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| 1 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 2 | Integrative Regulation of Drought Escape through ABA-Dependent and -Independent Pathways in Rice显示文摘许多植物发展了干旱逃跑(DE ) 机制弄短他们的生命周期当面对水赤字条件时。当干旱忍耐强烈地被调查了时, DE 的基因、分子的机制留下逃犯。在这研究,我们发现在米饭开发的早阶段的低水赤字处理(LWT ) 能触发早 flowering 并且减少 tiller 数字。LWT 导致了 abscisic 酸(骆驼毛的织物) 的累积,它接着由同时地调整许多花相关的基因支持早 flowering 在轻感觉和生理节奏的钟上有反馈效果。而且,,一些包括 OsTOC1 , Ghd7 ,和 PhyB 的轻受体,生理节奏的部件,和花相关的基因被发现以一种骆驼毛的织物依赖者方式涉及 LWT 一些包括 OsGI 的另外的花相关的基因, OsELF3 , OsPRR37 ,并且 OsMADS50 涉及独立于骆驼毛的织物的 DE 的规定。另外,我们发现 strigolactones 和 OsTB1 在 LWT 下面涉及 tillering 抑制,它独立于在米饭的 flowering 小径。一起拿,我们的调查结果提供在米饭的 DE 被多重小径并列地在繁殖(flowering ) 期间调整的引人注目的证据开关。 | Hao Du Fei Huang Nai Wu Xianghua Li Honghong Hu Lizhong Xiong | 2018 | Molecular Plant2018，11，4： | 9 |
| 3 | Reversible Histone H2B Monoubiquitination Fine-Tunes Abscisic Acid Signaling and Drought Response in Rice显示文摘Histone H2B monoubiquitination (H2Bub1) plays important roles in several physiological and developmental processes, but its roles in the regulation of plant stress responses remain elusive. Here, we report that H2Bub1 is crucially involved in abscisic acid (ABA) signaling and drought response in rice. We found that rice HISTONE MONOUBIQUITINATION2 (OsHUB2), an E3 ligase for H2Bub1, in teracted with OsbZIP46, a key transcription factor regulating ABA signaling and drought response in rice. Genetic analyses suggest that OsHUB2, upregulated by drought and ABA, positively modulates ABA sensitivity and drought resistance. The H2Bub1 levels were in creased in the target genes of OsbZIP46 under the drought stress and ABA treat- merits, which were positively correlated with their increased expression levels. Interestingly, MODD, a reported suppressor of ABA signaling and drought resistance by mediating OsbZIP46 deactivation and degradation, could reduce the H2Bub1 levels in the target genes of OsbZIP46 by recruiting a putative deubiquitinase OsOTLD1 . Suppression of OsOTLD1in vivo resulted in increased H2Bub1 levels and expression of OsbZIP46 target genes. Collectively, these fin dings established an elaborate mecha nism of histone monoubiquitination in the fine-turning of ABA signaling and drought response by balancing H2Bub1 deposition and removal. | Siqi Ma Ning Tang Xu Li Yongjun Xie Denghao Xiang Jie Fu Jianqiang Shen Jun Yang Haifu Tu Xianghua Li Honghong Hu Lizhong Xiong | 2019 | Molecular Plant2019，12，2： | 7 |
| 4 | The OsNAC23-Tre6P-SnRK1 a feed-forward loop regulates sugar homeostasis and grain yield in rice显示文摘Tre6P(trehalose-6-phosphate)mediates sensing of carbon availability to maintain sugar homeostasis in plants,which underpins crop yield and resilience.However,how Tre6P responds to fluctuations in sugar levels and regulates the utilization of sugars for growth remains to be addressed.Here,we report that the sugar-inducible rice NAC transcription factor OsNAC23 directly represses the transcription of the Tre6P phosphatase gene TPP1 to simultaneously elevate Tre6P and repress trehalose levels,thus facilitating carbon partitioning from source to sink organs.Meanwhile,OsNAC23 and Tre6P suppress the transcription and enzyme activity of SnRK1a,a low-carbon sensor and antagonist of OsNAC23,to prevent the SnRK1a-mediated phosphorylation and degradation of OsNAC23.Thus,OsNAC23,Tre6P,and SnRK1a form a feed-forward loop to sense sugar and maintain sugar homeostasis by transporting sugars to sink organs.Importantly,plants over-expressing OsNAC23 exhibited an elevated photosynthetic rate,sugar transport,and sink organ size,which consistently increased rice yields by 13%–17%in three elite-variety backgrounds and two locations,suggesting that manipulation of OsNAC23 expression has great potential for rice improvement.Collectively,these findings enhance our understanding of Tre6P-mediated sugar signaling and homeostasis,and provide a new strategy for genetic improvement of rice and possibly also other crops. | Zhiyong Li Xiangjin Wei Xiaohong Tong Juan Zhao Xixi Liu Huimei Wang Liqun Tang Yazhou Shu Guanghao Li Yifeng Wang Jiezheng Ying Guiai Jiao Honghong Hu Peisong Hu Jian Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 5 | Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression显示文摘Shuyusan, a traditional