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| 1 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 2 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 3 | effective treatment of post-intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy显示文摘Importance:Post-intubation subglottic stenosis(SGS)in children can be life threatening.Definitive treatment varies and lacks a universally accepted approach.Objective:We performed a prospective study to assess the safety and feasibility of holmium laser combined with cryotherapy delivered via flexible bronchoscopy for the treatment of post-intubation SGS in children.Methods:This study involved all patients with post-intubation SGS seen at the Interventional Pulmonology Department of Beijing Children's Hospital between July 2014 and December 2016.Holmium laser treatment and cryotherapy was then performed under flexible bronchoscopy,whose parents refused to accept the alternative standard treatment of tracheotomy and balloon dilation under direct laryngoscopy.results:Sixteen patients with post-intubation SGS were included in this study.Ages ranged from 2 months to 12.25 years old.According to the Cotton-Myer grading system,three cases were Grade II,12 cases were Grade III,and one case was Grade IV.According to the McCaffrey system,eight cases were Stage 1,two cases were Stage 2,and six cases were Stage 3.The average number of procedures was 4.88.Fifteen of the 16 patients achieved clinical cure.One patient achieved clinical improvement.The average treatment course duration was 55.31 days.No severe complications were seen.Post-treatment clinical symptoms,endoscopic findings and quality of life showed marked improvement.Interpretation:Our study supports the conclusion that holmium laser treatment combined with cryotherapy via flexible bronchoscopy appears to be a safe and feasible treatment for post-intubation SGS in children. | Anxia Jiao Fang Liu Andrew D.Lerner Xiaochun Rao Yan Guo Chenfang Meng Yuena Pan Gan Li Zheng Li Fang Wang Jing Zhao Yuyan Ma Xicheng Liu Xin Ni Kunling Shen | 2019 | Pediatric Investigation2019，3，1： | 10 |
| 4 | Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage显示文摘Objective To investigate the effect of simulated microgravity and carbon ion irradiation(CIR) on spermatogenic cell apoptosis and sperm DNA damage to the testis of male Swiss Webster mice,and assess the risk associated with space environment.Methods Sperm DNA damage indicated by DNA fragmentation index(DFI) and high DNA stainability(HDS) was measured by sperm chromatin structure assay(SCSA).Apoptosis of spermatogenic cells was detected by annexin V-propidium iodide assay.Bax(the expression levels of p53) and proliferating cell nuclear antigen(PCNA) were measured by immunoblotting;p53 and PCNA were located by immunohistology.Results HDS,DFI,apoptosis index,and the expression levels of p53 and Bax were detected to be significantly higher in the experimental groups(P<0.05) compared with those in the control group;however,the PCNA expression varied to a certain degree.p53-and PCNA-positive expression were detected in each group,mainly in relation to the spermatogonic cells and spermatocytes.Conclusion The findings of the present study demonstrated that simulated microgravity and CIR can induce spermatogenic cell apoptosis and sperm DNA damage.Sperm DNA damage may be one of the underlying mechanisms behind male fertility decline under space environment.These findings may provide a scientific basis for protecting astronauts and space traveler's health and safety. | LI Hong Yan ZHANG Hong MIAO Guo Ying XIE Yi SUN Chao DI Cui Xia LIU Yang LIU Yuan Yuan ZHANG Xin MA Xiao Fei XU Shuai GAN Lu ZHOU Xin | 2013 | Biomedical and Environmental Sciences2013，26，9： | 10 |
