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| 1 | Recent advances in fermentative biohydrogen production显示文摘Hydrogen energy, as a kind of clean energy with great potential, has been a hotspot for study worldwide. Based on the recent research on biohydrogen production, this paper gives a brief review on the following aspects: fermentative hydrogen production process and the engineering control statagy, key factors affecting the effciency of hydrogen production, such as substrates, cysteine, metal ions, anaerobic fermentation terminal products, and formic acid and ammonia. Moreover, anaerobic fermentative hydrogen-producing strain and reg- ulation and control of enzyme gene in fermentative hydrogen production are also discussed. Finally, the prospect of anaerobic fermen- tative biohydrogen production is proposed in three study areas, namely developing new techniques for breeding hydrogen-producing bacteria, exploitations of more strains and gene resources, and intensifying the application of microbial molecular breeding in hydrogen production. | Xuemei Liu Nanqi Ren Funan Song Chuanping Yang Aijie Wang | 2008 | Progress in Natural Science:Materials International2008，18，3： | 4 |
| 2 | Emerging systemic delivery strategies of oncolytic viruses:A key step toward cancer immunotherapy显示文摘Oncolytic virotherapy(OVT)is a novel type of immunotherapy that induces anti-tumor responses through selective self-replication within cancer cells and oncolytic virus(OV)-mediated immunostimulation.Notably,talimogene laherparepvec(T-Vec)developed by the Amgen company in 2015,is the first FDA-approved OV product to be administered via intratumoral injection and has been the most successful OVT treatment.However,the systemic administration of OVs still faces huge challenges,including in vivo pre-existing neutralizing antibodies and poor targeting delivery efficacy.Recently,state-of-the-art progress has been made in the development of systemic delivery of OVs,which demonstrates a promising step toward broadening the scope of cancer immunotherapy and improving the clinical efficacy of OV delivery.Herein,this review describes the general characteristics of OVs,focusing on the action mechanisms of OVs as well as the advantages and disadvantages of OVT.The emerging multiple systemic administration approaches of OVs are summarized in the past five years.In addition,the combination treatments between OVT and traditional therapies(chemotherapy,thermotherapy,immunotherapy,and radiotherapy,etc.)are highlighted.Last but not least,the future prospects and challenges of OVT are also discussed,with the aim of facilitating medical researchers to extensively apply the OVT in the cancer therapy. | Weiyue Ban Jianhuan Guan Hanwei Huang Zhonggui He Mengchi Sun Funan Liu Jin Sun | 2022 | Nano Research2022，15，5： | 2 |
| 3 | An active - site peptide containing the second essential carboxyl group of dextransucrase from Leuconostoc mesenteroides by chemical modification et al显示文摘 | masakazu Shiraiwa Kenya Hashimoto | 1993 | Biochemistry1993，32，13： | 1 |
| 4 | Extracellular production of cycloisomaltooligosaccharide glucanotransferase and cyclodextran by a protease-deficient Bacillus subtilis host-vector system 显示文摘 | Kawabata Y Kimura K Funane K | 2012 | Appl Microbiol Biotechnol2012，93，5： | 1 |
| 5 | Water-soluble and water-insoluble glucans produced by Escherichia coli recombinant dextransucrases from Leuconostoc mesenteroides NRRL B-512F 显示文摘 | Funane K Ishii T Matsushita M | 2001 | Carbohydr Res2001，334，1： | 1 |
| 6 | Chemiluminescence microfluidic system sensor on a chip fordetermination of glucose in human serum with immobilized reagents 显示文摘 | Lv Yi Zhang Zhujun Chen Funan | 2003 | Talanta2003，59，3： | 1 |
| 7 | Quantitative evaluation of deep and shallow tissue layers contribution to fNIRS signal using multi-distance optodes and independent component analysis显示文摘 | FUNANE T ATSUMORI H KATURA T | 2014 | Neuroimage2014，85，1： | 1 |
| 8 | A novel cyclic isomaltnoligosaccbaride (cyeloisomaltnde- caose,CI-10)produced by Bacillus circulans T-3040 displays remarkable inclusion ability compared with cy- clodextrins显示文摘 | Kazumi Funane Kazue Terasawa Yasuko Mizuno | 2007 | Journal of Biotechnology2007，130，： | 1 |
| 9 | Syn- chronous activity of two people's prefrontal cortices during a cooperative task measured by simultaneous near-infrared spectroscopy 显示文摘 | FUNANE T KIGUCH1 M ATSUMOR1 H | 2011 | J Biomed Opt2011，16，07： | 1 |
