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| 1 | Construction and Properties of Structure-and Size-controlled Micro/Nano-energetic Materials显示文摘The recent research progress of structure- and size-controlled micro/nano-energetic materials is reviewed, which properties are fundamentally different from those of their corresponding bulk materials. The development of the construction strategies for achieving zero-dimensional (0D), one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) micro/nanostructures from energetic molecules is introduced. Also, an overview of the unique properties induced by micro/nanostructures and size effects is provided. Special emphasis is focused on the size-dependent properties that are different from those of the conventional micro-sized energetic materials, such as thermal decomposition, sensitivity, combustion and detonation, and compaction behaviors. A conclusion and our view of the future development of micro/nano-energetic materials and devices are given. | HUANG Bing CAO Minhua NIE Fude HUANG Hui HU Changwen | 2013 | Defence Technology(防务技术)2013，9，2： | 20 |
| 2 | Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents,β-ionone and linalool显示文摘Sweet osmanthus(Osmanthus fragrans Lour.)is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.Here,manual sectioning,scanning electron microscopy,and transmission electron microscopy of sweet osmanthus petals revealed that large amounts of lipids are present inside the petal cells and on the cell surfaces.However,no secretory structures were observed.Instead,the petal cells protrude slightly outward,and the surfaces of the cells are adorned with highly regular brush-shaped hairs.The surfaces of the‘Yingui’petals possessed mostly curled and more numerous hairs,whereas the‘Dangui’petals possessed fewer brush-shaped and more sparsely arranged hairs.In addition,many granular substances were attached to the brush-shaped hairs,and the granules were denser on the hairs of the‘Yingui’petals compared to the hairs on the‘Dangui’petals.Furthermore,35 aromatic components in the‘Yingui’petals and 30 aromatic components in the‘Dangui’petals were detected via GC-MS.The main aromatic component of the‘Yingui’petals wasβ-ionone,whereas that of the‘Dangui’petals was linalool and its oxides.Transcriptome sequencing and qRT-PCR indicated that the highβ-ionone content in the‘Yingui’petals was due to the overexpression of CCD1 and CCD4 and that the high linalool content in the‘Dangui’petals was due to the overexpression of MECS,HDR,IDI1,and LIS1,which function upstream of the linalool synthetic pathway.In particular,the expression levels of CCD4 and LIS1 were upregulated by 5.5-and 5.1-fold in the‘Yingui’and‘Dangui’petals,respectively.One transcription factor(ERF61)was cloned and named,and the expression pattern of ERF61 in sweet osmanthus petals was found to be generally consistent with that of CCD4.Tobacco transformation experiments,yeast one-hybrid experiments,and electrophoretic mobility shift assays indicated that ERF61 binds to the CCD4 promoter and stimulates CCD4 expression,thereby regulating the synthesis ofβ-ionone in sweet osmanthus petals. | Yuanji Han Hongyun Wang Xiaodan Wang Ke Li Meifang Dong Yong Li Qian Zhu Fude Shang | 2019 | Horticulture Research2019，6，1： | 13 |
| 3 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 4 | Research on KOH/La-Ba-Al_2O_3 catalysts for biodiesel production via transesterification from microalgae oil显示文摘Alumina supports modified by lanthanum(La)and barium(Ba)were prepared by peptization.Catalysts with different KOH contents supported on modified alumina were prepared by impregnation method.Various techniques,including N2 adsorption-desorption(Brunauer-Emmet-Teller method,BET),X-ray diffraction(XRD),scanning electron microscopy(SEM),and fourier transform infrared absorption spectroscopy(FT-IR). Catalytic activity for microalgae oil conversion to methyl ester via transesterification was evaluated and analyzed by GC-MS and GC.BET results showed that the support possessed high specific surface area,suitable pore volume and pore size distribution.Activity results indicated that the catalyst with 25 wt%KOH showed the best activity for microalgae oil conversion.XRD and SEM results revealed that Al-O-K compound was the active phase for microalgae oil conversion.The agglomeration and changing of pore structure should be the main reasons for the catalyst deactivation when KOH content was higher than 30 wt%. | Xiaoyu Zhang Qing Ma Bibo Cheng Jun Wang Jinshan Li Fude Nie | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 7 |