| 5 | Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq显示文摘抄写和 post-transcriptional 过程例如其他的拼接,在在 metazoans 控制发展节目起关键作用。最近出现的 RNA-seq 方法把我们真核细胞的 transcriptomes 的理解带到新水平,因为它能两个都同时解决基因表示水平和其他的拼接事件。在性腺获得细胞的区别的更好的理解,我们用 RNA-seq 从果蝇睾丸和卵巢分析了 mRNA 侧面。我们识别了有性特定的 isoforms 在的一套基因野类型(WT ) 性腺,包括几个抄写因素。我们发现从无差别的细菌房间的精子的区别导致了拼接的 RNA 的戏剧的 downregulation 因素。我们的数据证实 RNA 拼接事件是显著地在云石(欺骗) 的无差别的充实房间的袋子里更经常在在 WT 的区别之上的变异的睾丸,而是 downregulated 睾丸。与这一致,我们证明基因在 WT 为成熟分裂和终端区别要求睾丸主要在 transcriptional 水平被调整,然而并非由选择拼接。出人意料地,我们在在无差别的充实房间的欺骗睾丸改变因素和 histone 修改酶的染色质的所有家庭的表示观察了增加。更有趣地,有相反的酶的活动的染色质管理者和 histone 修改酶是在在睾丸的无差别的房间的 coenriched,建议这些房间可以拥有动态染色质建筑学。最后,我们的数据表明果蝇 gonadal transcriptomes 的许多新特征,和愿望导致的更全面的理解微分基因表示并且拼接在果蝇调整 gametogenesis。我们的数据为在果蝇在细菌房间生物学的许多有趣的区域拼接的基因表示和选择的系统的学习提供了一个基础,例如性同种二形和在 germline 干细胞系的增长对终端区别程序的规定的分子的基础。为未加工、分析的 RNA-seq 数据的 GEO 就职数字是 GSE16960。 | Qiang Gan Iouri Chepelev Gang Wei Lama Tarayrah Kairong Cui Keji Zhao Xin Chen | 2010 | Cell Research2010，20，7： | 9 |
| 6 | Short- and long-term outcomes associated with enhanced recovery after surgery protocol vs conventional management in patients undergoing laparoscopic gastrectomy显示文摘BACKGROUND At present,the enhanced recovery after surgery(ERAS)protocol is widely implemented in the field of gastric surgery.However,the effect of the ERAS protocol on the long-term prognosis of gastric cancer has not been reported.AIM To compare the effects of ERAS and conventional protocols on short-term outcomes and long-term prognosis after laparoscopic gastrectomy.METHODS We retrospectively analyzed the data of 1026 consecutive patients who underwent laparoscopic gastrectomy between 2012 and 2015.The patients were divided into either an ERAS group or a conventional group.The groups were matched in a 1:1 ratio using propensity scores based on covariates that affect cancer survival.The primary outcomes were the 5-year overall and cancer-specific survival rates.The secondary outcomes were the postoperative short-term outcomes and inflammatory indexes.RESULTS The patient demographics and baseline characteristics were similar between the two groups after matching.Compared to the conventional group,the ERAS group had a significantly shorter postoperative hospital day(7.09 d vs 8.67 d,P<0.001),shorter time to first flatus,liquid intake,and ambulation(2.50 d vs 3.40 d,P<0.001;1.02 d vs 3.64 d,P<0.001;1.47 d vs 2.99 d,P<0.001,respectively),and lower medical costs($7621.75 vs$7814.16,P=0.009).There was a significantly higher rate of postoperative complications among patients in the conventional group than among those in the ERAS group(18.1 vs 12.3,P=0.030).Regarding inflammatory indexes,the C-reactive protein and procalcitonin levels on postoperative day 3/4 were significantly different between the two groups(P<0.001 and P=0.025,respectively).The ERAS protocol was associated with significantly improved 5-year overall survival and cancer-specific survival rates compared with conventional protocol(P=0.013 and 0.032,respectively).When stratified by tumour stage,only the survival of patients with stage III disease was significantly different between the two groups(P=0.044).CONCLUSION Adherence to the ERAS protocol improves both the short-term outcomes and the 5-year overall survival and cancer-specific survival of patients after laparoscopic gastrectomy. | Yu-Long Tian Shou-Gen Cao Xiao-Dong Liu Ze-Qun Li Gan Liu Xing-Qi Zhang Yu-Qi Sun Xin Zhou Dao-Sheng Wang Yan-Bing Zhou | 2020 | World Journal of Gastroenterology2020，26，37： | 8 |
| 7 | Two energy balance closure approaches: applications and comparisons over an oasis-desert ecotone显示文摘Studies of energy balance that rely on eddy covariance(EC) are always challenged by energy balance closure, which is mainly caused by the underestimations of latent heat flux(LE) and sensible heat flux(Hs). The Bowen ratio(BR) and energy balance residual(ER) approaches are two widely-used methods to correct the LE. A comprehensive comparison of those two approaches in different land-use types is essential to accurately correcting the LE and thus improving the EC experiments. In this study, two energy balance approaches(i.e., BR and ER) were compared to correct the LE measured at six EC sites(i.e., three vegetated, one mixed