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| 1 | New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2显示文摘The 2004 discovery of EGFR mutations,followed by ALK rearrangements,ushered in a targeted therapy era for advanced non-small cell lung cancer(NSCLC).Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with NSCLC.In the last decade,rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted strategies.Recent genome studies of lung adenocarcinoma have identified other possible therapeutic targets,including RET,NTRK fusions,c-MET alterations,and activating mutations in KRAS,BRAF,and HER2,all with frequencies greater than 1%.Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical development.This review updates the therapeutic arsenal that especially targets those genes. | Maria Eugenia Olmedo Raquel Cervera Luis Cabezon-Gutierrez Yolanda Lage Elena Corral de la Fuente Ana Gomez Rueda1,Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，4： | 3 |
| 2 | Identification and characterization of potentially algal-lytic marine bacteria strongly associated with the toxic Dinoflagellate alexandrium catenella 显示文摘 | Ana M Amaro Mafia S Fuentes Sandra R Ogalde | 2005 | Eukaryot Microbiol2005，52，3： | 1 |
| 3 | Ecotoxicity, phytotoxicity and extractability of heavy metals from different stabilised sewage sludges显示文摘 | Fuentes Ana Mercedes Llorens Jose Saez | 2006 | Environmental Pollution2006，143，： | 1 |
| 4 | Knowledge acquisition and corporate entrepreneurship:insights from spanish smes in the ict sector显示文摘 | Ana M Bojica Mariadel M F Fuentes | | 0，，02： | 1 |
| 5 | Ecotoxicity,phytotoxicity and extractability of heavy metals from different stabilised sewage sludges显示文摘 | Fuentes Ana Mercedes Llorens Jose Saez | 2006 | Environmental Pollution2006，143，： | 1 |
| 6 | Inhibitory processing in visuospatial attention in healthy adults and schizophrenic patients显示文摘 | Luis J. Fuentes Muriel Boucart Roberto Alvarez Ana B. Vivas Marie A. Zimmerman | 1999 | Schizophrenia Research1999，，1： | 1 |
| 7 | Strategic Flexibility and Change: The Impact of Social Networks显示文摘 | Virginia Ferndndez - Prrez Maria del Mar Fuentes - Fuentes Ana Bojica | 2012 | Journal of Management & Organization2012，18，1： | 1 |
| 8 | Phytotoxicity and heavy metals speciation of stabilized sewage sludges 显示文摘 | Ana Fuentes Mercedes Llorans Jose Saez | 2004 | Jounal of Hazardous Materials2004，108，： | 1 |
| 9 | Differentiation between fresh and frozen-thawed sea bream ( Sparus aurata ) using impedance spectroscopy techniques显示文摘 | Ana Fuentes Rafael Masot Isabel Fernández-Segovia María Ruiz-Rico Miguel Alca?iz José M. Barat | 2013 | Innovative Food Science and Emerging Technologies2013，，： | 1 |
| 10 | Knowl- edge acquisition and corporate entrepreneurship: Insights from Spanish SMEs in the ICT sector 显示文摘 | Ana Maria Bojica Maria del Mar Fuentes Fuentes | 2012 | Journal of World Business2012，，47： | 1 |
| 11 | Inhibitory tagging in inhibition of return:evidence from flanker interference with multiple distractor features显示文摘 | Ana B Vivas Luis J Fuentes Angeles F Estevez | 2007 | Psychonomic Bulletin & Review2007，14，2： | 1 |
| 12 | Hematoma hepático subcapsular secundario al empleo de una guía hidrofílica durante una colangiopancreatografía retrógrada endoscópica显示文摘 | Carlos de la Serna-Higuera Ana Fuentes Coronel Santiago J. Rodríguez gómez María Isabel Martín Arribas | 2008 | Gastroenterologia y Hepatologia2008，，4： | 1 |
| 13 | Prior knowledge and social networks in the exploitation of entrepreneurial opportunities显示文摘 | María del Mar Fuentes Fuentes Matilde Ruiz Arroyo Ana María Bojica Virginia Fernández Pérez | 2010 | International Entrepreneurship and Management Journal2010，，4： | 1 |
| 14 | Knowledge acquisition and corporate entrepreneurship:Insights from Spanish SMEs in the ICT sector显示文摘 | Ana Maria Bojica Maria del Mar Fuentes Fuentes | | 0，，47： | 1 |
| 15 | Use of the voltammetric tongue in fresh cod ( Gadus morhua ) quality assessment显示文摘 | María Ruiz-Rico Ana Fuentes Rafael Masot Miguel Alca?iz Isabel Fernández-Segovia José Manuel Barat | 2013 | Innovative Food Science and Emerging Technologies2013，，： | 1 |
| 16 | Hepatitis C virus NS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment显示文摘AIM To determine the number of mutations in the NS5 A region of the hepatitis C virus(HCV) and its relationship to the response to antiviral therapy in patients with chronic hepatitis C genotype 1 who are non-responders to two or more treatments. METHODS Sequences within HCV NS5 A [PKR binding domain(PKRBD) and the interferon-sensitivity-determining region(ISDR)] were analysed via direct sequencing in a selected cohort of 72 patients, with a total of 201 treatments [interferon-alpha(IFN-α), n = 49; IFN-α + ribavirin(RBV), n = 75; pegylated(peg) IFN-α + RBV, n = 47; first-generation direct-acting antivirals(DAAs), n = 13; and second-generation DAAs, n = 17]. Of these, 48/201 achieved a sustained virological response(SVR) and 