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| 1 | Genome resequencing and transcriptome profiling reveal structural diversity and expression patterns of constitutive disease resistance genes in Huanglongbing-tolerant Poncirus trifoliata and its hybrids显示文摘Huanglongbing(HLB)is the most destructive bacterial disease of citrus worldwide.While most citrus varieties are susceptible to HLB,Poncirus trifoliata,a close relative of Citrus,and some of its hybrids with Citrus are tolerant to HLB.No specific HLB tolerance genes have been identified in P.trifoliata but recent studies have shown that constitutive disease resistance(CDR)genes were expressed at much higher levels in HLB-tolerant Poncirus hybrids and the expression of CDR genes was modulated by Candidatus Liberibacter asiaticus(CLas),the pathogen of HLB.The current study was undertaken to mine and characterize the CDR gene family in Citrus and Poncirus and to understand its association with HLB tolerance in Poncirus.We identified 17 CDR genes in two citrus genomes,deduced their structures,and investigated their phylogenetic relationships.We revealed that the expansion of the CDR family in Citrus seems to be due to segmental and tandem duplication events.Through genome resequencing and transcriptome sequencing,we identified eight CDR genes in the Poncirus genome(PtCDR1-PtCDR8).The number of SNPs was the highest in PtCDR2 and the lowest in PtCDR7.Most of the deletion and insertion events were observed in the UTR regions of Citrus and Poncirus CDR genes.PtCDR2 and PtCDR8 were in abundance in the leaf transcriptomes of two HLB-tolerant Poncirus genotypes and were also upregulated in HLB-tolerant,Poncirus hybrids as revealed by real-time PCR analysis.These two CDR genes seem to be good candidate genes for future studies of their role in citrus-CLas interactions. | Nidhi Rawat Brajendra Kumar Ute Albrecht Dongliang Du Ming Huang Qibin Yu Yi Zhang Yong-Ping Duan Kim D Bowman Fred G Gmitter Jr Zhanao Deng | 2017 | Horticulture Research2017，4，1： | 5 |
| 2 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 3 | A kinetic model for pyrolysis of cellulose 显示文摘 | Bradbury allan G W Sakai Yoshio Shafizadeh Fred | 1979 | Journal of Applied Polymer Science1979，23，11： | 1 |
| 4 | Separation of trace metal complexes for analysis of samples of high salt content by inductively coupled plasma mass spectrometry显示文摘 | Michael R Plantz James S Fritz Fred G | 1989 | Anal Chem1989，61，2： | 1 |
| 5 | A wave generation toolbox for the open-source CFD library: OpenFOAM? 显示文摘 | JACOBSEN N G FUHRMAN D R FREDS E J | 2012 | International Journal for Numerical Methods in Fluids2012，70，9： | 1 |
| 6 | Advanced greedy algorithms and surrogate constraint method for linear and quadratic knapsack and covering problems显示文摘 | Fred G | 2013 | European Journal of Operational Research2013，230，2： | 1 |
| 7 | Mammalian neural stem cells 显示文摘 | Fred H G | 2000 | Science2000，287，25： | 1 |
| 8 | Variability of worked examples and transfer of geometrical problem-solving skills: A cognitive - load approach显示文摘 | Fred G W C Paas J G Van Merrienboer | 1994 | Journal of Educational Psychology1994，，1： | 1 |
| 9 | Mining and characterizing microsatellites from citrus ESTs显示文摘 | CHEN C X ZHOU P CHOI Y A HUANG S FRED G GMITTER J | 2006 | Theor Appl Genet2006，112，： | 1 |
| 10 | A Kinetic Model for Pyrolysis of Cellulose显示文摘 | Bradbury Allan G W Sakai Yoshio Shafizadeh Fred | 1979 | Journal of Applied Polymer Science1979，23，11： | 1 |
| 11 | Microvascular decomp ression forhemifacial spasm显示文摘 | Fred G Barker II Peter J | 1995 | J Neuro surg1995，82，： | 1 |
| 12 | Training strategies for attaining transfer of problem - solving skill in statistics: A cognitive - load approach 显示文摘 | Fred G W C Paas | 1992 | Journal of Educational Psychology1992，4，： | 1 |
| 13 | A novel thermostable nitrile hydratase 显示文摘 | Rui A Dan G Fred A | 1998 | Extremophiles1998，2，2： | 1 |
| 14 | An exploratory study of ' close ' supplier-manufacturer relationships显示文摘 | Keith G Fred L Marek S | 2006 | Journal of Operations Management2006，24，2： | 1 |
| 15 | Genetic algorithms and tabu search hybrids for optimization显示文摘 | Fred G James P K Manuel L | 1995 | Computers & Operations Research1995，22，1： | 1 |
| 16 | Applied Sport Psychology:Peak Performance显示文摘 | FRED G D E LACERDA | 1998 | Sport Aerobatics1998，27，6： | 1 |
| 17 | Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: A double-blind,pacebo-controlled comparison of efficacy and dafety显示文摘 | Gary SS Fred G Nassir G | 2002 | Am J Psychiatry2002，159，： | 1 |
| 18 | Short and long term prognosis after acute myocardial infarction in men versus women 显示文摘 | Huiberdina LK Agnes-de B Fred G | 2006 | J Am Cardiol2006，98，： | 1 |
| 19 | Word-of-Mouth Com-munication in the Service Marketplace显示文摘 | MANGOLD W G FRED M | 1999 | Journal ofServices Marketing1999，13，1： | 1 |
| 20 | Tabu search-part Ⅱ显示文摘 | Fred G | 1990 | ORSA Journal on Computing1990，2，1： | 1 |
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