and two non-vegetated sites) in an oasis-desert ecotone of the Heihe River Basin, China. The influences of meteorological factors on those two approaches were also quantitatively assessed. Our results demonstrated that the average energy closure ratio((LE+Hs)/(Rn–Gs); where Rn is the surface net radiation and Gs is the surface soil heat flux) was approximately close to 1.0 at wetland, maize and village sites, but far from 1.0 at orchard, Gobi and desert sites, indicating a significant energy imbalance at those three latter sites. After the corrections of BR and ER approaches that took into account of soil heat storage, the corrected LE was considerably larger than the EC-measured LE at five of six EC sites with an exception at Gobi site. The BR and ER approaches yielded approximately similar corrected LE at vegetated and mixed sites, but they generated dissimilar results at non-vegetated sites, especially at non-vegetated sites with low relative humidity, strong wind, and large surface-air temperature difference. Our findings provide insight into the applicability of BR and ER approaches to correcting EC-based LE measurements in different land-use types. We recommend that the BR-corrected and ER-corrected LE could be seriously reconsidered as validation references in dry and windy areas. | PAN Xin LIU Yuanbo FAN Xingwang GAN Guojing | 2017 | Journal of Arid Land2017，9，1： | 7 |
| 8 | Highly Transparent and Colorless Polyimide Film with Low Dielectric Constant by Introducing Meta-substituted Structure and Trifluoromethyl Groups显示文摘An effective design strategy for preparing highly transparent polyimide film with low dielectric constant is presented.The key to the strategy is to simultaneously introduce meta-substituted structure and trifluoromethyl in polymer chains.By using this design strategy,a highly transparent polyimide film with low-k was synthesized from 3,5-diaminobenzotrifluoride(m-TFPDA)and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)through a two-step method.The obtained m-TFPDA/6FDA(CPI)film(~30 pm)possesses high optical transparency(λ_(cutoff)=334 nm,T_(450nm)=85.26%,Haze=0.31)and is close to colorless(L^(*)=96.03,a^(*)=-0.34,b^(*)=2.12,yellow index=3.96).The intrinsic k and dielectric loss value of the film are 2.27 and 0.0013 at 10 kHz,respectively.More importantly,such low dielectric performance could remain stable up to 280℃,and the film shows a low moisture rate(~0.51%),which helps to maintain the low-k property stability in different humid environments.Meanwhile,the film also shows good thermal stability and mechanical properties,with a glass transition temperature(T_(g))of 296℃and the 5 wt%decomposition temperature(T_(d,s%))of 522℃under N_(2).The tensile strength and tensile modulus of the film are 85.1 MPa and 1.96 GPa,respectively.In addition,the film is soluble in common solvents,which allows simple solution processing and low-cost,continuous roll-to-roll processes.This design strategy is beneficial to improving the transparency,lightening yellow color,lowering the dielectric constant and meanwhile maintaining the comprehensive properties of polyimide films,which is mainly due to the introduced meta-substituted and trifluoromethyl structures effectively inhibiting the transfer of charge transfer complex(CTC)effects and increasing the free volume of film.This design strategy could also be extended to other high-performance polymer systems. | Hong-Tao Zuo Feng Gan Jie Dong Peng Zhang Xin Zhao Qing-Hua Zhang | 2021 | Chinese Journal of Polymer Science2021，39，4： | 6 |