Chinese medicine, was shown to improve depression symptoms and behavioral scores, as well as increase 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan levels, in a rat model of chronic stress-induced depression. However, dopamine, noradrenalin, and 3-methoxy-4-hydroxyphenylglycol expressions remained unchanged following Shuyusan treatment. Compared with the model group, the number of 5-HT-positive neurons in layers 4-5 of the frontal cortex, as well as hippocampal CA1 and CA3 regions, significantly increased following Shuyusan treatment. These results suggested that Shuyusan improved symptoms in a rat model of chronic stress-induced depression with mechanisms that involved 5-HT, 5-HT metabolite, 5-HT precursor expressions. | Yuanyuan Zhang Jianjun Jia Liping Chen Zhitao Han Yulan Zhao Honghong Zhang Yazhuo Hu | 2011 | Neural Regeneration Research2011，6，33： | 4 |
| 6 | Aldehyde dehydrogenase ALDH3F1 involvement in flowering time regulation through histone acetylation modulation on FLOWERING LOCUS C显示文摘Flowering time regulation is one of the most important processes in the whole life of flowering plants and FLOWERING LOCUS C(FLC)is a central repressor of flowering time.However,whether metabolic acetate level affects flowering time is unknown.Here we report that ALDEHYDE DEHYDROGENASE ALDH3F1 plays essential roles in floral transition via FLC-dependent pathway.In the aldh3f1-1 mutant,the flowering time was significant earlier than Col-0 and the FLC expression level was reduced.ALDH3F1 had aldehyde dehydrogenase activity to affect the acetate level in plants,and the amino acids of E214 and C252 are essential for its catalytic activity.Moreover,aldh3f1 mutation reduced acetate level and the total acetylation on histone H3.The H3K9Ac level on FLC locus was decreased in aldh3f1-1,which reduced FLC expression.Expression of ALDH3F1 could rescue the decreased H3K9Ac level on FLC,FLC expression and also the early-flowering phenotype of aldh3f1-1,however ALDH3F1E214A or ALDH3F1C252A could not.Our findings demonstrate that ALDH3F1 participates in flowering time regulation through modulating the supply of acetate for acetyl-CoA,which functions as histone acetylation donor to modulate H3K9Ac on FLC locus. | Danyun Xu Qing Liu Gang Chen Zhiqiang Yan Honghong Hu | 2020 | Journal of Integrative Plant Biology2020，62，8： | 2 |
| 7 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，： | 2 |
| 8 | Systematic analysis of NPK1 -like genes in rice reveals a stress-inducible gene cluster co-localized with a quantitative trait locus of drought resistance显示文摘 | Jing Ning Siyuan Liu Honghong Hu Lizhong Xiong | 2008 | Molecular Genetics and Genomics2008，，6： | 1 |
| 9 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，3： | 1 |
| 10 | Microstructure Evolution of Zr_(50)Cu_(18)Ni_(17)Al_(10)Ti_5 Bulk Metallic Glass during Cold-rolling显示文摘Zr50Cu18Ni17Al10Ti5 bulk metallic glass has been rolled at room temperature up to 95% in thickness reduction, and the dependence of microstructure on the strain was investigated. With increasing thickness reduction, the full width at half maximum (FWHM) and crystallization enthalpy decrease gradually till 80%, and then increase evidently at 95%. It is revealed that the reversible transition between the ordered and disordered atomic configurations was found in the metallic glass as the deformation proceeds, which is further verified by the high-resolution transmission electron microscopy images. The final microstructure in metallic glass during cold-rolling is the net result of two competing processes between shear-induced disordering and diffusion controlled reordering. | Honghong Yan Yong Hu Zhijie Yan Xiaohua Zheng Yongtang Li | 2012 | Journal of Materials Science & Technology2012，28，8： | 1 |
