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| 1 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 2 | Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation,apoptosis,and oxidative stress显示文摘Cordycepin(3-deoxyadenosine)is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis,species of the fungal genus Cordyceps.It has traditionally been a prized Chinese folk medicine for the human well-being.However,the actions of cordycepin against renal ischemia/reperfusion injury(/R)are still unknown.In the present study,rats were subject to VR and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal/R injury.The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury.Mechanistic studies showed that cordycepin significantly regulated inflammation,apoptosis,and oxidative stress.These data provide new insights for investigating the natural product with the nephroprotective effect against I/R,which should be developed as a new therapeutic agent for the treatment of I/R in the future. | Feng Han Meng Dou Yuxiang Wang Cuixiang Xu Yang Li Xiaoming Ding Wujun Xue Jin Zheng Puxun Tian Chenguang Ding | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 9 |
| 3 | Dual-channel type tunable field-effect transistors based on vertical bilayer WS2(1−x)Se2x/SnS2 heterostructures显示文摘Layered semiconductor heterostructures are essential elements in modern electronic and optoelectronic devices.Dynamically engineering the composition of these heterostructures may enable the flexible design of the properties of heterostructure-based electronics and optoelectronics as well as their optimization.Here,we report for the first time a two-step chemical vapor deposition approach for a series of WS2(1−x)Se2x/SnS2 vertical heterostructures with high-quality and large areas.The steady-state photoluminescence results exhibit an obvious composition-related quenching ratio,revealing a strong coherence between the band offset and the charge transfer efficiency at the junction interface.Based on the achieved heterostructures,dual-channel backgate field-effect transistors were successfully designed and exhibited typical composition-dependent transport behaviors,and pure n-type unipolar transistors to ambipolar transistors were realized in such systems.The direct vapor growth of these novel vertical WS2(1−x)Se2x/SnS2 heterostructures could offer an interesting system for probing new physical properties and provide a series of layered heterostructures for high-quality devices. | Biyuan Zheng Dong Li Chenguang Zhu Jianyue Lan Xingxia Sun Weihao Zheng Huawei Liu Xuehong Zhang Xiaoli Zhu Yexin Feng Tao Xu Litao Sun Gengzhao Xu Xiao Wang Chao Ma Anlian Pan | 2020 | InfoMat2020，2，4： | 3 |
| 4 | Pediatric cancer surveillance in China:A hospital-based introduction显示文摘Background In recent years,increasing numbers of families have been affected by childhood cancer.According to data from the International Agency for Research on Cancer(IARC)of the World Health Organization,approximately 279000 new cases of cancer were predicted in children and adolescents aged 0–19 years worldwide in 2020.The global incidence of childhood cancer is 10.9 per 100000(global standard rate)and the mortality rate is 4.2 per 100000.1 According to data from the China National Cancer Center,the incidences of cancer in 2017 were 9.9 per 100000 in children aged 0–14 years and 11.5 per 100000 in adolescents aged 15–19 years.2 There are estimated to be approximately 22000 new cases of childhood cancer in China each year,and the incidence of malignant tumors in children aged 0–14 years has increased by 2.5%annually in the past decade. | Zhe Li Rongshou Zheng Xin Xu Yuanhu Liu Chenguang Jia Guoshuang Feng Xiao Zhang Xinping Li Guoliang Bai Xin Ni | 2021 | Pediatric Investigation2021，5，2： | 3 |
| 5 | Effect of Curing Regime on the Distribution of Al^(3+) Coordination in Hardened Cement Pastes显示文摘The effect of curing regime on the distribution of Al3+coordination in hardened cement pastes within 28 d were investigated by29Si and27Al magic angle spinning(MAS) nuclear magnetic resonance(NMR) with deconvolution technique.The results indicate that the tetrahedral coordination Al3+incorporated in C-S-H structure mainly originate from the Al3+incorporated in the alite and belite phases in the Portland cement.The curing regime of constant temperature of 20 ℃ is beneficial to the octahedral coordination Al3+ transforming to tetrahedral coordination Al3+incorporated in C-S-H structure.However,at curing regime of variable temperature,the temperature rising process is more advantageous to the transformation from ettringite to monosulphate,substitution of Al3+for Si4+in the C-S-H structure and the formation of the third aluminate hydrate(TAH) than that at constant temperature of 20 ℃.The high temperature of 60 ℃ in the holding temperature process promotes the decomposition of ettringite,and enhances the consumption of the Al3+ incorporated in C-S-H phases and the Al3+in TAH for the monosulphate forming.The temperature decreasing promotes the transformation from monosulphate to ettringite,and increases the consumption of the Al3+ incorporated in C-S-H phases,and then increases the quantity of the TAH. | 丁庆军 HU Chenguang FENG Xiaoxin HUANG Xiulin | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，5： | 3 |