| 9 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 10 | Toxicity of Graphene Quantum Dots in Zebrafish Embryo显示文摘Objective To evaluate the bio-safety of graphene quantum dots(GQDs), we studied its effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/m L for 4-96 h post-fertilization(hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined. Results The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs(200 μg/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 μg/mL. The larval behavior testing(visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 μg/mL showed hyperactivity while exposure to higher concentrations(25, 50, 100, and 200 μg/mL) caused remarkable hypoactivity in the light-dark test. Conclusion Low concentrations of GQDs were relatively non-toxic. However, GQDs disrupt the progression of embryonic development at concentrations exceeding 50 μg/mL. | WANG Zhen Guo ZHOU Rong JIANG Dan SONG Jing E XU Qian SI Jing CHEN Yun Ping ZHOU Xin GAN Lu LI Jian Zhen ZHANG Hong LIU Bin | 2015 | Biomedical and Environmental Sciences2015，28，5： | 6 |
| 11 | Effects of arbuscular mycorrhizal fungi on the drought resistance of the mining area repair plant Sainfoin显示文摘To solve the problem of lack of water in arid areas and barren soil in the process of ecological restoration,the growth and drought resistance of Sainfoin(Onobrychis viciifolia Scop.) was studied by inoculation of AMF(arbuscular mycorrhizal fungi), under drought stress. The results show that the inoculation of AMF can significantly improve the growth and mycorrhizal infection rate of Sainfoin and accelerate the absorption of water and nutrients by the roots compared with uninoculated plants. On the 40 th day under drought stress, the relative water content, total nitrogen and total phosphorus content of the leaves of inoculated plants increased by 7.27%, 4.21% and 2.40%, respectively, the osmotic adjustment property in plant cells was improved, the protective enzyme system was improved and membrane lipid peroxidation was reduced. The inoculation of AMF can slow down the damage from drought, improve the drought resistance of Sainfoin, and will be of great significance to the ecologic restoration in arid areas. | Kong Jing Pei Zongping Du Min Sun Gan Zhang Xin | 2014 | International Journal of Mining Science and Technology2014，24，4： | 6 |
| 12 | Effect of neoadjuvant chemotherapy on the expression of hormone receptors and Ki67 in Chinese breast cancer patients:A retrospective study of 525 patients显示文摘This study was designed to investigate the effect of neoadjuvant chemotherapy on the expression of hormone receptors and Ki67 in Chinese female breast cancer patients. The expression of estrogen receptor(ER), progesterone receptor(PR) and Ki67 among 525 neoadjuvant chemotherapy cases was studied by immunohistochemistry.Differences between specimens made through preoperative core needle biopsy and excised tissue biopsy were observed. The positive rates of ER, PR and Ki67 in core needle biopsy and excised tissue biopsy were 65.3% and 63.2%, 51.0% and 42.6%, 65.6% and 43.4%, respectively. The expression of ER, PR and Ki67 in core needle biopsy and excised tissue biopsy had no statistically significant difference. However, after neoadjuvant chemotherapy, the discordance rates of ER, PR and Ki67 were 15.2%(79/521), 26.9%(140/520) and 44.8%(225/502), respectively. The ER, PR and Ki67 status changed from positive to negative in 7.5%(39/521), 13.3%(69/520) and 21.1%(106/502) of the patients, whereas ER, PR and Ki67 status changed from negative to positive in 7.7%(40/521), 13.6%(71/520)and 23.7%(119/502) of the patients, respectively. These results showed that the status of some biomarkers changes after neoadjuvant chemotherapy and biomarker status needs to be reexamined to optimize adjuvant systemic therapy and better prognosis assessment. | Yu-tuan Wu Xin Li Lin-jie Lu Lu Gan Wei Dai Yan-ling Shi Vishnu Prasad Adhikari Kai-nan Wu Ling-quan Kong | 2018 | The Journal of Biomedical Research2018，32，3： | 6 |
