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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Freeze drying of pharmaceutical excipients close to collapse temperature:Influence of the process conditions on process time and product quality显示文摘 | ANTONELLO A B SABRINA G DAVIDE F | 2009 | Drying Technology2009，27，： | 1 |
| 3 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 4 | Synthesis,redox behaviourand X-Ray structure of bis-TTF containing a pyridineunit as a potential building block in the construction ofconducting magnetic materials显示文摘 | Sabrina B Katel H Stéphane G | 2003 | New J Chem2003，27，： | 1 |
| 5 | CMOS active pixel image sensors for highly integrated imaging systems 显示文摘 | SUNETRA K M SABRINA E K RUSSELL C G | 1997 | IEEE Journal of Solidstate Circuits1997，32，2： | 1 |
| 6 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 7 | Tyrosine pbosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells显示文摘 | Vinicio C Massimo P Sabrina G | 2000 | Hepatol2000，31，1： | 1 |
| 8 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 9 | Aesthetic coatings for silver based alloys with improved protection efficiency 显示文摘 | Sabrina G Emma A Yangwu Mao | 2011 | Prog Org Coat2011，72，12： | 1 |
| 10 | Identification and quantification of six major c-dicarbonyl process contaminants in high-fructose corn syrup显示文摘 | Sabrina G Mittelmaier S Marcus A | 2012 | Analytical and Bioanalytical Chemistry2012，403，： | 1 |
| 11 | Development of a 5- plex SILAC Methodtuned for the quantitation of tyrosine phosphorylation dynamics 显示文摘 | Manuel T Sabrina G David A | 2013 | Mol Cell Proteomics2013，12，： | 1 |
| 12 | Shape reasoning on mis-egmented and mis-abeled objects using approximated fisher eriterion显示文摘 | Herv G Sabrina T Paseale G | 2006 | Computers and Graphics2006，30，2： | 1 |
| 13 | Freeze Drying of Pharmaceutical Excipients close to collapse temperature: Influence of the process conditions on process time and product quality, Drying Technology 显示文摘 | Antonello A B G Sabrina F Davide P Roberto | 2009 | (27): 805-8162009，，27： | 1 |
| 14 | Deletion of a 5 - cM rgion at chromosome 8p23 is associated with a spectrum of congenital heart defects显示文摘 | Sabrina G Sharon L G Giorgio G | 2000 | Circulation2000，102，： | 1 |
| 15 | Strangers help friends to communicate in opportunistic networks显示文摘 | Sabrina G Elena P and Gian P R | | 0，，18： | 1 |
| 16 | Expecting ankle tilts and wearing an ankle brace influence joint control in an imita- ted ankle sprain mechanism during walking 显示文摘 | Dominic G Sabrina W Heinz L | 2014 | Gait & Pos- ture2014，39，： | 1 |
| 17 | Detection of trace levels of atrazine using surface-enhanced Raman scattering and information visualization显示文摘 | Rafael J G Sabrina A C Pedro H B | 2014 | Colloid and Polymer Science2014，292，： | 1 |
| 18 | Shape reasoning on mis-segmented and mis-labeled objects using approximated Fisher criterion显示文摘 | HERVE G SABRINA T PASCALE G | 2006 | Computers & Graphics2006，30，2： | 1 |
| 19 | CXCR3 and its binding chemokines in myeloma cells:expression of isoforms and potential relationships with myeloma cell proliferation and survival显示文摘 | Nicola G Sabrina B Paola R | 2006 | Haematologica2006，91，11： | 1 |
| 20 | CMOS ac- tive pixel image sensors for highly integrated imaging sys- tems显示文摘 | SUNETRA K M SABRINA E K RUSSELL C G | 1997 | IEEE Journal OFSOLID-STATE Circuits1997，32，2： | 1 |
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