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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Machining deformation of single-sided component based on finishing allowance optimization显示文摘Owing to reliability and high strength-to-weight ratio,large thin-walled components are widely used in the aviation and aerospace industry.Due to the complex features and sequence involved in the machining process of large thin-walled components,machining deformation of component is easy to exceed the specification.In order to address the problem,it is important to retain the appropriate finishing allowance.To find the overall machining deformation,finishing allowance-induced deformation(web finishing allowance,sidewall finishing allowance)and initial residual stress-induced deformation were considered as major factors.Meanwhile,machined surface residual stress-induced deformation,clamping stress-induced deformation,thermal deformation,gravity-induced deformation and inertial force-induced deformation were neglected in the optimization model.Six-peak Gaussian function was introduced to fit the initial residual stress.Based upon the obtained function of initial residual stress,a deformation prediction model between initial residual stress and finishing allowance was established to attain the finishing allowanceinduced deformation.In addition,linear programming optimization model based on the simplex algorithm was developed to optimize the overall machining deformation.Results have concluded that the overall machining deformation reached the minimum value when sidewall finishing allowance and web finishing allowance varied between 1 and 2 mm.Additionally,web finishing allowance-induced deformation and sidewall finishing allowance-induced deformation were1.05 mm and 0.7 mm.Furthermore,the machining deformation decreased to 0.3–0.38 mm with the application of optimized finishing allowance allocation strategy,which made 39–56%reduction of the overall machining deformation compared to that in conventional method. | Xiaoyue LI Liang LI Yinfei YANG Guolong ZHAO Ning HE Xiaocen DING Yaowen SHI Longxin FAN Hui LAN Muhammad JAMIL | 2020 | Chinese Journal of Aeronautics2020，33，9： | 6 |
| 3 | Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia显示文摘Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia.However,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures.To clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy controls.The results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical thickness.In the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser extent.Importantly,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right hemisphere.These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness. | Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Study on Cutting Force,Cutting Temperature and Machining Residual Stress in Precision Turning of Pure Iron with Different Grain Sizes显示文摘Pure iron is one of the difficult-to-machine materials due to its large chip deformation,adhesion,work-hardening,and built-up edges formation during machining.This leads to a large workpiece deformation and challenge to meet the required technical indicators.Therefore,under varying the grain size of pure iron,the influence of cutting speed,feed,and depth of cut on the cutting force,heat generation,and machining residual stresses were explored in the turning process to improve the machinability without compromising the mechanical properties of the material.The experimental findings have depicted that the influence of grain size on cutting force in the precision turning process is not apparent.However,the cutting temperature and residual stress of machining fine-grain iron were much smaller than the coarse grain at all levels of cutting parameters. | Yinfei Yang Lu Jin Jinpeng Zhu Jinxing Kong Liang Li | 2020 | Chinese Journal of Mechanical Engineering2020，33，4： | 2 |
| 6 | Energy principle and material removal sequence optimization method in machining of aircraft monolithic parts显示文摘In the machining process of aircraft monolithic parts,the initial residual stress redistribution and structural stiffness evolution often lead to unexpected distortions.On the other hand,the stress redistribution and stiffness reduction during the machining process depend on the material removal sequence.The essence of the stress redistribution is releasing the initial elastic strain energy.In the present study,the influence of the material removal sequence on the energy release is studied.Moreover,a novel optimization method is proposed for the material removal sequence.In order to evaluate the performance of the proposed method,the mechanism of the machining distortion is firstly analyzed based on the energy principle.Then a calculative model for the machining distortion of long beam parts is established accordingly.Moreover,an energy parameter related to the bending distortion and the procedure of the material removal sequence optimization is defined.Finally,the bending distortion analysis and material removal sequence optimization are performed on a long beam with a Z-shaped cross-section.Furthermore,simulation and experiments are carried out.The obtained results indicate that the optimized sequence results in a low distortion fluctuation and decreases the bending distortion. | Yinfei YANG Longxin FAN Liang LI Guolong ZHAO Ning HAN Xiaoyue LI Hui TIAN Ning HE | 2020 | Chinese Journal of Aeronautics2020，33，10： | 2 |