| 10 | Development of a rifampicin-resistant Bacillus subtilis strain for natto-fermentation showing enhanced exoenzyme production显示文摘 | Yuji Kubo Takashi Inaoka Tsuyoshi Hachiya Masayuki Miyake Sumitaka Hase Rikio Nakagawa Hiromasa Hasegawa Kazumi Funane Yasubumi Sakakibara Keitarou Kimura | 2013 | Journal of Bioscience and Bioengineering2013，，6： | 1 |
| 11 | Corrosion Behavior of AZ91D Magnesium Alloy in Three Different Physiological Environments显示文摘 | Juncen Zhou Qing Li Haixiao Zhang Funan Chen | 2014 | Journal of Materials Engineering and Performance2014，，1： | 1 |
| 12 | An active-site peptide containing the second essential carboxyl group of dextransucrase from Leuconostoc mesenteroides by chemical modifications 显示文摘 | Funane K Shiraiwa M Hashimoto K | 1993 | Biochemistry1993，1432，13： | 1 |
| 13 | Modulation of ATP levels alters the of hydrogen peroxide induced cell death in primary cortical cultures:effects of putative neurprective agents显示文摘 | Funan Huang Mohan C Vemuri J S Schneider | 2004 | Brain Research2004，997，： | 1 |
| 14 | A Preliminary Analysis of Geologic & Seismologic Conditions for an Undersea Tunnel across the Taiwan Strait显示文摘The Taiwan Strait tunnel, as a great project, has been studied for a long time and met many challenges from the beginning of the feasibility study that has attracted attention among scientists and engineers on both sides of the Taiwan Strait and around the world as well. The key question is whether this undersea tunnel can be constructed with present technologies under such complex geologic and seismologic conditions. Results of current researches indicate that the sea floor of the Strait is covered with a horizontal layer composed of both the Pleistocene and the Holocene sandstone and shale with a thickness of about 200~300 m, without any large fault belt or fold.This can serve as a good bearing and impermeable layer for constructing such an undersea tunnel. The Penghu Islands and Penghu terrace, which are composed of hard basaltic rock over a wide area of 70 km (NS)×40 km (EW), might be connected each othar by a bridge instead of an undersea tunnel, and serve as a construction site. Although there are several geologic units separated by faults under the upper horizontal layer, these faults do not cut through the upper layer. Only the NE offshore fault along the Fujian coast and that along the west coast of Taiwan should be noticed, between which a suspension tunnel instead of an undersea tunnel can be constructed. Therefore it is judged that the tunnel beginning from Amoy, through the Jinmen Island and the Penghu Islands to the Peigang harbour is worth recommendation. | Peng Funan 1, Ye Yincan 1,Qi Xiaojun 2 (1. Second Institute of Oceanography, SOA, Hangzhou 310012) (2. Hydro electric Engineering Department, Tsinghua University, Beijing 100084) | 2003 | 工程科学(英文版)2003，1，1： | 1 |
| 15 | Microdialysis sampling and high-performance liquid chromatography with chemiluminescence detection for in-vivo on-line determination and study of the pharmacokineties of levodopa in blood显示文摘 | Funan C Zhujun Z Yingxue Z | 2005 | Anal Bioanal Chain2005，382，1： | 1 |
| 16 | Development of a rifampicin-resislant Bacillus suhtihs strain for natto-fermentation showing enhanced exoenzyme production 显示文摘 | Kubo Y lnaoka T Ilachiya T Miyake M Hase S Nakagawa R Hasegawa tt Funane K Sakakibara Y Kimura K | 2013 | Journal of Bioscience and Bioengineering2013，115，6： | 1 |
| 17 | Synchronous activity of two people ' s prefrontal cortices during a cooperative task measured by simultaneous near-infrared spectroscopy显示文摘 | Funane T Kiguchi M Atsumori H | 2011 | Journal of Biomedical Optics2011，16，7： | 1 |
| 18 | Microdialysis sampling and high-performance liquid chromatography with chemiluminescence detection for invivo on-line determination and study of the pharmacokinetics of levodopa in blood显示文摘 | Funan Chen Zhujun Zhang Yingxue Zhang | 2005 | Anal Bio Chem2005，382，1： | 1 |
| 19 | Effects of lead exposure on proliferation and differentiation of neural stern cells derived from different regions of embryonic rat brain显示文摘 | Funan H Schneider JS | 2004 | Neuro Toxicology2004，25，6： | 1 |
| 20 | Modulation of ATP levels alters the hydrogen peroxide - induced cell death in primary- cortical cultures:effects of putative neurprotective agents 显示文摘 | Funan Huang Mohan C Vemuri J SSchneider | 2004 | Brain Res2004，997，： | 1 |
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