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| 1 | Variations in zonal fruit starch concentrations of apples – a developmental phenomenon or an indication of ripening?显示文摘Patterns of starch hydrolysis in stem,equatorial,and calyx zones of‘Honeycrisp’and‘Empire’apples(Malus sylvestris(L.)Mill var.domestica(Borkh.)Mansf.)during maturation and ripening,and in‘Gala’apples in response to propylene or 1-methylcyclopropene(1-MCP)treatments after harvest,were studied.Differences in zonal starch concentrations were found for‘Empire’and‘Gala’fruits,but not for‘Honeycrisp’.During maturation and ripening of‘Empire’,the concentration of starch was highest in the calyx end and lowest in the stem region.Differences in rates of starch hydrolysis among zones were not detected.‘Honeycrisp’and‘Empire’had the highest concentration of sorbitol in the calyx region,whereas it was highest in the stem-end region in‘Gala’.The distribution differences of glucose,fructose,and sucrose were similar in all three cultivars;higher fructose and glucose concentrations in the stem region,and higher sucrose concentrations in the calyx end of the fruit.Postharvest treatment of‘Gala’with propylene did not affect the internal ethylene concentration of the fruit but 1-MCP markedly inhibited it.Starch concentrations were highest in the calyx end but gradients of starch among zones were not changed by postharvest treatment.The rate of hydrolysis was slowed by 1-MCP treatment,but was unaffected by propylene.Postharvest treatments influenced sorbitol,glucose,and fructose concentrations.Patterns of starch concentration among the zones did not confirm differences in ripening,but reflected its uneven distribution throughout the fruit during development.Therefore,measured differences in zonal starch are most likely related to starch accumulation during fruit development,rather than differences in rates of starch degradation during ripening. | Franziska C Doerflinger William B Miller Jacqueline F Nock Christopher B Watkins | 2015 | Horticulture Research2015，2，1： | 3 |
| 2 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | Pelvic floor muscle injuries 6 weeks post partum—an intra‐ and inter‐rater study显示文摘 | Jette St?r‐Jensen Franziska Siafarikas Gunvor Hilde Ingeborg H. Br?kken Kari B? Marie Ellstr?m Engh | 2013 | Neurourol Urodyn2013，，7： | 1 |
| 4 | Polycyclic aromatic hydrocarbons, black carbon, and molecular markers in soils of Switzerland 显示文摘 | Thomas D B Franziska B Andre D | 2004 | Chemosphere2004，56，11： | 1 |
| 5 | An elevated mutation frequence favors development of vancomycin resistance in Staphylococcus aureus 显示文摘 | Franziska S Andrea R Gabriele B | 2002 | Antimicrob Agents Chemother2002，46，11： | 1 |
| 6 | Comparison of Three Patent Foramen Ovale Closure Devices in a Randomized Trial (Amplatzer Versus CardioSEAL-STARflex Versus Helex Occluder)显示文摘 | Margaret Taaffe Evelyn Fischer Andreas Baranowski Nicolas Majunke Corinna Heinisch Michaela Leetz Ralph Hein Yves Bayard Franziska Büscheck Madlen Reschke Ilona Hoffmann Nina Wunderlich Neil Wilson Horst Sievert | 2008 | The American Journal of Cardiology2008，，9： | 1 |
| 7 | In vitro infant digestion of whey protein-dextran glycates显示文摘 | FRANZISKA H B MARK R E JOHN A L | 2013 | Food Digestion2013，，4： | 1 |
| 8 | Biodegradation rates of 2- methylisoborneol (MIB) and geosmin through sand filters and in bioreactors显示文摘 | Lionel H Daniel H Franziska B | 2007 | Chemosphere2007，66，： | 1 |
| 9 | Polycyclic aromatic hydrocarbons, black carbon, and molecular markers in soils of Switzerl and 显示文摘 | Thomas D B Franziska B Andre D | 2004 | Chemosphere2004，56，11： | 1 |
| 10 | Is EV experience related to EV acceptance? Results from a German field study显示文摘 | Franziska Bühler Peter Cocron Isabel Neumann Thomas Franke Josef F. Krems | 2014 | Transportation Research Part F: Psychology and Behaviour2014，，： | 1 |
| 11 | Ten Repeat Collections for Urinary Iodine from Spot Samples or 24-Hour Samples Are Needed to Reliably Estimate Individual Iodine Status in Women1-4显示文摘 | K?nig Franziska Andersson Maria Hotz Karin Aeberli Isabelle Zimmermann Michael B | 2011 | The Journal of Nutrition2011，，： | 1 |
| 12 | Climatic control of radial growth of Cedrela montana in a humid mountain rain forest in southern Ecuador显示文摘 | Achim B Franziska V V Iris B | 2009 | Erdkunde2009，63，： | 1 |
| 13 | Polyeyclie aromatic hydrocarbons, black carbon, and molecular markers in soils of Switzerland 显示文摘 | Thomas D B Franziska B Andre D | 2004 | Chemosphere2004，56，： | 1 |
| 14 | Betulinic acid, a natural compound with potent anticancer effects显示文摘 | Franziska B M Jan H K Jan P M | 2010 | Anti Cancer Drugs2010，21，3： | 1 |
| 15 | Presynaptic opioid reccptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex显示文摘 | Rothmaier AK Franziska W | 2006 | Br J Pharmacol2006，148，6： | 1 |
| 16 | Assessment of p-Glycopro-tein,glucathin-onebased detoxifying enzymes and Oalkylguanine-DNA alkyltransferase as potential indicators of constructive drug re-sistance in human colorectal tumors显示文摘 | Shiloh MS Franziska J Kathi B | 1991 | Cancer Res1991，51，： | 1 |
| 17 | Polycyclic aromatic hydrocarbons,black carbon,and molecular markers in soils of Switzerland显示文摘 | Thomas D B Franziska B Andre D | 2004 | Chemosphere2004，56，： | 1 |
| 18 | Polycyclic aromatic hydrocarbons,black carbon,and molecular markers in soils of Switzerland显示文摘 | Bucheli T D Franziska B Desaules A Gustafsson(O) | 2004 | Chemosphere2004，56，11： | 1 |
| 19 | Assessment of p-Glycoprotein,glucathin-onebased detoxifying enzymes and Oalkylguanine-DNA alkyltransferase as potential indicators of constructive drug resistance in human colorectal tumors显示文摘 | Franziska J Kathi B | 1991 | Cancer Res1991，51，： | 1 |
| 20 | Betulin is a potent antitumor agent that is enhanced by cholesterol显示文摘 | Franziska B M Jan H K Jan P M | 2009 | Plos one2009，4，4： | 1 |
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