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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Numerical simulation of sloshing waves in a 3D tank based on a finite element method显示文摘 | Wu G X Ma Q W Taylor R E | 1998 | Applied Ocean Research1998，20，： | 1 |
| 5 | Nitrogen and phos- phorus remediation by three floating aquatic macrophytes in green- house-based laboratory-scale subsurface constructed wetlands 显示文摘 | Polomski R F Taylor M D Bielenberg D G | 2009 | Water Air Soil Pollution2009，197，14： | 1 |
| 6 | Is Z- disk degradation responsible for postmortem tenderiza- tion显示文摘 | Taylor R G Geesink G H Thompson V F | 1995 | Journal of Animal Science1995，73，4： | 1 |
| 7 | Comprehensive system-level Optimization of thermoelectric devices for electronic cooling applications 显示文摘 | TAYLOR R A SOLBREKKEN G L | 2008 | Trans Comport Packg Technol2008，31，1： | 1 |
| 8 | Cysteine protease activity in the wall of abdominal aortic aneurysms显示文摘 | Abisi S Burnand K G Waltham M Humphries J Taylor P R Smith A | 2007 | J Vasc Surg2007，46，： | 1 |
| 9 | Nitrogen and phosphorus remediation by three floating aquatic macrophytesin greenhouse based laboratory-scale subsurface constructed wet- lands显示文摘 | POLOMSKI R F TAYLOR M D BIELENBERG D G | 2009 | WaterAir and Soil Pollution2009，197，14： | 1 |
| 10 | Composition and mierostructure of 20-year-old ordinary Portland cement-ground granulated blast-furnace slag blends containing 0 to 100% slag 显示文摘 | TAYLOR R RICHARDSON I G BRYDSON R M D | 2010 | Cem Coner Res2010，40，7： | 1 |
| 11 | The demand for wine tourism in canyon County,Idaho显示文摘 | Taylor R G Woodall S Wandschneider P Foltz J | 2004 | International Food and Agribusiness Management Review2004，，7： | 1 |
| 12 | Geochemical and mineral magnetic characterization of urban sediment particulates,Manchester,UK显示文摘 | Robertson D J Taylor K G Hoon S R | 2003 | Applied Geochemistry2003，18，2： | 1 |
| 13 | A communi- ty-based exercise and education scheme for stroke survi- vors: a randomized controlled trial and economic evaluation 显示文摘 | Harrington R Taylor G Hollinghurst S | 2010 | Clin Rehabil2010，24，1： | 1 |
| 14 | Robust statistical modelling using the t distribution显示文摘 | Lange K L Little R J A Taylor J M G | 1989 | Journal of American Statistical Association1989，84，： | 1 |
| 15 | Wave diffraction from linear arrays of cylinders 显示文摘 | Walker D A G Eatoek Taylor R | 2005 | Ocean Engineering2005，32，1718： | 1 |
| 16 | Regulation of the G2/M transition by p53显示文摘 | Taylor W R Stark G R | 2001 | Oneogene2001，20，15： | 1 |
| 17 | Gestational weight gain and adverse pregnancy outcomes in a nulliparous cohort 显示文摘 | Chung J G Taylor R S Thompson J M | 2013 | Eur J Obstet Gynecol Reprod Biol2013，167，2： | 1 |
| 18 | Direct photoaffinity labeling by dolastatin 10 of the amino terminal peptide of beta tubulin containing cysteine 12显示文摘 | Bai R Covell D G Taylor G F | 2004 | J Bio Chem2004，279，30： | 1 |
| 19 | Tuning fuzzy ship autopilots using artificial neural networks显示文摘 | Sutton R Rdserts G N Taylor D H | 1997 | Trans Inst Meas Contr1997，19，2： | 1 |
| 20 | Adaptive regulation of nonlinear systems with unmodeled dynamics 显示文摘 | TAYLOR D G KOKOTOVIC P V MARINO R | 1989 | IEEE Trans on Automatic Control1989，34，4： | 1 |
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