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| 1 | 252 Robotic Partial Nephrectomies: Evolving Renorrhaphy Technique and Surgical Outcomes at a Single Institution显示文摘 | Jihad H. Kaouk Shahab P. Hillyer Riccardo Autorino Georges-Pascal Haber Tianming Gao Fatih Altunrende Rakesh Khanna Gregory Spana Michael A. White Humberto Laydner Wahib Isac Robert J. Stein | 2011 | Urology2011，，6： | 2 |
| 2 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，： | 2 |
| 3 | Partial Nephrectomy Is Associated with Improved Overall Survival Compared to Radical Nephrectomy in Patients with Unanticipated Benign Renal Tumours 显示文摘 | Christopher J. Weight Gregory Lieser Benjamin T. Larson Tianming Gao Brian R. Lane Steven C. Campbell Inderbir S. Gill Andrew C. Novick Amr F. Fergany | 2010 | European Urology2010，，2： | 1 |
| 4 | Factory-level measurements on CO2emission factors of cement production in China显示文摘 | Shen Lei Gao Tianming Zhao Jian'an | 2014 | Renewable and Sustainable Energy Reviews2014，34，0： | 1 |
| 5 | Cu2~ modulated silver nanoclusters as an on-off-on fluorescence probe for the selective detection of L-histidine显示文摘 | Xuyue Zheng Tianming gao Ying Zhu eta1 | 2015 | Biosensors and Bioelectronics2015，66，： | 1 |
| 6 | Cardiac cerebral embolism of 50 cases of clinical analysis 显示文摘 | Li Xin Gao Shujie Li Tianming | 2008 | Journal of practical medicine in China2008，29，3： | 1 |
| 7 | Prefrontal cortical circuits in anxiety and fear:an overview显示文摘Pathological anxiety is among the most difficult neuropsychiatric diseases to treat pharmacologically,and it represents a major societal problem.Studies have implicated structural changes within the prefrontal cortex(PFC)and functional changes in the communication of the PFC with distal brain structures in anxiety disorders.Treatments that affect the activity of the PFC,including cognitive therapies and transcranial magnetic stimulation,reverse anxiety-and fear-associated circuit abnormalities through mechanisms that remain largely unclear.While the subjective experience of a rodent cannot be precisely determined,rodent models hold great promise in dissecting well-conserved circuits.Newly developed genetic and viral tools and optogenetic and chemogenetic techniques have revealed the intricacies of neural circuits underlying anxiety and fear by allowing direct examination of hypotheses drawn from existing psychological concepts.This review focuses on studies that have used these circuit-based approaches to gain a more detailed,more comprehensive,and more integrated view on how the PFC governs anxiety and fear and orchestrates adaptive defensive behaviors to hopefully provide a roadmap for the future development of therapies for pathological anxiety. | Yihua Chen Nengyuan Hu Jianming Yang Tianming Gao | 2022 | Frontiers of Medicine2022，16，4： | 1 |
| 8 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，4： | 1 |
| 9 | Spatial differences of exergy use of cement manufacturing industry in China based on extended exergy accounting method显示文摘从 23 个省的工厂级的数据和在在 2012 生产工业和 socio 经济的水泥的一些国家统计数据被用来为由扩大 Exergy 财务方法生产工业的瓷器水泥分析 exergy 使用的空间分发。这个方法拿精力和原料供应和另外的外部因素(资本,劳动和环境) 的包括的完整的报道进一个全面资源费用评价。在水泥生产的省的层次的扩大 exergy 消费和它的紧张份量上被计算然后在地区性的水平的 exergy 使用的凝块水平也被评估。把分析基于这,他们在在省的水平的 exergy 使用的尺寸和效率的空间差别被识别。而且,他们的地区性的特征被揭示。一些重要结果能如下被拉。首先,不可见的社会费用在生产工业的水泥说明了全部的 exergy 使用的 1/10,当精力元素关于 9/10 分享了时。第二,在生产工业的瓷器水泥的 exergy 使用的粗野分发主要在象安徽和山东省一样的东方区域,并且在象四川省一样的西方的区域被集中。以 exergy 使用,而资本,劳动和外部环境因素的费用在中央、西方的区域为水泥生产加亮不可见的社会费用到某程度,煤和电在东方区域的精力费用中是最高的。第三,在生产工业的瓷器水泥的 exergy 使用的效率分发从西方说明了一个增长特征到东方特别为精力,劳动和大写的效率。环境效率上的评估显示象西藏, Xinjiang,内部蒙古和山西一样的省或区域承担了高得多的环境费用。第四, 23 个省能被欧几里德几何学的距离模型分类进八个组用粗野并且 exergy 使用的效率结果。第五,高工业集中度是为在中国生产工业的水泥的 exergy 效率改进的主要开车因素。 | CHEN Fengnan SHEN Lei LIU Litao GAO Tianming | 2015 | Journal of Geographical Sciences2015，25，11： | 1 |