| 5 | Studies of the Genotoxicity of Glycidyl Methacrylate (GMA)显示文摘The following experiments were conducted to evaluate the genotoxic effects of GMA (glycidyl methacrylale) on mammalian and human cells.(1) Using the absorption spectrum shift method in vitro, we observed that the maximums of calf thymus DNA and GMA were shifted toward longer wavelengths (a change of more than 15nm) and the absorbance decreased after incubation at room temperature for 15min or more.The result indicates that binding of DNA and GMA had occurred.The binding force is strong, not affected by the addition of concentrated sodium chloride solution, and only slightly decreased by the addition of 8 M urea solution.Therefore the bond between DNA and GMA might be covalent.(2) In cell cultures, unscheduled DNA synthesis (UDS) in human and/or rat lymphocyte was induced and DNA semiconserva-tive replication was inhibited by GMA at concentrations of less than 5.2 mM.(3) Sperm abnormality tests and assays of UDS in germ cells of male mice were conducted to study the in vivo genotoxicity of GMA.The results revealed that GMA could damage DNA, increase sperm abnormality frequency, and reduce the number of sperm cells, 1990 Academic Press.Inc. | DAYING XIE, WEI ZHANG, LAIFU CAO, WENQING SUN, ZHONGSHENG LI, QING GAO, YILI WU, HUILAN GAO, HUIFANG YANG, JIM ZUO,~* AND FUDE FANG~* Institute oF Occupational Medicine. Chinese Academy ol Preventive Medicine. Beijing 100050. and *Institute of Basic Medical Sciences, Chinese Academy ol Medical Sciences. Beijing 100730, China | 1990 | Biomedical and Environmental Sciences1990，3，3： | 7 |
| 6 | Fragment Propagation and Colonization Ability Enhanced and Varied at Node Level after Escaping from Apical Dominance in Submerged Macrophytes显示文摘Aquatic plants develop strong fragment propagation and colonization ability to endure the natural disturbances. However,detailed research of ability to endure the natural disturbances has been lacking to date. Therefore,reproduction(shoot) and colonization(root) of shoot fragments of Potamogeton crispus L. with or without apices were investigated for the effect of apical dominance,and the growth of decapitated shoot fragments at three lengths(2,4,6 cm) was compared. Meanwhile,fragment propagation at levels of bud position was studied for bud position effect after escaping from apical dominance. The results showed significant increases occurred in the outgrowth of lateral branches on fragments decapitated compared with the fragments with apices,implying that apical dominance exists. Different lengths of fragments showed little difference in biomass allocations,but significant differences were noted in their propagation. Meanwhile,the effect of bud position was verified,due to the significant difference of average reproduction per node among the three length groups. Thus,the present study has made progress in the current understanding of aquatic plant dispersion among natural systems and contributes to improve methods of in vitro propagation for re-implantation purposes. | Jinhui Jiang Shuqing An Changfang Zhou Baohua Guan Zhiyi Sun Ying Cai Fude Liu | 2009 | Journal of Integrative Plant Biology2009，51，3： | 4 |
| 7 | Retinoic acid ameliorates high-fat diet-induced liver steatosis through Sirt1显示文摘In this study, treatment of C57 BL/6 J(wild type, WT) mice fed a high-fat diet(HFD) with retinoic acid(RA) decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular triglyceride and serum alanine transaminase(ALT) and aspartate aminotransferase(AST) concentrations. Moreover, RA treatment improved glucose tolerance and insulin sensitivity in WT mice fed a HFD. However, these RA-induced effects in WT mice fed a HFD were alleviated in liver specific Sirtuin 1(Sirt1) deficient(LKO) mice fed a HFD. Furthermore,RA also could not improve glucose tolerance and insulin sensitivity in LKO mice fed a HFD. The mechanism studies indicated that RA indeed increased the expression of hepatic Sirt1 and superoxide dismutase 2(Sod2), and inhibited the expression of sterol regulatory element binding protein 1 c(Srebp-1 c) in WT mice in vivo and in vitro. RA decreased mitochondrial reactive oxygen species(ROS) production in WT primary hepatocytes and increased mitochondrial DNA(mtDNA) copy number in WT mice liver. However, these RA-mediated molecular effects were also abolished in the liver and primary hepatocytes from LKO mice. In summary, RA protected against HFD-induced hepato steatosis by decreasing Srebp-1 c expression and improving antioxidant capacity through a Sirtl-mediated mechanism. | Chao Geng Haifeng Xu Yinliang Zhang Yong Gao Meixia Li Xiaoyan Liu Mingyue Gao Xiaojuan Wang Xiaojun Liu Fude Fang Yongsheng Chang | 2017 | Science China(Life Sciences)2017，60，11： | 3 |