| 13 | Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways显示文摘The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2 O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit Et OAc fraction(fruit-EFr., 12.5–50 μmol·L^(-1)) of G. xanthochymus for 24 h prior to H_2O_2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes(superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases(MMP), and scavenged reactive oxygen species(ROS). Fruit-EFr. also reduced BAX and cytochrome C expression and improved BCL-2 expression, thereby decreasing the ratio of BAX to BCL-2. Fruit-EFr. activated the nuclear translocation of NRF2 to increase HO-1 and induced the phosphorylation of AKT. Its cytoprotective effect was abolished by LY294002, a specific inhibitor of PI3 K. Taken together, the above findings suggested that fruit-EFr.of G. xanthochymus could enhance cellular antioxidant defense capacity, at least in part, through upregulating HO-1 expression and activating the PI3 K/AKT pathway and that it could suppress H_2O_2-induced oxidative damage via PI3 K/AKT and NRF2/HO-1 signaling pathways. | XU Jing GAN Sheng LI Jun WAND De-Bing CHEN Yu HU Xin YANG Guang-Zhong | 2017 | Chinese Journal of Natural Medicines2017，15，11： | 5 |
| 14 | Polyimide-derived carbon nanofiber membranes as anodes for high-performance flexible lithium ion batteries显示文摘The strategy of N-doping in carbon materials could provide additional Li-ion storage sites to improve their electrochemical properties. Heteroatom-containing polymers could serve as good precursors to fabricate doped carbons due to the capability to in situ dope heteroatoms into the structures. In this work,electrospun heterocyclic polyimide(PI) nanofiber membranes containing biphenyl and pyrimidine rings were carbonized to fabricate freestanding and flexible heteroatoms-containing carbon membranes.When the polymer membranes were subjected to various calcination temperatures(from 550℃ to950℃) and durations(0.5-10 h), the structural evolutions strongly affect their electrochemical properties as anodes for lithium ion batteries. It demonstrated that the reversible specific capacity of obtained sample treated at 650℃ for 3 h could achieve 695 mAh/g at 0.1 A/g and retain 245 mAh/g at 1.5 A/g after300 cycles. Furthermore, the electrospun membrane maintains a good electrochemical performance at bending state as a flexible electrode. | Fangyuan Zhao Xin Zhao Bo Peng Feng Gan Mengyao Yao Wenjun Tan Jie Dong Qinghua Zhang | 2018 | Chinese Chemical Letters2018，29，11： | 5 |
| 15 | Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta显示文摘人参皂甙被认为是主要 pharmacologically 活跃的人参成分,而 20 (S)-protopanaxadiol [20 (S)-PPD] 是在内脏的人参皂甙的活跃代谢物。在这研究,我们在孤立的老鼠上调查了 20 (S)-PPD 的效果象它的 vasorelaxant mechanisms.Methods 一样的胸的主动脉:大动脉的戒指与或没有内皮细胞层从 Wistar 老鼠被准备并且在器官房间推迟了。在准备的紧张的变化通过连接到一个数据获得系统的等轴的变换器被记录。大动脉的戒指是有 phenylephrine 的 precontracted (PE, 1 mol/L ) 或 high-K +(80 mmol/L ).Results:20 (S)-PPD (21.5-108.5 mol/L ) 的申请与分别地导致了 90.4 或 46.5 mol/L 的 EC 50 价值的 PE 或 high-K +, 引起了集中依赖者内皮细胞层未经触动的大动脉的戒指 precontracted 的 vasodilation。内皮细胞层的移动没在 20 (S)-PPD-induced 松驰上有效果。 20 (S) -PPD 的 vasorelaxant 效果没被 preincubation 也与肾上腺素能的受体对手 propranolol ,或与ATP敏感的 K +隧道 blocker glibenclamide 影响,电压依赖者 K +隧道 blocker 4-AP 和里面的整流器 K +隧道 blocker BaCl 2,而它被 preincubation 显著地与 Ca 2+-activated K +稀释(放射性元素 Ca )隧道 blocker 茶( 1 mmol/L )。而且,没有合成, cGMP 和 prostacyclin 小径的抑制没影响 20 (S)-PPD 的 vasorelaxant 效果。在 Ca 2+-free 答案, 20 (S)-PPD (108.5 mol/L ) 显著地减少了在有 PE 或 high-K + 的大动脉的戒指 precontracted 的细胞外的 Ca 2+-induced 收缩和减少的导致 PE 的短暂收缩。电压依赖者 Ca 2+ 隧道对手 nifedipine 禁止了导致 PE 的收缩;进一步的抑制在操作受体的 Ca 2+ 隧道禁止者 SK&F 96365 或 20 (S)-PPD.Conclusion 的申请以后被观察:20 (S)-PPD 经由一条内皮细胞层无关的小径导致 vasorelaxation。电压依赖者 Ca 2+ 隧道和操作受体的 Ca 2+ 隧道和 Ca 2+-activated K + 隧道的激活的抑制可能涉及松驰。 | Lu GAN Zhen-hua WANG Hong ZHANG Xin ZHOU Hui ZHOU Chao SUN Jing SI Rong ZHOU Cheng-jun MA Ji LI | 2016 | Acta Pharmacologica Sinica2016，37，12： | 5 |