| 10 | Office Based Transrectal Saturation Biopsy Improves Prostate Cancer Detection Compared to Extended Biopsy in the Repeat Biopsy Population显示文摘 | Osama M. Zaytoun Ayman S. Moussa Tianming Gao Khaled Fareed J. Stephen Jones | 2011 | The Journal of Urology2011，，3： | 1 |
| 11 | China' s coal policy since 1979: A brief overview显示文摘 | Lei Shen Tianming Gao | 2012 | Energy Policy2012，，40： | 1 |
| 12 | BMP4 preserves the developmental potential of mESCs through Ube2s-and Chmp4b-mediated chromosomal stability safeguarding显示文摘Chemically defined medium is widely used for culturing mouse embryonic stem cells(mESCs),in which N2B27 works as a substitution for serum,and GSK3βand MEK inhibitors(2i)help to promote ground-state pluripo-tency.However,recent studies suggested that MEKi might cause irreversible defects that compromise the developmental potential of mESCs.Here,we demon-strated the deficient bone morphogenetic protein(BMP)signal in the chemically defined condition is one of the main causes for the impaired pluripotency.Mechanisti-cally,activating the BMP signal pathway by BMP4 could safeguard the chromosomal integrity and proliferation capacity of mESCs through regulating downstream tar-gets Ube2s and Chmp4b.More importantly,BMP4 pro-motes a distinct in vivo developmental potential and a long-term pluripotency preservation.Besides,the pluripotent improvements driven by BMP4 are superior to those by attenuating MEK suppression.Taken together,our study shows appropriate activation of BMP signal is essential for regulating functional pluripotency and reveals that BMP4 should be applied in the serum-free culture system. | Mingzhu Wang Kun Zhao Meng Liu Mengting Wang Zhibin Qiao Shanru Yi Yonghua Jiang Xiaochen Kou Yanhong Zhao Jiqing Yin Tianming Li Hong Wang Cizhong Jiang Shaorong Gao Jiayu Chen | 2022 | Protein & Cell2022，13，8： | 0 |
| 13 | Prediction of cognitive scores by joint use of movie-watching fMRI connectivity and eye tracking via Attention-CensNet显示文摘Background:Brain functional connectivity under the naturalistic paradigm has been shown to be better at predicting individual behaviors than other brain states,such as rest and doing tasks.Nevertheless,the state-of-the-art methods have found it difcult to achieve desirable results from movie watching paradigm functional magnetic resonance imaging(mfMRI)-induced brain functional connectivity,especially when there are fewer datasets.Incorporating other physical measurements into the prediction method may enhance accuracy.Eye tracking,becoming popular due to its portability and lower expense,can provide abundant behavioral features related to the output of human's cognition,and thus might supplement the mfMRI in observing participants'subconscious behaviors.However,there are very few studies on how to effectively integrate the multimodal information to strengthen the performance by a unified framework.objective:A fusion approach with mfMRI and eye tracking,based on convolution with edge-node switching in graph neural networks(CensNet),is proposed in this article.Methods:In this graph model,participants are designated as nodes,mfMRI derived functional connectivity as node features,and different eye-tracking features are used to compute similarity between participants to construct heterogeneous graph edges.By taking multiple graphs as different channels,we introduce squeeze-and-excitation attention module to CensNet(A-CensNet)to integrate graph embeddings from multiple channels into one.Results:The proposed model outperforms those using a single modality and single channel,and state-of-the-art methods.Conclusions:The results indicate that brain functional activities and eye behaviors might complement each other in interpreting trait-like phenotypes. | Jiaxing Gao Lin Zhao Tianyang Zhong Changhe Li Zhibin He Yaonei Wei Shu Zhang Lei Guo Tianming Liu Junwei Han Xi Jiang Tuo Zhang | 2023 | Psychoradiology2023，3，1： | 0 |