| 8 | Exploring BH_2CN-based hydrophobic hypergolic fuels and effective fuel“additives”: Imidazolylidene cyanoborane complexes显示文摘Two hydrophobic imidazolylidene-cyanoborane complexes were prepared by the introduction of{BH2 CN} into the molecular formula via treatment of imidazolium iodide and Na BH3 CN avoiding literature's tedious and hazardous procedures. These two complexes were fully characterized using IR spectroscopy,~1 H NMR and^(13)C NMR spectroscopy and high-resolution mass spectrometer. The X-Ray structure of NHC-1 has been determined. NHC-2 was proved to be hypergolic with WFNA and displayed the attractive properties such as water immiscibility, wide liquid range(Tg= -22C), short ignition delay time(13 ms), high density(0.98 g/cm3), good density impulse(r Isp, 347 s g cm^(-3)), showing the promising application potential as a fuel and an efficient fuel additive. | Xingye Li Jiayu Nan Tian Lu Hongyu Huo Yanqiang Zhang Haibo Li Fude Nie Hongquan Yin Fu-Xue Chen | 2018 | Chinese Chemical Letters2018，29，6： | 3 |
| 9 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 10 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 11 | The first-principle study on the equation of state of HMX under high pressure显示文摘The equation of states (EOS) of high energy explosive HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) has been studied by using the first principle method. Our results include the lattice constants, elastic constants, and the dependence of total energy and pressure on volume for βand δ-HMX. The calculated elastic constants and the pressure-volume relationship of β-HMX are also compared with the experimental values. The theoretical tensile experiments are implemented on the β-HMX. The atomic-scale analysis displays that the fracture originates from the intermolecule of HMX and is possibly due to the weak interaction of intermolecules. | CHEN Jun LONG Yao LIU YongGang NIE FuDe SUN JinShan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，5： | 2 |
| 12 | Symmetry Reductions, Integrability and Solitary Wave Solutions to High-Order Modified Boussinesq Equations with Damping Term显示文摘Both the direct method due to Clarkson and Kruskal and the improved direct method due to Lou are extended to reduce the high-order modified Boussinesq equation with the damping term (HMBEDT) arising in the general Fermi-Pasta-Ulam model. As a result, several types of similarity reductions are obtained. It is easy to show that the nonlinear wave equation is not integrable under the sense of AblowRz's conjecture from the reduction results obtained. In addition, kink-shaped solitary wave solutions, which are of important physical significance, are found for HMBEDT based on the obtained reduction equation. | YAN ZhenYa XIE FuDing ZHANG HongQing | 2001 | Communications in Theoretical Physics2001，，7： | 2 |
| 13 | Effective electromagnetic and chiral parameters of chiral composite material显示文摘 | Fuding Ge Jing Zhu Limin Chen | 1996 | International Journal of Infrared and Millimeter Waves1996，17，2： | 1 |
| 14 | Reduction of Cr (VI) by a consortium of sulfate-reducing bacteria (SRBIII) 显示文摘 | FUDE L HARRIS B URRUTIA M M | 1994 | Appl Environ Microbiol1994，60，5： | 1 |
| 15 | Characteristics of water isotopes and hydrograph separation during the wet season in the Heishui River, China显示文摘 | Yuhong Liu Ningjiang Fan Shuqing An Xiaohua Bai Fude Liu Zhen Xu Zhongsheng Wang Shirong Liu | 2008 | Journal of Hydrology2008，，3： | 1 |
| 16 | Design of sustained-release nitrendipine microspheres having solid dispersion structure by quasi-emulsion solvent diffusion method显示文摘 | Fude Cui Mingshi Yang Yanyan Jiang | 2003 | Journal of Controlled Release2003，97，3： | 1 |
| 17 | Cationic conjugated polymers for optical detection of DNA methylation, lesions, and single nucleotide polymor- phisms 显示文摘 | Duan Xinrui Liu Libing Feng Fude | 2010 | Acc Chem Res2010，43，2： | 1 |
| 18 | Research on activity characteristics on composite cementitious materials based on phosphogypsum显示文摘 | Fuding M Jiaojiao H Zude L | 2012 | Procedia Engineering2012，43，： | 1 |
| 19 | Reflection characteristics of chiral microwave absorbing coatings显示文摘 | Fuding Ge Limin Chen Jing Zhu | 1996 | International Journal of Infrared and Millimeter Waves1996，17，1： | 1 |
| 20 | Fracture and tension properties of roller compacted concrete cores in u- niaxial tension显示文摘 | LI Qingbin ZHANG Fude ZHANG Wencui | 2002 | Journal of Materials in Civil Engineering2002，14，5： | 1 |
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