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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 4 | Treatment of pituitary tumors显示文摘 | Gabriella Iván Nikoletta Szigeti-Csúcs Márk Oláh Cy?rgy M. Nagy Miklós I. Góth | 2005 | Endocrine2005，，1： | 1 |
| 5 | Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype显示文摘 | Gabriella S L Richard L Bradley EK | 2003 | PNAS2003，100，10： | 1 |
| 6 | Glutathione as an Antioxidant and Regulatory Molecule in Plants Under Abiotic Stress Conditions显示文摘 | Gabriella Szalai Tibor Kell?s Gábor Galiba Gábor Kocsy | 2009 | Journal of Plant Growth Regulation2009，，1： | 1 |
| 7 | Heat transfer and pressure drop characteristics of spirally fluted annuli: Part II--Heat transfer 显示文摘 | Gabriella S Christensen R N | 1995 | Journal of Heat Transfer1995，117，4： | 1 |
| 8 | Strategies for improving early detection and diagnosis of neovascular age-related macular degeneration显示文摘 | Pearse K Gabriella S Dawn S | 2015 | Clin Ophthalmol2015，9，2： | 1 |
| 9 | Decrease in CD3-negative-CD8dim + and Vδ2/Vγ9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection显示文摘 | Gabriella Pár Daniel Rukavina Eckhard R Podack Margit Horányi Júlia Szekeres-Barthó Géza Hegedüs Mária Paál László Szereday Gyula Mózsik Alajos Pár | 2002 | Journal of Hepatology2002，，4： | 1 |
| 10 | Heat transferand pressure drop characteristics of spirally fluted an-nuli;part II-heat transfer显示文摘 | GABRIELLA S CHRISTENSEN R N | 1995 | Journal of Heat Trans-fer1995，117，4： | 1 |
| 11 | Protein and energy needs of the transition cow显示文摘 | Gabriella A Varga Ryan S | 2001 | J Dairy Sci2001，13，： | 1 |
| 12 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 13 | Determination of biogenic amines in fresh and processed meat by ion chromatography and integrated pulsed amperometric detection on Au electrode显示文摘 | Gabriella F Paolo P Giovanna S | 2007 | Food Chemistry2007，105，： | 1 |
| 14 | Relationship between Multidetector CT Imaging of the Vestibular Aqueduct and Inner Ear Path01ogies显示文摘 | Vincenzo M Gabriella S Giovanni C | 2013 | NeuroradiolJ2013，26，6： | 1 |
| 15 | Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma显示文摘 | Gabriella Lillsunde Larsson Gisela Helenius S?ren Andersson Bengt Sorbe Mats G. Karlsson | 2013 | Gynecologic Oncology2013，，： | 1 |
| 16 | Protein and energy needs of the transition cow显示文摘 | Gabriella A Varga Ryan S | 2001 | J Dairy Sci2001，13，： | 1 |
| 17 | Determination ofbiogenic amines in fresh and processed meat by ion chromatography and integrated pulsed amperometric detection on Au electrode显示文摘 | Gabriella F Paolo P Giovanna s | 2007 | Analytical Nutritional and Clinical Methods2007，105，： | 1 |
| 18 | The histone-like protein H1-S and the response of tomato leaves to water deficit显示文摘 | Gabriella S S Michela D M Elisabetta | 2003 | Journal of Expermental Botany2003，55，394： | 1 |
| 19 | Evaluation of the optimal cooking time of rice by using FT-NIR spectroscopy and an electronic nose显示文摘 | Nicoletta S Simona B Gabriella B | 2006 | Journal of Cereal Science2006，44，2： | 1 |
| 20 | Study of calcite scaling and corrosion processe in geothermal systems 显示文摘 | Gabriella S Gyrgy P Lszl W | 2000 | Geothermics2000，29，1： | 1 |
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