153/201 achieved no virological response(NVR).RESULTS For both regions, treatments resulting in SVR were associated with more baseline mutations than were treatments resulting in NVR(SVR vs NVR; PKRBD: 5.82 ± 3 vs 4.86 ± 2 mutations, P = 0.045; ISDR: 2.65 ± 2 vs 1.51 ± 1.7 mutations, P = 0.005). A decrease or no change in the number of mutations over time between treatments in the PKRBD or ISDR, as shown by sequencing, was associated with patients who usually failed to respond to treatment(PKRBD, P = 0.02; ISDR, P = 0.001). Moreover, patients showing a post-treatment baseline viral load > 600000 IU/m L and increased ISDR mutations with respect to the previous treatment were 9.21 times more likely to achieve SVR(P = 0.001). CONCLUSION The obtained results show that among patients who have shown no response to two or more antiviral treatments, the likelihood of achieving SVR increases with the genetic variability in the ISDR region(≥ 2 mutations or number of substitutions from the HCV-J and HCV-1 prototype), especially when the viral load is greater than 600000 IU/m L. | Paloma Munoz de Rueda José Manuel Fuentes RodríguezRosa Quiles Pérez Ana Gila Medina Ana Belén Martínálvarez Jorge Casado Ruíz ángeles Ruíz Extremera Javier Salmerón | 2017 | World Journal of Gastroenterology2017，23，25： | 0 |
| 17 | Acceptance of living liver donation among medical students: A multicenter stratified study from Spain显示文摘AIM: To analyze the attitude of Spanish medical students toward living liver donation(LLD) and to establish which factors have an influence on this attitude.METHODS: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain(n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire(PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student′s t test, χ2 test and logistic regression analysis.RESULTS: The completion rate was 95.7%(n = 9275). 89%(n = 8258) were in favor of related LLD, and 32%(n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude:(1) age(P = 0.008);(2) sex(P < 0.001);(3) academic year(P < 0.001);(4) geographical area(P = 0.013);(5) believing in the possibility of needing a transplant oneself in the future(P < 0.001);(6) attitude toward deceased donation(P < 0.001);(7) attitude toward living kidney donation(P < 0.001);(8) acceptance of a donated liver segment from a family member if one were needed(P < 0.001);(9) having discussed the subject with one's family(P < 0.001) and friends(P < 0.001);(10) a partner's opinion about the subject(P < 0.001);(11) carrying out activities of an altruistic nature; and(12) fear of the possible mutilation of the body after donation(P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD. | Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla | 2016 | World Journal of Gastroenterology2016，22，25： | 0 |
| 18 | Evaluation of patient visual comfort and repeatability of refractive values in non-presbyopic healthy eyes显示文摘AIM: To evaluate the intra-operator repeatability in healthy subjects using the WAM-5500 auto-kerato/refractometer and the i Trace aberrometer, to compare the refractive values and the subjective refraction obtained with both devices and to determine which of these three spherocylindrical corrections allows the subject to achieve the best visual comfort.·METHODS: Forty-two non-presbyopic healthy eyes of42 subjects were enrolled in this prospective study.Refractive values were compared, evaluating the repeatability, the relationship between the methods and the best visual comfort obtained.·RESULTS: Sphere, cylinder and axis results showed good intraclass correlation coefficients(ICC); the highest ICC was obtained using the spherical refraction with the autorefractometer and the aberrometer, achieving levels of 0.999 and 0.998, respectively. The power vector(PV)was calculated for each refraction method, and the results indicated that there were no statistically significant differences between them(P >0.05). Direct comparison of PV measurements using the three methods showed that aberrometer refraction gave the highest values, followed by the subjective values; the autorefractometer gave the lowest values. The subjective method correction was most frequently chosen as the first selection. Equal values were found for theautorefractometer and the aberrometer as the second selection.·CONCLUSION: The i Trace aberrometer and the WAM-5500 auto-kerato/refractometer showed high levels of repeatability in healthy eyes. Refractive corrections with the aberrometer, the autorefractometer and subjective methods presented similar results, but spherocylindrical subjective correction was the most frequently selected option. These technologies can be used as complements in refractive evaluation, but they should not replace subjective refraction. | Francisco Segura Ana Sanchez-Cano Carmen Lopez de la Fuente Lorena Fuentes-Broto Isabel Pinilla | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 0 |
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