| 6 | DNA tetrahedron-mediated immune-sandwich assay for rapid and sensitive detection of PSA through a microfluidic electrochemical detection system显示文摘Prostate-specific antigen(PSA)is the most widely used biomarker for the early diagnosis of prostate cancer.Existing methods for PSA detection are burdened with some limitations and require improvement.Herein,we developed a novel microfluidic–electrochemical(μFEC)detection system for PSA detection.First,we constructed an electrochemical biosensor based on screen-printed electrodes(SPEs)with modification of gold nanoflowers(Au NFs)and DNA tetrahedron structural probes(TSPs),which showed great detection performance.Second,we fabricated microfluidic chips by DNA TSP-Au NF-modified SPEs and a PDMS layer with designed dense meandering microchannels.Finally,theμFEC detection system was achieved based on microfluidic chips integrated with the liquid automatic conveying unit and electrochemical detection platform.TheμFEC system we developed acquired great detection performance for PSA detection in PBS solution.For PSA assays in spiked serum samples of theμFEC system,we obtained a linear dynamic range of 1–100 ng/mL with a limit of detection of 0.2 ng/mL and a total reaction time<25 min.Real serum samples of prostate cancer patients presented a strong correlation between the“gold-standard”chemiluminescence assays and theμFEC system.In terms of operation procedure,cost,and reaction time,our method was superior to the current methods for PSA detection and shows great potential for practical clinical application in the future. | Dezhi Feng Jing Su Yi Xu Guifang He Chenguang Wang Xiao Wang Tingrui Pan Xianting Ding Xianqiang Mi | 2021 | Microsystems & Nanoengineering2021，7，2： | 1 |
| 7 | Thermal behavior and kinetics of the pyrolysis of the coal used in the COREX process显示文摘 | Shengfu Zhang Feng Zhu Chenguang Bai Liangying Wen Chong Zou | 2013 | Journal of Analytical and Applied Pyrolysis2013，，： | 1 |
| 8 | Effect of Curing Regime on Polymerization of C-S-H in Hardened Cement Pastes显示文摘The effect of two different curing regimes on the polymerization degree of C-S-H in hardened cement pastes within 28 d were investigated by measuring the chemical environments of 29Si with magic angle spinning (MAS) nuclear magnetic resonance (NMR) and by analyzing the 29Si NMR spectra with deconvolution technique. The experimental results indicate that, at curing regime of constant temperature of 20 ℃, the polymerization of C-S-H increases and then decreases with curing age, and the Al/Si ratio increases gradually with curing age, furthermore, the two non-bridging oxygen bonds of bridging silicate tetrahedra in C-S-H structure mainly bond to H+. At curing regime of variable temperature, the polymerization of C-S-H firstly increases then changes slightly and subsequently decreases with the temperature from low to high and then to low, and the Al/Si ratio firstly increases then keeps invariant and subsequently slightly decreases. Moreover, the temperature decreasing is advantageous for the Ca2+ to be bonded to the bridging silicate tetrahedra and entering into the interlayer of C-S-H structure. The polymerization of C-S-H at curing regime of variable temperature is higher than that cured at constant temperature, but the curing regime of constant temperature is more beneficial to the substitution of Al3 for Si4+ than that of variable temperature. | 丁庆军 HU Chenguang FENG Xiaoxin HUANG Xiulin | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，4： | 1 |
| 9 | Moisture electricity generation:Mechanisms,structures,and applications显示文摘With the increasing concern of energy crisis and global warming,the whole globe is in an urgent need to develop clean energy that comes from renewable sources and does not harm the environment to fulfill the carbon neutralization and green earth commitments.Water is the most abundant substance on earth and has been historically used as the major energy carriers in watermill,water wheel,hydroelectricity.Moisture electricity generation is another emerging technology that can convert lowgrade energy in the widely-accessible moisture to electricity simply by the integration of moisture,electrodes,deliberatelydesigned hygroscopic films.Recent research on moisture electricity generators(MEGs)led to the creation