| 14 | Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy显示文摘Studies have suggested that the nucleus accumbens(NAc)is implicated in the pathophysiology of major depression;however,the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been elucidated.Here,we identified a specific reduction of cyclic adenosine monophosphate(cAMP)in the subset of dopamine D1 receptor medium spiny neurons(D1-MSNs)in the NAc that promoted stress susceptibility,while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like behaviors.Ketamine treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons(D2-MSNs)of depressed mice,however,the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc D1-MSNs.We discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration,but not a lower dose.The fast onset property of crocin was verified through multicenter studies.Moreover,crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on D2-MSN.These findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc,and provide a potential rapid antidepressant drug candidate,crocin. | Yue Zhang Jingwen Gao Na Li Peng Xu Shimeng Qu Jinqian Cheng Mingrui Wang Xueru Li Yaheng Song Fan Xiao Xinyu Yang Jihong Liu Hao Hong Ronghao Mu Xiaotian Li Youmei Wang Hui Xu Yuan Xie Tianming Gao Guangji Wang Jiye Aa | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 15 | Functional diversity of subgroup 5 R2R3-MYBs promoting proanthocyanidin biosynthesis and their key residues and motifs in tea plant显示文摘The tea plant(Camellia sinensis)is rich in polyphenolic compounds.Particularly,flavan-3-ols and proanthocyanidins(PAs)are essential for the flavor and disease-resistance property of tea leaves.The fifth subgroup of R2R3-MYB transcription factors comprises the primary activators of PA biosynthesis.This study showed that subgroup 5 R2R3-MYBs in tea plants contained at least nine genes belonging to the TT2,MYB5,and MYBPA types.Tannin-rich plants showed an expansion in the number of subgroup 5 R2R3-MYB genes compared with other dicotyledonous and monocot plants.The MYBPA-type genes of tea plant were slightly expanded.qRT–PCR analysis and GUS staining analysis of promoter activity under a series of treatments revealed the differential responses of CsMYB5s to biotic and abiotic stresses.In particular,CsMYB5a,CsMYB5b,and CsMYB5e responded to high-intensity light,high temperature,MeJA,and mechanical wounding,whereas CsMYB5f and CsMYB5g were only induced by wounding.Three genetic transformation systems(C.sinensis,Nicotiana tabacum,and Arabidopsis thaliana)were used to verify the biological function of CsMYB5s.The results show that CsMYB5a,CsMYB5b,and CsMYB5e could promote the gene expression of CsLAR and CsANR.However,CsMYB5f and CsMYB5g could only upregulate the gene expression of CsLAR but not CsANR.A series of site-directed mutation and domain-swapping experiments were used to verify functional domains and key amino acids of CsMYB5s responsible for the regulation of PA biosynthesis.This study aimed to provide insight into the induced expression and functional diversity model of PA biosynthesis regulation in tea plants. | Tianming Jiao Yipeng Huang Ying-Ling Wu Ting Jiang Tongtong Li Yanzhuo Liu Yvchen Liu Yunyun Han Yajun Liu Xiaolan Jiang Liping Gao Tao Xia | 2023 | Horticulture Research2023，10，8： | 0 |
