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| 1 | Reversible Histone H2B Monoubiquitination Fine-Tunes Abscisic Acid Signaling and Drought Response in Rice显示文摘Histone H2B monoubiquitination (H2Bub1) plays important roles in several physiological and developmental processes, but its roles in the regulation of plant stress responses remain elusive. Here, we report that H2Bub1 is crucially involved in abscisic acid (ABA) signaling and drought response in rice. We found that rice HISTONE MONOUBIQUITINATION2 (OsHUB2), an E3 ligase for H2Bub1, in teracted with OsbZIP46, a key transcription factor regulating ABA signaling and drought response in rice. Genetic analyses suggest that OsHUB2, upregulated by drought and ABA, positively modulates ABA sensitivity and drought resistance. The H2Bub1 levels were in creased in the target genes of OsbZIP46 under the drought stress and ABA treat- merits, which were positively correlated with their increased expression levels. Interestingly, MODD, a reported suppressor of ABA signaling and drought resistance by mediating OsbZIP46 deactivation and degradation, could reduce the H2Bub1 levels in the target genes of OsbZIP46 by recruiting a putative deubiquitinase OsOTLD1 . Suppression of OsOTLD1in vivo resulted in increased H2Bub1 levels and expression of OsbZIP46 target genes. Collectively, these fin dings established an elaborate mecha nism of histone monoubiquitination in the fine-turning of ABA signaling and drought response by balancing H2Bub1 deposition and removal. | Siqi Ma Ning Tang Xu Li Yongjun Xie Denghao Xiang Jie Fu Jianqiang Shen Jun Yang Haifu Tu Xianghua Li Honghong Hu Lizhong Xiong | 2019 | Molecular Plant2019，12，2： | 7 |
| 2 | Safety and feasibility of transulnar versus transradial artery approach for coronary catheterization in non-selective patients显示文摘 | Geng Wei Fu Xianghua Gu Xinshun Jiang Yunfa Fan Weize Wang Yanbo Li Wei Xing Kun Liu Chen | 2014 | Chinese Medical Journal2014，，7： | 5 |
| 3 | Bract suppression regulated by the miR156/529-SPLs-NL1-PLA1 module is required for the transition from vegetative to reproductive branching in rice显示文摘Reproductive transition of grasses is characterized by switching the pattern of lateral branches,featuring the suppression of outgrowth of the subtending leaves(bracts)and rapid formation of higher-order branches in the inflorescence(panicle).However,the molecular mechanisms underlying such changes remain largely unknown.Here,we show that bract suppression is required for the reproductive branching in rice.We identified a pathway involving the intrinsic time ruler microRNAI56/529,their targets SQUAMOSA PROMOTER BINDING PROTEIN LIKE(SPL)genes,NECK LEAF1(NL1),and PLASTOCHRON1(PLA1),which regulates the bract outgrowth and thus affects the pattern switch between vegetative and reproductive branching.Suppression of the bract results in global reprogramming of transcriptome and chromatin accessibility following the reproductive transition,while these processes are largely dysregu-lated in the mutants of these genes.These discoveries contribute to our understanding of the dynamic plant architecture and provide novel insights for improving crop yields. | Lei Wang Luchang Ming Keyan Liao Chunjiao Xia Shengyuan Sun Yu Chang Hongkai Wang Debao Fu Conghao Xu Zhengji Wang Xu Li Weibo Xie Yidan Ouyang Qinglu Zhang Xianghua Li Qinghua Zhang Jinghua Xiao Qifa Zhang | 2021 | Molecular Plant2021，14，7： | 2 |
| 4 | Multi-aspect sentiment analysis for Chinese online social reviews based on topic modeling and howNet lexicon 显示文摘 | Fu Xianghua Liu Guo Guo yanyan | 2012 | Knowledge-Based Systems2012，37，： | 1 |
| 5 | Multi- aspect sentiment analysis for Chinese online social reviews basedon topic modeling and HowNetlexicon显示文摘 | Fu Xianghua Liu Guo Guo Yanyan Wang 21aiqiang | 2013 | Knowledge- Based Systems2013，37，1： | 1 |
| 6 | Towards an effective personalized information filter for P2P based focused Web crawling 显示文摘 | Fu Xianghua Feng Boqin | 2006 | Journal of Computer Science2006，2，1： | 1 |
| 7 | Response and Long-Term Effect of Patients with Triple-Negative Breast Cancer Receiving Neo-Adjuvant Anthracycline-Based Chemotherapy显示文摘OBJECTIVE The breast cancer lack of expression of estrogenreceptor (ER), progesterone receptor (PR), and human epidermalgrowth factor receptor 2 (HER-2) is defined as the Triple-negativebreast cancer (TNBC). Our purpose is to compare the responseand long-term effect of the TNBC and non-TNBC patientsreceiving neo-adjuvant anthracycline-based chemotherapy, and toinvestigate the mechanisms of TNBC affecting the survivals.METHODS Data of long-term follow-up (median, 5.4 years)of 326 patients who received neo-adjuvant chemotherapy withanthracycline-based regimen, during a period from 2000 to 2003,were analyzed. Expressions of ER, PR, HER-2, P53, Ki-67 andE-cadherin were determined using immunohistochemical stainingmethod. A multivariate Cox regression analysis was used toanalyze independent prognostic factors affecting the relapse-freesurvival (RFS) and overall survival (OS) rates. Clinical effects ofthe neo-adjuvant anthracycline-based chemotherapeutic regimenand the RFS and OS rates were compared between the patientswith TNBC and non-TNBC, and the correlations among the triple-negative phenotype (TNP), tumor grading and the expressions ofP53, Ki-67 and E-cadherins were analyzed.RESULTS TNP, TNM staging, histological grades, clinicalresponse of the neo-adjuvant