of a series of selfpowered sensors and in some occasions they have replaced conventional batteries to power miniaturized devices.In this review,the basic mechanisms of MEGs are firstly clarified,three categories of them,i.e.,gradient structure,homogeneous structure,and heterogeneous structure depending on the structure of hygroscopic films,are then introduced.Furthermore,recent advances in the fabrication,characteristics,performance of MEGs are summarized,MEGs with continuous or transient output that could be applied in self-powered sensors and power sources are discussed.Finally,some remaining challenges and our perspectives on MEGs are highlighted. | Quanmao Wei Wenna Ge Zichao Yuan Shixu Wang Chenguang Lu Shile Feng Lei Zhao Yahua Liu | 2023 | Nano Research2023，16，5： | 1 |
| 10 | Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection显示文摘The worldwide epidemic of coronavirus disease 2019(COVID-19)is ongoing.Rapid and accurate detection of the causative virus SARSCoV-2 is vital for the treatment and control of COVID-19.In this study,the comparative sensitivity of different respiratory specimen types were retrospectively analyzed using 3,552 clinical samples from 410 COVID-19 patients confirmed by Guangdong CDC(Center for Disease Control and Prevention).Except for bronchoalveolar lavage fluid(BALF),the sputum possessed the highest positive rate(73.4%–87.5%),followed by nasal swabs(53.1%–85.3%)for both severe and mild cases during the first 14 days after illness onset(d.a.o.).Viral RNA could be detected in all BALF samples collected from the severe group within 14 d.a.o.and lasted up to 46 d.a.o.Moreover,although viral RNA was negative in the upper respiratory samples,it was also positive in BALF samples in most cases from the severe group during treatment.Notably,no viral RNA was detected in BALF samples from the mild group.Despite typical ground-glass opacity observed via computed tomographic scans,no viral RNA was detected in the first three or all upper respiratory tract specimens from some COVID-19 patients.In conclusion,sputum is most sensitive for routine laboratory diagnosis of COVID-19,followed by nasal swabs.Detection of viral RNA in BALF improves diagnostic accuracy in severe COVID-19 patients. | Yang Yang Minghui Yang Jing Yuan Fuxiang Wang Zhaoqin Wang Jinxiu Li Mingxia Zhang Jinli Wei Ling Peng Gary Wong Haixia Zheng Weibo Wu Chenguang Shen Mingfeng Liao Kai Feng Jianming Li Qianting Yang Juanjuan Zhao Lei Liu Yingxia Liu | 2020 | The Innovation2020，1，3： | 1 |
| 11 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | Study on Isomerous CAD Model Exchange Based on Feature显示文摘A model-exchange method based on feature between isomerous CAD systems is put forward in this paper.In this method,CAD model information is accessed at both feature and geometry levels and converted according to standard feature opera- tion.The feature information including feature tree,dimensions and constraints,which will be lost in traditional data conver- sion,as well as geometry are converted completely from source CAD system to destination one.So the transferred model can be edit- ed through feature operation,which cannot be implemented by general model-exchange interface. | SHAO Xiaodong CHEN Feng XU Chenguang (School of Mechano-electronic Engineering,Xidian Univ.,Xi’an 710071,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 13 | Mining Unknown Porcine Protein Isoforms by Tissue-based Map of Proteome Enhances Pig Genome Annotation显示文摘A lack of the complete pig proteome has left a gap in our knowledge of the pig genome and has restricted the feasibility of using pigs as a biomedical model.In this study,we developed a tissue-based proteome map using 34 major normal pig tissues.A total of 5841 unknown protein isoforms were identified and systematically characterized,including 2225 novel protein isoforms,669 protein isoforms from 460 genes symbolized beginning with LOC,and 2947 protein isoforms without clear NCBI annotation in the current pig reference genome.These newly identified protein isoforms were functionally annotated through profiling the pig transcriptome with high-throughput RNA sequencing of the same pig tissues,further improving the genome annotation of the corresponding protein-coding genes.Combining the well-annotated genes that have parallel expression pattern and subcellular witness,we predicted the tissue-related subcellular locations and potential functions for these unknown proteins.Finally,we mined 3081 orthologous genes for 52.7% of unknown protein isoforms across multiple species,referring to 68 KEGG pathways as well as 23 disease signaling pathways.These findings provide valuable insights and a rich resource for enhancing studies of pig genomics and biology,as well as biomedical model application to human medicine. | Pengju Zhao Xianrui Zheng Ying Yu Zhuocheng Hou Chenguang Diao Haifei Wang Huimin Kang Chao Ning Junhui Li Wen Feng Wen Wang George ELiu Bugao Li Jacqueline Smith Yangzom Chamba Jian-Feng Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 0 |
