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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | An Antifungal Tetrapeptide from the culture of Penicillium canescens 显示文摘 | Brenda V B Nora I P Gabriela M C | 2009 | Chem Biod2009，6，8： | 1 |
| 3 | Mismatch Negativ ity (MMN) response studies in elderly subjects显示文摘 | Gabriela B Marcella BB Cristiane F | 2009 | Braz J Otorhinolaryngol2009，75，： | 1 |
| 4 | Starch fractions as examples for nonrandomly branched marcromolecules(3): Angular dependence in static light scattering显示文摘 | GABRIELA G WALTHER B | 1997 | Macromolecules1997，30，： | 1 |
| 5 | Role of Bcl-2 Immunohistochemical Expression As An Independent Bi- ological Prognostic Marker At Diagnosis of Classical Hodgkin's Lymphoma 显示文摘 | Leyre B Gabriela R M Pascual B | 2011 | Blood ( ASHAnnual Meeting Abstracts)2011，11，8： | 1 |
| 6 | Hexagonal sodium yttrium fluoride based green and blue emitting upconversion phosphors显示文摘 | Karl W K Daniel B Gabriela | | 0，，07： | 1 |
| 7 | Hydrogenation of sunflower oil over different palladium supported catalysts: activity and selectivity 显示文摘 | Maria B Femandez Jhon F Sdnchez M Gabriela M Tonetto | 2009 | Chemical Engineering Journal2009，155，： | 1 |
| 8 | Revisiting the hydrogenation of sunflower oil over a Ni catalyst 显示文摘 | Maria B Femandez Gabriela M Tonetto Guillermo H Crapiste | 2007 | Journal of Food Engineering2007，82，： | 1 |
| 9 | Memory and the everyday land- scape of violence in post -genocide Cambodia显示文摘 | James A T Gabriela B A Alex R C | 2012 | Social and Cultur- al Geography2012，13，8： | 1 |
| 10 | Ternary interpenetrating networks of polyurethane-poly(methyl methacrylate)-silica:Preparation by the sol-gel process and characterization of films显示文摘 | Gabriela B Martina M | 2006 | European Polymer Journal2006，7，： | 1 |
| 11 | Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction显示文摘 | Elena FV Premysl B Gabriela EB | 2004 | Gastroenterology2004，127，3： | 1 |
| 12 | Quantitative determination of pneumococcal capsular polysaccharide serotype 14 using a modification of phenol - sulfuric acid method显示文摘 | Gabriela C Norma S Maria I B | 2003 | J Microbiol Meth2003，52，： | 1 |
| 13 | Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications显示文摘 | Patrícia B Malafaya Gabriela A Silva Rui L Reis | 2007 | Advanced Drug Delivery Reviews2007，59，： | 1 |
| 14 | Quantitative determination of pneumococcal capsuar polysaccharide serotype 14 using a modification of phenol-sulfuric acid method显示文摘 | Gabriela C Norma S Maria I B | 2003 | Journal of Microbiological Methods2003，52，： | 1 |
| 15 | Evalu- ation of the mechanical damage on wheat starch granules by SEM, ESEM, AFM and texture image analysis 显示文摘 | Gabriela N B Georgina C D Jorge C P | 2013 | Carbohydrate Polymers2013，98，： | 1 |
| 16 | Quantitative determination of pneumococcal capsular polysaccharide serotype 14 using a modifi cation of phenol-sulfuric acid method显示文摘 | Gabriela C Norma S Maria I B | 2003 | Journal of Microbiological Methods2003，52，1： | 1 |
| 17 | Removal of biorefractory compounds in industrial wastewater by chemical and electrochemical pretreatments 显示文摘 | CARLOS B D IVONNE L H GABRIELA R M | 2009 | Industrial and Engineering Chemistry Research2009，48，3： | 1 |
| 18 | Model of polymi-crobial peritonitis that induces the proinflammatory and im-munosuppressive phases of sepsis显示文摘 | Gabriela B Veronica L Daiana MG | 2011 | Infection&Immu-nity2011，79，3： | 1 |
| 19 | Dielectric and magnetic properties of ferrite/poly(vinylidene fluoride) nanocomposites 显示文摘 | PEDRO M CARLOS M C GABRIELA B | 2012 | Mater Chem Phys2012，131，3： | 1 |
| 20 | Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer’s and Prion diseases显示文摘 | Sanja Perovic Markus B?hm Erik Meesters Andrea Meinhardt Gabriela Pergande Werner E.G Müller | 1998 | Mechanisms of Ageing and Development1998，，1： | 1 |
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