| 16 | Amplitude Ratio of Regional Seismic Phases: An Efficient Indicator of Thermal State of the Lithosphere显示文摘By analyzing seismograms of short period records at the Beijing SeismoJogicaJ Observatory, the present paper investigates the amplitude ratio of seismic phases. The results indicate that the amplitude ratio of Sn/Lg is correlated with the lithosphere structure, the thermal state, and strong earthquake occurrence in the region the seismic rays pass through. The significance of such a correlation in the study on the genesis and prediction of strong earthquakes is discussed. | Gao Shiyu, Zhang Lianqiang, Tang Tianming, and Fu ChanghongInstitute of Geophysics, SSB, Beijing 100081, China | 1996 | Earthquake Research in China1996，10，2： | 0 |
| 17 | Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts显示文摘Although most fishes are ectothermic,some,including tuna and billfish,achieve endothermy through specialized heat producing tissues that are modified muscles.How these heat producing tissues evolved,and whether they share convergent molecular mechanisms,remain unresolved.Here,we generated a high-quality genome from the mackerel tuna(Euthynnus affinis)and investigated the heat producing tissues of this fish by single-nucleus and bulk RNA sequencing.Compared with other teleosts,tuna-specific genetic variation is strongly associated with muscle differentiation.Single-nucleus RNA-seq revealed a high proportion of specific slow skeletal muscle cell subtypes in the heat producing tissues of tuna.Marker genes of this cell subtype are associated with the relative sliding of actin and myosin,suggesting that tuna endothermy is mainly based on shivering thermogenesis.In contrast,cross-species transcriptome analysis indicated that endothermy in billfish relies mainly on nonshivering thermogenesis.Nevertheless,the heat producing tissues of the different species do share some tissue-specific genes,including vascular-related and mitochondrial genes.Overall,although tunas and billfishes differ in their thermogenic strategies,they share similar expression patterns in some respects,highlighting the complexity of convergent evolution. | Baosheng Wu Xueli Gao Mingling Hu Jing Hu Tianming Lan Tingfeng Xue Wenjie Xu Chenglong Zhu Yuan Yuan Jiangmin Zheng Tao Qin Peidong Xin Ye Li Li Gong Chenguang Feng Shunping He Huan Liu Haimeng Li Qing Wang Zhenhua Ma Qiang Qiu Kun Wang | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
| 18 | Two memory associated genes regulated by amyloid precursor protein intracellular domain Novel insights into the pathogenesis of learning and memory impairment in Alzheimer's disease显示文摘In this study,we employed chromatin immunoprecipitation,a useful method for studying the locations of transcription factors bound to specific DNA regions in specific cells,to investigate amyloid precursor protein intracellular domain binding sites in chromatin DNA from hippocampal neurons of rats,and to screen out five putative genes associated with the learning and memory functions.The promoter regions of the calcium/calmodulin-dependent protein kinase II alpha and glutamate receptor-2 genes were amplified by PCR from DNA products immunoprecipitated by amyloid precursor protein intracellular domain.An electrophoretic mobility shift assay and western blot analysis suggested that the promoter regions of these two genes associated with learning and memory were bound by amyloid precursor protein intracellular domain(in complex form).Our experimental findings indicate that the amyloid precursor protein intracellular domain is involved in the transcriptional regulation of learning-and memory-associated genes in hippocampal neurons.These data may provide new insights into the molecular mechanism underlying the symptoms of progressive memory loss in Alzheimer's disease. | Chuandong Zheng Xi Gu Zhimei Zhong Rui Zhu Tianming Gao Fang Wang | 2012 | Neural Regeneration Research2012，7，5： | 0 |
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