chemotherapy and pathologicalcomplete remission (pCR) rate were the independent prognosticfactors affecting the survival rates. Furthermore, 70 (21.5%) of the326 patients suffered TNBC. Compared with the subjects in non-TNBC group, the patients with TNBC had a significantly higherpCR rate (P = 0.046) and clinical response rate (P = 0.037), but alsodecreased 5-year RFS (P = 0.001) and OS (P = 0.004) rates. TheRFS and OS rates were not improved in the TNBC patients whoachieved a clinical remission after the neo-adjuvant chemotherapy.The triple-negative phenotype was positively correlated with thelevel of P53, Ki-67 expression (P = 0.007, P = 0.028), but negativelycorrelated with level of E-cadherin (P = 0.034).CONCLUSION Both clinical remission rate and pCR rate ofthe TNBC patients receiving neo-adjuvant anthracycline-basedchemotherapy are high, however, the long-term effect is poor.The mechanism may relate to a strong potential of proliferationand invasive metastasis, as well as lack of an effective therapeutictarget in the TNBC patients. | Zhengkui Sun Xingtian Ma Yudong Wu Fan Fan Xianghua Wan Airong Fu | 2009 | Clinical oncology and cancer resexreh2009，6，3： | 1 |
| 8 | Multi-aspect sentiment analysis for Chinese online social reviews based on Iopic modeling and HowNet lexicon 显示文摘 | FU Xianghua LIU Guo GUO Yanyan | 2013 | Knowledge-Based Systems2013，37，： | 1 |
| 9 | Tunable white light emission from glass-ceramics containing Eu 2+ , Tb 3+ , Eu 3+ co-doped SrLaF 5 nanocrystals显示文摘 | Hengyi Fu Xvsheng Qiao Shuo Cui Qun Luo Jiangyun Qian Xianping Fan Xianghua Zhang | 2011 | Materials Letters2011，，： | 1 |
| 10 | Effects of simvastatin on ion channel currents in ventricular myocytes from rabbit with acute myocardial infarction显示文摘Objective To investigate the effects of simvastatin on membrane ionic currents in left ventricular myocytes after acute myocardial infarction (AMI,so as to explore the ionic mechanism of statin treatment for antiarrhythmia.Methods Fourty-five New Zeland rabbits were randomly divided into three groups:AMI group,simvastatin intervention group (statin group) and sham-operated control group (CON).Rabbits were infarcted by ligation of the left anterior descending coronary artery after administration of oral simvastatin 5 mg·kg-1·d-1 (Statin group) or placebo (AMI group)for 3 days.Twenty-four hours later,single ventricular myocytes were isolated enzymatically from the epicardial zone of the infracted region.Whole cell patch clamp technique was used to record membrane ionic currents,including sodium current (INa),L-type calcium current (ICa-L) and transient outward potassium current (Ito).Results①There was no significant difference in serum cholesterol concentration among three groups.②The peak INa current density (at-30 mV) was significantly decreased in AMI group (-23.26±5.18) compared with CON (-42.78±5.48,P<0.05),while it was significantly increased in Statin group (-39.23±5.45) compared with AMI group (P<0.01);The peak ICa-L current density (at 0 mV) was significantly decreased in AMI group (-3.23±0.91) compared with CON (-4.56±1.01,P<0.05),while it was significantly increased in Statin group (- 4.18±0.95) compared with AMI group (P<0.05);The Ito current density(at +60 mV) was significantly decreased in AMI group(10.41±1.93)compared with CON (17.41±3.13,P<0.01),while it was significantly increased in Statin group(16.21±2.42)compared with AMI group (P<0.01).Conclusions AMI induces significant down-regulation of INa,ICa-L and Ito.Pretreatment with simvastatin could attenuate this change without lowering the serum cholesterol level,suggesting that simvastatin reverse this electrical remodeling,thus contributing to the ionic mechanism of statin treatment for antiarrhythmia. | Chao Ding~1 Xianghua Fu~2 Li Yang~1 Huixiao Chen~1 Junxia Li~1 Yuying Zhao~1 Jie Li~1 Jie Wang~1 1 Department of Cardiology, Bethune International Peace Hospital of Chinese PLA, Shijiazhuang Hebei 050082 China 2 Department of Cardiology, The Second Hospital, Hebei Medical University, Shijiazhuang Hebei 050000, China | 2008 | Journal of Geriatric Cardiology2008，5，3： | 0 |
| 11 | Flow boiling heat transfer in copper foam fin microchannels with different fin widths using R134a显示文摘Heat sinks of copper foam fin microchannels are developed to deal with cooling challenges.The heat sinks consist of fins made of copper foam and channels.The channels are 0.5 mm in width and 1 mm in height,and the fins are 0.5 and 2.0 mm in width.Flow boiling experiments are conducted using R134a at subcooled and saturated inlet conditions.The heat flux is between 22 and 172 W/cm^(2),and the mass flux ranges from 264 to 1213 kg/(m^(2)s).The influence of the quality,the heat flux,and the mass flow rate on the heat transfer coefficient is obtained.It is found that wider fin raises the heat transfer coefficient.A correlation is developed based on heat transfer mechanisms,and it predicts the experimental result with a 12%mean absolute error.Compared with a solid fin microchannels heat sink,the heat transfer coefficient of the copper foam fin microchannels is higher(up to 60%)when the heat flux is lower than 100 W/cm^(2).The copper foam fin microchannels may enhance the heat transfer coefficient and reduce the pressure drop at the same time. | GAO WuHuan FU Kai XU XiangHua LIANG XinGang | 2023 | Science China(Technological Sciences)2023，66，11： | 0 |
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