| 16 | Fast algorithm based on triplet Markov fields for unsupervised multi-class segmentation of SAR images显示文摘Non-Gaussian triplet Markov fields (TMF) model is suitable for dealing with multi-class segmentation of non-stationary and non-Gaussian synthetic aperture radar (SAR) images.Considering the complexity of the model and algorithm,as well as the requirement of real-time,and robust and efficient processing of SAR images,a fast algorithm based on TMF for unsupervised multi-class segmentation of SAR images is proposed in this paper.For the speckle noise in SAR images,numerical characteristic,threshold selection and QuadTree decomposition criterion are researched firstly.With the new method,a SAR image can quickly be mapped into an edge-based pixon-representation,which results in a coarse decomposition in smooth regions,and a fine decomposition in edges.Then by combining TMF model with the pixon-representation of SAR image,a new potential energy function of TMF based on pixon-representation is derived.Finally,the segmentation is finished by Bayesian maximum posterior mode (MPM).The effectiveness of the fast TMF algorithm is demonstrated by applying it to simulated data and real SAR images. | WU Yan WANG Xin XIAO Ping GAN Lu LIU ChunYan LIMing | 2011 | Science China(Information Sciences)2011，54，7： | 4 |
| 17 | The FAST Galactic Plane Pulsar Snapshot survey:I.Project design and pulsar discoveries显示文摘Discovery of pulsars is one of the main goals for large radio telescopes.The Five-hundredmeter Aperture Spherical radio Telescope(FAST),that incorporates an L-band 19-beam receiver with a system temperature of about 20 K,is the most sensitive radio telescope utilized for discovering pulsars.We designed the snapshot observation mode for a FAST key science project,the Galactic Plane Pulsar Snapshot(GPPS)survey,in which every four nearby pointings can observe a cover of a sky patch of 0.1575 square degrees through beam-switching of the L-band 19-beam receiver.The integration time for each pointing is 300 seconds so that the GPPS observations for a cover can be made in 21 minutes.The goal of the GPPS survey is to discover pulsars within the Galactic latitude of±10∘from the Galactic plane,and the highest priority is given to the inner Galaxy within±5∘.Up to now,the GPPS survey has discovered 201 pulsars,including currently the faintest pulsars which cannot be detected by other telescopes,pulsars with extremely high dispersion measures(DMs)which challenge the currently widely used models for the Galactic electron density distribution,pulsars coincident with supernova remnants,40 millisecond pulsars,16 binary pulsars,some nulling and mode-changing pulsars and rotating radio transients(RRATs).The follow-up observations for confirmation of new pulsars have polarization-signals recorded for polarization profiles of the pulsars.Re-detection of previously known pulsars in the survey data also leads to significant improvements in parameters for 64 pulsars.The GPPS survey discoveries are published and will be updated at http://gffzz656c80eee53645cch9kck5x9fn0oq69vn.ffgz.tsg.suse.edu.cn/GPPS/. | J.L.Han Chen Wang P.F.Wang Tao Wang D.J.Zhou Jing-Hai Sun Yi Yan Wei-Qi Su Wei-Cong Jing Xue Chen X.Y.Gao Li-Gang Hou Jun Xu K.J.Lee Na Wang Peng Jiang Ren-Xin Xu Jun Yan Heng-Qian Gan Xin Guan Wen-Jun Huang Jin-Chen Jiang Hui Li Yun-Peng Men Chun Sun Bo-Jun Wang H.G.Wang Shuang-Qiang Wang Jin-Tao Xie Heng Xu Rui Yao Xiao-Peng You D.J.Yu Jian-Ping Yuan Rai Yuen Chun-Feng Zhang Yan Zhu | 2021 | Research in Astronomy and Astrophysics2021，21，5： | 4 |
| 18 | New type flooding systems in enhanced oil recovery显示文摘Wormlike 微粒,面对钠磷酸盐在离子的表面活化剂钠油酸盐(NaOA ) 获得了答案(Na 3 PO 4), 用稳定、动态的变阻器被学习逻辑方法。充满实验的实验室模拟被用来调查为象微粒系统一样的蠕虫泛滥的效果。结果证明油恢复是 32.7% 。这个泛滥的系统是一种新类型并且与低费用举办高活动。 | Xin Ping Li Li Yu Yong Qiang Ji Bo Wu Gan Zuo Li Li Qiang Zheng | 2009 | Chinese Chemical Letters2009，20，10： | 4 |