| 14 | Monsoon boosted radiation of the endemic East Asian carps显示文摘Major historical events often trigger the rapid flourishing of a few lineages,which in turn shape established biodiversity patterns.How did this process occur and develop?This study provides a window into this issue.The endemic East Asian carps(EEAC)dominated the ichthyofauna of East Asia and exhibited a high degree of adaptation to monsoonal river-lake ecosystems.A series of evidence,including ecogeography,phylogenetics,and macroevolution,suggests that the EEAC is a lineage that arose with the East Asian monsoon and thrived intimately with subsequent monsoon activities.We further deduce the evolution of the EEAC and find that a range of historical events in the monsoon setting(e.g.,marine transgression and regression and glacial-interglacial cycle)have further reshaped the distribution patterns of EEAC’s members.Comparative genomics analyses reveal that introgressions during the initial period of EEAC radiation and innovations in the regulation of the brain and nervous system may have aided their adaptation to river-lake ecosystems in a monsoon setting,which boosted radiation.Overall,this study strengthens knowledge of the evolutionary patterns of freshwater fishes in East Asia and provides a model case for understanding the impact of major historical events on the evolution of biota. | Chenguang Feng Kun Wang Wenjie Xu Liandong Yang Kunyuan Wanghe Ning Sun Baosheng Wu Feixiang Wu Lei Yang Qiang Qiu Xiaoni Gan Yiyu Chen Shunping He | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 15 | Enhanced monopole transition strength from the cluster decay of ^(13)C显示文摘The inelastic excitations and cluster decay of ^(13)C have been measured using the reaction,9Be(^(13)C, ^(13)C* →~9Be + α)~9Be. We observe strong excitation to the 14.3-MeV(1/2-) resonant state from the cluster-decay channel, leading to an enhanced monopole matrix element of(6.3 ± 0.6) fm^2. This large cluster-related monopole strength is a clear indication of the cluster-structure domination of this state and is consistent with the recent prediction of the orthogonality condition model(OCM). It would be interesting to further explore the three-center molecular rotational band that is initiated from the observed band-head. | Jun Feng YanLin Ye Biao Yang ChengJian Lin HuiMin Jia DanYang Pang ZhiHuan Li JianLing Lou QiTe Li XiaoFei Yang Jing Li HongLiang Zang Qiang Liu Wei Jiang ChenGuang Li Yang Liu ZhiQiang Chen HongYi Wu ChunGuang Wang Wei Liu Xiang Wang JingJing Li DiWen Luo Ying Jiang ShiWei Bai JinYan Xu NanRu Ma LiJie Sun DongXi Wang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 0 |
| 16 | Mother&son volunteer together in museum显示文摘A mother and son have been serving as daily volunteer guides at the Panlongcheng Museum during the past Spring Festival,winning unanimous praise from visitors. | Yang Feng Ai Chenguang | 2022 | Changjiang Weekly2022，，6： | 0 |
| 17 | Sympatric or micro-allopatric speciation in a glacial lake?Genomic islands support neither显示文摘Apparent cases of sympatric speciation may actually be due to micro-allopatric or micro-parapatric speciation.One way to distinguish between these models is to examine the existence and nature of genomic islands of divergence,wherein divergent DNA segments are interspersed with low-divergence segments.Such islands should be rare or absent under micro-allopatric speciation but common in cases of speciation with gene flow.Sympatric divergence of endemic fishes is known from isolated saline,crater,postglacial,and ancient lakes.Two morphologically distinct cyprinid fishes,Gymnocypris eckloni scoliostomus(GS)and G.eckloni eckloni(GE),in a small glacial lake on the Qinghai-Tibet Plateau,Lake Sunmcuo,match the biogeographic criteria of sympatric speciation.In this study,we examined genome-wide variation in 46individuals from these two groups.The divergence time between the GS and GE lineages was estimated to be 20-60 Kya.We identified 54 large genomic islands(≥100 kb)of speciation,which accounted for 89.4%of the total length of all genomic islands.These islands harboured divergent genes related to olfactory receptors and olfaction signals that may play important roles in food selection and assortative mating in fishes.Although the genomic islands clearly indicated speciation with gene flow and rejected micro-allopatric speciation,they were too large to support the hypothesis of sympatric speciation.Theoretical and recent empirical studies suggested that continual gene flow in sympatry should give rise to many small genomic islands(as small as a few kilobases in size).Thus,the observed pattern is consistent with the extensive evidence on parapatric speciation,in which adjacent habitats facilitate divergent selection but also permit gene flow during speciation.We suggest that many,if not most,of the reported cases of sympatric speciation are likely to be micro-parapatric speciation. | Ning Sun Liandong Yang Fei Tian Honghui Zeng Ziwen He Kai Zhao Cheng Wang Minghui Meng Chenguang Feng Chengchi Fang Wenqi Lv Jing Bo Yongtao Tang Xiaoni Gan Zuogang Peng Yiyu Chen Shunping He | 2022 | National Science Review2022，9，12： | 0 |
