 1 |
| 19 | AC133/CD133/Prominin-1显示文摘 | SHMELKOV S V st CLAIR R LYDEN D | 2005 | Int Biochem Cell Biol2005，37，4： | 1 |
| 20 | Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth显示文摘 | LYDEN D HATTORI K DIAS S | 2001 | Nat Med2001，7，11： | 1 |
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