| 7 | A review of monitoring,calculation,and simulation methods for ground subsidence induced by coal mining显示文摘Subsidence data acquisition methods are crucial to mining subsidence research and an essential component of achieving the goal of environmentally friendly coal mining.The origin and history of the existing methods of field monitoring,calcula-tion,and simulation were introduced.It summarized and analyzed the main applications,flaws and solutions,and improve-ments of these methods.Based on this analysis,the future developing directions of subsidence data acquisition methods were prospected and suggested.The subsidence monitoring methods have evolved from conventional ground monitoring to combined methods involving ground-based,space-based,and air-based measurements.While the conventional methods are mature in technology and reliable in accuracy,emerging remote sensing technologies have obvious advantages in terms of reducing field workload and increasing data coverage.However,these remote sensing methods require further technological development to be more suitable for monitoring mining subsidence.The existing subsidence calculation methods have been applied to various geological and mining conditions,and many improvements have already been made.In the future,more attention should be paid to unifying the studies of calculation methods and mechanical principles.The simulation methods are quite dependent on the similarity of the model to the site conditions and are generally used as an auxiliary data source for subsidence studies.The cross-disciplinary studies between subsidence data acquisition methods and other technologies should be given serious consideration,as they can be expected to lead to breakthroughs in areas such as theories,devices,software,and other aspects. | Yinfei Cai Yutian Jin Zuoyang Wang Tao Chen Yaru Wang Weiyu Kong Wu Xiao Xiaojing Li Xugang Lian Haifeng Hu | 2023 | International Journal of Coal Science & Technology2023，10，3： | 0 |
| 8 | Effect of Magnetic Field Technology on Preservation Quality of Fresh-cut Apple显示文摘[Objectives]The paper was to study the effect of magnetic field technology on physicochemical properties of fresh-cut apple during storage.[Methods]Using fresh-cut apples as materials,magnetic field assisted refrigeration and conventional refrigeration control groups were set up,and the preservation effects of magnetic field assisted refrigeration on fresh-cut apples were tested by measuring the changes of microorganisms and physicochemical indicators.In this experiment,the conditions of magnetic field assisted refrigeration group was set as follows:temperature 4℃,magnetic field intensity 5 mT,static magnetic field,and storage for 6 d.[Results]At 6 d post storage,the weight loss rate,total number of colonies and total number of fungi of fresh-cut apples increased;the L value and hardness showed a downward trend;the soluble solid content first increased and then decreased;and the total acid decreased first and then increased.The above indicators in magnetic field assisted refrigeration group changed more gently than that in conventional refrigeration group.Compared with conventional assisted refrigeration,the weight loss rate of fresh-cut apples treated by magnetic field combined with 4℃refrigeration was reduced by 68.00%;the hardness was increased by 12.23%;the total number of colonies and total number of fungi were reduced by 64.15%and 37.50%;and the L value did not change much.High content of soluble solids and total acid was maintained.[Conclusions]Magnetic field assisted refrigeration delays quality deterioration of fresh-cut apples during storage,prolongs shelf life,and further improves their edible quality and commodity value. | Le CHU Jie SHEN Gen LI Ye SONG Yinfei MA Guangpeng LIU Maoyu WU Fatao HE Yan ZHAO | 2023 | Asian Agricultural Research2023，15，3： | 0 |
| 9 | Residual Stress Relaxation of Thin‑walled Long Stringer Made of Aluminum Alloy 7050‑T7451 under Transportation Vibration显示文摘Thin-walled long stringer made of aluminum alloy 7050-T7451 is prone to deformation during transportation,so a research of residual stress relaxation was launched in this paper.The transport resonance stress of long stringer was analyzed based on the power spectral density of road transport acceleration.The residual stress relaxation experiment of aluminum alloy 7050-T7451 under different equivalent stress levels was designed and carried out.According to the amount of residual stress relaxation in the experiment,an analytical model was established with the equivalent stress level coefficient.The deflection range of long stringer was evaluated under different damping ratios.The results show that when the equivalent stress exceeds 0.8σ0.2,the residual stress relaxation of the thin-walled samples occurs.The residual stress relaxation increases linearly with the equivalent stress,which is logarithmically related to the loading cycle.The deformation caused by residual stress relaxation of the long stringer is proportional to the square of the length and the bending moment caused by stress rebalance,and inversely proportional to the moment of inertia of the structure.As the damping ratio decreases from 0.03 to 0.01,the total deflection of the long stringer increases from 0 to above 1.55 mm. | Yinfei Yang Lu Jin Jixing Du Liang Li Wei Yang | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 0 |
| 10 | Mechanochemical transformation of fluorescent hydrogel based on dynamic lanthanide-terpyridine coordination显示文摘As a burgeoning research field, ultrasound-responsive materials have attracted intense interest in healthcare research. However, the basic mechanism of sonochemical effect in the quasi-solid state is far from being well understood than those in the solution. Herein, we showcase mechanochemical transformations of europium(Ⅲ) complexes in a supramolecular hydrogel matrix. With the combination of labile terpyridine-europium complexes(TPY-Eu^(3+)) as mechanochromic moieties and an ultrasound-responsive fluorogen(URF) as a molecular tweezer, the hydrogel produces a notable fluorescence change in response to ultrasound. The mechanochemical transformation was elucidated by molecular dynamics(MD) simulations, and fully probed and evidenced by electrochemical experiments, X-ray photoelectron spectroscopy(XPS), and attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopy. | Guangqiang Yin Jianxiang Huang Depeng Liu Rui Li Shuxin Wei Muqing Si Feng Ni Yinfei Zheng Qiu Yang Ruhong Zhou Xiaoxia Le Wei Lu Tao Chen | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
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