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| 1 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Could the burden of pancreatic cancer originate in childhood?显示文摘The presence of pancreatic cancer during childhood is extremely rare,and physicians may be tempted to overlook this diagnosis based on age criteria.However,there are primary malignant pancreatic tumors encountered in pediatric patients,such as pancreatoblastoma,and tumors considered benign in general but may present a malignant potential,such as the solid pseudo-papillary tumor,insulinoma,gastrinoma,and vasoactive intestinal peptide secreting tumor.Their early diagnosis and management are of paramount importance since the survival rates tend to differ for various types of these conditions.Many pediatric cancers may present pancreatic metastases,such as renal cell carcinoma,which may evolve with pancreatic metastatic disease even after two or more decades.Several childhood diseases may create a predisposition for the development of pancreatic cancer during adulthood;hence,there is a need for extensive screening strategies and complex programs to facilitate the transition from pediatric to adult healthcare.Nevertheless,genetic studies highlight the fact the specific gene mutations and family aggregations may be correlated with a special predisposition towards pancreatic cancer.This review aims to report the main pancreatic cancers diagnosed during childhood,the most important childhood diseases predisposing to the development of pancreatic malignancies,and the gene mutations associates with pancreatic malignant tumors. | Smaranda Diaconescu Georgiana Emmanuela Gîlcă-Blanariu Silvia Poamaneagra Otilia Marginean Gabriela Paduraru Gabriela Stefanescu | 2021 | World Journal of Gastroenterology2021，27，32： | 3 |
| 4 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 5 | Formation of polymeric nano - emulsions by a low - energy method and their use tbr nanopar-ticle preparation显示文摘 | GABRIELA C MARIA J G SOLANS C | 2011 | Journal of Colloid and Interface Science2011，353，： | 1 |
| 6 | Metabolism and growth of juveniles of Litopenaeus vannamei: effect of salinity and dietary carbohydrate levels 显示文摘 | Carlos R Gerard C Gabriela G | 2001 | Journal of Experimental Marine Biology and Ecology2001，259，： | 1 |
| 7 | Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease 显示文摘 | Mikihito K Gabriela G Martin A | 2010 | J Oral Microbiol2010，2，10： | 1 |
| 8 | Factorial effects of salinity, dietary carbohydrate and moult cycle on digestive carbohydrases and hexokinases in Litopenaeus vannamei (Boone, 1931 ) 显示文摘 | Gabriela G Gerard C Tomds G | 2005 | Comparative Biochemistry and Physiology2005，140，1： | 1 |
| 9 | Operational Snow Mapping Using Multitemporal Meteosat SEVIRI Imagery显示文摘 | Martijn de Ruyter de Wildt Gabriela S Armin G | 2007 | Remote Sensing of Environment2007，109，： | 1 |
| 10 | Starch fractions as examples for nonrandomly branched marcromolecules(3): Angular dependence in static light scattering显示文摘 | GABRIELA G WALTHER B | 1997 | Macromolecules1997，30，： | 1 |
| 11 | Use and application of stem cells in toxicology 显示文摘 | JULIO C GABRIELA G | 2004 | Toxicol Sci2004，79，2： | 1 |
| 12 | Relation between reproductive, physiological, and immunological condition of Litopenaeus setiferus pre-adult males fed different dietary protein levels ( Crustaeea; Penaeidae)显示文摘 | Yannick G Ariadna S Gabriela G | 2006 | Animal Reproduction Science2006，92，： | 1 |
| 13 | Toll-like receptor 3 ligand, polylC induces proteinuria and glomerular CD80, and increases urinary CD80 in mice显示文摘 | ISHIMOTO T SHIMADA M GABRIELA G | 2013 | Nephrol Dial Transplant2013，28，6： | 1 |
| 14 | Testing various mixing rules for calculatiuon of viscosity of petroleum blends显示文摘 | Centeno G Gabriela Sánchez-Reyna Ancheyta J | | 0，，12： | 1 |
| 15 | Intensive insulin therapy in severely burned pediatric patientsa prospective randomized trial显示文摘 | Marc G Gabriela A Robert K | 2010 | Am J Respir Crit Care Med2010，182，3： | 1 |
| 16 | Use and Application of Stem Cells in Toxicology显示文摘 | Julio C Davila Gabriela G Cezar Mark Thiede | 2004 | Toxicological Sciences2004，79，： | 1 |
| 17 | Cryptosporidium parvum, a potential cause of colic adenoearcinoma 显示文摘 | GABRIELA C TRAMY N KARINE G | 2007 | Infect Agents Cancer2007，2，： | 1 |
| 18 | Photophysical characterization and photodynamic activity of metallo 5-( 4-(trimethylammonium) phenyl)- 10, 15,20-tris ( 2,4, 6-trimethoxyphenyl ) porphyrin in homogeneous and biomimetic media显示文摘 | Milanesio M Elisa Alvarez M Gabriela Bertolotti Sonia G | 2008 | Photochemical & Photobiological Sciences2008，7，8： | 1 |
| 19 | Nutrition of Litopenaeus vannamei reared in tanks or in ponds显示文摘 | Gérard Cuzon Addison Lawrence Gabriela Gaxiola Carlos Rosas J Guillaume | 2004 | Aquaculture2004，，1： | 1 |
| 20 | Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy 显示文摘 | GABRIELA S NICOLE G SUSANNE H | 2009 | Journal of Allergy and Clinical Immunology2009，124，5： | 1 |
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