| 19 | Genetic diagnosis history and osteoarticular phenotype of a nontransfusion secondary hemochromatosis显示文摘BACKGROUND It is not easy to identify the cause of various iron overload diseases because the phenotypes overlap.Therefore,it is important to perform genetic testing to determine the genetic background of patients.AIM To investigate the genetic background of a patient with hemochromatosis complicated by psoriasis on both lower extremities.METHODS Ten years ago,a 61-year-old male presented with iron overload,jaundice,hemolytic anemia and microcytic hypochromic anemia.Computed tomography of the left knee joint showed enlargement of the tibial medullary cavity and thinned bone cortices.Magnetic resonance imaging showed hepatic hemochromatosis,extensive abnormal signals from bone marrow cavities and nodular lesions in the lateral medullary cavity of the upper left lateral tibia.Single photon emission computed tomography showed radial dots of abnormal concentration in the upper end of the left tibia and radial symmetry of abnormal concentrations in joints of the extremities.The patient showed several hot spot mutations of the HFE and G6PD genes detected by next-generation sequencing,but no responsible gene mutation was found.The thalassemia gene was detected by gap-PCR.RESULTS The patient was found to carry the-α4.2 and--SEA deletion mutations of the globin gene.These two mutations are common causes of Southeast Asianα-thalassemia,but rarely cause severe widespread non-transfusion secondary hemochromatosis osteoarthropathy.The simultaneous presence of an auxiliary superposition effect of a rare missense mutation of the PIEZO1 gene(NM_001142864,c.C4748T,p.A1583V)was considered.Moreover,several rare mutations of the IFIH1,KRT8,POFUT1,FLG,KRT2,and TGM5 genes may be involved in the pathogenesis of psoriasis.CONCLUSION The selection of genetic detection methods for hemochromatosis still needs to be based on an in-depth study of the clinical manifestations of the disease. | Dan-Dan Ruan Yu-Mian Gan Tao Lu Xiao Yang Yao-Bin Zhu Qing-Hua Yu Li-Sheng Liao Ning Lin Xin Qian Jie-Wei Luo Fa-Qiang Tang | 2020 | World Journal of Clinical Cases2020，8，23： | 4 |
| 20 | Occurrence conditions of positive cloud-to-ground flashes in severe thunderstorms显示文摘The purpose of this study was to understand the reasons why frequent positive cloud-to-ground(+CG) flashes occur in severe thunderstorms. A three-dimensional dynamics-electrification coupled model was used to simulate a severe thunderstorm to permit analysis of the conditions that might easily cause +CG flashes. The results showed that strong updrafts play an important role in the occurrence of intracloud flashes. However, frequent +CG flashes require not only strong updrafts but also strong downdrafts in the lower cloud region, conditions that correspond to the later phase of the mature stage and the period of the heaviest solid precipitation of a thunderstorm. During this stage, strong updrafts elevated each charge area in the updraft region to a higher level, which resulted in an inverted tripole charge structure. A wide mid-level region of strong positive charge caused largely by positively charged graupel, presented in the middle of the updraft region because of a non-inductive ice-ice collisional charging mechanism. The charge structure in the downdraft region was consistently more complex and revealed several vertically stacked charge regions, alternating in polarity. Much of the graupel/hail outside the updrafts was lowered to cloud-base by strong downdrafts. In this area, the graupel/hail was charged negatively because of the transportation of negatively charged graupel/hail from higher regions of negative charge in the updrafts, and via the inductive charging mechanism of collisions between graupel/hail and cloud droplets at the bottom of the cloud. Consequently, a large region of negative charge formed near the ground. This meant that +CG flashes were initiated more easily in the lower inverted dipole, i.e., the middle region of positive charge and lower region of negative charge. Frequent +CG flashes began almost synchronously with dramatic increases in the storm updrafts, hail volume, and total flash rate. Therefore, the occurrence of +CG flashes appears a good indicator of storm intensification and it could have some use as a predictor of severe weather in the form of hail. | GUO Feng Xia LU Gan Yi WU Xin WANG Hao Liang LIU Zu Pei BAO Min LI Ya Wen | 2016 | Science China Earth Sciences2016，59，7： | 3 |
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