| 18 | β-decay study of neutron-rich nucleus ^(34)Al显示文摘The'island of inversion'has been known for over a quarter century,since Warburton et al.[1]proposed that nuclei with intruder ground states would constitute a 3×3 square with Z=10-12,N=20-22 in 1990.Uncovering the underlying inversion mechanism and exploring the scope of the island have attracted significant theoretical and experimental efforts in the following years.Now it is well known that the reduction of N=20 shell gap,which is likely caused by the | Rui Han XiangQing Li WeiGuang Jiang ZhiHuan Li Hui Hua ShuangQuan Zhang CenXi Yuan DongXing Jiang YanLin Ye Jing Li ZongHao Li FuRong Xu QiBo Chen Jie Meng JianSong Wang Chuan Xu YeLei Sun ChunGuang Wang HongYi Wu ChenYang Niu ChenGuang Li Chao He Wei Jiang PengJie Li HongLiang Zang Jun Feng SiDong Chen Qiang Liu XiaoChi Chen HuShan Xu ZhengGuo Hu YanYun Yang Peng Ma JunBing Ma ShiLun Jin Zhen Bai MeiRong Huang Yuan Jie Zhou WeiHu Ma Yong Li XiaoHong Zhou YuHu Zhang GuoQing Xiao WenLong Zhan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 0 |
| 19 | Adaptive dynamic surface control for quadrotor-slung load transportation system with uncertainties显示文摘Quadrotors play a significant role in our lives and are transforming our lives.Transporting cable-suspended loads is an unavoidable quadrotor application trend and a hot research topic in the control field.Nonetheless,the load swing and unpredictability pose significant challenges to the quadrotor's stability.In this paper,an anti-swing controller with an inner-outer control strategy for the quadrotor-slung load transportation system is presented.To facilitate the controller design,the outer position dynamics are restructured in the form of cascades.Then,a virtual controller is created to force the underactuated states to the dynamic surface to ensure the position subsystem's stability.To improve robustness,an adaptive law is used to eliminate the effects of uncertain cable length.Lastly,a dynamic surface controller for the inner attitude subsystem is presented to drive the actual force to the virtual force.It is demonstrated that the control strategy can stabilize the quadrotor despite mass and cable length uncertainties.Comparative results are provided to demonstrate the efficacy and durability of the proposed method. | DING Feng HUANG Jian SUN Chong AI Yong XU WenXia YANG ChenGuang | 2023 | Science China(Technological Sciences)2023，66，10： | 0 |
| 20 | Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts显示文摘Although most fishes are ectothermic,some,including tuna and billfish,achieve endothermy through specialized heat producing tissues that are modified muscles.How these heat producing tissues evolved,and whether they share convergent molecular mechanisms,remain unresolved.Here,we generated a high-quality genome from the mackerel tuna(Euthynnus affinis)and investigated the heat producing tissues of this fish by single-nucleus and bulk RNA sequencing.Compared with other teleosts,tuna-specific genetic variation is strongly associated with muscle differentiation.Single-nucleus RNA-seq revealed a high proportion of specific slow skeletal muscle cell subtypes in the heat producing tissues of tuna.Marker genes of this cell subtype are associated with the relative sliding of actin and myosin,suggesting that tuna endothermy is mainly based on shivering thermogenesis.In contrast,cross-species transcriptome analysis indicated that endothermy in billfish relies mainly on nonshivering thermogenesis.Nevertheless,the heat producing tissues of the different species do share some tissue-specific genes,including vascular-related and mitochondrial genes.Overall,although tunas and billfishes differ in their thermogenic strategies,they share similar expression patterns in some respects,highlighting the complexity of convergent evolution. | Baosheng Wu Xueli Gao Mingling Hu Jing Hu Tianming Lan Tingfeng Xue Wenjie Xu Chenglong Zhu Yuan Yuan Jiangmin Zheng Tao Qin Peidong Xin Ye Li Li Gong Chenguang Feng Shunping He Huan Liu Haimeng Li Qing Wang Zhenhua Ma Qiang Qiu Kun Wang | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
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