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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Transplacental uptake of glucose is decreased in embryonic lethal connexin 26 - deficient mice显示文摘 | Gabriel H - D Jung D Butzler C | 2008 | J Cell Biol2008，140，： | 1 |
| 4 | Pulmonaryhypertension and cor pulmonale显示文摘 | Henk C B Gabriel H Fleischmann D | 1997 | Radiology1997，37，5： | 1 |
| 5 | Apoptosis in u- terine epithelium and decidua in response to implantation:evidence for two different pathways 显示文摘 | JOSWIG A GABRIEL H D KIBSCHULL M | 2003 | Reprod Biol Endocrinol2003，1，1： | 1 |
| 6 | Monitoring intravascular volumes for postoperative volume therapy 显示文摘 | Brock H Gabriel C Bibl D | 2002 | Enr J Anaesthesiol2002，19，4： | 1 |
| 7 | Exercise endurance and fuel utilization: a reevaluation of the effects of fasting显示文摘 | KOUBI H E DESPLANCHES D GABRIELLE C | 1991 | J Appl Physiol1991，70，3： | 1 |
| 8 | Hysteretic current-voltage characteristics in RF-sputtered nanocrystalline TiO2 thin films显示文摘 | Manuel V Gabriel J Silvia P D H | | 0，，： | 1 |
| 9 | Enhancement of connexin 43 expression increases proliferation and differentiation of an osteoblast-like cell line显示文摘 | Gramsch B Gabriel H D Wiemann M | 2001 | Exp Cell Res2001，264，2： | 1 |
| 10 | Short-course antiretroviral therapy in primary HIV infection 显示文摘 | SPARTAC Trial Investigators Fidler S Porter K Ewings F Frater J Ramjee G Cooper D Rees H Fisher M Schechter M Kaleebu P Tambussi G Kinloch S Miro JM Kelleher A McClure M Kaye S Gabriel M Phillips R Weber J Babiker A | 2013 | N Engl J Med2013，368，3： | 1 |
| 11 | Dental and oral anomalies in incontinentia pigmenti: a systematic review显示文摘 | Minic S Trpinac D Gabriel H | 2013 | Clin Oral Invest2013，17，1： | 1 |
| 12 | Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus显示文摘 | Gabriel G Herwig A Klenk H D | 2008 | PLoS Pathog2008，4，： | 1 |
| 13 | Emergence of Zaire ebola virus disease in Guinea-Preliminary report 显示文摘 | Baize S Pannetier D Oestereich L Rieger T Koivogui L Magassouba N Soropogui B Sow MS Keita S De Clerck H Tiffany A Dominguez G Loua M Traore A Kolie M Malano ER Heleze E Bocquin A Mely S Raoul H Caro V Cadar D Gabriel M Pahlmann M Tappe D Schmidt- Chanasit J Impouma B Diallo AK Formenty P Van Herp M G/inther S | 2014 | N Engl J Med2014，371，15： | 1 |
| 14 | Dental and oral anomalies in incontinentia pigmenti: a systematic review显示文摘 | Mini6 S Trpinac D Gabriel H | 2013 | Clin Oral Investig2013，17，1： | 1 |
| 15 | Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse显示文摘 | GABRIEL B DENSCHLAG D GOBEL H | 2005 | Int Urogynecol J Pelvic Floor Dysfunct2005，16，6： | 1 |
| 16 | Soil-water characteristic curves of gap-graded soils显示文摘 | Rahardjo H Satyanaga A D' Amore Gabriele A R | | Engineering Geology0，，： | 1 |
| 17 | Effect of different dietary levels of natural-source vitamin E in grow-finish pigs on pork quality and shelf life显示文摘 | Boler D D Gabriel S R Yang H | | 0，，04： | 1 |
| 18 | Murine mast cells synthesis basement membrane components:a potential role in early fibrosis显示文摘 | Thompson H L Bubelo P D Gabriel G | 1991 | J Clin Invest1991，87，2： | 1 |
| 19 | Emergence of Zaire Ebola virus disease in Guinea 显示文摘 | Baize S Pannetier D Oestereich L Rieger T Koivogui L Magassouba N Soropogui B Sow MS Keita S De Clerck H Tiffany A Dominguez G Loua M Traore A Kolie M Malano ER Heleze E Bocquin A Mely S Raoul H Caro V Cadar D Gabriel M Pahlmann M Tappe D Schmidt- Chanasit J Impouma B Diallo AK Formenty P Van Herp M Gtinther S | 2014 | N Engl J Med2014，371，15： | 1 |
| 20 | Study of the behaviour of Lactobacillus plantarum and Leuconostoc starters during a complete wheat sourdough breadmaking process显示文摘 | ROBERT H GABRIEL V LEFEBVRE D | 2006 | LWT2006，39，： | 1 |
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