| 11 | Recent advances based on Mg anodes and their interfacial modulation in Mg batteries显示文摘Magnesium(Mg)batteries(MBs),as post-lithium-ion batteries,have received great attention in recent years due to their advantages of high energy density,low cost,and safety insurance.However,the formation of passivation layers on the surface of Mg metal anode and the poor compatibility between Mg metal and conventional electrolytes during charge-discharge cycles seriously affect the performance of MBs.The great possibility of generating Mg dendrites has also caused controversy among researchers.Moreover,the regulation of Mg deposition and the enhancement of battery cycle stability is largely limited by interfacial stability between Mg metal anode and electrolyte.In this review,recent advances in interfacial science and engineering of MBs are summarized and discussed.Special attention is given to interfacial chemistry including passivation layer formation,incompatibilities,ion transport,and dendrite growth.Strategies for building stable electrode/interfaces,such as anode designing and electrolyte modification,construction of artificial solid electrolyte interphase(SEI)layers,and development of solid-state electrolytes to improve interfacial contacts and inhibit Mg dendrite and passivation layer formation,are reviewed.Innovative approaches,representative examples,and challenges in developing high-performance anodes are described in detail.Based on the review of these strategies,reference is provided for future research to improve the performance of MBs,especially in terms of interface and anode design. | Fanfan Liu Guoqin Cao Jinjin Ban Honghong Lei Yan Zhang Guosheng Shao Aiguo Zhou Li zhen Fan Junhua Hu | 2022 | Journal of Magnesium and Alloys2022，10，10： | 1 |
| 12 | Genetic Engineering and Breeding of Drought-Resistant Crops显示文摘 | Honghong Hu Lizhong Xiong | 2014 | Annual Review of Plant Biology2014，，： | 1 |
| 13 | Overexpressing a NAM,ATAF,and CUC (NAC) transcription factor enhances drought resistance and salt tolerance in rice显示文摘 | Hu Honghong Dai Mingqiu Yao Jialing | 2006 | Proc Natl Acad Sci USA2006，103，12： | 1 |
| 14 | Characterization of transcription factor gene SNAC2 conferring cold and salt tolerance in rice显示文摘 | Honghong Hu Jun You Yujie Fang Xiaoyi Zhu Zhuyun Qi Lizhong Xiong | 2008 | Plant Molecular Biology (-)2008，，1： | 1 |
| 15 | Over- expressing a NAM, ATAF, and CUC (NAC) tran- scription factor enhances drought resistance and salt tolerance in riee显示文摘 | Hu Honghong Dai Mingqiu Yao Jialing | 2006 | Proe Natl Aead Sci USA2006，103，12： | 1 |
| 16 | Systematic analysis of GT factor family of rice reveals a novel subfamily involved in stress responses显示文摘 | Yujie Fang Kabin Xie Xin Hou Honghong Hu Lizhong Xiong | | 0，，： | 1 |
| 17 | Regulation of FLC nuclear import by coordinated action of the NUP62-subcomplex and importinβSAD2显示文摘Flowering locus C(FLC)is a central transcriptional repressor that controls flowering time.However,how FLC is imported into the nucleus is unknown.Here,we report that Arabidopsis nucleoporins 62(NUP62),NUP58,and NUP54 composed NUP62-subcomplex modulates FLC nuclear import during floral transition in an importinα-independent manner,via direct interaction.NUP62 recruits FLC to the cytoplasmic filaments and imports it into the nucleus through the NUP62-subcomplex composed central channel.Importinβsupersensitive to ABA and drought 2(SAD2),a carrier protein,is critical for FLC nuclear import and flower transition,which facilitates FLC import into the nucleus mainly through the NUP62-subcomplex.Proteomics,RNAseq,and cell biological analyses indicate that the NUP62-subcomplex mainly mediates the nuclear import of cargos with unconventional nuclear localization sequences(NLSs),such as FLC.Our findings illustrate the mechanisms of the NUP62-subcomplex and SAD2 on FLC nuclear import process and floral transition,and provide insights into the role of NUP62-subcomplex and SAD2 in protein nucleocytoplasmic transport in plants. | Gang Chen Danyun Xu Qing Liu Zhichuang Yue Biao Dai Shujuan Pan Yongqiang Chen Xinhua Feng Honghong Hu | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 18 | Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells显示文摘Multicellular organisms such as plants contain various cell types with specialized functions.Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level.Guard cells(GCs)are specialized epidermal cells that regulate the movement of the stomata and gaseous exchange,and provide a model genetic system for analyzing cell fate,signaling,and function.Several proteomics analyses of GC are available,but these are limited in depth.Here we used enzymatic isolation and flow cytometry to enrich GC and mesophyll cell protoplasts and perform in-depth proteomics in these two major cell types in Arabidopsis leaves.We identified approximately 3,000 proteins not previously found in the GC proteome and more than600 proteins that may be specific to GC.The depth of our proteomics enabled us to uncover a guard cell-specific kinase cascade whereby Raf15and Snf1-related kinase2.6(SnRK2.6)/OST1(open stomata 1)mediate abscisic acid(ABA)-induced stomatal closure.RAF15 directly phosphorylated SnRK2.6/OST1 at the conserved Ser175 residue in its activation loop and was sufficient to reactivate the inactive form of SnRK2.6/OST1.ABAtriggered SnRK2.6/OST1 activation and stomatal closure was impaired in raf15 mutants.We also showed enrichment of enzymes and flavone metabolism in GC,and consistent,dramatic accumulation of flavone metabolites.Our study answers the long-standing question of how ABA activates SnRK2.6/OST1 in GCs and represents a resource potentially providing further insights into the molecular basis of GC and mesophyll cell development,metabolism,structure,and function. | Hongliang Wang Yubei Wang Tian Sang Zhen Lin Rongxia Li Weiwei Ren Xin Shen Bing Zhao Xiao Wang Xuebin Zhang Shaoqun Zhou Shaojun Dai Honghong Hu Chun-Peng Song Pengcheng Wang | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 19 | Assessment of community health needs of Chongqing residents: a qualitative study显示文摘Objective: The aim of this preliminary qualitative study was to gain insight into community health needs in order to develop health program for community in Chongqing. Methods: Totally 40 participants were assigned into 6 focus group discussions. All groups were led by local language speakers, and their talking was recorded after gaining informed consent. Transcribed data were coded and subjected to thematic analysis. Results: The main obtained themes were that community health problems were chronic noncommunicable disease, main health service needs included regularly free check-up and health education, and perceived health risk factors were unhealthy lifestyle and behavior as well as environment problems. Conclusion: Our community health needs assessment (CHNA) with FGDs indicate that residents realize the importance of prevention of disease. Our study identifies that primarily community health promotion is one of the priorities of community health service needs, including reorienting health service, health education, guiding behavior or lifestyle, and creating healthy environments. The findings of this study can provide guidance to the development of more effective and pertinent health program in this community. | Li Ying Li Daikun He Jia Shi Kai Liu HongHong Zhang Hu | 2008 | Journal of Medical Colleges of PLA(China)2008，23，5： | 0 |
| 20 | Application of Wavelength Selection Combined with DS Algorithm for Model Transfer between NIR Instruments显示文摘This study aims to realize the sharing of near-infrared analysis models of lignin and holocellulose content in pulp wood on two different batches of spectrometers and proposes a combined algorithm of SPA-DS,MCUVE-DS and SiPLS-DS.The Successive Projection Algorithm(SPA),the Monte-Carlo of Uninformative Variable Elimination(MCUVE)and the Synergy Interval Partial Least Squares(SiPLS)algorithms are respectively used to reduce the adverse effects of redundant information in the transmission process of the full spectrum DS algorithm model.These three algorithms can improve model transfer accuracy and efficiency and reduce the manpower and material consumption required for modeling.These results show that the modeling effects of the characteristic wavelengths screened by the SPA,MCUVE and SiPLS algorithms are all greatly improved compared with the full-spectrum modeling,in which the SPA-PLS result in the best prediction with RPDs above 6.5 for both components.The three wavelength selection methods combined with the DS algorithm are used to transfer the models of the two instruments.Among them,the MCUVE combined with the DS algorithm has the best transfer effect.After the model transfer,the RMSEP of lignin is 0.701,and the RMSEP of holocellulose is 0.839,which was improved significantly than the full-spectrum model transfer of 0.759 and 0.918. | Honghong Wang Zhixin Xiong Yunchao Hu Zhijian Liu Long Liang | 2023 | Journal of Renewable Materials2023，11，6： | 0 |
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